58 research outputs found

    British Activist Authors Addressing Children of Colour

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    Exploring a history of activists writing for and about children of colour from abolition to Black Lives Matter, this open access book examines issues such as the space given to people of colour by white activists; the voice, agency and intersectionality in activist writing for young people; how writers used activism to expand definitions of Britishness for child readers; and how activism and writing about it has changed in the 21st century. From abolitionists and anti-colonialists such as Amelia Opie, Una Marson and Rabindranath Tagore; communist and feminist activists concerned with broader children’s rights including Chris Searle and Rosemary Stones; to Black Panthers and contemporary advocates for people of colour from Farrukh Dhondy to Len Garrison, Catherine Johnson and Corinne Fowler, Karen Sands-O’Connor traces how these activists translated their values for children of colour. Beginning with historical events that sparked activism and the first cultural products for children and continuing to contemporary activism in the wake of the Windrush Scandal, this book analyses the choices, struggles and successes of writers of activist literature as they tried to change Britain and British literature to make it a welcoming place for all child readers

    Cost-effectiveness of screening tools for identifying depression in early pregnancy: a decision tree model

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    Background: Although the effectiveness of screening tools for detecting depression in pregnancy has been investigated, there is limited evidence on the cost-effectiveness. This is vital in providing full information to decision makers. This study aimed to explore the cost-effectiveness of different screening tools to identify depression in early pregnancy compared to no screening. Methods: A decision tree was developed to model the identification and treatment pathways of depression from the first antenatal appointment to 3-months postpartum using the Whooley questions, the Edinburgh Postnatal Depression Scale (EPDS) and the Whooley questions followed by the EPDS, compared to no screening. The economic evaluation took an NHS and Personal Social Services perspective. Model parameters were taken from a combination of sources including a cross-sectional survey investigating the diagnostic accuracy of screening tools, and other published literature. Cost-effectiveness was assessed in terms of the incremental cost per quality adjusted life years (QALYs). Cost-effectiveness planes and cost-effectiveness acceptability curves were produced using a net-benefit approach based on Monte Carlo simulations of cost-outcome data. Results: In a 4-way comparison, the Whooley, EPDS and Whooley followed by the EPDS each had a similar probability of being cost-effective at around 30% for willingness to pay values from £20,000–30,000 per QALY compared to around 20% for the no screen option. Conclusions: All three screening approaches tested had a higher probability of being cost-effective than the no-screen option. In the absence of a clear cost-effectiveness advantage for any one of the three screening options, the choice between the screening approaches could be made on other grounds, such as clinical burden of the screening options. Limitations include data availability and short time horizon, thus further research is needed

    The lure of postwar London:networks of people, print and organisations

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    'Vernacular Voices: Black British Poetry'

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    ABSTRACT Black British poetry is the province of experimenting with voice and recording rhythms beyond the iambic pentameter. Not only in performance poetry and through the spoken word, but also on the page, black British poetry constitutes and preserves a sound archive of distinct linguistic varieties. In Slave Song (1984) and Coolie Odyssey (1988), David Dabydeen employs a form of Guyanese Creole in order to linguistically render and thus commemorate the experience of slaves and indentured labourers, respectively, with the earlier collection providing annotated translations into Standard English. James Berry, Louise Bennett, and Valerie Bloom adapt Jamaican Patois to celebrate Jamaican folk culture and at times to represent and record experiences and linguistic interactions in the postcolonial metropolis. Grace Nichols and John Agard use modified forms of Guyanese Creole, with Nichols frequently constructing gendered voices whilst Agard often celebrates linguistic playfulness. The borders between linguistic varieties are by no means absolute or static, as the emergence and marked growth of ‘London Jamaican’ (Mark Sebba) indicates. Asian British writer Daljit Nagra takes liberties with English for different reasons. Rather than having recourse to established Creole languages, and blending them with Standard English, his heteroglot poems frequently emulate ‘Punglish’, the English of migrants whose first language is Punjabi. Whilst it is the language prestige of London Jamaican that has been significantly enhanced since the 1990s, a fact not only confirmed by linguistic research but also by its transethnic uses both in the streets and on the page, Nagra’s substantial success and the mainstream attention he receives also indicate the clout of vernacular voices in poetry. They have the potential to connect with oral traditions and cultural memories, to record linguistic varieties, and to endow ‘street cred’ to authors and texts. In this chapter, these double-voiced poetic languages are also read as signs of resistance against residual monologic ideologies of Englishness. © Book proposal (02/2016): The Cambridge History of Black and Asian British Writing p. 27 of 4

    “Education Is a Cultural Weapon”: The Inner London Education Authority and the Politics of Literature for Young People

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    The Inner London Education Authority (ILEA) was founded in 1965 to manage education in London’s inner boroughs; by the early 1970s, it was held up as one of the most progressive education experiments in British history. One of the marks of this progressiveness was its attention to London’s Black child population and its attempts to connect with Black culture through multiculturalism. However, while the ILEA prided itself on its anti-racist, multicultural education methods, its publication arm often provided mixed messages about the value and place of Black students in the education system and society. Multiculturalism, which the ILEA used to guide the production of reading materials, often resulted in a lack of cultural specificity and an avoidance of issues facing Black students, such as racism. Partnering with Black educators allowed the ILEA to offer more culturally specific and anti-racist material, but doing so also brought the ILEA to the attention of critical governmental authorities, who would eventually disband the ILEA out of fear of Black radicalism

    Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease

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    Mucopolysaccharidosis type IIIA is a neurodegenerative lysosomal storage disorder characterized by progressive loss of learned skills, sleep disturbance and behavioural problems. Absent or greatly reduced activity of sulphamidase, a lysosomal protein, results in intracellular accumulation of heparan sulphate. Subsequent neuroinflammation and neurodegeneration typify this and many other lysosomal storage disorders. We propose that intra-cerebrospinal fluid protein delivery represents a potential therapeutic avenue for treatment of this and other neurodegenerative conditions; however, technical restraints restrict examination of its use prior to adulthood in mice. We have used a naturally-occurring Mucopolysaccharidosis type IIIA mouse model to determine the effectiveness of combining intravenous protein replacement (1 mg/kg) from birth to 6 weeks of age with intra-cerebrospinal fluid sulphamidase delivery (100 μg, fortnightly from 6 weeks) on behaviour, the level of heparan sulphate-oligosaccharide storage and other neuropathology. Mice receiving combination treatment exhibited similar clinical improvement and reduction in heparan sulphate storage to those only receiving intra-cerebrospinal fluid enzyme. Reductions in micro- and astrogliosis and delayed development of ubiquitin-positive lesions were seen in both groups. A third group of intravenous-only treated mice did not exhibit clinical or neuropathological improvements. Intra-cerebrospinal fluid injection of sulphamidase effectively, but dose-dependently, treats neurological pathology in Mucopolysaccharidosis type IIIA, even when treatment begins in mice with established disease.Kim M. Hemsley, Amanda J. Luck, Allison C. Crawley, Sofia Hassiotis, Helen Beard, Barbara King, Tomas Rozek, Tina Rozaklis, Maria Fuller and John J. Hopwoo
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