El acontecer de la revelación. Estudio de una experiencia personal de Dios

Licenciado (a) en TeologíaPregrad

Acompañamiento pedagógico y desempeño docente de una Institución Educativa, Ica - 2018

La presente investigación tuvo como propósito determinar la relación del acompañamiento pedagógico con el desempeño docente del personal docente de la Institución Educativa San Luís Gonzaga del distrito de Ica durante el año escolar 2018. La investigación basó su estudio desde una perspectiva cuantitativa y de diseño descriptivo - correlacional. Se contó con una población de 78 docentes seleccionados a través del muestreo no probabilístico. Se utilizaron como instrumentos de recolección de datos un “Cuestionario de acompañamiento pedagógico” y una “ficha de evaluación de desempeño docente” debidamente validados y sometidos a criterios de confiabilidad. Los datos fueron procesados utilizando la estadística descriptiva e inferencial. Como resultados, la investigación da cuenta que existe relación significativa entre el acompañamiento pedagógico y el desempeño docente, situación que fue comprobada vía la utilización de la prueba Rho de Spearman. Se infiere que el acompañamiento pedagógico y desempeño docente son variables trascendentales para la conducción de un adecuado proceso educativo

Mutanome and expression of immune response genes in microsatellite stable colon cancer

The aim of this study was to analyze the impact of the mutanome in the prognosis of microsatellite stable stage II CRC tumors. The exome of 42 stage II, microsatellite stable, colon tumors (21 of them relapse) and their paired mucosa were sequenced and analyzed. Although some pathways accumulated more mutations in patients exhibiting good or poor prognosis, no single somatic mutation was associated with prognosis. Exome sequencing data is also valuable to infer tumor neoantigens able to elicit a host immune response. Hence, putative neoantigens were identified by combining information about missense mutations in each tumor and HLAs genotypes of the patients. Under the hypothesis that neoantigens should be correctly presented in order to activate the immune response, expression levels of genes involved in the antigen presentation machinery were also assessed. In addition, CD8A level (as a marker of T-cell infiltration) was measured. We found that tumors with better prognosis showed a tendency to generate a higher number of immunogenic epitopes, and up-regulated genes involved in the antigen processing machinery. Moreover, tumors with higher T-cell infiltration also showed better prognosis. Stratifying by consensus molecular subtype, CMS4 tumors showed the highest association of expression levels of genes involved in the antigen presentation machinery with prognosis. Thus, we hypothesize that a subset of stage II microsatellite stable CRC tumors are able to generate an immune response in the host via MHC class I antigen presentation, directly related with a better prognosis

La fertilidad del suelo afecta el crecimiento, nutrición y rendimiento de algodón cultivado en dos sistemas de riego y diferentes dosis de nitrógeno

La fertilidad intrínseca del suelo y la forma de riego podrían afectar la eficiencia de la fertilización con nitrógeno (N), modificar la meta de rendimiento, el crecimiento y el estado nutrimental de los cultivos. Se realizó un estudio con el objetivo de conocer el rendimiento, crecimiento, eficiencia en el uso del agua (EUA), eficiencia agronómica del N (EAN), además de medir la concentración de NO3- en el extracto celular de peciolo (ECP) y el índice de clorofila (SPAD) en el cultivo de algodón por efecto de diferentes dosis de N y dos formas de aplicar el riego. El estudio consistió en dos experimentos establecidos en suelos considerados de alta fertilidad [˃13.0 g kg-1 materia orgánica (MO) y N-NO3- ˃ 30 mg kg-1], variando la dosis de fertilización nitrogenada en cada uno de ellos: a) riego rodado (FRR; 11 y 220 kg N ha-1) y b) riego por goteo (FRG; 11 a 440 kg N ha-1). La altura y número de nudos en las plantas no se afectaron por los tratamientos aplicados. Los valores encontrados en el SPAD y la concentración de NO3- en ECP se relacionaron en forma cúbica con el rendimiento del cultivo. El mayor rendimiento y la EUA se obtuvo en el experimento manejado con riego goteo. En el experimento FRR no se encontró respuesta a los tratamientos de fertilización nitrogenada. En el experimento FRG la aplicación de 440 kg N ha-1, redujo en un 43% el rendimiento en comparación con el resto de las dosis evaluadas. La EAN fue estadísticamente mayor (P < 0.001) en los tratamientos fertilizados con 11 kg N ha-1. La disminuida respuesta en rendimiento en el cultivo de algodón debido a la aplicación de N fue atribuida a las altas concentraciones de N-NO3- y MO que estuvo presente en los suelos en donde se realizaron los experimentos

Colon cancer therapy with calcium phosphate nanoparticles loading bioactive compounds from Euphorbia lathyris: In vitro and in vivo assay

Amorphous calcium phosphate nanoparticles (ACP NPs) exhibit excellent biocompatibility and biodegradability properties. ACP NPs were functionalized with two coumarin compounds (esculetin and euphorbetin) extracted from Euphorbia lathyris seeds (BC-ACP NPs) showing high loading capacity (0.03% and 0.34% (w/w) for esculetin and euphorbetin, respectively) and adsorption efficiency (2.6% and 33.5%, respectively). BC-ACP NPs, no toxic to human blood cells, showed a more selective cytotoxicity against colorectal cancer (CRC) cells (T-84 cells) (IC50, 71.42 μg/ml) compared to non-tumor (CCD18) cells (IC50, 420.77 μg/ml). Both, the inhibition of carbonic anhydrase and autophagic cell death appeared to be involved in their action mechanism. Interestingly, in vivo treatment with BC-ACPs NPs using two different models of CRC induction showed a significant reduction in tumor volume (62%) and a significant decrease in the number and size of polyps. A poor development of tumor vasculature and invasion of normal tissue were also observed. Moreover, treatment increased the bacterial population of Akkermansia by restoring antioxidant systems in the colonic mucosa of mice. These results show a promising pathway to design innovative and more efficient therapies against CRC based on biomimetic calcium phosphate NPs loaded with natural products.Spanish GovernmentEuropean Commission PTQ-17-09172 RTC-2017-6540-1 RTI2018-100934-B-I00 RTC2019-006870-1 RYC2016-21042Junta de Andalucia FEDER program P18-TP-1420 A-CTS666-UGR20 B-CTS-122-UGR20 P18-HO-3882 P18-TP-0969Andalusian Government AGR145 FQM-368 CTS-10

The neglected role of LITHOlogy in the response of Mediterranean FORest ecosystems to climate change: rationale and endorsing results from project LITHOFOR

XV Congreso Nacional de la AEET (El valor ,de la Naturaleza para una sociedad global), 18-21 de octubre, Plasencia, Cáceres.One of the main concerns of ecologists is to understand which factors (biogeographical, physiographical, disturbance, etc.) control ecosystem structure and function. It is surprising that lithology has rarely been considered despite its potential cascading effects on resource availability and ecological conditions. The project LITHOFOR aims to shed light on the role of lithology in forest ecosystem responses to climate change by focusing on pine (Pinus pinaster), Andalusian-fir (Abies pinsapo) and cork-oak (Quercus suber) forests across the unique natural laboratory representedby the Baetic and Rif ranges (S. Spain- N.-Morocco). In the western Mediterranean-Alborán region, climate conditions shift from hyperhumid to semiarid in scarcely a hundred kilometers along West to East longitudinal gradients, and its world-wide renowned geotectonic and lithological complexity allows for abundant forest stands across contrasting lithological contacts. The project is a coordinated multidisciplinary effort of forest ecologists, plant physiologists, geologists, soil scientists, biodiversity researchers and modelers to compare forest structure and functio n among three contrasting lithologies (carbonated, metapelites and ultramafic rocks). Results illustrate that lithological types influence the shape and intensity of patterns along climatic gradients (and in respo nse to drought) for variables as stand structure, tree growth, foliar and root functional traits, litter decomposition and nutrient cycling, and bi ological communities composition (plants, soil nematodes and microbes). This advocates that litho/edaphological factors deserve greater attention

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Bose-Einstein correlations of charged hadrons in proton-proton collisions at s\sqrt s = 13 TeV

Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s}$ = 7 TeV, as well as with theoretical predictions.[graphic not available: see fulltext]Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at $\sqrt{s} =$ 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at $\sqrt{s} =$ 7 TeV, as well as with theoretical predictions