Redução do uso da Cannabis Sativa nas pessoas com deficiência motora em treino de basquete em cadeiras de rodas: ensaio clinico randomizado

Introdução: as pessoas com deficiências têm anormalidade de estrutura ou função anatômica, fisiológica ou psicológica. Sendo que nas lesões crônicas e deficiências permanentes aumenta as taxas de prevalência de alterações mentais ou comportamentais. O uso de cannabis sativa nos esportes tornou-se questão polêmica proeminente e debatida pelas autoridades governamentais e por movimentos esportivos que lutam contra o doping no esporte. Objetivos: analisar o uso de Cannabis Sativa  e aspectos saúde no Treino de Basquete em Cadeiras de Rodas (BCR) das Pessoas com Deficiência Motora (PCD-M). Métodos: estudo experimental tipo ensaio clínico randomizado. A amostra foi triada da população do sexo masculino PCD-M, em  idade igual e superior a 18 anos até 55 anos, residentes na Baixada Cuiabana-MT, Brasil, sendo  recrutadas por sorteio (n=100), e randomizadas para avaliação (n=48), alocados em dois braços sendo experimental (GE n=21) e controle (GC n=27).  A coleta foi realizada por entrevista estruturada e avaliação clínica incluindo os aspectos sociodemográficos, hábitos de estilo de vida, autorrelatos de álcool e drogas. O treino de basquete foi feito duas vezes da semana às 2º e 4º feiras das 19h as 21h com @ 2 horas de tempo de duração. Para análise de dados foi utilizada a teste quiquadrado e cálculo estimativo do efeito da intervenção, com significância em p<0.05 e 95% de intervalo e confiança. Resultados: A idade média foi de 35 (±8,8) anos.  O tempo de prevalência das deficiências por etiologia Poliomielite foram superiores a 20 anos.  Foram encontrados eventos de aspecto mental e comportamental com uso (Cannabis sativa, 25%); alterações no aspecto físico (úlcera de pressão=21%, infecção de urina=40%); previdência social pública (zero auxílio percapita, 10%). Houve  melhora e o Número Necessário para Tratamento com Ulcera Pressão (NTT 3,0 e p=0.03); e redução de usuários de Cannabis Sativa (NNT= 5,50 e p=0.02) neste ensaio clínico. Conclusão:  houve melhora dos aspectos da clínica pós intervenção no GE denotando redução do uso de Cannabis Sativa melhora da condição de saúde na PCD-M. Então, as técnicas de preleção com motivação de equipe, dinâmicas de grupo, a compreensão das regras antidoping nos campeonato de BCR corroborou no equilíbrio do comportamento mental reduzindo consumo de Cannabis Sativa. Assim programas de esportes coletivos para PCD-M podem contribuir no tratamento redução de consumo de Cannabis Sativa e ser estratégia de equilíbrio comportamental e de ressignificação da vida

Role of the ecto-nucleotidases in the cooperative effect of adenosine and neuropeptide-S on locomotor activity in mice.

Abstract Activation of adenosine receptors modifies the action of classic neurotransmitters (i.e. dopamine, glutamate and acetylcholine) and other neuromodulators, like vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and neuropeptide S (NPS). Similarly to adenosine, NPS is involved in the regulation of stimulus and response to fear and arousal. Thus, the present study investigates the effects of NPS on locomotor activity in mice treated with or without α,β-methylene adenosine 5′-diphosphate (AOPCP), the inhibitor of ecto-5′-nucleotidase. Additionally, we evaluate the activity of ecto-5′-nucleotidase in brain slices of mice treated with or without NPS. Male adult CF-1 mice received i.c.v. NPS as 0.1 nmol injection with or without pre-treatment with 1 nmol α,β-methylene adenosine 5′-diphosphate (AOPCP), the selective inhibitor of ecto-5′-nucleotidase, to evaluate locomotor activity. In another set of experiments, mice received i.c.v. infusion of 0.1 nmol NPS to assay enzymatic activity in brain slices. The results demonstrated that the pre-treatment with AOPCP, which was inactive per se, prevented NPS-induced hyperlocomotion in mice. The dose of 0.1 nmol NPS was efficient to induce hyperlocomotion in animals during the observation period in the activity cage. Regarding enzymatic activity, i.c.v. NPS injection did not induce any significant alterations in ATP and AMP hydrolysis in striatum and hippocampus brain slices of mice. The present study shows that the hyperlocomotor effect of NPS depends on the ecto-5′-nucleotidase activity

Oral Angiotensin-(1–7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet

AbstractObesity is characterized by a pro-inflammatory state commonly associated with type 2 diabetes and fat-liver disease. In the last few years, different studies pointed out the role of Angiotensin (Ang)-(1–7) in the metabolic regulation. The aim of the present study was to evaluate the effect of oral-administration of Ang-(1–7) in metabolism and inflammatory state of high-fat feed rats. Twenty-four male Sprague Dawley rats were randomized into three groups: High Fat Diet (HFD); Standard Diet (ST); High Fat Diet+Angiotensin-(1–7) [HFD+Ang-(1–7)]. Glycemic profile was evaluated by glucose tolerance and insulin sensitivity tests, plasmatic glucose and insulin. Cholesterol, HDL and triglycerides analyses presented lipidic profile. RT-PCR evaluated mRNA expression to ACE, ACE2, resistin, TLR4, IL-6, TNF-α and NF-κB genes. The main results showed that oral Ang-(1–7) decreased body weight and abdominal fat-mass. In addition, HFD+Ang-(1–7) treated rats presented enhanced glucose tolerance, insulin-sensitivity and decreased plasma-insulin levels, as well as a significant decrease in circulating lipid levels. These alterations were accompanied by a marked decreased expression of resistin, TLR4, ACE and increased ACE2 expression in liver. Furthermore, Ang-(1–7) decreases phosphorylation of MAPK and increases NF-κB expression. These alterations diminished expression of interleukin-6 and TNF-α, ameliorate inflammatory state in liver. In summary, the present study showed that oral-treatment with Ang-(1–7) in high-fat feed rats improved metabolism down-regulating resistin/TLR4/NF-κB-pathway

Quantitative methods and analysis of health performance and environmental conditions in the city of Porto Velho: 6 years after the hydroelectric dams of Jirau and Santo Antônio, on the Madeira River

Objective: to analyze the IQVU of the city of Porto Velho, Rondônia, Brazil, in a perspective of quality of life from the construction of the UHEs on the Madeira River. Methods: the model developed by Paraguassú-Chaves et al [3] was used to analyze the performance index in health and environmental conditions. 552 forms and interviews were applied, which contributed to the collection of primary data in the sample survey in the 69 neighborhoods grouped by the four urban areas of Porto Velho, involving 8 households per neighborhood. The data were submitted to Factor Analysis to calculate the quality of life indexes. In the analysis phase, the IQVU model of the Hair et al classification index scale [4] was used. Results: After 6 years, the quality of life indexes found in this research are similar to those found previously. Central Zone IQVU (0.456) Regular, East Zone IQVU (0.406), North Zone IQVU (0.428) and South Zone IQVU (0.393), with the average IQVU (0.420) of the city of Porto Velho. Conclusions: there was a significant drop in the quality of life index with the construction of the Jirau and Santo Antônio hydroelectric dams on the Madeira River, in Porto Velho. The city\u27s quality of urban life index, which had already suffered a negative impact during the construction of the dams and 1 year later, worsened six years later

DOENÇA DE HIRSCHSPRUNG: UM RELATO DE CASO

Objetivo: Relatar um caso de doença de Hirschsprung em um paciente de 23 anos, diagnosticado na Santa Casa de Misericórdia de Anápolis, Goiás. Descrição do caso: Paciente do sexo feminino, 23 anos, com história de distensão abdominal, parada de eliminação de fezes. Constipação intestinal desde o nascimento, com necessidade de uso de laxantes orais para evacuação. Biópsia retal evidenciou a ausência de células ganglionares, além de hiperplasia de filetes nervosos e discreta hipertrofia de muscular própria, confirmando uma forma ultra-curta de aganglionose. Considerações finais: Torna-se evidente a importância em saber reconhecer os sinais e sintomas desta doença o que permite, assim, o diagnóstico precoce da doença de Hirschsprung de forma a trazer uma melhora na qualidade de vida do paciente

Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil

Chagas disease is caused by a parasitic protozoan transmitted to humans by the contaminated feces of blood-feeding assassin bugs from the Triatominae subfamily. It may also be transmitted from mother to baby during pregnancy, by breastfeeding, blood transfusion or organ transplant. In rare cases, the disease can also be caused by accidental ingestion of contaminated food (sugar cane or açaí juice, drinking water, etc.). Acute Chagas disease often presents itself as a mononucleosis-like syndrome, with symptoms including fever, lymph node enlargement and muscle pain. The mortality rate of acute Chagas disease is high, mainly due to heart failure as a consequence of cardiac fiber lesions. There are few studies describing clinical outcomes and the disease progression of patients who receive therapeutic treatment, especially with regard to cardiac exam findings. In this report, the authors describe clinical findings from two micro-outbreaks occurring in impoverished towns in northeastern Brazil. Prior to receiving treatment, patient mortality rate was 28.6% in one of the outbreaks, and one pregnant woman experienced a spontaneous abortion due to the disease in the other outbreak. Most patients complained of fever, dyspnea, myalgia and periorbital edema. After receiving a two-month course of treatment, clinical symptoms improved and the number of abnormalities in cardiac exams decreased

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured