475 research outputs found
Neutral H density at the termination shock: a consolidation of recent results
We discuss a consolidation of determinations of the density of neutral
interstellar H at the nose of the termination shock carried out with the use of
various data sets, techniques, and modeling approaches. In particular, we focus
on the determination of this density based on observations of H pickup ions on
Ulysses during its aphelion passage through the ecliptic plane. We discuss in
greater detail a novel method of determination of the density from these
measurements and review the results from its application to actual data. The H
density at TS derived from this analysis is equal to 0.087 \pm 0.022 cm-3, and
when all relevant determinations are taken into account, the consolidated
density is obtained at 0.09 \pm 0.022 cm-3. The density of H in CHISM based on
literature values of filtration factor is then calculated at 0.16 \pm 0.04
cm-3.Comment: Submitted to Space Science Review
Identifying a gender-inclusive pedagogy from Maltese science teachers' personal practical knowledge
Teachers bring with them into the science classrooms their own gendered identitities and their views and perceptions about how boys and girls learn and achieve in science. This paper tries to explore the way in which fourteen Maltese science teachers use their own 'personal practical knowledge' to identify their views about gender and science and create their own individual gender-inclusive pedagogy. The study suggests that the science teachers focus more on the individuality of students and on the social and cultural background of the students in their classrooms rather than on gender. The teachers try to develop pedagogies and assessment practices which take into consideration the personal constructs of individual learners. The ideas for such a gender-inclusive pedagogy emerge from their common-sense experience in the classroom, their training as teachers and are closely interrelated to current ideas of social constructivism
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder associated with severe and medically refractory early-life epilepsy, motor, cognitive, visual, and autonomic disturbances in the absence of any structural brain pathology. Analysis of genetic variants in CDD has indicated that CDKL5 kinase function is central to disease pathology. CDKL5 encodes a serine-threonine kinase with significant homology to GSK3β, which has also been linked to synaptic function. Further, Cdkl5 knock-out rodents have increased GSK3β activity and often increased long-term potentiation (LTP). Thus, development of a specific CDKL5 inhibitor must be careful to exclude cross-talk with GSK3β activity. We synthesized and characterized specific, high-affinity inhibitors of CDKL5 that do not have detectable activity for GSK3β. These compounds are very soluble in water but blood-brain barrier penetration is low. In rat hippocampal brain slices, acute inhibition of CDKL5 selectively reduces postsynaptic function of AMPA-type glutamate receptors in a dose-dependent manner. Acute inhibition of CDKL5 reduces hippocampal LTP. These studies provide new tools and insights into the role of CDKL5 as a newly appreciated key kinase necessary for synaptic plasticity. Comparisons to rodent knock-out studies suggest that compensatory changes have limited the understanding of the roles of CDKL5 in synaptic physiology, plasticity, and human neuropathology
Compatibilidade entre a inoculação de rizóbios e fungicidas aplicados em sementes de feijoeiro-comum
Fontes de informação sobre nutrição e saúde utilizadas por estudantes de uma universidade privada de São Paulo
Solar parameters for modeling interplanetary background
The goal of the Fully Online Datacenter of Ultraviolet Emissions (FONDUE)
Working Team of the International Space Science Institute in Bern, Switzerland,
was to establish a common calibration of various UV and EUV heliospheric
observations, both spectroscopic and photometric. Realization of this goal
required an up-to-date model of spatial distribution of neutral interstellar
hydrogen in the heliosphere, and to that end, a credible model of the radiation
pressure and ionization processes was needed. This chapter describes the solar
factors shaping the distribution of neutral interstellar H in the heliosphere.
Presented are the solar Lyman-alpha flux and the solar Lyman-alpha resonant
radiation pressure force acting on neutral H atoms in the heliosphere, solar
EUV radiation and the photoionization of heliospheric hydrogen, and their
evolution in time and the still hypothetical variation with heliolatitude.
Further, solar wind and its evolution with solar activity is presented in the
context of the charge exchange ionization of heliospheric hydrogen, and in the
context of dynamic pressure variations. Also the electron ionization and its
variation with time, heliolatitude, and solar distance is presented. After a
review of all of those topics, we present an interim model of solar wind and
the other solar factors based on up-to-date in situ and remote sensing
observations of solar wind. Results of this effort will further be utilised to
improve on the model of solar wind evolution, which will be an invaluable asset
in all heliospheric measurements, including, among others, the observations of
Energetic Neutral Atoms by the Interstellar Boundary Explorer (IBEX).Comment: Chapter 2 in the planned "Cross-Calibration of Past and Present Far
UV Spectra of Solar System Objects and the Heliosphere", ISSI Scientific
Report No 12, ed. R.M. Bonnet, E. Quemerais, M. Snow, Springe
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Track A Basic Science
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138319/1/jia218438.pd
Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV
Peer reviewe
Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV
Peer reviewe
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