Using manufacturing message specification for monitor and control at Venus

The flexibility and robustness of a monitor and control (M&C) system are a direct result of the underlying interprocessor communications architecture. A new architecture for M&C at the Deep Space Communications Complexes (DSCC's) has been developed based on the Manufacturing Message Specification (MMS) process control standard of the Open System Interconnection (OSI) suite of protocols. This architecture has been tested both in a laboratory environment and under operational conditions at the Deep Space Network (DSN) experimental Venus station (DSS-13). The Venus experience in the application of OSI standards to support M&C has been extremely successful. MMS meets the functional needs of the station and provides a level of flexibility and responsiveness previously unknown in that environment. The architecture is robust enough to meet current operational needs and flexible enough to provide a migration path for new subsystems. This paper will describe the architecture of the Venus M&C system, discuss how MMS was used and the requirements this imposed on other parts of the system, and provide results from systems and operational testing at the Venus site

Causal diffusion and its backwards diffusion problem

This article starts over the backwards diffusion problem by replacing the \emph{noncausal} diffusion equation, the direct problem, by the \emph{causal} diffusion model developed in \cite{Kow11} for the case of constant diffusion speed. For this purpose we derive an analytic representation of the Green function of causal diffusion in the wave vector-time space for arbitrary (wave vector) dimension $N$. We prove that the respective backwards diffusion problem is ill-posed, but not exponentially ill-posed, if the data acquisition time is larger than a characteristic time period $\tau$ ($2\,\tau$) for space dimension $N\geq 3$ (N=2). In contrast to the noncausal case, the inverse problem is well-posed for N=1. Moreover, we perform a theoretical and numerical comparison between causal and noncausal diffusion in the \emph{space-time domain} and the \emph{wave vector-time domain}. The paper is concluded with numerical simulations of the backwards diffusion problem via the Landweber method.Comment: In the replacement I have rewritten the abstract and the introduction. Moreover, I have added Remark 1 and simplified a little bit the proof of Theorem 4. The reference 25 is updated, since the paper is now publishe

Green's function for a Schroedinger operator and some related summation formulas

Summation formulas are obtained for products of associated Lagurre polynomials by means of the Green's function K for the Hamiltonian H = -{d^2\over dx^2} + x^2 + Ax^{-2}, A > 0. K is constructed by an application of a Mercer type theorem that arises in connection with integral equations. The new approach introduced in this paper may be useful for the construction of wider classes of generating function.Comment: 14 page

11 de setembro, arte de vanguarda?

Pode o ataque de 11 de Setembro ser considerado um evento artístico de vanguarda? O presente artigo propõe discutir, do ponto de vista da intencionalidade do ato e de sua recepção, o caráter performativo do fato histórico. Para levar a termo o intento, apresenta um panorama histórico da arte de vanguarda, assim como discorre sobre condições históricas e culturais que supostamente operariam como disparadores de tal acontecimento. O texto se debruça, ademais, sobre o caráter espetacular do evento e das condições de sua apreciação numa sociedade balizada sobremaneira pelos aparelhos midiáticos.Can the attacks of 9/11 be considered an avant-garde artistic event? This article aims to discuss, from the point of view of the intentionality of the act and of its reception, the performative character of that historical fact. To carry forward this intent, it presents a historical overview of avant-garde art, and discusses some of the historical and cultural conditions that supposedly operated as triggers of such an event. The text also focuses on the spectacular character of the event and the conditions for its appreciation in a society greatly limited by the media.Les attentats du 11 septembre peuvent-ils être considérés comme un événement artistique d'avant-garde ? Le présent article constitue une réflexion, aussi bien du point de vue de l'intentionnalité de l'acte que de sa réception, sur le caractère performatif de ce fait historique. Dans cette perspective, l'auteur fournit d'abord un panorama historique de l'art d'avant-garde et examine ensuite les conditions historiques et culturelles supposées fonctionner comme les déclencheurs d'un tel événement. Il se penche, par ailleurs, sur le caractère spectaculaire de l'événement et des conditions de son appréciation dans une société excessivement encadrée par des outils médiatiques

R&D Paths of Pixel Detectors for Vertex Tracking and Radiation Imaging

This report reviews current trends in the R&D of semiconductor pixellated sensors for vertex tracking and radiation imaging. It identifies requirements of future HEP experiments at colliders, needed technological breakthroughs and highlights the relation to radiation detection and imaging applications in other fields of science.Comment: 17 pages, 2 figures, submitted to the European Strategy Preparatory Grou

Molecular landscape and prognostic impact of FLT3 -ITD insertion site in acute myeloid leukemia : RATIFY study results

In acute myeloid leukemia (AML) internal tandem duplications of the FLT3 gene (FLT3- ITD) are associated with poor prognosis. Retrospectively, we investigated the prognostic and predictive impact of FLT3 -ITD insertion site (IS) in 452 patients randomized within the RATIFY trial, which evaluated midostaurin additionally to intensive chemotherapy. Next-generation sequencing identified 908 ITDs, with 643 IS in the juxtamembrane domain (JMD) and 265 IS in the tyrosine kinase domain-1 (TKD1). According to IS, patients were categorized as JMDsole (n = 251, 55%), JMD and TKD1 (JMD/TKD1; n = 117, 26%), and TKD1sole (n = 84, 19%). While clinical variables did not differ among the 3 groups, NPM1 mutation was correlated with JMDsole (P = 0.028). Overall survival (OS) differed significantly, with estimated 4-year OS probabilities of 0.44, 0.50, and 0.30 for JMDsole, JMD/TKD1, and TKD1sole, respectively (P = 0.032). Multivariate (cause-specific) Cox models for OS and cumulative incidence of relapse using allogeneic hematopoietic cell transplantation (HCT) in first complete remission as a time-dependent variable identified TKD1sole as unfavorable and HCT as favorable factors. In addition, Midostaurin exerted a significant benefit only for JMDsole. Our results confirm the distinct molecular heterogeneity of FLT3 -ITD and the negative prognostic impact of TKD1 IS in AML that was not overcome by midostaurin

Atezolizumab in combination with bevacizumab for the management of patients with hepatocellular cancer in the first-line setting: systematic literature review and meta-analysis

Background & aims: The objective of this systematic literature review (SLR) and network meta-analysis (NMA) is to compare randomised controlled trial evidence for atezolizumab-bevacizumab with globally relevant pharmacological comparators for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). Methods: Randomised controlled trials investigating first-line treatment of HCC in adults with no prior systemic treatment were eligible for inclusion into the SLR and were retrieved from Embase, MEDLINE, and Evidence Based Medicine (EBM) Reviews. Interventions of interest for the NMA included atezolizumab-bevacizumab, sorafenib, lenvatinib, durvalumab (including in combination with tremelimumab), cabozantinib (including in combination with atezolizumab), camrelizumab (including in combination with rivoceranib), pembrolizumab (including in combination with lenvatinib) and tislelizumab. Random effects NMA was conducted for survival endpoints within a Bayesian framework with an informative prior distribution for between study heterogeneity. The hazard ratios for relative treatment effect were estimated with 95% credible intervals (CrIs). Results: The SLR identified 49 studies, of which eight formed a connected evidence network permitting the indirect treatment comparison of atezolizumab-bevacizumab with comparators of interest. The indirect comparisons suggested an improved overall survival (OS) with atezolizumab-bevacizumab versus most comparators. All indirect treatment comparison results for atezolizumab-bevacizumab included the null value within the 95% CrI (n=1) for OS and progression free survival (PFS). Conclusions: The results of the NMA indicate atezolizumab-bevacizumab is associated with superior or comparable OS and PFS together with a manageable safety profile compared with globally relevant comparators in the unresected HCC indication. The findings support that atezolizumab-bevacizumab remains standard of care for the management of first-line unresectable HCC patients

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio

Search for charginos in e+e- interactions at sqrt(s) = 189 GeV

An update of the searches for charginos and gravitinos is presented, based on a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by combining the chargino searches with neutralino searches at the Z resonance implies a limit on the mass of the lightest neutralino which, for a heavy sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure

Search for lightest neutralino and stau pair production in light gravitino scenarios with stau NLSP

Promptly decaying lightest neutralinos and long-lived staus are searched for in the context of light gravitino scenarios. It is assumed that the stau is the next to lightest supersymmetric particle (NLSP) and that the lightest neutralino is the next to NLSP (NNLSP). Data collected with the Delphi detector at centre-of-mass energies from 161 to 183 \GeV are analysed. No evidence of the production of these particles is found. Hence, lower mass limits for both kinds of particles are set at 95% C.L.. The mass of gaugino-like neutralinos is found to be greater than 71.5 GeV/c^2. In the search for long-lived stau, masses less than 70.0 to 77.5 \GeVcc are excluded for gravitino masses from 10 to 150 \eVcc . Combining this search with the searches for stable heavy leptons and Minimal Supersymmetric Standard Model staus a lower limit of 68.5 \GeVcc may be set for the stau mas