14 research outputs found

    Correlated long-range mixed-harmonic fluctuations measured in pp, p+Pb and low-multiplicity Pb+Pb collisions with the ATLAS detector

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    Performance of top-quark and W -boson tagging with ATLAS in Run 2 of the LHC

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    The performance of identification algorithms (“taggers”) for hadronically decaying top quarks and W bosons in pp collisions at √s=13 TeV recorded by the ATLAS experiment at the Large Hadron Collider is presented. A set of techniques based on jet shape observables are studied to determine a set of optimal cut-based taggers for use in physics analyses. The studies are extended to assess the utility of combinations of substructure observables as a multivariate tagger using boosted decision trees or deep neural networks in comparison with taggers based on two-variable combinations. In addition, for highly boosted top-quark tagging, a deep neural network based on jet constituent inputs as well as a re-optimisation of the shower deconstruction technique is presented. The performance of these taggers is studied in data collected during 2015 and 2016 corresponding to 36.1 fb −1 for the tt ¯ and γ+jet and 36.7 fb −1 −1 for the dijet event topologies

    In situ calibration of large-radius jet energy and mass in 13 TeV proton–proton collisions with the ATLAS detector

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    The response of the ATLAS detector to largeradius jets is measured in situ using 36.2 fb−1 of √s = 13 TeV proton–proton collisions provided by the LHC and recorded by the ATLAS experiment during 2015 and 2016. The jet energy scale is measured in events where the jet recoils against a reference object, which can be either a calibrated photon, a reconstructed Z boson, or a system of well-measured small-radius jets. The jet energy resolution and a calibration of forward jets are derived using dijet balance measurements. The jet mass response is measured with two methods: using mass peaks formed by W bosons and top quarks with large transverse momenta and by comparing the jet mass measured using the energy deposited in the calorimeter with that using the momenta of charged-particle tracks. The transversemomentum and mass responses in simulations are found to be about 2–3% higher than in data. This difference is adjusted for with a correction factor. The results of the different methods are combined to yield a calibration over a large range of transverse momenta (pT). The precision of the relative jet energy scale is 1–2% for 200 GeV < pT < 2 TeV, while that of the mass scale is 2–10%. The ratio of the energy resolutions in data and simulation is measured to a precision of 10–15% over the same pT range

    Measurement of the photon identification efficiencies with the ATLAS detector using LHC Run 2 data collected in 2015 and 2016

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    The efficiency of the photon identification criteria in the ATLAS detector is measured using 36.1 fb1 to 36.7 fb1 of pp collision data at s√=13 TeV collected in 2015 and 2016. The efficiencies are measured separately for converted and unconverted isolated photons, in four different pseudorapidity regions, for transverse momenta between 10 GeV and 1.5 TeV. The results from the combination of three data-driven techniques are compared with the predictions from simulation after correcting the variables describing the shape of electromagnetic showers in simulation for the average differences observed relative to data. Data-to-simulation efficiency ratios are determined to account for the small residual efficiency differences. These factors are measured with uncertainties between 0.5% and 5% depending on the photon transverse momentum and pseudorapidity. The impact of the isolation criteria on the photon identification efficiency, and that of additional soft pp interactions, are also discussed. The probability of reconstructing an electron as a photon candidate is measured in data, and compared with the predictions from simulation. The efficiency of the reconstruction of photon conversions is measured using a sample of photon candidates from Z→μμγ events, exploiting the properties of the ratio of the energies deposited in the first and second longitudinal layers of the ATLAS electromagnetic calorimeter

    Primary cervical carcinoma cell lines overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody

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    Introduction: Epithelial cell adhesion molecule (EpCAM) is a surface glycoprotein highly differentially expressed in many epithelial malignancies. The goal of this study was to evaluate the expression of EpCAM and the potential of MT201 (adecatumumab), a human monoclonal antibody targeting EpCAM, against multiple primary cervical carcinoma cell lines. Methods: Epithelial cell adhesion molecule expression was evaluated by real-time polymerase chain reaction and flow cytometry in a total of 8 primary cervical cancer cell lines. Sensitivity to MT201-mediated cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity was tested in standard 4-hour 51Cr release assays. To investigate the effect of interleukin-2 (IL-2) on MT201-mediated ADCC, 4-hour 51Cr release assays were also conducted in the presence of low doses of IL-2. Results: High messenger RNA expression by real-time polymerase chain reaction and high EpCAM surface expression by flow cytometry were detected in 4 (50%) of 8 primary cervical carcinoma cell lines. With no exception, the primary cell lines derived from clinically aggressive tumors showed EpCAM overexpression. Whereas these cell lines were highly resistant to complement-dependent cytotoxicity and natural killer (NK)-dependent cytotoxicity in vitro (range of killing, 4%Y19%), EpCAM-positive cell lines showed high sensitivity to MT201-mediated ADCC (range of killing, 23%Y59%). Incubation with IL-2 in addition to MT201 significantly increased the cytotoxic activity against EpCAM-positive cervical cancer cell lines (P = 0.007). Addition of human serum also further increased the MT201-mediated killing of EpCAM-positive cell lines (P = 0.03). Conclusions: Epithelial cell adhesion molecule is highly expressed in primary cervical carcinoma cell lines, and these biologically aggressive tumors are highly sensitive to MT201-mediated cytotoxicity in vitro. MT201 may represent a novel, potentially highly effective treatment option for patients with cervical carcinoma, especially for those with advanced, recurrent, or metastatic disease refractory to standard salvage therapy

    ATLAS Collaboration

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    Erratum: Search for Resonant and Nonresonant Higgs Boson Pair Production in the bb[over \uaf]\u3c4^+\u3c4^- Decay Channel in pp Collisions at sqrt[s]=13\u2009\u2009TeV with the ATLAS Detector [Phys. Rev. Lett. 121, 191801 (2018)]

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    This corrects the article DOI: 10.1103/PhysRevLett.121.191801

    Берёзовский рабочий. 2019. № 28

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    Measurements of fiducial integrated and differential cross sections for inclusive W+W^+, WW^- and ZZ boson production are reported. They are based on 25.0±0.525.0 \pm 0.5 pb1^{-1} of pppp collision data at s=5.02\sqrt{s} = 5.02 TeV collected with the ATLAS detector at the CERN Large Hadron Collider. Electron and muon decay channels are analysed, and the combined W+W^+, WW^- and ZZ integrated cross sections are found to be σW+\sigma_{W^+} = 2266 ±\pm 9 (stat) ±\pm 29 (syst) ±\pm 43 (lumi) pb, σW\sigma_{W^-} = 1401 ±\pm 7 (stat) ±\pm 18 (syst) ±\pm 27 (lumi) pb, and σZ\sigma_Z = 374.5 ±\pm 3.4 (stat) ±\pm 3.6 (syst) ±\pm 7.0 (lumi) pb, in good agreement with next-to-next-to-leading-order QCD cross-section calculations. These measurements serve as references for Pb+Pb interactions at the LHC at this nucleon--nucleon centre-of-mass energy

    Observation of Light-by-Light Scattering in Ultraperipheral Pb plus Pb Collisions with the ATLAS Detector

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    This letter describes the observation of the light-by-light scattering process, γγγγ\gamma\gamma\rightarrow\gamma\gamma, in Pb+Pb collisions at sNN\sqrt{s_\mathrm{NN}} = 5.02 TeV. The analysis is conducted using a data sample corresponding to an integrated luminosity of 1.73 nb1^{-1}, collected in November 2018 by the ATLAS experiment at the LHC. Light-by-light scattering candidates are selected in events with two photons produced exclusively, each with transverse energy ETγ>3E_{\textrm{T}}^{\gamma} > 3 GeV and pseudorapidity ηγ<2.37|\eta_{\gamma}| < 2.37, diphoton invariant mass above 6 GeV, and small diphoton transverse momentum and acoplanarity. After applying all selection criteria, 59 candidate events are observed for a background expectation of 12 ±\pm 3 events. The observed excess of events over the expected background has a significance of 8.2 standard deviations. The measured fiducial cross section is 78 ±\pm 13 (stat.) ±\pm 7 (syst.) ±\pm 3 (lumi.) nb.Comment: 29 pages in total, author list starting page 13, 2 figures, 0 tables, final version published in PRL. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2018-1

    Search for Higgs boson decays into pairs of light (pseudo)scalar particles in the \u3b3\u3b3jj final state in pp collisions at s=13TeV with the ATLAS detector

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