139 research outputs found
From Courtroom to Classroom: Operationalizing Adequacy in Funding Teaching and Learning
A quality, standards-based reform would provide a framework and system of accountability that elevates the most possible number of our students to acquisition of an academic foundation and allows students the greatest number of future academic options and careers
RELICS: High-Resolution Constraints on the Inner Mass Distribution of the z=0.83 Merging Cluster RXJ0152.7-1357 from strong lensing
Strong gravitational lensing (SL) is a powerful means to map the distribution
of dark matter. In this work, we perform a SL analysis of the prominent X-ray
cluster RXJ0152.7-1357 (z=0.83, also known as CL 0152.7-1357) in \textit{Hubble
Space Telescope} images, taken in the framework of the Reionization Lensing
Cluster Survey (RELICS). On top of a previously known galaxy multiply
imaged by RXJ0152.7-1357, for which we identify an additional multiple image,
guided by a light-traces-mass approach we identify seven new sets of multiply
imaged background sources lensed by this cluster, spanning the redshift range
[1.79-3.93]. A total of 25 multiple images are seen over a small area of ~0.4
, allowing us to put relatively high-resolution constraints on the
inner matter distribution. Although modestly massive, the high degree of
substructure together with its very elongated shape make RXJ0152.7-1357 a very
efficient lens for its size. This cluster also comprises the third-largest
sample of z~6-7 candidates in the RELICS survey. Finally, we present a
comparison of our resulting mass distribution and magnification estimates with
those from a Lenstool model. These models are made publicly available through
the MAST archive.Comment: 15 Pages, 7 Figures, 4 Tables Accepted for publication in Ap
Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally-occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally-occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting
RELICS: A Very Large () Cluster Lens -- RXC J0032.1+1808
Extensive surveys with the \textit{Hubble Space Telescope} (HST) over the
past decade, targeting some of the most massive clusters in the sky, have
uncovered dozens of galaxy-cluster strong lenses. The massive cluster
strong-lens scale is typically \theta_{E}\sim10\arcsec to \sim30-35\arcsec,
with only a handful of clusters known with Einstein radii
\theta_{E}\sim40\arcsec or above (for , nominally). Here we
report another very large cluster lens, RXC J0032.1+1808 (), the
second richest cluster in the redMapper cluster catalog and the 85th most
massive cluster in the Planck Sunyaev-Zel'dovich catalog. With our
Light-Traces-Mass and fully parametric (dPIEeNFW) approaches, we construct
strong lensing models based on 18 multiple images of 5 background galaxies
newly identified in the \textit{Hubble} data mainly from the
\textit{Reionization Lensing Cluster Survey} (RELICS), in addition to a known
sextuply imaged system in this cluster. Furthermore, we compare these models to
Lenstool and GLAFIC models that were produced independently as part of the
RELICS program. All models reveal a large effective Einstein radius of
\theta_{E}\simeq40\arcsec (), owing to the obvious
concentration of substructures near the cluster center. Although RXC
J0032.1+1808 has a very large critical area and high lensing strength, only
three magnified high-redshift candidates are found within the field targeted by
RELICS. Nevertheless, we expect many more high-redshift candidates will be seen
in wider and deeper observations with \textit{Hubble} or \emph{JWST}. Finally,
the comparison between several algorithms demonstrates that the total error
budget is largely dominated by systematic uncertainties.Comment: 23 pages, accepted for publication in Ap
RELICS: Strong Lensing analysis of the galaxy clusters Abell S295, Abell 697, MACS J0025.4-1222, and MACS J0159.8-0849
We present a strong-lensing analysis of four massive galaxy clusters imaged
with the Hubble Space Telescope in the Reionization Lensing Cluster Survey. We
use a Light-Traces-Mass technique to uncover sets of multiply images and
constrain the mass distribution of the clusters. These mass models are the
first published for Abell S295 and MACS J0159.8-0849, and are improvements over
previous models for Abell 697 and MACS J0025.4-1222. Our analysis for MACS
J0025.4-1222 and Abell S295 shows a bimodal mass distribution supporting the
merger scenarios proposed for these clusters. The updated model for MACS
J0025.4-1222 suggests a substantially smaller critical area than previously
estimated. For MACS J0159.8-0849 and Abell 697 we find a single peak and
relatively regular morphology, revealing fairly relaxed clusters. Despite being
less prominent lenses, three of these clusters seem to have lensing strengths,
i.e. cumulative area above certain magnification, similar to the Hubble
Frontier Fields clusters (e.g., A() arcmin, A()
arcmin), which in part can be attributed to their merging
configurations. We make our lens models publicly available through the Mikulski
Archive for Space Telescopes. Finally, using Gemini-N/GMOS spectroscopic
observations we detect a single emission line from a high-redshift
galaxy candidate lensed by Abell 697. While we cannot rule
out a lower-redshift solution, we interpret the line as Ly at
, in agreement with its photometric redshift and dropout
nature. Within this scenario we measure a Ly rest-frame equivalent
width of \AA, and an observed Gaussian width of km/s.Comment: 23 pages, 16 figures; V2, accepted for publication in Ap
RELICS: Reionization Lensing Cluster Survey
Large surveys of galaxy clusters with the Hubble and Spitzer Space
Telescopes, including CLASH and the Frontier Fields, have demonstrated the
power of strong gravitational lensing to efficiently deliver large samples of
high-redshift galaxies. We extend this strategy through a wider, shallower
survey named RELICS, the Reionization Lensing Cluster Survey. This survey,
described here, was designed primarily to deliver the best and brightest
high-redshift candidates from the first billion years after the Big Bang.
RELICS observed 41 massive galaxy clusters with Hubble and Spitzer at 0.4-1.7um
and 3.0-5.0um, respectively. We selected 21 clusters based on Planck PSZ2 mass
estimates and the other 20 based on observed or inferred lensing strength. Our
188-orbit Hubble Treasury Program obtained the first high-resolution
near-infrared images of these clusters to efficiently search for lensed
high-redshift galaxies. We observed 46 WFC3/IR pointings (~200 arcmin^2) with
two orbits divided among four filters (F105W, F125W, F140W, and F160W) and ACS
imaging as needed to achieve single-orbit depth in each of three filters
(F435W, F606W, and F814W). As previously reported by Salmon et al., we
discovered 322 z ~ 6 - 10 candidates, including the brightest known at z ~ 6,
and the most distant spatially-resolved lensed arc known at z ~ 10. Spitzer
IRAC imaging (945 hours awarded, plus 100 archival) has crucially enabled us to
distinguish z ~ 10 candidates from z ~ 2 interlopers. For each cluster, two HST
observing epochs were staggered by about a month, enabling us to discover 11
supernovae, including 3 lensed supernovae, which we followed up with 20 orbits
from our program. We delivered reduced HST images and catalogs of all clusters
to the public via MAST and reduced Spitzer images via IRSA. We have also begun
delivering lens models of all clusters, to be completed before the JWST GO call
for proposals.Comment: 29 pages, 6 figures, submitted to ApJ. For reduced images, catalogs,
lens models, and more, see relics.stsci.ed
The Hobby–Eberly Telescope Dark Energy Experiment (HETDEX) Survey Design, Reductions, and Detections
We describe the survey design, calibration, commissioning, and emission-line detection algorithms for the Hobby–Eberly Telescope Dark Energy Experiment (HETDEX). The goal of HETDEX is to measure the redshifts of over a million Lyα emitting galaxies between 1.88 < z < 3.52, in a 540 deg2 area encompassing a comoving volume of 10.9 Gpc3. No preselection of targets is involved; instead the HETDEX measurements are accomplished via a spectroscopic survey using a suite of wide-field integral field units distributed over the focal plane of the telescope. This survey measures the Hubble expansion parameter and angular diameter distance, with a final expected accuracy of better than 1%. We detail the project’s observational strategy, reduction pipeline, source detection, and catalog generation, and present initial results for science verification in the Cosmological Evolution Survey, Extended Groth Strip, and Great Observatories Origins Deep Survey North fields. We demonstrate that our data reach the required specifications in throughput, astrometric accuracy, flux limit, and object detection, with the end products being a catalog of emission-line sources, their object classifications, and flux-calibrated spectra
Institutionelle Arrangements und Formen der Handlungskoordination im Mehrebenensystem der USA
Das Verhältnis zwischen den Politikebenen im Mehrebenensystem der USA kann durch drei Typen charakterisiert werden: erstens die zentrale Regulierung, d.h. die hierarchische Koordination der Politikebenen. Zweitens die dezentrale Regulierung, die sowohl den regulativen Wettbewerb als auch die Entstehung horizontaler Verhandlungssysteme zwischen den Einzelstaaten umfasst. Beide Formen verlieren an Bedeutung, da sich stattdessen mehr und mehr ein dritter Typus, die Mehrebenenregulierung, durchsetzt. Dargestellt werden zwei Varianten dieser neuartigen institutionellen Arrangements, die den beiden anderen Typen der Regulierung überlegen sind: Zum einen wird der Wettbewerb zwischen den Politikebenen durch eine Kombination hierarchischer Elemente mit dem regulativen Wettbewerb zwischen den Einzelstaaten gefördert, z.B. durch die Festsetzung nationaler Mindeststandards. Zum anderen kann ein Wandel der intergouvernementalen Beziehungen beobachtet werden, der die Entstehung vertikaler Verhandlungssysteme zwischen dem Bund und den Einzelstaaten begünstigt. Die Entwicklung in den USA zeigt, dass bei der Kombination institutioneller Arrangements auf hierarchische Elemente kaum verzichtet werden kann. Außerdem kann man feststellen, dass dynamische Politikentwicklungen nicht nur aus dem regulativen Wettbewerb zwischen den Einzelstaaten, sondern auch aus dem Wettbewerb zwischen den Politikebenen resultieren können.The relationship between the policy levels in the U.S. multi-level system can be characterized by three types: first, central regulation, i.e. the hierarchical coordination of the policy levels. Second, decentral regulation comprising regulatory competition as well as the emergence of horizontal joint-decision systems between the states. Both forms lose importance as a third type, multi-level regulation, becomes prevalent. Two variants of these novel institutional arrangements that are superior to both other types of regulation, are described. On the one hand, competition between the policy levels is stimulated by a combination of hierarchical elements with the regulative competition between the states, e.g., by setting national minimum standards. On the other hand, a change of the intergovernmental relations between the federal government and the states can be observed, fostering the emergence of vertical joint-decision systems. The U.S. development shows that hierarchical elements are hardly dispensable when institutional arrangements are combined. Moreover, it can be seen that dynamic policy developments result not only from regulative competition between states but also from competition between policy levels
Rapid glaciation and a two-step sea-level plunge into The Last Glacial Maximum
The approximately 10,000-year-long Last Glacial Maximum, before the termination of the last ice age, was the coldest period in Earth’s recent climate history1. Relative to the Holocene epoch, atmospheric carbon dioxide was about 100 parts per million lower and tropical sea surface temperatures were about 3 to 5 degrees Celsius lower2,3. The Last Glacial Maximum began when global mean sea level (GMSL) abruptly dropped by about 40 metres around 31,000 years ago4 and was followed by about 10,000 years of rapid deglaciation into the Holocene1. The masses of the melting polar ice sheets and the change in ocean volume, and hence in GMSL, are primary constraints for climate models constructed to describe the transition between the Last Glacial Maximum and the Holocene, and future changes; but the rate, timing and magnitude of this transition remain uncertain. Here we show that sea level at the shelf edge of the Great Barrier Reef dropped by around 20 metres between 21,900 and 20,500 years ago, to −118 metres relative to the modern level. Our findings are based on recovered and radiometrically dated fossil corals and coralline algae assemblages, and represent relative sea level at the Great Barrier Reef, rather than GMSL. Subsequently, relative sea level rose at a rate of about 3.5 millimetres per year for around 4,000 years. The rise is consistent with the warming previously observed at 19,000 years ago1,5, but we now show that it occurred just after the 20-metre drop in relative sea level and the related increase in global ice volumes. The detailed structure of our record is robust because the Great Barrier Reef is remote from former ice sheets and tectonic activity. Relative sea level can be influenced by Earth’s response to regional changes in ice and water loadings and may differ greatly from GMSL. Consequently, we used glacio-isostatic models to derive GMSL, and find that the Last Glacial Maximum culminated 20,500 years ago in a GMSL low of about −125 to −130 metres.Financial support of this research was provided by the JSPS KAKENHI (grant numbers JP26247085, JP15KK0151, JP16H06309 and JP17H01168), the Australian Research Council (grant number DP1094001), ANZIC, NERC grant NE/H014136/1 and Institut Polytechnique de Bordeaux
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