Towards a science and practice of resilience in the face of pain

The primary objective of this paper is to discuss how a resilience approach to (chronic) pain may advance our current understanding of (mal)adaptation to pain. Different resilience perspectives are described, and future challenges for research, prevention and treatment of (chronic) pain are discussed. Literature searches were performed in Web of Science and PubMed to identify relevant literature on risk and resilience in the context of pain. Resilience can be best defined as the ability to restore and sustain living a fulfilling life in the presence of pain. The Psychological Flexibility Model, the Broaden-and-Build Theory, and Self-Determination Theory are described as theories that may provide insight into resilience within the context of (chronic) pain. We describe how a resilience paradigm shifts the outcomes to pursue in pain research and intervention and argue the need for including positive outcomes in addition to negative outcomes. Psychological flexibility, positive affect and basic psychological needs satisfaction are described as potentially important resilience mechanisms with the potential to target both sustainability and recovery from pain. A resilience approach to chronic pain may have important implications for the prevention and treatment of chronic pain problems, as it may give specific indications on how to empower patients to continue living a fulfilling life (in the presence of pain)

Model selection with estimated factors and idiosyncratic components

This paper provides consistent information criteria for the selection of forecasting models which use a subset of both the idiosyncratic and common factor components of a big dataset. This hybrid model approach has been explored by recent empirical studies to relax the strictness of pure factor-augmented model approximations, but no formal model selection procedures have been developed. The main difference to previous factor-augmented model selection procedures is that we must account for estimation error in the idiosyncratic component as well as the factors. Our main contribution is to show the conditions required for selection consistency of a class of information criteria which reflect this additional source of estimation error. We show that existing factor-augmented model selection criteria are inconsistent in circumstances where N is of larger order than root-T, where N and T are the cross-section and time series dimensions of the dataset respectively, and that the standard BIC is inconsistent regardless of the relationship between N and T. We therefore propose a new set of information criteria which guarantee selection consistency in the presence of estimated idiosyncratic components. The properties of these new criteria are explored through a Monte Carlo simulation study. The paper concludes with an empirical application to long-horizon exchange rate forecasting using a recently proposed model with country-specific idiosyncratic components from a panel of global exchange rates

Of journal editors and editorial boards: who are the trailblazers in increasing editorial board gender equality?

Female academics continue to be under-represented on the editorial boards of many, but not all, management journals. This variability is intriguing, because it is reasonable to assume that the size of the pool of female faculty available and willing to serve on editorial boards is similar for all management journals. Thus, we focus on the characteristics of the journal editors to explain this variability; journal editors or editors-in-chief are the most influential people in the selection of editorial board members. We draw on social identity and homosocial reproduction theories, and on the gender and careers literature to examine the relationship between an editor’s academic performance, professional age and gender, and editorial board gender equality. We collected longitudinal data at five points in time, using five-year intervals, from 52 management journals. To account for the nested structure of the data, a 3-level multilevel model was estimated. Overall, we found that the prospects of board membership improve for women when editors are high performing, professionally young, or female. We discuss these findings and their implications for management journals with low, stagnant, or declining representation of women in their boards

Identification of the barrier to gene flow between phylogeographic lineages of the common hamster Cricetus cricetus

In anthropogenically disturbed habitats, natural barriers still exist and have to be recognized, as they are important for conservation measures. Areas of phylogeographic breaks within a species are often stabilized in inhospitable regions which act as natural barriers. An area of contact between phylogeographic lineages of the common hamster (Cricetus cricetus) was found in the Małopolska Upland in Poland. A total of 142 common hamsters were captured between 2005 and 2009. All hamsters were genotyped at 17 microsatellite loci and partial sequences of the mitochondrial (mtDNA) control region were obtained. No mixed populations with mtDNA haplotypes of both lineages were found. The distance between marginal populations was about 20 km; no hamsters were found in the area between. A principal components analysis (PCA) was performed on microsatellite data and the greatest change in PC1 scores was found between marginal samples. To define the habitat components responsible for the phylogeographic break, we compared the habitat composition of sites occupied by hamsters with those from which hamsters were absent. We found that hamsters avoided forested areas and sandy soils. The area of the potential barrier was characterized by a high proportion of woodland and unfavorable soils in comparison with neighboring areas inhabited by hamsters. They cannot settle in this area due to their high winter mortality in shallow burrows and high predation in the fields adjacent to forests

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits that information to the cell nucleus, where it drives a transcriptional program that is tailored to re-establish homeostasis. Using thin section electron microscopy, we found that yeast cells expand their ER volume at least 5-fold under UPR-inducing conditions. Surprisingly, we discovered that ER proliferation is accompanied by the formation of autophagosome-like structures that are densely and selectively packed with membrane stacks derived from the UPR-expanded ER. In analogy to pexophagy and mitophagy, which are autophagic processes that selectively sequester and degrade peroxisomes and mitochondria, the ER-specific autophagic process described utilizes several autophagy genes: they are induced by the UPR and are essential for the survival of cells subjected to severe ER stress. Intriguingly, cell survival does not require vacuolar proteases, indicating that ER sequestration into autophagosome-like structures, rather than their degradation, is the important step. Selective ER sequestration may help cells to maintain a new steady-state level of ER abundance even in the face of continuously accumulating unfolded proteins

Modularity of the Hrd1 ERAD complex underlies its diverse client range

Additional factors combine with the core Hrd1 complex in a modular fashion, enabling it to recognize a variety of substrates

Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover

The relevance of serine 5 phosphorylation of RNA polymerase II carboxy-terminal domain during initiation has been difficult to determine in mammalian cells as no general in vivo Ser5 kinase has been identified. Here, we demonstrate that deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced Pol II Ser5 phosphorylation. This is associated with defective capping and reduced Ser2 phosphorylation, decreased Pol II progression into elongation and severely attenuated transcription detected through analysis of nascent mRNAs, establishing a general requirement for mammalian Mat1 in transcription. Surprisingly, the general defect in Pol II transcription in Mat1−/− fibroblasts is not reflected in the majority of steady-state mRNAs. This indicates widespread stabilization of mRNAs and points to the existence of a regulatory mechanism to stabilize mRNAs following transcriptional attenuation, thus revealing a potential caveat in similar studies limited to analysis of steady-state mRNAs