375 research outputs found
Many-body Chemical Reactions in a Quantum Degenerate Gas
Chemical reactions in the quantum degenerate regime are described by mixing
of matterwave fields. Quantum coherence and bosonic enhancement are two unique
features of many-body reactions involving bosonic reactants and products. Such
collective reactions of chemicals, dubbed "super-chemistry", is an elusive goal
in quantum chemistry research. Here we report the observation of coherent and
collective reactive coupling between Bose condensed atoms and molecules near a
Feshbach resonance. Starting from an atomic condensate, the reaction begins
with a rapid formation of molecules, followed by oscillations of their
populations in the equilibration process. Faster oscillations are observed in
samples with higher densities, indicating bosonic enhancement. We present a
quantum field model which describes the dynamics well and identifies three-body
recombination as the dominant reaction process. Our findings exemplify the
highly sought-after quantum many-body chemistry and offer a new paradigm for
the control of quantum chemical reactions.Comment: 15 pages, 10 figures. Nat. Phys. (2023
Genetic Elucidation for Response of Flowering Time to Ambient Temperatures in Asian Rice Cultivars
Climate resilience of crops is critical for global food security. Understanding the genetic basis of plant responses to ambient environmental changes is key to developing resilient crops. To detect genetic factors that set flowering time according to seasonal temperature conditions, we evaluated differences of flowering time over years by using chromosome segment substitution lines (CSSLs) derived from japonica rice cultivars "Koshihikari" x "Khao Nam Jen", each with different robustness of flowering time to environmental fluctuations. The difference of flowering times in 9 years' field tests was large in "Khao Nam Jen" (36.7 days) but small in "Koshihikari" (9.9 days). Part of this difference was explained by two QTLs. A CSSL with a "Khao Nam Jen" segment on chromosome 11 showed 28.0 days' difference; this QTL would encode a novel flowering-time gene. Another CSSL with a segment from "Khao Nam Jen" in the region around Hd16 on chromosome 3 showed 23.4 days" difference. A near-isogenic line (NIL) for Hd16 showed 21.6 days' difference, suggesting Hd16 as a candidate for this QTL. RNA-seq analysis showed differential expression of several flowering-time genes between early and late flowering seasons. Low-temperature treatment at panicle initiation stage significantly delayed flowering in the CSSL and NIL compared with "Koshihikari". Our results unravel the molecular control of flowering time under ambient temperature fluctuations
Association between periodontal condition and kidney dysfunction in Japanese adults : A crossâsectional study
Recent studies have demonstrated that chronic kidney disease (CKD) may be associated with the progression of periodontal disease. Diabetes mellitus (DM) is a major risk factor for CKD. The objective of this study was to clarify the relationship between periodontal condition and kidney dysfunction in patients who had kidney failure with or without DM. One hundred sixtyâfour patients with kidney dysfunction were enrolled (male: N = 105; female: N = 59), and the relationship between periodontal condition and kidney dysfunction was analyzed in a crossâsectional study. The subjects were divided into three groups: (a) patients with DM, (b) dialysis patients with nephropathy due to various kidney diseases, and (c) dialysis patient with nephropathy due to DM (diabetic nephropathy). Then, the effect of DM on the periodontal condition was analyzed. The patients were also stratified by CKD stage (into G1âG5) using the estimated glomerular filtration rate (eGFR), and the G5 group was divided in patients with or without DM. Correlations between eGFR and parameters of periodontal condition were calculated in patients from G1 to G4. The number of missing teeth was significantly higher in dialysis patients with diabetic nephropathy than in patients with DM, whereas alveolar bone loss did not show a significant difference among the three groups. In addition, the G5 patients with DM had a significantly higher number of missing teeth than the other CKD groups, whereas alveolar bone loss did not show a significant difference. In G5 patients with DM, Community Periodontal Index and Oral Hygiene Index scores were significantly higher than in G1â4 patients with DM. There was a significant negative correlation between eGFR and the number of missing teeth. Patients with diabetic nephropathy have a higher rate of periodontal problems such as missing teeth in Japanese adults
Spectra from the shocked nebulae revealing turbulence near the Galactic Centre
The spectra emitted from clouds near the Galactic Centre are investigated
calculating the UV-optical-IR lines using the physical parameters and the
element abundances constrained by the fit of mid-IR observations. The
characteristic line ratios are compared with those observed in active galaxies.
We have found that the physical conditions in the nebulae near the GC are
different from those of starburst galaxies and AGN, namely, gas velocities and
densities as well as the photoionization fluxes are relatively low. The
geometrical thickness of the emitting nebulae is particularly small suggesting
that matter is strongly fragmented by instabilities leading to an underlying
shock-generated turbulence.Comment: 16 pages, 11 figures, 4 Tables. MNRAS, accepte
Characterization of two receptors for TRAIL.
Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals
Biological Stoichiometry in Human Cancer
A growing tumor in the body can be considered a complex ecological and evolutionary system. A new eco-evolutionary hypothesis (the "Growth Rate Hypothesis", GRH) proposes that tumors have elevated phosphorus (P) demands due to increased allocation to P-rich nucleic acids, especially ribosomal RNA, to meet the protein synthesis demands of accelerated proliferation.We determined the elemental (C, N, P) and nucleic acid contents of paired malignant and normal tissues from colon, lung, liver, or kidney for 121 patients. Consistent with the GRH, lung and colon tumors were significantly higher (by approximately two-fold) in P content (fraction of dry weight) and RNA content and lower in nitrogen (N):P ratio than paired normal tissue, and P in RNA contributed a significantly larger fraction of total biomass P in malignant relative to normal tissues. Furthermore, patient-specific differences for %P between malignant and normal tissues were positively correlated with such differences for %RNA, both for the overall data and within three of the four organ sites. However, significant differences in %P and %RNA between malignant and normal tissues were not seen in liver and kidney and, overall, RNA contributed only approximately 11% of total tissue P content.Data for lung and colon tumors provide support for the GRH in human cancer. The two-fold amplification of P content in colon and lung tumors may set the stage for potential P-limitation of their proliferation, as such differences often do for rapidly growing biota in ecosystems. However, data for kidney and liver do not support the GRH. To account for these conflicting observations, we suggest that local environments in some organs select for neoplastic cells bearing mutations increasing cell division rate ("r-selected," as in colon and lung) while conditions elsewhere may select for reduced mortality rate ("K-selected," as in liver and kidney)
Epidemiologic Studies of Isoflavones & Mammographic Density
Isoflavones, phytoestrogens in soy beans with estrogen-like properties, have been examined for their cancer protective effects. Mammographic density is a strong predictor of breast cancer. This review summarizes studies that have examined the association between isoflavones and breast density. Observational investigations in Hawaii and Singapore suggest slightly lower breast density among women of Asian descent with regular soy intake, but two larger studies from Japan and Singapore did not observe a protective effect. The findings from seven randomized trials with primarily Caucasian women indicate that soy or isoflavones do not modify mammographic density. Soy foods and isoflavone supplements within a nutritional range do not appear to modify breast cancer risk as assessed by mammographic density
Cross-National Differences in Victimization : Disentangling the Impact of Composition and Context
Varying rates of criminal victimization across countries are assumed to be the outcome of countrylevel structural constraints that determine the supply ofmotivated oÂĄenders, as well as the differential composition within countries of suitable targets and capable guardianship. However, previous empirical tests of these âcompositionalâ and âcontextualâ explanations of cross-national diÂĄerences
have been performed upon macro-level crime data due to the unavailability of comparable individual-level data across countries. This limitation has had two important consequences for cross-national crime research. First, micro-/meso-level mechanisms underlying cross-national differences cannot be truly inferred from macro-level data. Secondly, the eÂĄects of contextual measures (e.g. income inequality) on crime are uncontrolled for compositional heterogeneity. In this
paper, these limitations are overcome by analysing individual-level victimization data across 18 countries from the International CrimeVictims Survey. Results from multi-level analyses on theft and violent victimization indicate that the national level of income inequality is positively related to risk, independent of compositional (i.e. micro- and meso-level) diÂĄerences. Furthermore, crossnational variation in victimization rates is not only shaped by diÂĄerences in national context, but
also by varying composition. More speciÂącally, countries had higher crime rates the more they consisted of urban residents and regions with lowaverage social cohesion.
The Role of Soy in Vegetarian Diets
Soyfoods have long been prized among vegetarians for both their high protein content and versatility. Soybeans differ markedly in macronutrient content from other legumes, being much higher in fat and protein, and lower in carbohydrate. In recent years however, soyfoods and specific soybean constituents, especially isoflavones, have been the subject of an impressive amount of research. Nearly 2,000 soy-related papers are published annually. This research has focused primarily on the benefits that soyfoods may provide independent of their nutrient content. There is particular interest in the role that soyfoods have in reducing risk of heart disease, osteoporosis and certain forms of cancer. However, the estrogen-like effects of isoflavones observed in animal studies have also raised concerns about potential harmful effects of soyfood consumption. This review addresses questions related to soy and chronic disease risk, provides recommendations for optimal intakes, and discusses potential contraindications. As reviewed, the evidence indicates that, with the exception of those individuals allergic to soy protein, soyfoods can play a beneficial role in the diets of vegetarians. Concerns about adverse effects are not supported by the clinical or epidemiologic literature. Based on the soy intake associated with health benefits in the epidemiologic studies and the benefits noted in clinical trials, optimal adult soy intake would appear to be between two and four servings per day
Circumstellar disks around Herbig Ae/Be stars: polarization, outflows and binary orbits
The geometrical relationship between the distribution of circumstellar
matter, observed optical linear polarization, outflows and binary orbital plane
in Herbig Ae/Be stars is investigated. Optical linear polarization measurements
carried out for a number of Herbig Ae/Be stars that are either known to be in
binary systems and/or have bipolar jets are presented in this paper. Available
information on the position angles of polarization, outflows and binary
companions for Herbig Ae/Be stars is compiled and analysed for any possible
correlations. In of the sources the outflow position angle is
within of being parallel or perpendicular to the polarization
position angle. In of the sources the binary position angle is
within of being parallel or perpendicular to the polarization
position angle. Out of 15 sources with bipolar outflows, 10 sources have the
binary position angle within of being perpendicular to the outflow
position angle. These results favour those binary formation mechanisms in which
the binary components and the disks around individual stars or circumbinary
disks are coplanar.Comment: 11 pages, 2 figures, accepted by Astronomy & Astrophysic
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