746 research outputs found

    Situational awareness and safety

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    This paper considers the applicability of situation awareness concepts to safety in the control of complex systems. Much of the research to date has been conducted in aviation, which has obvious safety implications. It is argued that the concepts could be extended to other safety critical domains. The paper presents three theories of situational awareness: the three-level model, the interactive sub-systems approach, and the perceptual cycle. The difference between these theories is the extent to which they emphasise process or product as indicative of situational awareness. Some data from other studies are discussed to consider the negative effects of losing situational awareness, as this has serious safety implications. Finally, the application of situational awareness to system design, and training are presented

    Slow-light enhanced light-matter interactions with applications to gas sensing

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    Optical gas detection in microsystems is limited by the short micron scale optical path length available. Recently, the concept of slow-light enhanced absorption has been proposed as a route to compensate for the short path length in miniaturized absorption cells. We extend the previous perturbation theory to the case of a Bragg stack infiltrated by a spectrally strongly dispersive gas with a narrow and distinct absorption peak. We show that considerable signal enhancement is possible. As an example, we consider a Bragg stack consisting of PMMA infiltrated by O2. Here, the required optical path length for visible to near-infrared detection (~760 nm) can be reduced by at least a factor of 10^2, making a path length of 1 mm feasible. By using this technique, optical gas detection can potentially be made possible in microsystems

    Phase transition between synchronous and asynchronous updating algorithms

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    We update a one-dimensional chain of Ising spins of length LL with algorithms which are parameterized by the probability pp for a certain site to get updated in one time step. The result of the update event itself is determined by the energy change due to the local change in the configuration. In this way we interpolate between the Metropolis algorithm at zero temperature for pp of the order of 1/L and for large LL, and a synchronous deterministic updating procedure for p=1p=1. As function of pp we observe a phase transition between the stationary states to which the algorithm drives the system. These are non-absorbing stationary states with antiferromagnetic domains for p>pcp>p_c, and absorbing states with ferromagnetic domains for ppcp\leq p_c. This means that above this transition the stationary states have lost any remnants to the ferromagnetic Ising interaction. A measurement of the critical exponents shows that this transition belongs to the universality class of parity conservation.Comment: 5 pages, 3 figure

    Shell evolution and nuclear forces

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    We present a quantitative study of the role played by different components characterizing the nucleon-nucleon interaction in the evolution of the nuclear shell structure. It is based on the spin-tensor decomposition of an effective two-body shell-model interaction and the subsequent study of effective single-particle energy variations in a series of isotopes or isotones. The technique allows to separate unambiguously contributions of the central, vector and tensor components of the realistic effective interaction. We show that while the global variation of the single-particle energies is due to the central component of the effective interaction, the characteristic behavior of spin-orbit partners, noticed recently, is mainly due to its tensor part. Based on the analysis of a well-fitted realistic interaction in sdpf-shell model space, we analyze in detail the role played by the different terms in the formation and/or disappearance of N=16, N=20 and N=28 shell gaps in neutron-rich nuclei.Comment: 6 pages, 4 figure

    Inter-rater reliability of the EPUAP pressure ulcer classification system using photographs

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    Background. Many classification systems for grading pressure ulcers are discussed in the literature. Correct identification and classification of a pressure ulcer is important for accurate reporting of the magnitude of the problem, and for timely prevention. The reliability of pressure ulcer classification systems has rarely been tested. Aims and objectives. The purpose of this paper is to examine the inter-rater reliability of classifying pressure ulcers according to the European Pressure Ulcer Advisory Panel classification system when using pressure ulcer photographs.Design. Survey was among pressure ulcer experts.Methods. Fifty-six photographs were presented to 44 pressure ulcer experts. The experts classified the lesions as normal skin, blanchable erythema, pressure ulcer (four grades) or incontinence lesion. Inter-rater reliability was calculated.Results. The multirater-Kappa for the entire group of experts was 0.80 (P < 0.001).Various groups of experts obtained comparable results. Differences in classifications are mainly limited to 1 degree of difference. Incontinence lesions are most often confused with grade 2 (blisters) and grade 3 pressure ulcers (superficial pressure ulcers).Conclusions. The inter-rater reliability of the European Pressure Ulcer Advisory Panel classification appears to be good for the assessment of photographs by experts. The difference between an incontinence lesion and a blister or a superficial pressure ulcer does not always seem clear.Relevance to clinical practice. The ability to determine correctly whether a lesion is a pressure ulcer lesion is important to assess the effectiveness of preventive measures. In addition, the ability to make a correct distinction between pressure ulcers and incontinence lesions is important as they require different preventive measures. A faulty classification leads to mistaken measures and negative results. Photographs can be used as a practice instrument to learn to discern pressure ulcers from incontinence lesions and to get to know the different grades of pressure ulcers. The Pressure Ulcer Classification software package has been developed to facilitate learning

    A comment on multiple vacua, particle production and the time dependent AdS/CFT correspondence

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    We give an explicit formulation of the time dependent AdS/CFT correspondence when there are multiple vacua present in Lorentzian signature. By computing sample two point functions we show how different amplitudes are related by cosmological particle production. We illustrate our methods in two example spacetimes: (a) a ``bubble of nothing'' in AdS space, and (b) an asymptotically locally AdS spacetime with a bubble of nothing on the boundary. In both cases the alpha vacua of de Sitter space make an interesting appearance.Comment: 9 page

    Complete sequence-based pathway analysis by differential on-chip DNA and RNA extraction from a single cell

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    Abstract We demonstrate on-chip, differential DNA and RNA extraction from a single cell using a microfluidic chip and a two-stage lysis protocol. This method enables direct use of the whole extract, without additional washing steps, reducing sample loss. Using this method, the tumor driving pathway in individual cells from a colorectal cancer cell line was determined by applying a Bayesian computational pathway model to sequences obtained from the RNA fraction of a single cell and, the mutations driving the pathway were determined by analyzing sequences obtained from the DNA fraction of the same single cell. This combined functional and mutational pathway assessment of a single cell could be of significant value for dissecting cellular heterogeneity in tumors and analyzing single circulating tumor cells

    Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children

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    A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection

    Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

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    A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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