Full Mouth Rehabilitation of a Patient with Severely Worn Molars: A Case Report

The severe wear of mandibular molar teeth with loss of few teeth, resulting in collapse of vertical dimension at occlusion and also, change in normal occlusal plane. This case report describes a 45yr old female patient who had severely attrited lower molars and loss of vertical dimension. Provisional crown and bridge was used for 4 months with increased vertical dimension, after, taking into consideration of anatomical landmark, facial and physiologic measurement. Once compatibility of stomatognathic system confirmed permanent restoration was initiated. This case reports that a satisfactory clinical result can be achieved by restoring vertical dimension to restore esthetics and function

E. coli AB 1157 susceptibility test, MTT assay on MCF-7 and HeLa cell lines of root and leaf fractions of Viburnum Linn. species

525-530The aim of this study was to evaluate mutagenic bacterial susceptibility and cytotoxic potency of Viburnum coriaceum Blume and Viburnum erubescens Wall.ex DC in order to report the actual chemotherapeutic potentials of these two species. The methanolic (80%) leaf and chloroform root extracts of Viburnum Linn. Species were tested for their bacterial strain based cytotoxicity employing Agar diffusion method suing E. coli AB 1157 strain. Also, the MTT assay was carried out employing MCF-7 breast cancer cell lines and HeLa cervical cell lines. It was started with IC50 value determination of the selected test extracts from the results of bacterial strain based cytotoxicity. Upon increase in concentration up to 1000 µg/mL in agar diffusion cytotoxicity studies VCMLE, VEMLE and VCCRE had shown diameter of inhibition zone 10 mm, 9 mm and 10 mm respectively. Among other extracts, the VEMLE and VCCRE were selected to go ahead with anticancer activity by MTT assay. The potentials of extracts through cytotoxicity mechanism had produced 30-40% protection against cancer cell lines. It was concluded that VEMLE and VCCRE had produced the cytotoxic effect on E. coli AB 1157 strain. and were selected for the cytotoxic studies. The effects exhibited by the selected extracts may be due to the presence of diverse number of active constituents present in Viburnum Linn species also may be to the presence of unreported constituents

E. coli AB 1157 susceptibility test, MTT assay on MCF-7 and HeLa cell lines of root and leaf fractions of Viburnum Linn. species

The aim of this study was to evaluate mutagenic bacterial susceptibility and cytotoxic potency of Viburnum coriaceumBlume and Viburnum erubescens Wall.ex DC in order to report the actual chemotherapeutic potentials of these two species.The methanolic (80%) leaf and chloroform root extracts of Viburnum Linn. Species were tested for their bacterial strainbased cytotoxicity employing Agar diffusion method suing E. coli AB 1157 strain. Also, the MTT assay was carried outemploying MCF-7 breast cancer cell lines and HeLa cervical cell lines. It was started with IC50 value determination of theselected test extracts from the results of bacterial strain based cytotoxicity. Upon increase in concentration up to 1000μg/mL in agar diffusion cytotoxicity studies VCMLE, VEMLE and VCCRE had shown diameter of inhibition zone 10 mm,9 mm and 10 mm respectively. Among other extracts, the VEMLE and VCCRE were selected to go ahead with anticanceractivity by MTT assay. The potentials of extracts through cytotoxicity mechanism had produced 30-40% protection againstcancer cell lines. It was concluded that VEMLE and VCCRE had produced the cytotoxic effect on E. coli AB 1157 strain.and were selected for the cytotoxic studies. The effects exhibited by the selected extracts may be due to the presenceof diverse number of active constituents present in Viburnum Linn species also may be to the presence ofunreported constituents

Interaction of atomic energy levels- V

This article does not have an abstract

Synthesis and antimicrobial activity evaluation of poly ethylene imine (pei) dendrimer modified with 1,3,4 oxadiazole derivatives

Dendrimers have wide range of applications in industry, Pharmaceutical and medicine. Oxadiazole compounds also have many applications in Pharmaceutical and medicine. Modification of dendrimers which have many branches like NH2 functional groups with heterocyclic derivatives make them capable to show variety properties. In this article, PEI-dend-4N(Ts)(2-(methyl)-5-aryl-1,3,4 oxadiazole) ]] 8a-f have been synthesized from PEI (Poly ethylene imine) dendrimer which modified with 1,3,4 oxadiazole derivatives and investigated their antimicrobial activitie

Alcohol use and burden for 195 countries and territories, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016

Background Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2.2% (95% uncertainty interval [UI] 1.5-3.0) of age-standardised female deaths and 6.8% (5.8-8.0) of age-standardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3.8% (95% UI 3.2-4-3) of female deaths and 12.2% (10.8-13-6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2.3% (95% UI 2.0-2.6) and male attributable DALYs were 8.9% (7.8-9.9). The three leading causes of attributable deaths in this age group were tuberculosis (1.4% [95% UI 1. 0-1. 7] of total deaths), road injuries (1.2% [0.7-1.9]), and self-harm (1.1% [0.6-1.5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27.1% (95% UI 21.2-33.3) of total alcohol-attributable female deaths and 18.9% (15.3-22.6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0.0-0.8) standard drinks per week. Interpretation Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption.Peer reviewe