The aim of this study was to evaluate mutagenic bacterial susceptibility and cytotoxic potency of Viburnum coriaceumBlume and Viburnum erubescens Wall.ex DC in order to report the actual chemotherapeutic potentials of these two species.The methanolic (80%) leaf and chloroform root extracts of Viburnum Linn. Species were tested for their bacterial strainbased cytotoxicity employing Agar diffusion method suing E. coli AB 1157 strain. Also, the MTT assay was carried outemploying MCF-7 breast cancer cell lines and HeLa cervical cell lines. It was started with IC50 value determination of theselected test extracts from the results of bacterial strain based cytotoxicity. Upon increase in concentration up to 1000μg/mL in agar diffusion cytotoxicity studies VCMLE, VEMLE and VCCRE had shown diameter of inhibition zone 10 mm,9 mm and 10 mm respectively. Among other extracts, the VEMLE and VCCRE were selected to go ahead with anticanceractivity by MTT assay. The potentials of extracts through cytotoxicity mechanism had produced 30-40% protection againstcancer cell lines. It was concluded that VEMLE and VCCRE had produced the cytotoxic effect on E. coli AB 1157 strain.and were selected for the cytotoxic studies. The effects exhibited by the selected extracts may be due to the presenceof diverse number of active constituents present in Viburnum Linn species also may be to the presence ofunreported constituents