318 research outputs found
Distribution of Glycated Haemoglobin According to Early-Life and Contemporary Characteristics in Adolescents and Adults without Diabetes:The 1982 and 1993 Pelotas Birth Cohorts
AIM:Glycated haemoglobin (HbA1c), a marker of glucose control in individuals with diabetes mellitus, is also related with the incidence of cardiometabolic risk in populations free of disease. The aim of this study was to describe the distribution of HbA1c levels according to early-life and contemporary factors in adolescents and adults without diabetes mellitus. METHODS:HbA1c was measured in adults aged 30 years and adolescents aged 18 years who are participants in the 1982 and 1993 Pelotas Birth Cohorts, respectively. Bivariate and multivariate analyses were performed to describe the HbA1c mean values according to early-life and contemporary characteristics collected prospectively since birth. RESULTS:The distribution of the HbA1c was approximately normal in both cohorts, with a mean (SD) 5.10% (0.43) in the 1982 cohort, and 4.89% (0.50) in the 1993 cohort. HbA1c mean levels were significantly higher in individuals self-reported as black/brown skin color compared to those self-reported as white in both cohorts. Parental history of diabetes was associated with higher HbA1c mean in adults, while stunting at one year old presented an inverse relation with the outcome in adolescents. No other early and contemporary factors were associated with HbA1c levels in adults or adolescents. CONCLUSIONS:We found a consistent relationship between HbA1c and skin color in both cohorts. Further research is needed to understand the role of genomic ancestry on levels of HbA1c concentrations which may inform policies and preventive actions for diabetes mellitus and cardiometabolic risk
Molecular analysis of the distribution and phylogeny of the soxB gene among sulfur-oxidizing bacteria - evolution of the Sox sulfur-oxidizing enzyme system
The soxB gene encodes the SoxB component of the periplasmic thiosulfate-oxidizing Sox enzyme complex, which has been proposed to be widespread among the various phylogenetic groups of sulfur-oxidizing bacteria (SOB) that convert thiosulfate to sulfate with and without the formation of sulfur globules as intermediate. Indeed, the comprehensive genetic and genomic analyses presented in the present study identified the soxB gene in 121 phylogenetically and physiologically divergent SOB, including several species for which thiosulfate utilization has not been reported yet. In first support of the previously postulated general involvement of components of the Sox enzyme complex in the thiosulfate oxidation process of sulfur-storing SOB, the soxB gene was detected in all investigated photo- and chemotrophic species that form sulfur globules during thiosulfate oxidation (Chromatiaceae, Chlorobiaceae, Ectothiorhodospiraceae, Thiothrix, Beggiatoa, Thiobacillus, invertebrate symbionts and free-living relatives). The SoxB phylogeny reflected the major 16S rRNA gene-based phylogenetic lineages of the investigated SOB, although topological discrepancies indicated several events of lateral soxB gene transfer among the SOB, e.g. its independent acquisition by the anaerobic anoxygenic phototrophic lineages from different chemotrophic donor lineages. A putative scenario for the proteobacterial origin and evolution of the Sox enzyme system in SOB is presented considering the phylogenetic, genomic (sox gene cluster composition) and geochemical data
Supersymmetric Electroweak Corrections to Charged Higgs Boson Production in Association with a Top Quark at Hadron Colliders
We calculate the and supersymmetric electroweak corrections to the cross section
for the charged Higgs boson production in association with a top quark at the
Tevatron and the LHC. These corrections arise from the quantum effects which
are induced by potentially large Yukawa couplings from the Higgs sector and the
chargino-top(bottom)-sbottom(stop) couplings,
neutralino-top(bottom)-stop(sbottom) couplings and charged Higgs-stop-sbottom
couplings. They can decrease or increase the cross section depending on
but are not very sensitive to the mass of the charged Higgs boson
for high . At low the corrections decrease the total
cross sections significantly, which exceed -12% for below
at both the Tevatron and the LHC, but for the
corrections can become very small at the LHC. For high
these corrections can decrease or increase the total cross sections, and the
magnitude of the corrections are at most a few percent at both the Tevatron and
the LHC.Comment: 28 pages including 4 eps figure
Broken-Symmetry States in Quantum Hall Superlattices
We argue that broken-symmetry states with either spatially diagonal or
spatially off-diagonal order are likely in the quantum Hall regime, for clean
multiple quantum well (MQW) systems with small layer separations. We find that
for MQW systems, unlike bilayers, charge order tends to be favored over
spontaneous interlayer coherence. We estimate the size of the interlayer
tunneling amplitude needed to stabilize superlattice Bloch minibands by
comparing the variational energies of interlayer-coherent superlattice miniband
states with those of states with charge order and states with no broken
symmetries. We predict that when coherent miniband ground states are stable,
strong interlayer electronic correlations will strongly enhance the
growth-direction tunneling conductance and promote the possibility of Bloch
oscillations.Comment: 9 pages LaTeX, 4 figures EPS, to be published in PR
Red blood cell transfusion practices for patients with cervical cancer undergoing radiotherapy
Biological, physical and clinical aspects of cancer treatment with ionising radiatio
Electroweak Symmetry Breaking at the LHC
One of the major goals of the Large Hadron Collider is to probe the
electroweak symmetry breaking mechanism and the generation of the masses of the
elementary particles. We review the physics of the Higgs sector in the Standard
Model and some of its extensions such as supersymmetric theories and models of
extra dimensions. The prospects for discovering the Higgs particles at the LHC
and the study of their fundamental properties are summarised.Comment: 27 pages, 45 figures, uses LaTeX (insa.sty). Invited review for
volume on LHC physics to celebrate the Platinum Jubilee of the Indian
National Science Academy, edited by Amitava Datta, Biswarup Mukhopadhyaya and
Amitava Raychaudhuri. Expanded the acronym in the title in the annoncement.
No other change in the text or reference
The VANDELS ESO public spectroscopic survey
VANDELS is a uniquely deep spectroscopic survey of high-redshift galaxies with the VIMOS spectrograph on ESO’s Very Large Telescope (VLT). The survey has obtained ultradeep optical (0.48 < λ < 1.0 μ m) spectroscopy of ≃2100 galaxies within the redshift interval 1.0 ≤ z ≤ 7.0, over a total area of ≃0.2 deg2 centred on the CANDELS Ultra Deep Survey and Chandra Deep Field South fields. Based on accurate photometric redshift pre-selection, 85 per cent of the galaxies targeted by VANDELS were selected to be at z ≥ 3. Exploiting the red sensitivity of the refurbished VIMOS spectrograph, the fundamental aim of the survey is to provide the high-signal-to-noise ratio spectra necessary to measure key physical properties such as stellar population ages, masses, metallicities, and outflow velocities from detailed absorption-line studies. Using integration times calculated to produce an approximately constant signal-to-noise ratio (20 < tint< 80 h), the VANDELS survey targeted: (a) bright star-forming galaxies at 2.4 ≤ z ≤ 5.5, (b) massive quiescent galaxies at 1.0 ≤ z ≤ 2.5, (c) fainter star-forming galaxies at 3.0 ≤ z ≤ 7.0, and (d) X-ray/Spitzer-selected active galactic nuclei and Herschel-detected galaxies. By targeting two extragalactic survey fields with superb multiwavelength imaging data, VANDELS will produce a unique legacy data set for exploring the physics underpinning high-redshift galaxy evolution. In this paper, we provide an overview of the VANDELS survey designed to support the science exploitation of the first ESO public data release, focusing on the scientific motivation, survey design, and target selection
Strange particle production in proton-proton collisions at TeV with ALICE at the LHC
The production of mesons containing strange quarks (K, ) and both
singly and doubly strange baryons (, Anti-, and
+Anti-) are measured at central rapidity in pp collisions at
= 0.9 TeV with the ALICE experiment at the LHC. The results are
obtained from the analysis of about 250 k minimum bias events recorded in 2009.
Measurements of yields (dN/dy) and transverse momentum spectra at central
rapidities for inelastic pp collisions are presented. For mesons, we report
yields () of 0.184 0.002 stat. 0.006 syst. for K and
0.021 0.004 stat. 0.003 syst. for . For baryons, we find
= 0.048 0.001 stat. 0.004 syst. for , 0.047
0.002 stat. 0.005 syst. for Anti- and 0.0101 0.0020 stat.
0.0009 syst. for +Anti-. The results are also compared with
predictions for identified particle spectra from QCD-inspired models and
provide a baseline for comparisons with both future pp measurements at higher
energies and heavy-ion collisions.Comment: 33 pages, 21 captioned figures, 10 tables, authors from page 28,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/387
Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at TeV
Inclusive transverse momentum spectra of primary charged particles in Pb-Pb
collisions at = 2.76 TeV have been measured by the ALICE
Collaboration at the LHC. The data are presented for central and peripheral
collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross
section. The measured charged particle spectra in and GeV/ are compared to the expectation in pp collisions at the same
, scaled by the number of underlying nucleon-nucleon
collisions. The comparison is expressed in terms of the nuclear modification
factor . The result indicates only weak medium effects ( 0.7) in peripheral collisions. In central collisions,
reaches a minimum of about 0.14 at -7GeV/ and increases
significantly at larger . The measured suppression of high- particles is stronger than that observed at lower collision energies,
indicating that a very dense medium is formed in central Pb-Pb collisions at
the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98
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