Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation

The editorial services of iS Health, involved in the preparation of this manuscript, were supported by Astellas Pharma Europe Ltd

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper

The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells

A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity

A communal catalogue reveals Earth's multiscale microbial diversity

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe

The link between family identification, loneliness, and symptom severity in people with eating disorders

Families play an important role in eating disorder (ED) recovery, and it has been suggested that they can ameliorate the loneliness associated with EDs. However, the psychological mechanisms through which this occurs have yet to be systematically explored. Utilising the Social Identity Approach to Health, we explore whether identification with one’s family group positively predicts health in people with self-reported EDs due to its potential to reduce feelings of loneliness. We investigate this in two online questionnaire studies (N=82; N=234), one conducted before the COVID-19 pandemic and the second conducted in its early stages. In both studies, mediation analyses demonstrated that family identification was associated with fewer and less severe self-reported ED symptoms, and in the context of the COVID-19 pandemic, reduced self-reported ED-related impact and anxiety. In both studies, these benefits were suggestive of a protective role of family identification against loneliness. Our findings provide a framework for understanding in general why families can be considered an important social recovery resource and should be included in the treatment of adult EDs. Please refer to the Supplementary Material section to find this article’s Community and Social Impact Statement

Family identification is a protective resource for people with eating disorders because it ameliorates feelings of loneliness

Families play an important role in eating disorder recovery. Recently, it has been suggested that they can ameliorate the loneliness and social isolation associated with an eating disorder. However, the psychological mechanisms through which this occurs have yet to be systematically explored. Utilising the Social Identity Approach to Health, we explore whether identification with one’s family group positively predicts health and wellbeing in people with eating disorders due to its capacity to reduce feelings of loneliness. We investigate this in two studies (N=82; N=234), one of which was conducted in the early stages of the COVID-19 pandemic. In both studies, we demonstrated that family identification protects health. This was apparent in participants reporting fewer and less severe ED symptoms, and in the context of the COVID-19 pandemic, reduced eating disorder-related impact and reduced anxiety. In both studies, these benefits were attributable to the protective role of family identification against loneliness. Our findings provide a framework for understanding in general why family is so important in treatment, including in the case of adults. It also supports the focus in treatment on the family as a group rather than as a collection of interpersonal relationships