93 research outputs found

    Bose-Einstein correlations of same-sign charged pions in the forward region in pp collisions at √s=7 TeV

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    Bose-Einstein correlations of same-sign charged pions, produced in protonproton collisions at a 7 TeV centre-of-mass energy, are studied using a data sample collected by the LHCb experiment. The signature for Bose-Einstein correlations is observed in the form of an enhancement of pairs of like-sign charged pions with small four-momentum difference squared. The charged-particle multiplicity dependence of the Bose-Einstein correlation parameters describing the correlation strength and the size of the emitting source is investigated, determining both the correlation radius and the chaoticity parameter. The measured correlation radius is found to increase as a function of increasing charged-particle multiplicity, while the chaoticity parameter is seen to decreas

    Search for pair-produced resonances decaying to quark pairs in proton-proton collisions at root s=13 TeV

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    A general search for the pair production of resonances, each decaying to two quarks, is reported. The search is conducted separately for heavier resonances (masses above 400 GeV), where each of the four final-state quarks generates a hadronic jet resulting in a four-jet signature, and for lighter resonances (masses between 80 and 400 GeV), where the pair of quarks from each resonance is collimated and reconstructed as a single jet resulting in a two-jet signature. In addition, a b-tagged selection is applied to target resonances with a bottom quark in the final state. The analysis uses data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 35.9 fb(-1), from proton-proton collisions at a center-of-mass energy of 13 TeV. The mass spectra are analyzed for the presence of new resonances, and are found to be consistent with standard model expectations. The results are interpreted in the framework of R-parity-violating supersymmetry assuming the pair production of scalar top quarks decaying via the hadronic coupling lambda ''(312) or lambda ''(323) and upper limits on the cross section as a function of the top squark mass are set. These results probe a wider range of masses than previously explored at the LHC, and extend the top squark mass limits in the (t) over tilde -> qq' scenario.Peer reviewe

    AI is a viable alternative to high throughput screening: a 318-target study

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    : High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

    Comparison of inclusive and photon-tagged jet suppression in 5.02 TeV Pb+Pb collisions with ATLAS

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    Parton energy loss in the quark–gluon plasma (QGP) is studied with a measurement of photon-tagged jet production in 1.7 nb−1 of Pb+Pb data and 260 pb−1 of pp data, both at √sNN = 5.02 TeV, with the ATLAS detector. The process pp → γ +jet+X and its analogue in Pb+Pb collisions is measured in events containing an isolated photon with transverse momentum (pT) above 50 GeV and reported as a function of jet pT. This selection results in a sample of jets with a steeply falling pT distribution that are mostly initiated by the showering of quarks. The pp and Pb+Pb measurements are used to report the nuclear modification factor, RAA, and the fractional energy loss, Sloss, for photon-tagged jets. In addition, the results are compared with the analogous ones for inclusive jets, which have a significantly smaller quark-initiated fraction. The RAA and Sloss values are found to be significantly different between those for photon-tagged jets and inclusive jets, demonstrating that energy loss in the QGP is sensitive to the colour-charge of the initiating parton. The results are also compared with a variety of theoretical models of colour-charge-dependent energy loss

    Corrigendum to "Search for flavour-changing neutral-current couplings between the top quark and the photon with the ATLAS detector at √s=13 TeV" (Physics Letters B, 842 (2023), 137379)

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    Observation of the decay Λb0 → pK−μ+μ− and a search for CP violation

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    A search for CP violation in the decay Λb 0 → pK−μ+μ− is presented. This decay is mediated by flavour-changing neutral-current transitions in the Standard Model and is potentially sensitive to new sources of CP violation. The study is based on a data sample of proton-proton collisions recorded with the LHCb experiment, corresponding to an integrated luminosity of 3 fb−1. The Λb 0 → pK−μ+μ− decay is observed for the first time, and two observables that are sensitive to different manifestations of CP violation are measured, (Formula Presented.)where the latter is based on asymmetries in the angle between the μ+μ− and pK− decay planes. These are measured to be(Formula Presented.)and no evidence for CP violation is found.[Figure not available: see fulltext.].</p

    Measurement of prompt D+ and Ds+ production in pPb collisions at √sNN = 5. 02 TeV

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    The production of prompt D+ and D+s mesons is studied in proton-lead collisions at a centre-of-mass energy of √sNN = 5.02 TeV. The data sample corresponding to an integrated luminosity of (1.58 ± 0.02)nb−1 is collected by the LHCb experiment at the LHC. The differential production cross-sections are measured using D+ and D+s candidates with transverse momentum in the range of 0 &lt; pT &lt; 14 GeV/c and rapidities in the ranges of 1.5 &lt; y∗ &lt; 4.0 and –5.0 &lt; y∗ &lt; –2.5 in the nucleon-nucleon centre-of-mass system. For both particles, the nuclear modification factor and the forward-backward production ratio are determined. These results are compared with theoretical models that include initial-state nuclear effects. In addition, measurements of the cross-section ratios between D+, D+s and D0 mesons are presented, providing a baseline for studying the charm hadronization in lead-lead collisions at LHC energies

    Prompt and nonprompt ψ (2S) production in pPb collisions at √sNN = 8. 16 TeV

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    The production of ψ(2S) mesons in proton-lead collisions at a centre-of-mass energy per nucleon pair of √sNN = 8.16 TeV is studied with the LHCb detector using data corresponding to an integrated luminosity of 34 nb−1. The prompt and nonprompt ψ(2S) production cross-sections and the ratio of the ψ(2S) to J/ψ cross-section are measured as a function of the meson transverse momentum and rapidity in the nucleon-nucleon centre-of-mass frame, together with forward-to-backward ratios and nuclear modification factors. The production of prompt ψ(2S) is observed to be more suppressed compared to pp collisions than the prompt J/ψ production, while the nonprompt productions have similar suppression factors

    Measurement of the CKM angle γ using the B± → D*h± channels

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    A measurement of the CP-violating observables from B± → D*K± and B± → D*π± decays is presented, where D*(D) is an admixture of D*0 and D¯∗0 (D0 and D¯0) states and is reconstructed through the decay chains D*→ Dπ0/γ and D→KS0π+π−/KS0K+K−. The measurement is performed by analysing the signal yield variation across the D decay phase space and is independent of any amplitude model. The data sample used was collected by the LHCb experiment in proton-proton collisions and corresponds to a total integrated luminosity of 9 fb−1 at centre-of-mass energies of 7, 8 and 13 TeV. The CKM angle γ is determined to be 69−14+13∘ using the measured CP-violating observables. The hadronic parameters rBD∗K±, rBD∗π±, δBD∗K±, δBD∗π±, which are the ratios and strong phase differences between favoured and suppressed B± decays, are also reported

    Search for CP violation in the phase space of D0 → KS0K±π∓ decays with the energy test

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    A search for CP violation in D0 → KS0K+π− and D0 → KS0K−π+ decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb−1 collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of √s = 13 TeV, amounting to approximately 950 thousand and 620 thousand signal candidates for the D0 → KS0K−π+ and D0 → KS0K+π− modes, respectively. The method is validated using D0 → K−π+π−π+ and D0 → KS0π+π− decays, where CP-violating effects are expected to be negligible, and using background-enhanced regions of the signal decays. The results are consistent with CP symmetry in both the D0 → KS0K−π+ and the D0 → KS0K+π− decays, with p-values for the hypothesis of no CP violation of 70% and 66%, respectively
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