Religion, Morality, and the Law

Some Reflections on Multiculturalism, \u27Equal Concern and Respect,\u27 and the Establishment Clause of the First Amendment lecture given by Sanford Levinson, who occupies the W. St. John Garwood and W. St. John Garwood Jr., Regents Chair in the Law at the University of Texas Law School. Abraham, Isaac, and the State: Faith-healing and Legal Intervention lecture given by Henry J. Abraham, who is the James Hart Professor of Government and Foreign Affairs at the University of Virginia. Is the Idea of Human Rights Ineliminably Religious? lecture given by Michael Perry who occupies the Howard J. Trienens Chair in Law at Northwestern University

Bespoke cell therapy manufacturing platforms - a contradiction in terms?

Advanced biological therapies, such as cell and viral therapeutics, will have a transformative effect on healthcare. In many cases these therapies are curative rather than palliative and aim to treat a wide range of diseases including malignancies, cardiovascular, immune, and metabolic disorders. As cell therapies begin to enter commercialization stages, some of the bigger challenges that need to be addressed include bottlenecks in production and high cost of goods. At the same time, switching to manufacturing platforms that might allow scale-up (allogeneic) and scale-out (autologous) to allow commercialization at an acceptable cost of goods could result in changes to the cell product critical quality attributes. For the field to move forward, it is imperative to enable the use of production platforms that allow commercialization, yielding high quality and quantity of cells at acceptable costs. Yet, as opposed to the highly commercialized mammalian cell protein manufacturing, in which the same cell types and processes are used to produce many different proteins, the diversity of cell types and processes in cell therapy may require significantly different manufacturing methods. Does this mean that a multitude of different manufacturing platforms is needed and feasible for cell therapy manufacturing? Or is the development of a one-size-fits-all platform a superior and possible approach? How would an optimal bespoke platform approach look like, and would it work for different modalities (allogeneic vs. autologous), and a diversity of cell types and processes? These questions will be addressed and possible considerations and solutions presented

Heavy Nuclei Synthesized in Gamma-Ray Burst Outflows as the Source of UHECRs

Recent measurements by the Pierre Auger Observatory suggest that the composition of ultra-high energy cosmic rays (UHECRs) becomes dominated by heavy nuclei at high energies. However, until now there has been no astrophysical motivation for considering a source highly enriched in heavy elements. Here we demonstrate that the outflows from Gamma-Ray Bursts (GRBs) may indeed be composed primarily of nuclei with masses A ~ 40-200, which are synthesized as hot material expands away from the central engine. In particular, if the jet is magnetically-dominated (rather than a thermally-driven fireball) its low entropy enables heavy elements to form efficiently. Adopting the millisecond proto-magnetar model for the GRB central engine, we show that heavy nuclei are both synthesized in proto-magnetar winds and can in principle be accelerated to energies >1e20 eV in the shocks or regions of magnetic reconnection that are responsible for powering the GRB. Similar results may apply to accretion-powered GRB models if the jet originates from a magnetized disk wind. Depending on the precise distribution of nuclei synthesized, we predict that the average primary mass may continue to increase beyond Fe group elements at the highest energies, possibly reaching the A ~ 90 (Zirconium), A ~ 130 (Tellurium), or even A ~ 195 (Platinum) peaks. Future measurements of the UHECR composition at energies >~ 1e20 eV can thus confirm or constrain our model and, potentially, probe the nature of GRB outflows. The longer attenuation length of ultra-heavy nuclei through the extragalactic background light greatly expands the volume of accesible sources and alleviates the energetic constraints on GRBs as the source of UHECRs.Comment: 10 pages, 3 figures, final version now accepted to MNRA

Constraints on the Local Sources of Ultra High-Energy Cosmic Rays

Ultra high-energy cosmic rays (UHECRs) are believed to be protons accelerated in magnetized plasma outflows of extra-Galactic sources. The acceleration of protons to ~10^{20} eV requires a source power L>10^{47} erg/s. The absence of steady sources of sufficient power within the GZK horizon of 100 Mpc, implies that UHECR sources are transient. We show that UHECR "flares" should be accompanied by strong X-ray and gamma-ray emission, and that X-ray and gamma-ray surveys constrain flares which last less than a decade to satisfy at least one of the following conditions: (i) L>10^{50} erg/s; (ii) the power carried by accelerated electrons is lower by a factor >10^2 than the power carried by magnetic fields or by >10^3 than the power in accelerated protons; or (iii) the sources exist only at low redshifts, z<<1. The implausibility of requirements (ii) and (iii) argue in favor of transient sources with L>10^{50} erg/s.Comment: 7 pages, 1 figure, submitted to JCA

Non-thermal high-energy emissions from black holes by a relativistic capillary effect

Gravitational spin-orbit interactions induce a relativistic capillary effect along open magnetic flux-tubes, that join the event horizon of a spinning black hole to infinity. It launches a leptonic outflow from electron-positron pairs created near the black hole, which terminates in an ultra-relativistic Alfv\'en wave. Upstream to infinity, it maintains a clean linear accelerator for baryons picked-up from an ionized ambient environment. We apply it to the origin of UHECRs and to spectral energy correlations in cosmological gamma-ray bursts. The former is identified with the Fermi-level of the black hole event horizon, the latter with a correlation $E_pT_{90}^{1/2}\simeq E_\gamma$ in HETE-II and Swift data.Comment: 1 figur

THE PERIODONTAL CONDITION OF INSTITUTIONALIZED CHILDREN; IMPROVEMENT THROUGH ORAL HYGIENE *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65609/1/j.1752-7325.1968.tb03921.x.pd

Effects of plasma magnesium and prolactin on quantitative ultrasound measurements of heel bone among schizophrenic patients

<p>Abstract</p> <p>Background</p> <p>Osteoporosis is a bone disease that can reduce both bone mass and bone strength. It can cause serious fractures of bones, along with causing significant and even devastating physical, psychological and financial consequences for patients and their family members. Many reports have revealed that the prevalence of decreased bone density is higher in schizophrenic patients than in the non-psychological diseased population. The previous report of our group revealed that chronic schizophrenia patients have poorer BUA levels since they were young as compared to the general community population. Hyperprolactinemia and antipsychotics are reported to be among the risk factors for osteoporosis in chronic schizophrenic patients.</p> <p>Methods</p> <p>93 schizophrenic patients with severely poor adjusted BUA values and 93 age and gender matched patients with normal adjusted BUA values from a previous survey study were selected. Data were collected via questionnaires and via reviews of antipsychotic medications. Blood samples were drawn, and serum levels of prolactin, estradiol, testosterone, magnesium, calcium, phosphate, osteocalcin, Cross-linked N-teleopeptide of type I collagen (NTX), thyroid hormone and parathyroid hormone were checked. The association between BUA levels and serum levels of the above items, along with the type of received antipsychotic medication, was evaluated.</p> <p>Results</p> <p>There was no significant association found between reduced BUA levels and serum prolactin, calcium, phosphate, osteocalcin, NTX, thyroid stimulating hormone and parathyroid hormone levels. There was also no association between BUA levels and types of currently received antipsychotics. There was no association between BUA levels and menstruation condition in female patients. Hypermagnesemia had a borderline association with classical and combined (classical and atypical) antipsychotic medications in male patients. Nevertheless, hypermagnesemia is a significant protective factor of reduced BUA levels in female patients. Hyperprolactinemia had a significant association with classical and combined antipsychotic medications in female patients. Hyperprolactinemia, however, provides a protective effect on reduced BUA levels in male patients. There was no significant association found between serum prolactin level and the type of antipsychotic medication received.</p> <p>Conclusions</p> <p>The results of this study are in contrast with literature that has reported an association between bone mass and serum prolactin levels, serum magnesium levels and type of received antipsychotics. Further study to investigate the pathophysiological process and the association between bone mass and serum prolactin level, serum magnesium level and specific antipsychotics is necessary.</p

Blazars as Ultra-High-Energy Cosmic-Ray Sources: Implications for TeV Gamma-Ray Observations

The spectra of BL Lac objects and Fanaroff-Riley I radio galaxies are commonly explained by the one-zone leptonic synchrotron self-Compton (SSC) model. Spectral modeling of correlated multiwavelength data gives the comoving magnetic field strength, the bulk outflow Lorentz factor and the emission region size. Assuming the validity of the SSC model, the Hillas condition shows that only in rare cases can such sources accelerate protons to much above 10^19 eV, so > 10^20 eV ultra-high-energy cosmic rays (UHECRs) are likely to be heavy ions if powered by this type of radio-loud active galactic nuclei (AGN). Survival of nuclei is shown to be possible in TeV BL Lacs and misaligned counterparts with weak photohadronic emissions. Another signature of hadronic production is intergalactic UHECR-induced cascade emission, which is an alternative explanation of the TeV spectra of some extreme non-variable blazars such as 1ES 0229+200 or 1ES 1101-232. We study this kind of cascade signal, taking into account effects of the structured extragalactic magnetic fields in which the sources should be embedded. We demonstrate the importance of cosmic-ray deflections on the gamma-ray flux, and show that required absolute cosmic-ray luminosities are larger than the average UHECR luminosity inferred from UHECR observations and can even be comparable to the Eddington luminosity of supermassive black holes. Future TeV gamma-ray observations using the Cherenkov Telescope Array and the High Altitude Water Cherenkov detector array can test for UHECR acceleration by observing >25 TeV photons from relatively low-redshift sources such as 1ES 0229+200, and > TeV photons from more distant radio-loud AGN.Comment: 14 pages, 9 figures, 2 tables, accepted for publication in ApJ, references and discussions adde

Non-thermal transient sources from rotating black holes

Rotating black holes can power the most extreme non-thermal transient sources. They have a long-duration viscous time-scale of spin-down and produce non-thermal emissions along their spin-axis, powered by a relativistic capillary effect. We report on the discovery of exponential decay in BATSE light curves of long GRBs by matched filtering, consistent with a viscous time-scale, and identify UHECRs energies about the GZK threshold in linear acceleration of ion contaminants along the black hole spin-axis, consistent with black hole masses and lifetimes of FR II AGN. We explain the absence of UHECRs from BL Lac objects due to UHECR emissions preferably at appreciable angles away from the black hole spin-axis. Black hole spin may be key to unification of GRBs and their host environments, and to AGN and their host galaxies. Our model points to long duration bursts in radio from long GRBs without supernovae and gravitational-waves from all long GRBs.Comment: Accepted by MNRA

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13