23 research outputs found

    Assessing the Origin of Noise in the Precipitation Gauge Geonor T-200B

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    The Geonor T-200B is an all-weather precipitation gauge utilized by the Research Applications Laboratory (RAL) under the University Corporation for Atmospheric Research (UCAR) and the National Center for Atmospheric Research (NCAR). RAL has been dealing with a persistent issue of noise within the Geonor Devices during non-precipitation events. When there is not precipitation occurring, the data reading off the Geonor would be expected to be a constant value, as no precipitation is being collected. However, the device is producing unaccounted variation (noise) causing tremor like lines to appear in the data. The noise in the data is an issue for RAL because it makes it complicated to pinpoint the exact beginning and end of a precipitation event. Many airports use the Geonor sensors to predict unsafe flying conditions. Being able to pinpoint the beginning and ending weather patterns during storms would lead to more accurate and efficient airport scheduling. To isolate the source of the undesired noise two correlation experiments were run on the Geonor gauges. The experiments were conducted at the NCAR Marshal Field test site. The first test was to understand the effect of temperature change on the noise. The second test provided assess the effect of electrical interference on the noise in the device. The change in temperature correlated 63% to a change in frequency from the Geonor. The electrical interference test provided a reduction of variation in the frequency by two hertz. From the result of the study it can be stated that a change in temperature has a great effect on the noise from the Geonor and causes diurnal variation in the data. The electrical interference test showed promising results as a possible origin of the noise. Further experiments should be conducted to prove that adding an electrical shield reduces the noise within the device. Another source of noise to asses in further experiments would be the effect of temperature on the electrical panel that collects the data

    Characterization and Generation of Male Courtship Song in Cotesia congregata (Hymenoptera: Braconidae)

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    Background Male parasitic wasps attract females with a courtship song produced by rapid wing fanning. Songs have been described for several parasitic wasp species; however, beyond association with wing fanning, the mechanism of sound generation has not been examined. We characterized the male courtship song of Cotesia congregata (Hymenoptera: Braconidae) and investigated the biomechanics of sound production. Methods and Principal Findings Courtship songs were recorded using high-speed videography (2,000 fps) and audio recordings. The song consists of a long duration amplitude-modulated “buzz” followed by a series of pulsatile higher amplitude “boings,” each decaying into a terminal buzz followed by a short inter-boing pause while wings are stationary. Boings have higher amplitude and lower frequency than buzz components. The lower frequency of the boing sound is due to greater wing displacement. The power spectrum is a harmonic series dominated by wing repetition rate ~220 Hz, but the sound waveform indicates a higher frequency resonance ~5 kHz. Sound is not generated by the wings contacting each other, the substrate, or the abdomen. The abdomen is elevated during the first several wing cycles of the boing, but its position is unrelated to sound amplitude. Unlike most sounds generated by volume velocity, the boing is generated at the termination of the wing down stroke when displacement is maximal and wing velocity is zero. Calculation indicates a low Reynolds number of ~1000. Conclusions and Significance Acoustic pressure is proportional to velocity for typical sound sources. Our finding that the boing sound was generated at maximal wing displacement coincident with cessation of wing motion indicates that it is caused by acceleration of the wing tips, consistent with a dipole source. The low Reynolds number requires a high wing flap rate for flight and predisposes wings of small insects for sound production

    A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.

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    The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of their anti-emetic properties and repurposing from one indication to another is a continuing trend. Notably, the discoveries have occurred against a background of company mergers and changing anti-emetic requirements. Major drug classes include: (i) Muscarinic receptor antagonists-originated from historical accounts of plant extracts containing atropine and hyoscine with development stimulated by the need to prevent sea-sickness among soldiers during beach landings; (ii) Histamine receptor antagonists-searching for replacements for the anti-malaria drug quinine, in short supply because of wartime shipping blockade, facilitated the discovery of histamine (H1) antagonists (e.g., dimenhydrinate), followed by serendipitous discovery of anti-emetic activity against motion sickness in a patient undergoing treatment for urticaria; (iii) Phenothiazines and dopamine receptor antagonists-investigations of their pharmacology as "sedatives" (e.g., chlorpromazine) implicated dopamine receptors in emesis, leading to development of selective dopamine (D2) receptor antagonists (e.g., domperidone with poor ability to penetrate the blood-brain barrier) as anti-emetics in chemotherapy and surgery; (iv) Metoclopramide and selective 5-hydroxytryptamine3(5-HT3) receptor antagonists-metoclopramide was initially assumed to act only via D2 receptor antagonism but subsequently its gastric motility stimulant effect (proposed to contribute to the anti-emetic action) was shown to be due to 5-hydroxytryptamine4 receptor agonism. Pre-clinical studies showed that anti-emetic efficacy against the newly-introduced, highly emetic, chemotherapeutic agent cisplatin was due to antagonism at 5-HT3 receptors. The latter led to identification of selective 5-HT3 receptor antagonists (e.g., granisetron), a major breakthrough in treatment of chemotherapy-induced emesis; (v) Neurokinin1receptor antagonists-antagonists of the actions of substance P were developed as analgesics but pre-clinical studies identified broad-spectrum anti-emetic effects; clinical studies showed particular efficacy in the delayed phase of chemotherapy-induced emesis. Finally, the repurposing of different drugs for treatment of nausea and vomiting is examined, particularly during palliative care, and also the challenges in identifying novel anti-emetic drugs, particularly for treatment of nausea as compared to vomiting. We consider the lessons from the past for the future and ask why there has not been a major breakthrough in the last 20 years

    Multidimensional signals and analytic flexibility: Estimating degrees of freedom in human speech analyses

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    Recent empirical studies have highlighted the large degree of analytic flexibility in data analysis which can lead to substantially different conclusions based on the same data set. Thus, researchers have expressed their concerns that these researcher degrees of freedom might facilitate bias and can lead to claims that do not stand the test of time. Even greater flexibility is to be expected in fields in which the primary data lend themselves to a variety of possible operationalizations. The multidimensional, temporally extended nature of speech constitutes an ideal testing ground for assessing the variability in analytic approaches, which derives not only from aspects of statistical modeling, but also from decisions regarding the quantification of the measured behavior. In the present study, we gave the same speech production data set to 46 teams of researchers and asked them to answer the same research question, resulting insubstantial variability in reported effect sizes and their interpretation. Using Bayesian meta-analytic tools, we further find little to no evidence that the observed variability can be explained by analysts’ prior beliefs, expertise or the perceived quality of their analyses. In light of this idiosyncratic variability, we recommend that researchers more transparently share details of their analysis, strengthen the link between theoretical construct and quantitative system and calibrate their (un)certainty in their conclusions

    Tradition, tribe and state in Kenya: the Mijikenda Union, 1945-1980

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    The apparent mobilizing power of ethnic sentiment in recent African history has been the subject of vigorous debate. Studies that emphasize the centrality of colonialism and the instrumental use of ethnicity have been criticized by a scholarship arguing that the affective power of ethnicity is culturally rooted through longstanding experience and practice, and that both manipulation and invention are constrained by this. This paper contributes to that debate through a discussion of the history of the Mijikenda, one of the “super-tribes” of modern Kenyan politics. It suggests that there were indeed “limits to invention,” but that there was nonetheless substantial entrepreneurship and creativity in the politics of Mijikenda identity. This drew heavily on the productive, discursive tension between tradition and modernity that lay at the heart of colonialism and was drawn into vigorous debates over legitimacy and representation in the “critical juncture” of the final years of colonial rule
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