How the Badinter Commission on Yugoslavia laid the roots for Crimea’s secession from Ukraine

The Russian annexation of Crimea, together with the on-going war in eastern Ukraine, have raised fundamental questions concerning the right of a territory to secede from a larger state. Cornelia Navari writes on the influence of the Badinter Commission, which was set up to provide legal advice during the breakup of Yugoslavia. She argues that while the secession of Crimea from Ukraine remains deeply controversial, it largely followed the ‘template’ set by Badinter

Palonosetron for the prevention of chemotherapy-induced nausea and vomiting: approval and efficacy

Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles, and patient characteristics (female gender, younger age, low alcohol consumption, history of motion sickness) are the major risk factors for CINV. This review provides a detailed description of palonosetron, a second-generation 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. The chemistry and pharmacology of palonosetron are described, as well as the initial and recent clinical trials. Palonosetron has a longer half-life and a higher binding affinity than the first-generation 5-HT3 receptor antagonists. Palonosetron has been approved for the prevention of acute CINV in patients receiving either moderately or highly emetogenic chemotherapy and for the prevention of delayed CINV in patients receiving moderately emetogenic chemotherapy. In recent studies, compared to the first-generation 5-HT3 receptor antagonists, palonosetron in combination with dexamethasone demonstrated better control of delayed CINV in patients receiving highly emetogenic chemotherapy. There were no clinically relevant adverse reactions reported in the palonosetron clinical trials which were different from the common reactions reported for the 5-HT3 receptor antagonist class. Due to its efficacy in controlling both acute and delayed CINV, palonosetron may be very effective in the clinical setting of multiple-day chemotherapy and bone marrow transplantation

PENGARUH STATUS SOSIAL EKONOMI ORANG TUA DAN EFIKASI DIRI TERHADAP MINAT MELANJUTKAN PENDIDIKAN KE PERGURUAN TINGGI PADA SISWA SMA KECAMATAN CENGKARENG.

Ravita Gesit Navari, 1709617004, Pengaruh Status Sosial Ekonomi Orang Tua Dan Efikasi Diri Terhadap Minat Melanjutkan Pendidikan Ke Perguruan Tinggi Pada Siswa Sma Kecamatan Cengkareng, Skripsi, Jakarta: Fakultas Ekonomi, Universitas Negeri Jakarta, 2022. Tujuan dari penelitian ini adalah untuk mengetahui Status Sosial Ekonomi Orang Tua Dan Efikasi Diri Terhadap Minat Melanjutkan Pendidikan Ke Perguruan Tinggi Pada Siswa Sma Kecamatan Cengkareng. Metode penelitian yang peneliti gunakan adalah metode survei dengan pendekatan deskriptif, populasi yang digunakan adalah siswa kelas XII SMA Kecamatan Cengkareng dengan populasi sebanyak 165 siswa dengan jumlah sampel 110 siswa. Model dalam penelitian ini menggunakan model analisis regresi berganda. Teknik pengambilan sampel menggunakan teknik proportional random sampling. pengumpulan data dilakukan melalui kuesioner dengan skala likert yang dioperasikan dengan program SPSS untuk pengujian hipotesis. Teknik analisis yang dilakukan dalam SPSS meliputi Hasil penelitian yang didapatkan adalah status sosial ekonomi orang tua berpengaruh positif dan signifikan terhadap minat melanjutkan pendidikan ke perguruan tinggi, efikasi diri berpengaruh positif dan signifikan terhadap minat melanjutkan pendidikan ke perguruan tinggi. status sosial ekonomi orang tua dan efikasi diri berpengaruh positif dan signifikan terhadap minat melanjutkan pendidikan ke perguruan tinggi Kata kunci: status sosial ekonomi orang tua, efikasi diri, minat melanjutkan pendidikan ke perguruan tingg

Lipid composition of pea (Pisum sativum L.) and maize (Zea mays L.) root plasma membrane and membrane-bound peroxidase and superoxide dismutase

Plasma membrane was isolated from roots of pea and maize plants and used to analyze POD and SOD isoforms, as well as lipid composition. Among lipids, phospholipids were the main lipid class, with phosphatidylcholine being the most abundant individual component in both pea and maize plasma membranes. Significant differences between the two plant species were found in the contents of cerebrosides, free sterols, and steryl glycosides. Most maize POD isoforms were with neutral and anionic pI values, but the opposite was observed in pea. While both anionic and cationic SOD isoforms were isolated from maize, only two anionic SOD isoforms were detected in pea

EOLO: Sistema per la regolazione controllata di gas ad uso medico per terapia e diagnosi

not availableIl progetto riguarda principalmente l\u27ossigeno terapia e la somministrazione di ossido nitrico per terapia e diagnostica La somministrazione controllata di gas ad uso terapeutico ? oggi una pratica clinica consolidata in special modo nella ossigeno terapia per patologie quali le broncopneumopatie croniche ostruttive (BPCO). Nuove terapie con altri gas quali l\u27ossido nitrico NO rappresentano metodiche in corso di validazione clinica ma gi? accettate da organismi di controllo quali FDA, soprattutto nei casi di ipertensione polmonare primitiva. Ci si riferisce quindi a sistemi di somministrazione di gas, come quelli rammentati, mettendo a punto metodiche originarie di "feedback" su parametri fisiologici, misurati durante la terapia in modo incruento, per gestire i relativi dispositivi di erogazione del gas stesso e al monitoraggio delle variabili biologiche rilevanti da parte di centri opportuni. Le malattie respiratorie, dopo le malattie cardiocircolatorie ed i tumori, sono tra le maggiori cause di morte nel mondo. Il loro trend ? crescente, essendo esse causate, fra l\u27altro, da fattori come il fumo e l\u27inquinamento, che sono a loro volta in crescita. Da qui la necessit? di realizzare sistemi semplici ed efficaci per il controllo della strumentazione di ossigenoterapia in una vasta popolazione, anche per gli usi domiciliari. Non ultimo diventa importante con questi numeri, pensare ad una razionalizzazione automatica dei consumi di ossigeno. Per quel che riguarda l\u27ipertensione polmonare, altra patologia verso cui EOLO ? rivolto, un potenziale rimedio ? costituito dalla somministrazione in dosi terapeutiche di Ossido Nitrico in sostituzione ad esempio delle prostacicline con il vantaggio di non ricorrere ad applicazioni invasive cruente e di evitare effetti collaterali sistemici. L\u27uso di questo gas medicale ? per? limitata in quanto il mercato non propone dispositivi per la somministrazione di ossido nitrico ottimizzati alle sue indicazioni d\u27uso. Le indicazione d\u27uso prevedono, infatti, la somministrazione di ossido nitrico a bassi dosaggi(5-40 ppm) e la limitazione del tempo di contatto tra l\u27ossido nitrico e i gas inalatori che il paziente deve respirare. Tale metodologia di somministrazione ? requisito essenziale per il suo impiego, in quanto questo gas si combina molto velocemente con l\u27ossigeno formando Biossido d\u27Azoto (NO2), un gas altamente nocivo. Il biossido di azoto reagendo a sua volta con l\u27acqua forma acido nitrico (HNO3), che ? un acido particolarmente reattivo quindi pericoloso

The English School in retrospect and prospect: Barry Buzan’s an introduction to the English School of International Relations: the societal approach

Over the last few decades the English School (ES) has not only emerged, but has been acknowledged as a distinctive approach to the study of International Relations (IR). It is routinely listed in textbooks and disciplinary surveys as one of IR’s primary modes of inquiry, attracting interest and adherents in many parts of the world. This state of affairs is attributable to the work of a number of people, but especially to that of Barry Buzan. More than ‘reconvening’ the school, a metaphor misleading in some ways, Buzan has led, pushed and challenged his colleagues to better clarify and define their ideas, concepts and theories, as well as to put the ES on a much sounder organizational footing. Buzan’s (2014) latest book builds on his previous volume (Buzan, 2004a) to provide an introduction for readers new to the school. However, it does much more than this, providing a ‘state of the debate’ on such demanding matters as the expansion of international society, and the pluralist–solidarist divide. It also links present research efforts to the classics, putting into perspective and defining the school’s current research agenda for the next phase of its development. It has the potential to become a landmark work on a par with the classic work of the early ES, Hedley Bull’s The Anarchical Society. But how does Buzan’s research agenda respond to the requirements of an increasingly diverse and fragmenting discipline? Are his preferred analytical concepts and categories sound? Of what pitfalls should newcomers to the school be aware? In this symposium five established scholars, closely associated with the ES, seek to answer these questions, and in dialogue with Buzan, further advance our understanding of the school’s ‘societal’ approach and its potential for deepening our understanding of what at times appears a highly unsocial world. The approach of the section is ‘internal’ as opposed to ‘external’ critique. External critiques of the ES are well known (see, e.g., Finnemore, 2001). The section proceeds on the assumption that at this stage of its development the school’s approach can be most effectively advanced by vigorous debate between those who share the same broad research agenda with little purpose being served by reiterating the already well-known ‘external’ objections. The section is based on a roundtable discussion held at the EISA conference, Warsaw, September 2013, in which Zhang, Wilson, Navari and Buzan took part. I am grateful to these contributors as well as to Knudsen and Sharp for their timely and thought-provoking contributions