ベトナムダイオキシン高濃度汚染地域における授乳中の母親の唾液中ホルモン値の検討

【目的】アメリカ軍は１９６１年から１９７１年の間に８０００万リットル以上の枯葉剤を南ベトナムに撒布した。この研究の目的はベトナムの枯葉剤高濃度汚染地域（Binh Dinh省Phu Cat県）と非汚染地域（Ha Nam省Kim Bang県）において枯葉剤（オレンジ剤）の暴露と人体への健康影響との関連を検討することである。【方法】２つの地域において疫学的調査を実施した。対象者は授乳中で生後４週から１６週の乳児を持つ２０－３０歳の母親とし、汚染地域では５８名、非汚染地域では５３名であった。疾患の危険因子等に関する情報は母親への面接調査から得た。母乳をすべての対象者から採取したが、唾液を採取したのは汚染地域４１名、非汚染地域１９名であった。母親と子どもの身体計測を行い２地域間で比較を行った。【結果と考察】汚染地域における乳児の体重と胸囲は有意に非汚染地域よりも小さいが、年齢(週数)も汚染地域の方が有意に低かった。汚染地域における母親とその家族の現病歴は非汚染地域よりも有意に多かった。母親の視力は両眼とも２地域間で有意差は認められなかった。汚染地域と非汚染地域双方の母親の唾液中のコルチゾン値は、母乳中のコルチゾン値と高い相関を示した。汚染地域と非汚染地域間で唾液中のホルモン値には有意差は認められなかった。Objective : Between 1961 and 1971 the US military used over 80 million litres of herbicides in southern Vietnam. This study aims to assess hormone levels in the saliva of lactating Vietnamese mothers and human health effects in a dioxin hot spot (Phu Cat district, Binh Dinh province) and a non-exposed (Kim Bang district, Ha Nam province) area in Vietnam. Materials and Methods : An epidemiological study was carried out in both areas. The subjects were 58 lactating females in the hot spot area and 53 lactating females in the non-exposed area. All were aged between 20 and 30 years with infants aged between 4 and 16 weeks. Information about disease risk factors was obtained through interviews with mothers. Breastmilk samples were taken from all subjects, whereas saliva samples were obtained from 41 mothers in the hot spot area and 19 in the non-exposed area. Body measurements for both mothers and their infants were compared between the two areas. Result and Discussion : The weight and chest circumference of infants in the hot spot area were significantly lower than those in the non-exposed area, whereas age (weeks) is also significantly younger in hot spot area than non-exposed area. Present maternal and family diseases in the hot spot area were significantly higher than those in the non-exposed area. Maternal eyesight in both eyes did not differ significantly between the two areas. The cortisone levels in saliva have been found to be closely related to those in breast milk samples of both mothers in hot spot and non-exposed areas. No significant difference was found between salivary hormone levels of mothers in the hot spot and non-exposed areas

Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam

Objectives : The incidence of carbapenem resistance among nosocomial Gram-negative bacteria in Vietnam is high and increasing, including among Enterobacterales. In this study, we assessed the presence of one of the main carbapenemase genes, blaKPC, among carbapenem-resistant Enterobacterales (CRE) from four large hospitals in Hanoi, Vietnam, between 2010 and 2015, and described their key molecular characteristics. Methods : KPC-producing Enterobacterales were detected using conventional PCR and were further analysed using S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and whole-genome sequencing (WGS) for sequence typing and genetic characterisation. Results : blaKPC genes were detected in 122 (20.4%) of 599 CRE isolates. blaKPC-carrying plasmids were diverse in size. Klebsiella pneumoniae harbouring blaKPC genes belonged to ST15 and ST11, whereas KPC-producing Escherichia coli showed more diverse sequence types including ST3580, ST448, ST709 and ST405. Genotypic relationships supported the hypothesis of circulation of a population of ‘resident’ resistant bacteria in one hospital through the years and of transmission among these hospitals via patient transfer. WGS results revealed co-carriage of several other antimicrobial resistance genes and three different genetic contexts of blaKPC-2. Among these, the combination of ISEcp1–blaCTX-M and ISKpn27–blaKPC–ΔISKpn6 on the same plasmid is reported for the first time. Conclusion : We describe the dissemination of blaKPC-expressing Enterobacterales in four large hospitals in Hanoi, Vietnam, since 2010, which may have started earlier, along with their resistance patterns, sequence types, genotypic relationship, plasmid sizes and genetic context, thereby contributing to the overall picture of the antimicrobial resistance situation in Enterobacterales in Vietnam

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe

Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

Peer reviewe

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Measurement of the Splitting Function in &ITpp &ITand Pb-Pb Collisions at root&ITsNN&IT=5.02 TeV

Data from heavy ion collisions suggest that the evolution of a parton shower is modified by interactions with the color charges in the dense partonic medium created in these collisions, but it is not known where in the shower evolution the modifications occur. The momentum ratio of the two leading partons, resolved as subjets, provides information about the parton shower evolution. This substructure observable, known as the splitting function, reflects the process of a parton splitting into two other partons and has been measured for jets with transverse momentum between 140 and 500 GeV, in pp and PbPb collisions at a center-of-mass energy of 5.02 TeV per nucleon pair. In central PbPb collisions, the splitting function indicates a more unbalanced momentum ratio, compared to peripheral PbPb and pp collisions.. The measurements are compared to various predictions from event generators and analytical calculations.Peer reviewe