Land Grant Application- Lassel, Caleb (Waterboro)

Land grant application submitted to the Maine Land Office for Caleb Lassel for service in the Revolutionary War.https://digitalmaine.com/revolutionary_war_me_land_office/1550/thumbnail.jp

Venezuelas Sozial- und Medienpolitik unter Hugo Chávez

Seit Hugo Chávez im Jahr 1999 das Amt des Staatspräsidenten der Bolivarischen Republik Venezuela antrat, hat sich in dem südamerikanischen Land viel verändert. Diese Tatsache gab Anlass dazu, die politische Transformation des Landes seid Hugo Chávez Machtantritt näher zu untersuchen, wobei der Schwerpunkt der Forschung in dieser Arbeit auf dem sozialen sowie medialen Sektor lag. Die Kernfrage der Arbeit konzentriert sich auf die Art und Weise, wie sich die Situation für die venezolanische Bevölkerung seither verändert hat, wobei hinsichtlich der Sozialpolitik die Lebensqualität und dessen Veränderung nach Einführung von den sogenannten Missionen – welche sich beispielsweise auf den Gesundheits- oder Bildungsbereich spezialisiert haben – ins Blickfeld rückte. In Bezug auf die Medienpolitik wurden die wichtigsten öffentlich-rechtlichen sowie privaten (meist oppositionellen) TV – Sender näher erläutert, um einerseits die Differenz der Berichterstattung sowie andererseits Hugo Chávez Position darin aufzeigen zu können, da Hugo Chávez selbst Moderator einer eigenen politischen TV – Show ist. Des Weiteren wurde mithilfe von Max Webers theoretischer Überlegung der charismatischen Herrschaft bzw. Charismathese versucht, die Motive von Hugo Chávez Handlungen zu erklären, wobei besonders das Verhältnis des charismatischen Herrschers zu seinen Beherrschten näher dargelegt wurde. Somit war das Ziel dieser Arbeit zu klären, welche Auswirkungen der – von Chávez ins Leben gerufene – Bolivarismus (als Prozess) sowie die bisherige Sozial- und Medienpolitik von Hugo Chávez auf die venezolanische Bevölkerung hat, indem anhand von statistischen Daten wie der Alphabetisierungsrate, der Erklärung der Menschenrechte der Vereinten Nationen nach Artikel 19, welcher für eine Medien- sowie Pressefreiheit plädiert oder auch mit dem Wohlstandindikators der Vereinten Nationen und dessen Platzierung versucht wurde, die Veränderungen argumentativ zu untermauern. Aus diesem Grund versteht sich die vorliegende Arbeit als eine Untersuchung, welche vor allem den Vergleichsmoment der beiden Politikbereiche in Relation zur Situation der Bevölkerung stellt und schlussendlich als Bilanz ein positives wie auch negatives Resultat aufzeigt

Rotation of an oblate satellite: Chaos control

Aims. This paper investigates the chaotic rotation of an oblate satellite in the context of chaos control. Methods. A model of planar oscillations, described with the Beletskii equation, was investigated. The Hamiltonian formalism was utilized to employ a control method for suppressing chaos. Results. An additive control term, which is an order of magnitude smaller than the potential, is constructed. This allows not only for significantly diminished diffusion of the trajectory in the phase space, but turns the purely chaotic motion into strictly periodic motion.Comment: 9 pages, 4 figures; accepted in A&

Nonlinear time-series analysis of Hyperion's lightcurves

Hyperion is a satellite of Saturn that was predicted to remain in a chaotic rotational state. This was confirmed to some extent by Voyager 2 and Cassini series of images and some ground-based photometric observations. The aim of this aticle is to explore conditions for potential observations to meet in order to estimate a maximal Lyapunov Exponent (mLE), which being positive is an indicator of chaos and allows to characterise it quantitatively. Lightcurves existing in literature as well as numerical simulations are examined using standard tools of theory of chaos. It is found that existing datasets are too short and undersampled to detect a positive mLE, although its presence is not rejected. Analysis of simulated lightcurves leads to an assertion that observations from one site should be performed over a year-long period to detect a positive mLE, if present, in a reliable way. Another approach would be to use 2---3 telescopes spread over the world to have observations distributed more uniformly. This may be achieved without disrupting other observational projects being conducted. The necessity of time-series to be stationary is highly stressed.Comment: 34 pages, 12 figures, 4 tables; v2 after referee report; matches the version accepted in Astrophysics and Space Scienc

Caesarean section at term: the relationship between neonatal respiratory morbidity and microviscosity in amniotic fluid.

None of the authors report any conflicts of interest.International audienceOBJECTIVES: The incidence of neonatal respiratory morbidity following an elective caesarean section is 2-3 times higher than after a vaginal delivery. The microviscosity of surfactant phospholipids, as measured with fluorescence polarisation, is linked with the functional characteristics of fetal surfactant and thus fetal lung maturity, but so far this point has received little attention in new-borns at term. The aim of the study is to evaluate the correlation between neonatal respiratory morbidity and amniotic microviscosity (Fluorescence Polarisation Index) in women undergoing caesarean section after 37 weeks' gestation. STUDY DESIGN: The files of 136 women who had undergone amniotic microviscosity studies during elective caesarean deliveries at term were anonymised. Amniotic fluid immaturity (AFI) was defined as a Fluorescence Polarisation Index higher than 0.335. RESULTS: Respiratory morbidity was observed in 10 babies (7.3%) and was independently associated with AFI (OR: 6.11 [95% CI, 1.20-31.1] with p=0.029) and maternal body mass index (OR: 1.12 [95% CI, 1.02-1.22] with p=0.019). Gestational age at the time of caesarean delivery was inversely associated with AFI (odds ratio, 0.46 [95% confidence interval, 0.29-0.71], p<0.001), especially before 39 weeks, and female gender was associated with an increased risk (odds ratio, 3.29 [95% confidence interval, 1.48-7.31], p=0.004). CONCLUSIONS: AFI assessed by amniotic microviscosity was significantly associated with respiratory morbidity and independently correlated with shorter gestational age especially before 39 weeks. This finding provides a physiological rationale for recommending delaying elective caesarean section delivery until 39 weeks of gestation to decrease the risk for respiratory morbidity

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

Subnormal plasma levels of high-density lipoprotein cholesterol (HDL-C) constitute a major cardiovascular risk factor; raising low HDL-C levels may therefore reduce the residual cardiovascular risk that frequently presents in dyslipidaemic subjects despite statin therapy. Cholesteryl ester transfer protein (CETP), a key modulator not only of the intravascular metabolism of HDL and apolipoprotein (apo) A-I but also of triglyceride (TG)-rich particles and low-density lipoprotein (LDL), mediates the transfer of cholesteryl esters from HDL to pro-atherogenic apoB-lipoproteins, with heterotransfer of TG mainly from very low-density lipoprotein to HDL. Cholesteryl ester transfer protein activity is elevated in the dyslipidaemias of metabolic disease involving insulin resistance and moderate to marked hypertriglyceridaemia, and is intimately associated with premature atherosclerosis and high cardiovascular risk. Cholesteryl ester transfer protein inhibition therefore presents a preferential target for elevation of HDL-C and reduction in atherosclerosis. This review appraises recent evidence for a central role of CETP in the action of current lipid-modulating agents with HDL-raising potential, i.e. statins, fibrates, and niacin, and compares their mechanisms of action with those of pharmacological agents under development which directly inhibit CETP. New CETP inhibitors, such as dalcetrapib and anacetrapib, are targeted to normalize HDL/apoA-I levels and anti-atherogenic activities of HDL particles. Further studies of these CETP inhibitors, in particular in long-term, large-scale outcome trials, will provide essential information on their safety and efficacy in reducing residual cardiovascular risk

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Even at low-density lipoprotein cholesterol (LDL-C) goal, patients with cardiometabolic abnormalities remain at high risk of cardiovascular events. This paper aims (i) to critically appraise evidence for elevated levels of triglyceride-rich lipoproteins (TRLs) and low levels of high-density lipoprotein cholesterol (HDL-C) as cardiovascular risk factors, and (ii) to advise on therapeutic strategies for management. Current evidence supports a causal association between elevated TRL and their remnants, low HDL-C, and cardiovascular risk. This interpretation is based on mechanistic and genetic studies for TRL and remnants, together with the epidemiological data suggestive of the association for circulating triglycerides and cardiovascular disease. For HDL, epidemiological, mechanistic, and clinical intervention data are consistent with the view that low HDL-C contributes to elevated cardiovascular risk; genetic evidence is unclear however, potentially reflecting the complexity of HDL metabolism. The Panel believes that therapeutic targeting of elevated triglycerides (≥1.7 mmol/L or 150 mg/dL), a marker of TRL and their remnants, and/or low HDL-C (<1.0 mmol/L or 40 mg/dL) may provide further benefit. The first step should be lifestyle interventions together with consideration of compliance with pharmacotherapy and secondary causes of dyslipidaemia. If inadequately corrected, adding niacin or a fibrate, or intensifying LDL-C lowering therapy may be considered. Treatment decisions regarding statin combination therapy should take into account relevant safety concerns, i.e. the risk of elevation of blood glucose, uric acid or liver enzymes with niacin, and myopathy, increased serum creatinine and cholelithiasis with fibrates. These recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal