Early massive clusters and the bouncing coupled dark energy

The abundance of the most massive objects in the Universe at different epochs is a very sensitive probe of the cosmic background evolution and of the growth history of density perturbations, and could provide a powerful tool to distinguish between a cosmological constant and a dynamical dark energy field. In particular, the recent detection of very massive clusters of galaxies at high redshifts has attracted significant interest as a possible indication of a failure of the standard LCDM model. Several attempts have been made in order to explain such detections in the context of non-Gaussian scenarios or interacting dark energy models, showing that both these alternative cosmologies predict an enhanced number density of massive clusters at high redshifts, possibly alleviating the tension. However, all the models proposed so far also overpredict the abundance of massive clusters at the present epoch, and are therefore in contrast with observational bounds on the low-redshift halo mass function. In this paper we present for the first time a new class of interacting dark energy models that simultaneously account for an enhanced number density of massive clusters at high redshifts and for both the standard cluster abundance at the present time and the standard power spectrum normalization at CMB. The key feature of this new class of models is the "bounce" of the dark energy scalar field on the cosmological constant barrier at relatively recent epochs. We present the background and linear perturbations evolution of the model, showing that the standard amplitude of density perturbations is recovered both at CMB and at the present time, and we demonstrate by means of large N-body simulations that our scenario predicts an enhanced number of massive clusters at high redshifts without affecting the present halo abundance. (Abridged)Comment: 11 pages, 6 figures, 2 tables. Minor changes, references added. Accepted for publication in MNRA

A complete sample of bright Swift Gamma-Ray Bursts: X-ray afterglow luminosity and its correlation with the prompt emission

We investigate wheter there is any correlation between the X-ray afterglow luminosity and the prompt emission properties of a carefully selected sub-sample of bright Swift long Gamma-Ray Bursts (GRBs) nearly complete in redshift (~90%). Being free of selection effects (except flux limit), this sample provides the possibility to compare the rest frame physical properties of GRB prompt and afterglow emission in an unbiased way. The afterglow X-ray luminosities are computed at four different rest frame times (5 min, 1 hr, 11 hr and 24 hr after trigger) and compared with the prompt emission isotropic energy E_iso, the isotropic peak luminosity L_iso and the rest frame peak energy E_peak. We find that the rest frame afterglow X-ray luminosity do correlate with these prompt emission quantities, but the significance of each correlation decreases over time. This result is in agreement with the idea that the GRB X-ray light curve can be described as the result of a combination of different components whose relative contribution and weight change with time, with the prompt and afterglow emission dominating at early and late time, respectively. In particular, we found evidence that the plateau and the shallow decay phase often observed in GRB X-ray light curves are powered by activity from the central engine. The existence of the L_X-E_iso correlation at late times (t_rf > 11 hr) suggests a similar radiative efficiency among different bursts with on average about 6% of the total kinetic energy powering the prompt emission.Comment: 8 pages, 4 figures, 3 tables. Accepted for publication in MNRA

First modulation of high-frequency polar mesospheric summer echoes by radio heating of the ionosphere

The first high-frequency (HF, 8 MHz) observations of the modulation of polar mesospheric summer echoes (PMSE) by artificial radio heating of the ionosphere are presented and compared to observations at 224 MHz and model predictions. The experiments were performed at the European Incoherent Scatter facility in northern Norway. It is shown that model results are in qualitative and partial quantitative agreement with the observations, supporting the prediction that with certain ranges of ice particle radii and concentration, PMSE at HF radar wavelengths can be enhanced by heating due to the dominance of dust charging over plasma diffusion

The physical oceanography of the transport of floating marine debris

Marine plastic debris floating on the ocean surface is a major environmental problem. However, its distribution in the ocean is poorly mapped, and most of the plastic waste estimated to have entered the ocean from land is unaccounted for. Better understanding of how plastic debris is transported from coastal and marine sources is crucial to quantify and close the global inventory of marine plastics, which in turn represents critical information for mitigation or policy strategies. At the same time, plastic is a unique tracer that provides an opportunity to learn more about the physics and dynamics of our ocean across multiple scales, from the Ekman convergence in basin-scale gyres to individual waves in the surfzone. In this review, we comprehensively discuss what is known about the different processes that govern the transport of floating marine plastic debris in both the open ocean and the coastal zones, based on the published literature and referring to insights from neighbouring fields such as oil spill dispersion, marine safety recovery, plankton connectivity, and others. We discuss how measurements of marine plastics (both in situ and in the laboratory), remote sensing, and numerical simulations can elucidate these processes and their interactions across spatio-temporal scales

Comparison of the Effects of Propofol and Midazolam on Inflammation and Oxidase Stress in Children with Congenital Heart Disease Undergoing Cardiac Surgery

*These authors contributed equally to this work. ∙ The authors have no financial conflicts of interest. Purpose: To investigate and compare the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. Materials and Methods: Thirty-two ASA class I-II children with congenital heart disease undergoing cardiac surgery were randomly divided into two groups: propofol combined with low dose fentanyl (PF group, n = 16) and midazolam combined with low dose fentanyl (MF group, n = 16). Tracheal extubation time and length of Intensive Care Unit (ICU) stay were recorded. Blood samples were taken before operation (T0), at 2 h after release of the aorta cross-clamp (T3) and at 24 h after operation (T4) to measure interleukin 6 (IL-6), IL-8, superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Myocardium samples were collected at 10-20 min after aorta cross-clamp (T1) and at 10

Organizational factors and depression management in community-based primary care settings

Abstract Background Evidence-based quality improvement models for depression have not been fully implemented in routine primary care settings. To date, few studies have examined the organizational factors associated with depression management in real-world primary care practice. To successfully implement quality improvement models for depression, there must be a better understanding of the relevant organizational structure and processes of the primary care setting. The objective of this study is to describe these organizational features of routine primary care practice, and the organization of depression care, using survey questions derived from an evidence-based framework. Methods We used this framework to implement a survey of 27 practices comprised of 49 unique offices within a large primary care practice network in western Pennsylvania. Survey questions addressed practice structure (e.g., human resources, leadership, information technology (IT) infrastructure, and external incentives) and process features (e.g., staff performance, degree of integrated depression care, and IT performance). Results The results of our survey demonstrated substantial variation across the practice network of organizational factors pertinent to implementation of evidence-based depression management. Notably, quality improvement capability and IT infrastructure were widespread, but specific application to depression care differed between practices, as did coordination and communication tasks surrounding depression treatment. Conclusions The primary care practices in the network that we surveyed are at differing stages in their organization and implementation of evidence-based depression management. Practical surveys such as this may serve to better direct implementation of these quality improvement strategies for depression by improving understanding of the organizational barriers and facilitators that exist within both practices and practice networks. In addition, survey information can inform efforts of individual primary care practices in customizing intervention strategies to improve depression management.http://deepblue.lib.umich.edu/bitstream/2027.42/78269/1/1748-5908-4-84.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78269/2/1748-5908-4-84-S1.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78269/3/1748-5908-4-84.pdfPeer Reviewe

Multilocus Bayesian Estimates of Intra-Oceanic Genetic Differentiation, Connectivity, and Admixture in Atlantic Swordfish (Xiphias gladius L.)

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A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode

<p>Abstract</p> <p>Background</p> <p>Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased in the lung with IPF. We evaluated the effect of single nucleotide polymorphisms (SNPs) of the IL-8 gene on the risk of IPF.</p> <p>Methods</p> <p>One promoter (rs4073T>A) and two intronic SNPs (rs2227307T>G and rs2227306C>T) of the IL-8 genes were genotyped in 237 subjects with IPF and 456 normal controls. Logistic regression analysis was applied to evaluate the association of these SNPs with IPF. IL-8 in BAL fluids was measured using a quantitative sandwich enzyme immunoassay, and promoter activity was assessed using the luciferase reporter assay.</p> <p>Results</p> <p>The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in the 162 subjects with surgical biopsy-proven IPF and 75 subjects with clinical IPF compared with normal controls in the recessive model (OR = 0.46 and 0.48, <it>p </it>= 0.006 and 0.007, respectively). The IL-8 protein concentration in BAL fluids significantly increased in 24 subjects with IPF compared with 14 controls (<it>p </it>= 0.009). Nine IPF subjects homozygous for the rs4073 T>A common allele exhibited higher levels of the IL-8 protein compared with six subjects homozygous for the minor allele (<it>p </it>= 0.024). The luciferase activity of the rs4073T>A common allele was significantly higher than that of the rs4073T>A minor allele (<it>p </it>= 0.002).</p> <p>Conclusion</p> <p>The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8.</p