527 research outputs found
Exact Solutions of Model Hamiltonian Problems with Effective Interactions
We demonstrate with soluble models how to employ the effective Hamiltonian
approach of Lee and Suzuki to obtain all the exact eigenvalues of the full
Hamiltonian. We propose a new iteration scheme to obtain the effective
Hamiltonian and demonstrate its convergence properties.Comment: 12 pages and 1 figur
Minimizing Effective Many-Body Interactions
A simple two-level model is developed and used to test the properties of
effective interactions for performing nuclear structure calculations in
truncated model spaces. It is shown that the effective many-body interactions
sensitively depend on the choice of the single-particle basis and they appear
to be minimized when a self- consistent Hartree-Fock basis is used.Comment: (15 pages of text and 1 postscript figure (Figure available upon
request), Preprint Number not assigned ye
Simple approximation for the starting-energy-independent two-body effective interaction with applications to 6Li
We apply the Lee-Suzuki iteration method to calculate the linked-folded
diagram series for a new Nijmegen local NN potential. We obtain an exact
starting-energy-independent effective two-body interaction for a multi-shell,
no-core, harmonic-oscillator model space. It is found that the resulting
effective-interaction matrix elements can be well approximated by the Brueckner
G-matrix elements evaluated at starting energies selected in a simple way.
These starting energies are closely related to the energies of the initial
two-particle states in the ladder diagrams. The ``exact'' and approximate
effective interactions are used to calculate the energy spectrum of 6Li in
order to test the utility of the approximate form.Comment: 15 text pages and 2 PostScript figures (available upon request).
University of Arizona preprint, Number unassigne
Large-space shell-model calculations for light nuclei
An effective two-body interaction is constructed from a new Reid-like
potential for a large no-core space consisting of six major shells and is used
to generate the shell-model properties for light nuclei from =2 to 6. (For
practical reasons, the model space is partially truncated for =6.) Binding
energies and other physical observables are calculated and compare favorably
with experiment.Comment: prepared using LaTex, 21 manuscript pages, no figure
1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes. Cyclophellitol epoxides and aziridines are recently established covalent glycosidase inactivators. Inspired by the application of cyclic sulfates as electrophilic equivalents of epoxides in organic synthesis, we sought to test whether cyclophellitol cyclosulfates would similarly act as irreversible glycosidase inhibitors. Here we present the synthesis, conformational analysis, and application of novel 1,6-cyclophellitol cyclosulfates. We show that 1,6-epi-cyclophellitol cyclosulfate (ι-cyclosulfate) is a rapidly reacting ι-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by ι-glucosidase Michaelis complexes. The 1,6-cyclophellitol cyclosulfate (β-cyclosulfate) reacts more slowly, likely reflecting its conformational restrictions. Selective glycosidase inhibitors are invaluable as mechanistic probes and therapeutic agents, and we propose cyclophellitol cyclosulfates as a valuable new class of carbohydrate mimetics for application in these directions
1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes. Cyclophellitol epoxides and aziridines are recently established covalent glycosidase inactivators. Inspired by the application of cyclic sulfates as electrophilic equivalents of epoxides in organic synthesis, we sought to test whether cyclophellitol cyclosulfates would similarly act as irreversible glycosidase inhibitors. Here we present the synthesis, conformational analysis, and application of novel 1,6-cyclophellitol cyclosulfates. We show that 1,6-epi-cyclophellitol cyclosulfate (ι-cyclosulfate) is a rapidly reacting ι-glucosidase inhibitor whose 4C1 chair conformation matches that adopted by ι-glucosidase Michaelis complexes. The 1,6-cyclophellitol cyclosulfate (β-cyclosulfate) reacts more slowly, likely reflecting its conformational restrictions. Selective glycosidase inhibitors are invaluable as mechanistic probes and therapeutic agents, and we propose cyclophellitol cyclosulfates as a valuable new class of carbohydrate mimetics for application in these directions
Activity-based probes for functional interrogation of retaining β-glucuronidases
Humans express at least two distinct β-glucuronidase enzymes that are involved in disease: exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis type VII, and endo-acting heparanase (HPSE), whose overexpression is implicated in inflammation and cancers. The medical importance of these enzymes necessitates reliable methods to assay their activities in tissues. Herein, we present a set of β-glucuronidase-specific activity-based probes (ABPs) that allow rapid and quantitative visualization of GUSB and HPSE in biological samples, providing a powerful tool for dissecting their activities in normal and disease states. Unexpectedly, we find that the supposedly inactive HPSE proenzyme proHPSE is also labeled by our ABPs, leading to surprising insights regarding structural relationships between proHPSE, mature HPSE, and their bacterial homologs. Our results demonstrate the application of β-glucuronidase ABPs in tracking pathologically relevant enzymes and provide a case study of how ABP-driven approaches can lead to discovery of unanticipated structural and biochemical functionality
The genome of Nectria haematococca: Contribution of supernumerary chromosomes to gene expansion
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
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