123 research outputs found
Human embryonic stem cell research: Why the discarded-created-distinction cannot be based on the potentiality argument
Universality, vortices and confinement: modified SO(3) lattice gauge theory at non-zero temperature
We investigate the adjoint SU(2) lattice gauge theory in 3+1 dimensions with
the Wilson plaquette action modified by a Z(2) monopole suppression term. For
the zero-twist sector we report indications for the existence of a finite
temperature effect decoupled from the unphysical bulk transitions.Comment: 17 pages, 10 figures. Some figures and text added. To appear on Phys.
Rev.
HUMAN EMBRYONIC STEM CELL RESEARCH: WHY THE DISCARDED-CREATED-DISTINCTION CANNOT BE BASED ON THE POTENTIALITY ARGUMENT
Inflation and late time acceleration in braneworld cosmological models with varying brane tension
Braneworld models with variable brane tension introduce a new
degree of freedom that allows for evolving gravitational and cosmological
constants, the latter being a natural candidate for dark energy. We consider a
thermodynamic interpretation of the varying brane tension models, by showing
that the field equations with variable can be interpreted as
describing matter creation in a cosmological framework. The particle creation
rate is determined by the variation rate of the brane tension, as well as by
the brane-bulk energy-matter transfer rate. We investigate the effect of a
variable brane tension on the cosmological evolution of the Universe, in the
framework of a particular model in which the brane tension is an exponentially
dependent function of the scale factor. The resulting cosmology shows the
presence of an initial inflationary expansion, followed by a decelerating
phase, and by a smooth transition towards a late accelerated de Sitter type
expansion. The varying brane tension is also responsible for the generation of
the matter in the Universe (reheating period). The physical constraints on the
model parameters, resulted from the observational cosmological data, are also
investigated.Comment: 25 pages, 8 figures, accepted for publication in European Physical
Journal
Multi-Modal Magnetic Resonance Imaging in the Acute and Sub-Acute Phase of Mild Traumatic Brain Injury: Can We See the Difference?
Characterization factors to assess land use impacts on pollinator abundance in life cycle assessment
While wild pollinators play a key role in global food production, their assessment is currently missing from the most commonly used environmental impact assessment method, Life Cycle Assessment (LCA). This is mainly due to constraints in data availability and compatibility with LCA inventories. To target this gap, relative pollinator abundance estimates were obtained with the use of a Delphi assessment, during which 25 experts, covering 16 nationalities and 45 countries of expertise, provided scores for low, typical, and high expected abundance associated with 24 land use categories. Based on these estimates, this study presents a set of globally generic characterization factors (CFs) that allows translating land use into relative impacts to wild pollinator abundance. The associated uncertainty of the CFs is presented along with an illustrative case to demonstrate the applicability in LCA studies. The CFs based on estimates that reached consensus during the Delphi assessment are recommended as readily applicable and allow key differences among land use types to be distinguished. The resulting CFs are proposed as the first step for incorporating pollinator impacts in LCA studies, exemplifying the use of expert elicitation methods as a useful tool to fill data gaps that constrain the characterization of key environmental impacts.Industrial EcologyEnvironmental Biolog
First cosmology results using type Ia supernovae from the Dark Energy Survey: constraints on cosmological parameters
We present the first cosmological parameter constraints using measurements of type Ia supernovae (SNe Ia) from the Dark Energy Survey Supernova Program (DES-SN). The analysis uses a subsample of 207 spectroscopically confirmed SNe Ia from the first three years of DES-SN, combined with a low-redshift sample of 122 SNe from the literature. Our "DES-SN3YR" result from these 329 SNe Ia is based on a series of companion analyses and improvements covering SN Ia discovery, spectroscopic selection, photometry, calibration, distance bias corrections, and evaluation of systematic uncertainties. For a flat LCDM model we find a matter density Omega_m = 0.331 +_ 0.038. For a flat wCDM model, and combining our SN Ia constraints with those from the cosmic microwave background (CMB), we find a dark energy equation of state w = -0.978 +_ 0.059, and Omega_m = 0.321 +_ 0.018. For a flat w0waCDM model, and combining probes from SN Ia, CMB and baryon acoustic oscillations, we find w0 = -0.885 +_ 0.114 and wa = -0.387 +_ 0.430. These results are in agreement with a cosmological constant and with previous constraints using SNe Ia (Pantheon, JLA)
Joint analysis of Dark Energy Survey Year 3 data and CMB lensing from SPT and Planck . II. Cross-correlation measurements and cosmological constraints
Cross-correlations of galaxy positions and galaxy shears with maps of gravitational lensing of the cosmic microwave background (CMB) are sensitive to the distribution of large-scale structure in the Universe. Such cross-correlations are also expected to be immune to some of the systematic effects that complicate correlation measurements internal to galaxy surveys. We present measurements and modeling of the cross-correlations between galaxy positions and galaxy lensing measured in the first three years of data from the Dark Energy Survey with CMB lensing maps derived from a combination of data from the
2500
deg
2
SPT-SZ survey conducted with the South Pole Telescope and full-sky data from the Planck satellite. The CMB lensing maps used in this analysis have been constructed in a way that minimizes biases from the thermal Sunyaev Zel’dovich effect, making them well suited for cross-correlation studies. The total signal-to-noise of the cross-correlation measurements is 23.9 (25.7) when using a choice of angular scales optimized for a linear (nonlinear) galaxy bias model. We use the cross-correlation measurements to obtain constraints on cosmological parameters. For our fiducial galaxy sample, which consist of four bins of magnitude-selected galaxies, we find constraints of
Ω
m
=
0.272
+
0.032
−
0.052
and
S
8
≡
σ
8
√
Ω
m
/
0.3
=
0.736
+
0.032
−
0.028
(
Ω
m
=
0.245
+
0.026
−
0.044
and
S
8
=
0.734
+
0.035
−
0.028
) when assuming linear (nonlinear) galaxy bias in our modeling. Considering only the cross-correlation of galaxy shear with CMB lensing, we find
Ω
m
=
0.270
+
0.043
−
0.061
and
S
8
=
0.740
+
0.034
−
0.029
. Our constraints on
S
8
are consistent with recent cosmic shear measurements, but lower than the values preferred by primary CMB measurements from Planck
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits : A Multi-Ethnic Meta-Analysis of 45,891 Individuals
J. Kaprio, S. Ripatti ja M.-L. Lokki työryhmien jäseniä.Peer reviewe
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Peer reviewe
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