Child and Adolescent Psychiatry Pre-Clinical Elective Effects on Intentions to Choose a Career in Child and Adolescent Psychiatry

The purpose of this study was to examine first and second year medical students’ level of interest, their knowledge and factors influencing their intent to pursue child psychiatry as a career field. The authors implemented a pre-clinical elective in child and adolescent psychiatry (CAP) for first and second year medical students.  A pre- and post-elective questionnaire was used to evaluate the students’ interest and intentions to select CAP as a career and to evaluate various factors influencing their career choice. Results showed that prior to the elective, 64.3% reported being “Interested” or “Very Interested” in a career in CAP.  Despite this, only 17.9% of the sample reported that they were “Likely” or “Very Likely” to choose a career in CAP.  After the elective, 52.63% reported being likely to choose a career in CAP. Multiple regression revealed that interest predicted intentions for a career in the field, but estimated salary and expected years of residency did not. Patient contact and case discussions were the experiences that students most frequently reported lead them to be more interested in CAP.  Though limited by small sample size, this study provides preliminary information on early exposure of medical students to the field of CAP. Early exposure leads to an increase in students’ interest, knowledge and their intention to choose child psychiatry as a career field.

Reclaiming Global Environmental Leadership: Why the United States Should Ratify Ten Pending Environmental Treaties

For more than a century, the United States has taken the lead in organizing international responses to international environmental problems. In the last two decades, however, U.S. environmental leadership has faltered. The best-known example is the lack of an effective response to climate change, underscored by the U.S. decision not to join the Kyoto Protocol. But that is not the only shortfall. The United States has also failed to join a large and growing number of treaties directed at other environmental threats, including marine pollution, the loss of biological diversity, persistent organic pollutants, and trade in toxic substances. This white paper identifies ten of these critical, pending environmental treaties and explains their importance and the actions needed to fully join them. The failure of the United States to join these treaties undermines global environmental protection and undermines U.S. interests in protecting a wide range of natural resources. The treaties set out standards and create institutions designed to find and implement solutions to problems of critical importance. They have attracted support from other countries, including our closest allies. Indeed, several are among the most widely ratified treaties in history. In every case, the regimes these treaties have established are less successful without U.S. membership than they could be with the full engagement of the country with the largest economy and the largest environmental impact

Long-term functional recovery after facial nerve transection and repair in the rat

BACKGROUND: The rodent model is commonly used to study facial nerve injury. Because of the exceptional regenerative capacity of the rodent facial nerve, it is essential to consider the timing when studying facial nerve regeneration and functional recovery. Short-term functional recovery data following transection and repair of the facial nerve has been documented by our laboratory. However, because of the limitations of the head fixation device, there is a lack of long-term data following facial nerve injury. The objective of this study was to elucidate the long-term time course and functional deficit following facial nerve transection and repair in a rodent model. METHODS: Adult rats were divided into group 1 (controls) and group 2 (experimental). Group 1 animals underwent head fixation, followed by a facial nerve injury, and functional testing was performed from day 7 to day 70. Group 2 animals underwent facial nerve injury, followed by delayed head fixation, and then underwent functional testing from months 6 to 8. RESULTS: There was no statistical difference between the average whisking amplitudes in group 1 and group 2 animals. CONCLUSION: Functional whisking recovery 6 months after facial nerve injury is comparable to recovery within 1 to 4 months of transection and repair, thus the ideal window for evaluating facial nerve recovery falls within the 4 months after injury

Mechanical Structural Design of a MEMS-Based Piezoresistive Accelerometer for Head Injuries Monitoring: A Computational Analysis by Increments of the Sensor Mass Moment of Inertia.

This work focuses on the proof-mass mechanical structural design improvement of a tri-axial piezoresistive accelerometer specifically designed for head injuries monitoring where medium-G impacts are common; for example, in sports such as racing cars or American Football. The device requires the highest sensitivity achievable with a single proof-mass approach, and a very low error (<1%) as the accuracy for these types of applications is paramount. The optimization method differs from previous work as it is based on the progressive increment of the sensor proof-mass mass moment of inertia (MMI) in all three axes. Three different designs are presented in this study, where at each step of design evolution, the MMI of the sensor proof-mass gradually increases in all axes. The work numerically demonstrates that an increment of MMI determines an increment of device sensitivity with a simultaneous reduction of cross-axis sensitivity in the particular axis under study. This is due to the linkage between the external applied stress and the distribution of mass (of the proof-mass), and therefore of its mass moment of inertia. Progressively concentrating the mass on the axes where the piezoresistors are located (i.e., x- and y-axis) by increasing the MMI in the x- and y-axis, will undoubtedly increase the longitudinal stresses applied in that areas for a given external acceleration, therefore increasing the piezoresistors fractional resistance change and eventually positively affecting the sensor sensitivity. The final device shows a sensitivity increase of about 80% in the z-axis and a reduction of cross-axis sensitivity of 18% respect to state-of-art sensors available in the literature from a previous work of the authors. Sensor design, modelling, and optimization are presented, concluding the work with results, discussion, and conclusion

The distribution of estuarine fish larvae: nutritional condition and co-occurrence with predators and prey

Fish larvae were collected monthly between March and September 1997 in the Mira and Guadiana estuaries (southern Portugal). Hydrological parameters were registered and zooplankton samples were obtained simultaneously. Densities of fish larvae (ind.100 m(-3)) were calculated from 211 samples and larval nutritional condition measured as RNA/DNA ratios were obtained for 346 individuals, using a fluorimetric method for nucleic acid quantification. Correlating variables were further studied using multiple regression analysis in order to assess the relative importance of abiotic and biotic factors affecting within-year trends in abundance and nutritional condition of estuarine fish larvae. Results indicated that: 1) the abundance of fish larvae seems conditioned by temperature and predation; and 2) their nutritional condition is dependent on temperature and prey availability. Temperature is an important variable structuring estuaries and therefore conditions the behaviour and physiology of fish larvae. Furthermore, the co-occurrence of predators and larvae might be related to similar feeding patterns or comensalism. Whenever feeding conditions are suitable, they usually determine enhanced growth and nutritional condition. However, predation seems to control this latter relationship through its effect on larval mortality. (C) 2000 Editions scientifiques et Medicales Elsevier SAS.info:eu-repo/semantics/publishedVersio

The garden as a laboratory: the role of domestic gardens as places of scientific exploration in the long 18th century

This is an Accepted Manuscript of an article published by Taylor & Francis in Post-Medieval Archaeology on 24/06/2014, available online: http://www.tandfonline.com/doi/full/10.1179/0079423614Z.00000000054Eighteenth-century gardens have traditionally been viewed as spaces designed for leisure, and as representations of political status, power and taste. In contrast, this paper will explore the concept that gardens in this period could be seen as dynamic spaces where scientific experiment and medical practice could occur. Two examples have been explored in the pilot study which has led to this paper — the designed landscapes associated with John Hunter’s Earl’s Court residence, in London, and the garden at Edward Jenner’s house in Berkeley, Gloucestershire. Garden history methodologies have been implemented in order to consider the extent to which these domestic gardens can be viewed as experimental spaces

Benznidazole biotransformation and multiple targets in <i>Trypanosoma</i> cruzi revealed by metabolomics

&lt;b&gt;Background&lt;/b&gt;&lt;p&gt;&lt;/p&gt; The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully understood. In the present work we used a non-targeted MS-based metabolomics approach to study the metabolic response of T. cruzi to Bzn.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methodology/Principal findings&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Parasites treated with Bzn were minimally altered compared to untreated trypanosomes, although the redox active thiols trypanothione, homotrypanothione and cysteine were significantly diminished in abundance post-treatment. In addition, multiple Bzn-derived metabolites were detected after treatment. These metabolites included reduction products, fragments and covalent adducts of reduced Bzn linked to each of the major low molecular weight thiols: trypanothione, glutathione, γ-glutamylcysteine, glutathionylspermidine, cysteine and ovothiol A. Bzn products known to be generated in vitro by the unusual trypanosomal nitroreductase, TcNTRI, were found within the parasites, but low molecular weight adducts of glyoxal, a proposed toxic end-product of NTRI Bzn metabolism, were not detected.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions/significance&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Our data is indicative of a major role of the thiol binding capacity of Bzn reduction products in the mechanism of Bzn toxicity against T. cruzi