Concepções de discurso político: caminhos para uma discussão teórica

A concepção de discurso político tem causado inúmeras discussões na área de Linguística e de Análise Crítica de Discurso, devido à amplitude de seus objetivos e demandas. Comumente o discurso político representa uma seara de textos, oficiais ou não, produzidos por agentes políticos reconhecidos pelo sistema político vigente em uma sociedade. Em nossa visão, tal tema merece mais detalhamento, uma vez que as esferas sociais em que a política é discutida são variadas, o que gera práticas discursivas distintas. Dessa forma, este estudo visa a promover uma discussão sobre concepções de discurso político e apresentar uma ampliação de conceitos, o que pode auxiliar as investigações em discursos dessa área. Como resultado de nossa investigação, propomos uma tripartição discursiva: discurso político; discurso do político; discurso sobre política, como o discurso praticado pelos meios de comunicação ou até mesmo pelas conversas individuais, tomando por base acontecimentos da esfera política

Utilization of cervical cancer screening services and its associated factors in Iran: a case–control study

Background Considering the high incidence rate of cervical cancer (CC) in Iran, screening is an efective way of reducing the impact of the disease due to early detection. Thus, the recognition of the factors afecting the use of cervical cancer screening (CCS) services is essential.The present study aimed to determine the associated factors of CCS in women living in the suburbs of Bandar Abbas in the south of Iran. Methods The present case–control study was conducted between January and March 2022 in the suburban areas of Bandar abbas. Two hundred participants were assigned to the case group and 400 participants were assigned to the control group. A self-constructed questionnaire was used to collect the data. This questionnaire contained demographic information, reproductive information, knowledge of CC, knowledge of CCS and access to the screening. Univariate and multivariate regression analyses were run to analyze the data. The data were analyzed in STATA 14.2 at a signifcance level of p<0.05. Results The mean and standard deviation of participants’ age in the case group was 30.33±4.892, and in the control group was 31.35±6.149. The mean and standard deviation of knowledge in the case group was 10.21±1.815 and in the control group was 7.24±2.447. The mean and standard deviation of access was 43.72±6.339 in the case and 37.17±4.828 in the control group. The results of multivariate regression analysis showed the following factors increased the odds of CCS: knowledge (OR medium=18.697, OR high=13.413), access (OR medium=4.028, OR high=8.126), being married (OR=3.193), being educated (OR diploma=2.587, OR university degree=1.432), middle and high SES (OR Middle=6.078, OR Upper=6.608), and not smoking (OR=1.144). Also, women’s reproductive status, including history of sexually transmitted diseases (OR=2.612), use of oral contraceptives (OR=1.579), sexual hygiene (OR=8.718). Conclusions In the light of the present fndings, it can be concluded that besides increasing suburban women’s knowledge, their access to screening facilities should be improved. The present fndings showed the need to remove the barriers to CCS in women of low SES to increase the rate of CCS. The present fndings contribute to a better understanding of factors involved in CCS

Wearable activity technology and action-planning (WATAAP) to promote physical activity in cancer survivors: Randomised controlled trial protocol

FUNDAMENTOS/OBJETIVO: Los sobrevivientes de cáncer colorrectal y ginecológico corren riesgo cardiovascular debido a las comorbilidades y al comportamiento sedentario, lo que justifica una intervención factible para aumentar la actividad física. El Enfoque del Proceso de Acción Sanitaria (HAPA) es un marco teórico prometedor para el cambio de comportamiento en materia de salud, y los rastreadores de actividad física que se pueden llevar puestos ofrecen un medio novedoso de autocontrol de la actividad física para los supervivientes de cáncer. MÉTODO: Sesenta y ocho sobrevivientes de cáncer colorrectal y ginecológico serán asignados al azar a grupos de intervención y control de 12 semanas. Los participantes del grupo de intervención recibirán: un Fitbit AltaTM para monitorear la actividad física, sesiones de grupo basadas en HAPA, un folleto y una llamada telefónica de apoyo. Los participantes del grupo de control sólo recibirán el folleto basado en HAPA. La actividad física (utilizando acelerómetros), la presión sanguínea, el IMC y las construcciones HAPA se evaluarán en la línea de base, a las 12 semanas (después de la intervención) y a las 24 semanas (seguimiento). El análisis de los datos utilizará la interacción Grupo x Tiempo de un análisis de Modelo Mixto Lineal General. CONCLUSIONES: Las intervenciones de actividad física que son aceptables y que tienen sólidos fundamentos teóricos son prometedoras para mejorar la salud de los sobrevivientes de cáncer.BACKGROUND/OBJECTIVE: Colorectal and gynecologic cancer survivors are at cardiovascular risk due to comorbidities and sedentary behaviour, warranting a feasible intervention to increase physical activity. The Health Action Process Approach (HAPA) is a promising theoretical framework for health behaviour change, and wearable physical activity trackers offer a novel means of self-monitoring physical activity for cancer survivors. METHOD: Sixty-eight survivors of colorectal and gynecologic cancer will be randomised into 12-week intervention and control groups. Intervention group participants will receive: a Fitbit AltaTM to monitor physical activity, HAPA-based group sessions, booklet, and support phonecall. Participants in the control group will only receive the HAPA-based booklet. Physical activity (using accelerometers), blood pressure, BMI, and HAPA constructs will be assessed at baseline, 12-weeks (post-intervention) and 24-weeks (follow-up). Data analysis will use the Group x Time interaction from a General Linear Mixed Model analysis. CONCLUSIONS: Physical activity interventions that are acceptable and have robust theoretical underpinnings show promise for improving the health of cancer survivors.• The Tonkinson Colorectal Cancer Research. Subvención 57838 • St. John of God Gynecologic Oncology Research Group (Western Australia). AyudapeerReviewe

Effects of Electrohydraulic Therapy of Shock Waves on Pain and Lymphedema Measurement Post-Radical Mastectomy

Background: Lymphedema post-mastectomy remains a challenging problem. This study aimed to investigate the efficacy of shock wave electrohydraulic treatment (ESWT) for patients with pain and lymphedema. Methods: Thirty patients (30 women) with pain & lymphedema post-radical mastectomy were evaluated to participate in this Clinical trial. They were recruited from the Minia Cancer Institute- Minia University and Deraya University outpatient clinics. Their ages varied between the ages of 40 and 50 years. They were divided into two groups. Group (1) 'Group of studies': 15 patients seeking ESWT in addition to conventional medical care. Group (2) 'Control group': 15 people seeking conventional medical care only. Patients of the study group (1) were treated with a number of impulses, at least 500 shocks at E2 at 4Hz (equivalent to 0.11mJ/mm square energy). Treatment sessions were delivered twice weekly for six treatments (3 weeks). The assessment used a Visual analogue scale (VAS) for pain and arm circumference midway between the shoulder and elbow for lymphedema measurement. Results: showed that (ESWT) on pain and lymphedema measurement post-radical mastectomy effectively decreased pain as evidenced by the highly significant decreases in the visual analogue scale. These results revealed a substantial VAS reduction (P<0.0001). Effects of the ESWT on lymphedema measurement via the arm circumference measurement at the point where the shoulder and the elbow meet post-radical mastectomy were investigated. These results revealed a notable reduction in the mean value of the arm circumference measurement (ACM) (P<0.0001). Conclusion: The significant reductions in VAS and assessment of the ACM arm range show that the ESWT, in addition to conventional therapy, significantly impacted upper limb structural components following radical mastectomy

The effect of fruit cultivar/origin and storage time on sorbets quality

Fruit quality is one of the main factors that influence the sorbets’ quality. The aim of this study was to evaluate the effects of two different cultivars of five fruits (mandarin, lemon, melon and mango) or origin (strawberries) on the overall quality of sorbets, right after being produced and after being preserved for 21 days at 18 C. Total soluble solids (TSS), titratable acidity (TA) and firmness were used to characterize the fruits. Colour, pH, antioxidant capacity (AC) and total phenolic content (TPC), as well as sensory attributes, were evaluated on fruits and respective sorbets. Fruit processing led to a loss of TPC and AC. Nevertheless, no significant changes were observed on sorbets over storage time. In spite of chemical, physical and sensorial differences registered among fruits from different cultivars or origin, the sensory profiles of sorbets from the same pair of studied fruits are very similar. Multivariate analysis clearly shows that the sorbets produced maintain the same sensorial quality regardless of the cultivar or the origin of the fruitsinfo:eu-repo/semantics/publishedVersio

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!).

BACKGROUND: rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa. METHODS: We did an open-label, cluster-randomised ring vaccination trial (Ebola ça Suffit!) in the communities of Conakry and eight surrounding prefectures in the Basse-Guinée region of Guinea, and in Tomkolili and Bombali in Sierra Leone. We assessed the efficacy of a single intramuscular dose of rVSV-ZEBOV (2×107 plaque-forming units administered in the deltoid muscle) in the prevention of laboratory confirmed Ebola virus disease. After confirmation of a case of Ebola virus disease, we definitively enumerated on a list a ring (cluster) of all their contacts and contacts of contacts including named contacts and contacts of contacts who were absent at the time of the trial team visit. The list was archived, then we randomly assigned clusters (1:1) to either immediate vaccination or delayed vaccination (21 days later) of all eligible individuals (eg, those aged ≥18 years and not pregnant, breastfeeding, or severely ill). An independent statistician generated the assignment sequence using block randomisation with randomly varying blocks, stratified by location (urban vs rural) and size of rings (≤20 individuals vs >20 individuals). Ebola response teams and laboratory workers were unaware of assignments. After a recommendation by an independent data and safety monitoring board, randomisation was stopped and immediate vaccination was also offered to children aged 6-17 years and all identified rings. The prespecified primary outcome was a laboratory confirmed case of Ebola virus disease with onset 10 days or more from randomisation. The primary analysis compared the incidence of Ebola virus disease in eligible and vaccinated individuals assigned to immediate vaccination versus eligible contacts and contacts of contacts assigned to delayed vaccination. This trial is registered with the Pan African Clinical Trials Registry, number PACTR201503001057193. FINDINGS: In the randomised part of the trial we identified 4539 contacts and contacts of contacts in 51 clusters randomly assigned to immediate vaccination (of whom 3232 were eligible, 2151 consented, and 2119 were immediately vaccinated) and 4557 contacts and contacts of contacts in 47 clusters randomly assigned to delayed vaccination (of whom 3096 were eligible, 2539 consented, and 2041 were vaccinated 21 days after randomisation). No cases of Ebola virus disease occurred 10 days or more after randomisation among randomly assigned contacts and contacts of contacts vaccinated in immediate clusters versus 16 cases (7 clusters affected) among all eligible individuals in delayed clusters. Vaccine efficacy was 100% (95% CI 68·9-100·0, p=0·0045), and the calculated intraclass correlation coefficient was 0·035. Additionally, we defined 19 non-randomised clusters in which we enumerated 2745 contacts and contacts of contacts, 2006 of whom were eligible and 1677 were immediately vaccinated, including 194 children. The evidence from all 117 clusters showed that no cases of Ebola virus disease occurred 10 days or more after randomisation among all immediately vaccinated contacts and contacts of contacts versus 23 cases (11 clusters affected) among all eligible contacts and contacts of contacts in delayed plus all eligible contacts and contacts of contacts never vaccinated in immediate clusters. The estimated vaccine efficacy here was 100% (95% CI 79·3-100·0, p=0·0033). 52% of contacts and contacts of contacts assigned to immediate vaccination and in non-randomised clusters received the vaccine immediately; vaccination protected both vaccinated and unvaccinated people in those clusters. 5837 individuals in total received the vaccine (5643 adults and 194 children), and all vaccinees were followed up for 84 days. 3149 (53·9%) of 5837 individuals reported at least one adverse event in the 14 days after vaccination; these were typically mild (87·5% of all 7211 adverse events). Headache (1832 [25·4%]), fatigue (1361 [18·9%]), and muscle pain (942 [13·1%]) were the most commonly reported adverse events in this period across all age groups. 80 serious adverse events were identified, of which two were judged to be related to vaccination (one febrile reaction and one anaphylaxis) and one possibly related (influenza-like illness); all three recovered without sequelae. INTERPRETATION: The results add weight to the interim assessment that rVSV-ZEBOV offers substantial protection against Ebola virus disease, with no cases among vaccinated individuals from day 10 after vaccination in both randomised and non-randomised clusters. FUNDING: WHO, UK Wellcome Trust, the UK Government through the Department of International Development, Médecins Sans Frontières, Norwegian Ministry of Foreign Affairs (through the Research Council of Norway's GLOBVAC programme), and the Canadian Government (through the Public Health Agency of Canada, Canadian Institutes of Health Research, International Development Research Centre and Department of Foreign Affairs, Trade and Development)

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Meat and bone meal as a partial replacement for fish meal in diets for gilthead seabream (Spares aurata): growth, feed efficiency angry amino acid utilization, and economic efficiency

[EN] A trial was conducted to evaluate fish meal (FM) replacement with meat and bone meal (MBM; 53% CP, 15% CL, 27% Ash) in diets for gilthead seabream (Sparus aurata) juveniles. Three extruded experimental diets were formulated (45% CP; 20% CL) to include 0, 50 and 75% of protein from MBM (diets MBM0; MBM50; MBM75). Triplicate groups of seabream (IBW = 25 g) were fed these diets to satiety for 12 weeks. Growth performance and feed efficiency were similar with the diets MBM0 and MBM50, but were lower with diet MBM75, while the opposite was true for feed intake. Whole-body composition was not affected by diets composition except for crude lipid and energy content, which were lower with the diet MBM75. Protein and essential amino acids retention were unaffected by diet composition, while energy retention was lower with the diet MBM75. In terms of economic efficiency, diets with MBM resulted in a lower production costs, with the lowest economic conversion ratio ( kg&#8722; 1 fish produced) being obtained for the MBM diets while the maximum economic profit ( kg fish&#8722; 1) was obtained for diet MBM50. Overall, up to 50% of FM protein can be replaced by MBM protein in diets for gilthead seabream juveniles, without compromising growth performance, feed utilization, and nutrient retention.Moutinho, S.; Martínez-Llorens, S.; Tomas-Vidal, A.; Jover Cerda, M.; Oliva-Teles, A.; Peres, H. (2017). Meat and bone meal as a partial replacement for fish meal in diets for gilthead seabream (Spares aurata): growth, feed efficiency angry amino acid utilization, and economic efficiency. Aquaculture. 468(1):271-277. doi:10.1016/j.aquaculture.2016.10.024S271277468

Characterizing Associations and SNP-Environment Interactions for GWAS-Identified Prostate Cancer Risk Markers—Results from BPC3

Genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with prostate cancer risk. However, whether these associations can be consistently replicated, vary with disease aggressiveness (tumor stage and grade) and/or interact with non-genetic potential risk factors or other SNPs is unknown. We therefore genotyped 39 SNPs from regions identified by several prostate cancer GWAS in 10,501 prostate cancer cases and 10,831 controls from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). We replicated 36 out of 39 SNPs (P-values ranging from 0.01 to 10−28). Two SNPs located near KLK3 associated with PSA levels showed differential association with Gleason grade (rs2735839, P = 0.0001 and rs266849, P = 0.0004; case-only test), where the alleles associated with decreasing PSA levels were inversely associated with low-grade (as defined by Gleason grade <8) tumors but positively associated with high-grade tumors. No other SNP showed differential associations according to disease stage or grade. We observed no effect modification by SNP for association with age at diagnosis, family history of prostate cancer, diabetes, BMI, height, smoking or alcohol intake. Moreover, we found no evidence of pair-wise SNP-SNP interactions. While these SNPs represent new independent risk factors for prostate cancer, we saw little evidence for effect modification by other SNPs or by the environmental factors examined