Sustainable development in the design of online degree programmes for national cross-studies

This study examines the integration of sustainable development in the holistic design of higher education online degree programmes for national cross-studies in Finland. The methodology adopted is design-based research. The literature combines works from the fields of online degree programme design and sustainable development. The empirical data is collected from an Online Degree Working Group representing various online degree expertise in applied higher education. The results of this study highlight the importance of national level collaboration in efforts to reach sustainable development goals in online degree programmes for national cross-studies in higher education. Key sustainability competencies are combined into online degree programme design to reveal new considerations for sustainable development in the online degree education context. The results can be utilised by managers, administrators, and educators of online degree programmes in higher education organisations who are interested in implementing sustainable development in the design phase of the online degree programmes.This study examines the integration of sustainable development in the holistic design of higher education online degree programmes for national cross-studies in Finland. The methodology adopted is design-based research. The literature combines works from the fields of online degree programme design and sustainable development. The empirical data is collected from an Online Degree Working Group representing various online degree expertise in applied higher education. The results of this study highlight the importance of national level collaboration in efforts to reach sustainable development goals in online degree programmes for national cross-studies in higher education. Key sustainability competencies are combined into online degree programme design to reveal new considerations for sustainable development in the online degree education context. The results can be utilised by managers, administrators, and educators of online degree programmes in higher education organisations who are interested in implementing sustainable development in the design phase of the online degree programmes

Media Choice in Multicultural Business Interactions

The aim of this study was to identify which media is chosen for Computed-mediated Communication (CMC) in multicultural business interactions when the main language of communication is English as a lingua franca. The second aim was to determine how the results of this study should be taken into consideration at Higher Educational Institutions (HEIs) in curriculum development. The analyses employed in this survey followed Media synchronicity theory (MST), originally proposed by Dennis/Valacich (1997) and later refined by Dennis et al. (2008). This study was conducted using a mixed method approach with data from a quantitative survey regarding media usage of 274 respondents and qualitative theme interviews of five working life representatives. The findings indicate that the choice of media varies between different countries and is dependent on the different capabilities and synchronicity of the media. The team structure, communication processes, choice of language, cultural diversity and ethical rules of the company play an important role in communication and are meaningful when choosing the media for communication. The main conclusion is that the ability to choose the media that is suitable for varying communicative situations in working life has become essential and therefore needs to be developed as part of curriculum development work at HEIs

Media Choice in Multicultural Business Interactions

[EN] The aim of this study was to identify which media is chosen for Computed-mediated Communication (CMC) in multicultural business interactions when the main language of communication is English as a lingua franca. The second aim was to determine how the results of this study should be taken into consideration at Higher Educational Institutions (HEIs) in curriculum development. The analyses employed in this survey followed Media synchronicity theory (MST), originally proposed by Dennis/Valacich (1997) and later refined by Dennis et al. (2008). This study was conducted using a mixed method approach with data from a quantitative survey regarding media usage of 274 respondents and qualitative theme interviews of five working life representatives. The findings indicate that the choice of media varies between different countries and is dependent on the different capabilities and synchronicity of the media. The team structure, communication processes, choice of language, cultural diversity and ethical rules of the company play an important role in communication and are meaningful when choosing the media for communication. The main conclusion is that the ability to choose the media that is suitable for varying communicative situations in working life has become essential and therefore needs to be developed as part of curriculum development work at HEIs.This work was supported by the Erasmus+ Project CoMoViWo, Communication in Mobile and Virtual Work under Grant KA 2014-1-F101-KA203-00851.Varhelahti, M.; Joshi, M.; Mikkilä-Erdmann, M.; Pérez-Sabater, C. (2017). Media Choice in Multicultural Business Interactions. Hermes. (56):163-180. https://doi.org/10.7146/hjlcb.v0i56.97230S1631805

Media Choice in Multicultural Business Interactions

The aim of this study was to identify which media is chosen for Computed-mediated Communication (CMC) in multicultural business interactions when the main language of communication is English as a lingua franca. The second aim was to determine how the results of this study should be taken into consideration at Higher Educational Institutions (HEIs) in curriculum development. The analyses employed in this survey followed Media synchronicity theory (MST), originally proposed by Dennis/Valacich (1997) and later refined by Dennis et al. (2008). This study was conducted using a mixed method approach with data from a quantitative survey regarding media usage of 274 respondents and qualitative theme interviews of five working life representatives. The findings indicate that the choice of media varies between different countries and is dependent on the different capabilities and synchronicity of the media. The team structure, communication processes, choice of language, cultural diversity and ethical rules of the company play an important role in communication and are meaningful when choosing the media for communication. The main conclusion is that the ability to choose the media that is suitable for varying communicative situations in working life has become essential and therefore needs to be developed as part of curriculum development work at HEIs.</p

Variation in the SERPINA6SERPINA1 locusalters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expressionin peripheral tissues, and risk of cardiovascular disease

The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning plasma cortisol. Identifying additional genetic variants that explain more of the variance in cortisol could provide new insights into cortisol biology and provide statistical power to test the causative role of cortisol in common diseases. The CORNET consortium extended its genome-wide association meta-analysis for morning plasma cortisol from 12,597 to 25,314 subjects and from ~2.2 M to ~7 M SNPs, in 17 population-based cohorts of European ancestries. We confirmed the genetic association with SERPINA6/SERPINA1. This locus contains genes encoding corticosteroid binding globulin (CBG) and α1-antitrypsin. Expression quantitative trait loci (eQTL) analyses undertaken in the STARNET cohort of 600 individuals showed that specific genetic variants within the SERPINA6/SERPINA1 locus influence expression of SERPINA6 rather than SERPINA1 in the liver. Moreover, trans-eQTL analysis demonstrated effects on adipose tissue gene expression, suggesting that variation

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forced expiratory volume in 1 second) or FEV1/FVC (FEV1/forced vital capacity). Although the main effects of smoking and genetic loci are well established, the question of potential gene-by-smoking interaction effect remains unanswered. The aim of the present study was to assess, using a genetic risk score approach, whether the effect of these 26 loci on pulmonary function is influenced by smoking. Methods: We evaluated the interaction between smoking exposure, considered as either ever vs never or pack-years, and a 26-single nucleotide polymorphisms (SNPs) genetic risk score in relation to FEV1 or FEV1/FVC in 50 047 participants of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and SpiroMeta consortia. Results: We identified an interaction (beta(int) = -0.036, 95% confidence interval, -0.040 to -0.032, P = 0.00057) between an unweighted 26 SNP genetic risk score and smoking status (ever/never) on the FEV1/FVC ratio. In interpreting this interaction, we showed that the genetic risk of falling below the FEV1/FVC threshold used to diagnose chronic obstructive pulmonary disease is higher among ever smokers than among never smokers. A replication analysis in two independent datasets, although not statistically significant, showed a similar trend in the interaction effect. Conclusions: This study highlights the benefit of using genetic risk scores for identifying interactions missed when studying individual SNPs and shows, for the first time, that persons with the highest genetic risk for low FEV1/FVC may be more susceptible to the deleterious effects of smoking.Peer reviewe

Genome-wide characterization of circulating metabolic biomarkers

Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11. Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts. We identify more than 400 independent loci and assign probable causal genes at two-thirds of these using manual curation of plausible biological candidates. We highlight the importance of sample and participant characteristics that can have significant effects on genetic associations. We use detailed metabolic profiling of lipoprotein- and lipid-associated variants to better characterize how known lipid loci and novel loci affect lipoprotein metabolism at a granular level. We demonstrate the translational utility of comprehensively phenotyped molecular data, characterizing the metabolic associations of intrahepatic cholestasis of pregnancy. Finally, we observe substantial genetic pleiotropy for multiple metabolic pathways and illustrate the importance of careful instrument selection in Mendelian randomization analysis, revealing a putative causal relationship between acetone and hypertension. Our publicly available results provide a foundational resource for the community to examine the role of metabolism across diverse diseases

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.Peer reviewe

Association of Forced Vital Capacity with the Developmental Gene <i>NCOR2</i>

Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 chi