859 research outputs found

    Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India

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    BACKGROUND: The present study was undertaken to find out the role of estrogen pathway related gene polymorphisms in susceptibility to migraine in Northern Indian population. Aromatase, CYP19A1 (rs10046 and rs4646); estrogen receptors, ESR1 (rs2234693, rs1801132, rs2228480 and rs9340799) and ESR2 (rs1271572 and rs1256049) polymorphisms were selected for the present study. METHODOLOGY/PRINCIPAL FINDINGS: The patients were recruited in two cohorts - primary (207) and replicative (127) along with 200 healthy controls and genotyped for various polymorphisms. Logistic regression analysis was applied for statistical analyses. The results were validated in the replicative cohort and pooled by meta analysis using Fisher's and Mantel-Haenszel test. Furthermore, Benjamini - Hochberg false discovery rate test was used to correct for multiple comparisons. CYP19A1 rs10046 and CYP19A1 rs4646 polymorphisms were found to confer risk and protective effect, respectively. Out of four ESR1 polymorphisms, only rs2234693 variant allele was significantly associated in migraine with aura. No significant associations were observed for ESR2 polymorphisms. Significant haplotypes were identified for CYP19A1 and ESR1 polymorphisms. Gene- gene interactions of genotypes as well as haplotypes were observed for CYP19A1- ESR1 showing both risk and protective combinations. CONCLUSION: We strongly suggest CYP19A1 polymorphisms to be the major contributing factors in migraine susceptibility instead of genetic variants of estrogen receptors

    Search for disappearing tracks in proton-proton collisions at √s=8 TeV

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    Search for vector-like T quarks decaying to top quarks and Higgs bosons in the all-hadronic channel using jet substructure

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    Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV

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    Search for the production of dark matter in association with top-quark pairs in the single-lepton final state in proton-proton collisions at √s=8 TeV

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    Search for Resonant Production of High-Mass Photon Pairs in Proton-Proton Collisions at root s=8 and 13 TeV

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    Search for a massive resonance decaying into a Higgs boson and a W or Z boson in hadronic final states in proton-proton collisions at s√=8 TeV

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    A search for a massive resonance decaying into a standard-model-like Higgs boson (H) and a W or Z boson is reported. The analysis is performed on a data sample corresponding to an integrated luminosity of 19.7 fb1^{-1}, collected in proton-proton collisions at a centre-of-mass energy of 8TeV with the CMS detector at the LHC. Signal events, in which the decay products of Higgs, W, or Z bosons at high Lorentz boost are contained within single reconstructed jets, are identified using jet substructure techniques, including the tagging of b hadrons. This is the first search for heavy resonances decaying into HW or HZ resulting in an all-jet final state, as well as the first application of jet substructure techniques to identify H → WW* → 4q decays at high Lorentz boost. No significant signal is observed and limits are set at 95% confidence level on the production cross sections of W` and Z` in a model with mass-degenerate charged and neutral spin-1 resonances. Resonance masses are excluded for W0 in the interval [1.0, 1.6]TeV, for Z` in the intervals [1.0, 1.1] and [1.3, 1.5]TeV, and for mass-degenerate W` and Z` in the interval [1.0, 1.7]TeV

    Search for supersymmetry in events with a photon, a lepton, and missing transverse momentum in pp collisions at root s=8 TeV

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    Measurement of the tt¯ production cross section in the all-jets final state in pp collisions at √s = 8 TeV

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    The cross section for tt¯ production in the all-jets final state is measured in pp collisions at a centre-of-mass energy of 8 TeV at the LHC with the CMS detector, in data corresponding to an integrated luminosity of 18.4 fb-1 . The inclusive cross section is found to be 275.6±6.1(stat)±37.8(syst)±7.2(lumi) \,pb . The normalized differential cross sections are measured as a function of the top quark transverse momenta, pT , and compared to predictions from quantum chromodynamics. The results are reported at detector, parton, and particle levels. In all cases, the measured top quark pT spectra are significantly softer than theoretical predictions
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