La dimensión ética del desarrollo local

The nowadays conceptions about the community development, have a certain technocratic focus when conceiving just the economic, scientific, technic and environmental dimension bound to the knowledge management. This criteria doesn't recognize the central role that means the moral athics dimension in the social life. The aim of this research is to perform a critic analisis of the problem itself as it is showed in the nowadays Cuban society, beginning with Marti's and Marx's conception of the cultural development in the Cuban Revolution.Las concepciones actuales sobre el desarrollo local tienen cierto enfoque tecnocrático al concebir solo la dimensión económica, ecológica y científica tecnológica vinculada a la gestión del conocimiento. Este criterio no reconoce el papel medular que desempeña la dimensión ético moral en el ámbito social. El propósito fundamental de este trabajo es realizar un enfoque crítico del problema, tal y como se presenta en la realidad cubana actual, partiendo de la concepción martiana y marxista en la obra cultural de la Revolución Cubana

DESARROLLO MODULAR DE UN MODELO GENÉRICO PARA LA DOMÓTICA MEDIANTE COMUNICACIÓN INALÁMBRICA BASADA EN EL PROTOCOLO ZIGBEE

ResumenEn este artículo se presenta el desarrollo y los resultados de un proyecto de investigación aplicada, vigente en el Departamento de Ingeniería Eléctrica y Electrónica del Instituto Tecnológico de Oaxaca.El proyecto consiste en integrar componentes de hardware y software para crear un sistema en domótica, que gestione los sensores y actuadores de manera inalámbrica mediante una red de equipos basados en el protocolo ZigBee perteneciente al grupo de Estándares del IEEE 802.15.4 en el área de redes inalámbricas personales(WPAN), utilizando la frecuencia de 2.4 GHz, en este se utilizan distintas herramientas tecnológicas para su implementación, digitalización, cuantificación, y transmisión; hasta llevar esos datos a un controlador que tiene la capacidad de generar el monitoreo y seguridad en nuestros hogares. El modelo de la arquitectura del proyecto corresponde a una topología estrella, en esta se establece el coordinador de la red, el cual con la instalación de sensores configurados con Arduino se manipularán con los dispositivos XBee, permitiendo así la creación de los circuitos y programación de los sensores.Palabras Claves: automatización, control, coordinador, monitoreo, señales. AbstractThis article describes the development and the results of a research project applied force at the Department of Electrical and Electronic Engineering Institute of Technology of Oaxaca.The project is to integrate hardware and software to create a system in home automation, which manages the sensors and actuators wirelessly through a network based on ZigBee protocol equipment belonging to the group of IEEE 802.15.4 standars in equipment wireless personal area networks (WPAN) using the 2.4 Ghz frequency in which various technological tools for implementation, digitization, quantification, and transmission are used; to bring that data to a controller that has the ability to generate monitoring and safety in our homes. The model of the project architecture corresponds to a star topology, where the network coordinator, which with installing configured with Arduino will be handled with XBee sensor devices is established, enabling the creation of circuits and programming sensors.Keywords: automation, control, coordinator, monitoring, signals

DISEÑO, IMPLEMENTACIÓN Y PRUEBAS DE UN SISTEMA PARA LA EVALUACIÓN DE ALGORITMOS DE BÚSQUEDA DE MÁXIMA POTENCIA PARA CELDAS SOLARES (DESIGN, IMPLEMENTATION, AND TESTING OF A SYSTEM FOR THE EVALUATION OF MAXIMUM POWER POINT TRACKING ALGORITHMS FOR SOLAR CELLS)

Resumen Este trabajo presenta el diseño, implementación y pruebas de un sistema de evaluación para algoritmos de busqueda de máxima potencia (MPPT) en aplicaciones fotovoltaicas (PV). La plataforma de pruebas utiliza un emulador fotovoltaico para simular una celda solar que opera bajo las condiciones de irradiación y temperatura deseadas. Un microcontrolador se programa con el script del algoritmo de MPPT a evaluar. Basado en esto, el microcontrolador envia la señal de control a una placa de potencia con un convertidor tipo boost para llevar al sistema a un punto de operación determinado. Por último, las mediciones requeridas por el estándar de pruebas se registran en una base de datos para su posterior análisis. Se comprobó que la plataforma implementada simuló satisfactoriamente el comportamiento del algoritmo seleccionado de acuerdo con lo reportado en la literatura. El objetivo principal del trabajo es facilitar la creación de plataformas de prueba para diversos sistemas de control en aplicaciones fotovoltaicas. Palabras Clave: MPPT, Fotovoltaico, Plataforma de pruebas. Abstract This work presents the design, implementation, and testing of a system that evaluates maximum power point tracking (MPPT) algorithms for photovoltaic applications. The test platform integrates a photovoltaic (PV) emulator to simulate a solar cell that operates under the desired irradiance and temperature conditions. A microcontroller is programmed with the script of the algorithm being tested. Based on this, the microcontroller sends the control signal to a boost converter that drives the system to the operating point determined by the MPPT algorithm. Lastly, the measurements required by the test standard are stored in a database for further analysis. The implemented platform successfully simulated the behavior reported in the literature of the selected algorithm. The main objective of this work is to accelerate the creation of tests platforms for diverse control systems in photovoltaic applications. Keywords: MPPT, Photovoltaic, Test-platform

Caracterización clínico epidemiológica de pacientes con ébola en un centro de tratamiento de Sierra Leona

Introducción: La enfermedad del ébola se dio a conocer por primera vez en 1976, con una letalidad muy elevada en todos los brotes detectados. Objetivo: Caracterizar clínica y epidemiológicamente a los pacientes portadores de la enfermedad por el virus del Ébola. Métodos: Se realizó un estudio observacional, descriptivo y transversal en 424 pacientes ingresados en un centro de tratamiento de ébola en la República de Sierra Leona, África occidental, con el diagnóstico confirmado mediante la técnica de reacción en cadena de la polimerasa para virus Ébola, durante el período de noviembre de 2014 hasta marzo de 2015. Resultados: Se muestra que el grupo etario más afectado fue el de 25 a 34 con un 25,9 %. La mayor letalidad se presentó en los pacientes con más de 65 años de edad con un 44,4 %. El síntoma que prevaleció fue la fiebre para un 61,8 %, y el hipo se presentó en el 88,8 % de los fallecidos. Conclusión: Se concluye que la enfermedad no tuvo distinción significativa con el sexo. La mayor letalidad se presentó en las edades geriátricas. Los síntomas más frecuentes fueron la fiebre, diarrea y el decaimiento. El hipo fue el signo que más se presentó en los pacientes que fallecieron

Dolabelladienols A–C, New Diterpenes Isolated from Brazilian Brown Alga Dictyota pfaffii

[Abstract:]The marine brown alga Dictyota pfaffii from Atol das Rocas, in Northeast Brazil is a rich source of dolabellane diterpene, which has the potential to be used in future antiviral drugs by inhibiting reverse transcriptase (RT) of HIV-1. Reexamination of the minor diterpene constituents yielded three new dolabellane diterpenes, (1R*,2E,4R*,7S,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (1), (1R*,2E,4R*,7R*,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (2), (1R*,2E,4R*,8E,10S*,11S,12R*)10,18-diacetoxy-7-hydroxy-2,8-dolabelladiene (3), termed dolabelladienols A–C (1–3) respectively, in addition to the known dolabellane diterpenes (4–6). The elucidation of the compounds 1–3 was assigned by 1D and 2D NMR, MS, optical rotation and molecular modeling, along with the relative configuration of compound 4 and the absolute configuration of 5 by X-ray diffraction. The potent anti-HIV-1 activities displayed by compounds 1 and 2 (IC50 = 2.9 and 4.1 μM), which were more active than even the known dolabelladienetriol 4, and the low cytotoxic activity against MT-2 lymphocyte tumor cells indicated that these compounds are promising anti-HIV-1 agents.Brasil. Conselho Nacional de Desenvolvimento Científico e Tecnológico; 490425/2010-0Brasil. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro ; E-26/103.176/2011Ministerio de Economia y Competitividad; AGL2012-12266-C0

A Case of Bicuspid Aorta with Stanford Type a Aortic Dissection

Bicuspid aortic valve disease (BAV) is a congenital disease that frequently produces complications during adulthood, and is considered not only a problem of valvulogenesis, but also a more complex genetic alteration that involves the development of the heart and the aorta, which entails a high morbidity and mortality in these patients. In 50% of adults with this pathology, non-valvular anomalies are observed, with dilation of the ascending aorta being the most common. Genes such as NOTCH1, UFDL1, ACTA2, eNOS, among others, have been identified as responsible for the appearance of aneurysms, which increases the risk in these patients of complications such as aortic dissection and its subsequent rupture. Painless aortic dissection may be seen in less than 5% of patients and may have an atypical clinical presentation. A case and review of the literature is presented in which we can observe the great complexity of this pathology, in the case of a patient with BAV, annulo-ectatic dilation of the aortic root and ascending aorta who developed heart failure, syncope and presented as a complication Stanford type A aortic dissection, requiring highly specialized surgical treatment

Kinematics of gas and stars in the circumnuclear starforming ring of NGC 3351

We have measured gas and stellar velocity dispersions in 5 circumnuclear starforming regions (CNSFRs) and the nucleus of the barred spiral galaxy NGC 3351. The stellar dispersions have been obtained from high resolution spectra of the CaT lines at $\lambda\lambda$ 8494, 8542, 8662 \AA, while the gas velocity dispersions have been measured by Gaussian fits to the H$\beta$ $\lambda$ 4861 \AA line on high dispersion spectra. The CNSFRs, with sizes of about 100 to 150 pc in diameter, are seen to be composed of several individual star clusters with sizes between 1.7 and 4.9 pc on an HST image. Using the stellar velocity dispersions, we have derived dynamical masses for the entire starforming complexes and for the individual star clusters. Values of the stellar velocity dispersions are between 39 and 67 km s$^{-1}$. Dynamical masses for the whole CNSFRs are between 4.9 $\times$ 10$^6$ and 4.3 $\times$ 10$^7$ M$_\odot$ and between 1.8 and 8.7 $\times$ 10$^6$ M$_\odot$ for the individual star clusters. Stellar and gas velocity dispersions are found to differ by about 20 km s$^{-1}$ with the H$\beta$ lines being narrower than both the stellar lines and the [O{\sc iii}] $\lambda$ 5007 \AA lines. We have found indications for the presence of two different kinematical components in the ionised gas of the regions. The radial velocity curve shows deviation from circular motions for the ionised hydrogen consistent with its infall towards the central regions of the galaxy at a velocity of about 25 km s$^{-1}$. To disentangle the origin of these two components it will be necessary to map these regions with high spectral and spatial resolution and much better S/N in particular for the O$^{2+}$ lines.Comment: 17 pages, 13 figures, 7 tables - Accepted by MNRA

Intermediate Molecular Phenotypes to Identify Genetic Markers of Anthracycline-Induced Cardiotoxicity Risk.

Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (n = 165) generated by backcrossing were treated with doxorubicin and docetaxel. We quantified heart fibrosis using an Ariol slide scanner and intramyocardial levels of IMPs using multiplex bead arrays and QPCR. We identified quantitative trait loci linked to IMPs (ipQTLs) and cdaQTLs via linkage analysis. In three cancer patient cohorts, CDA was quantified using echocardiography or Cardiac Magnetic Resonance. CDA behaves as a complex trait in the mouse cohort. IMP levels in the myocardium were associated with CDA. ipQTLs integrated into genetic models with cdaQTLs account for more CDA phenotypic variation than that explained by cda-QTLs alone. Allelic forms of genes encoding IMPs associated with CDA in mice, including AKT1, MAPK14, MAPK8, STAT3, CAS3, and TP53, are genetic determinants of CDA in patients. Two genetic risk scores for pediatric patients (n = 71) and women with breast cancer (n = 420) were generated using machine-learning Least Absolute Shrinkage and Selection Operator (LASSO) regression. Thus, IMPs associated with heart damage identify genetic markers of CDA risk, thereby allowing more personalized patient management.J.P.L.’s lab is sponsored by Grant PID2020-118527RB-I00 funded by MCIN/AEI/10.13039/ 501100011039; Grant PDC2021-121735-I00 funded by MCIN/AEI/10.13039/501100011039 and by the “European Union Next Generation EU/PRTR”, the Regional Government of Castile and León (CSI144P20). J.P.L. and P.L.S. are supported by the Carlos III Health Institute (PIE14/00066). AGN laboratory and human patients’ studies are supported by an ISCIII project grant (PI18/01242). The Human Genotyping unit is a member of CeGen, PRB3, and is supported by grant PT17/0019 of the PE I + D + i 2013–2016, funded by ISCIII and ERDF. SCLl is supported by MINECO/FEDER research grants (RTI2018-094130-B-100). CH was supported by the Department of Defense (DoD) BCRP, No. BC190820; and the National Cancer Institute (NCI) at the National Institutes of Health (NIH), No. R01CA184476. Lawrence Berkeley National Laboratory (LBNL) is a multi-program national laboratory operated by the University of California for the DOE under contract DE AC02-05CH11231. The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023 of the PE I + D +i, 2017–2020, funded by ISCIII and FEDER. RCC is funded by fellowships from the Spanish Regional Government of Castile and León. NGS is a recipient of an FPU fellowship (MINECO/FEDER). hiPSC-CM studies were funded in part by the “la Caixa” Banking Foundation under the project code HR18-00304 and a Severo Ochoa CNIC Intramural Project (Exp. 12-2016 IGP) to J.J.S

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

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