Entstehung der Leitlinie zur „Diagnostik und Behandlung der Rechenstörung“ und Beteiligung der GDM

Die anstehende Überarbeitung der ICD-10 (ICD=International Classification of Diseases) durch die Weltgesundheitsorganisation (WHO) hat zu der inzwischen veröffentlichten Leitlinie zur Diagnostik und Behandlung der Rechenstörungen geführt. Im Beitrag versuchen wir die Entstehung, die Absicht und den Geltungsbereich der Leitlinie sowie die Rolle der GDM dabei zu erläutern

Frühe mathematische Bildung - Ziele und Gelingensbedingungen für den Elementar- und Primarbereich

Im Rahmen der Schriftenreihe "Wissenschaftliche Untersuchungen zur Arbeit der Stiftung 'Haus der kleinen Forscher'" werden regelmäßig wissenschaftliche Beiträge von renommierten Expertinnen und Experten aus dem Bereich der frühen Bildung veröffentlicht. Diese Schriftenreihe dient einem fachlichen Dialog zwischen Stiftung, Wissenschaft und Praxis, mit dem Ziel, allen Kitas, Horten und Grundschulen in Deutschland fundierte Unterstützung für ihren frühkindlichen Bildungsauftrag zu geben. Der vorliegende achte Band der Reihe mit einem Geleitwort von Kristina Reiss stellt die Ziele und Gelingensbedingungen mathematischer Bildung im Elementar- und Primarbereich in den Fokus. Christiane Benz, Meike Grüßing, Jens Holger Lorenz, Christoph Selter und Bernd Wollring spezifizieren in ihrer Expertise pädagogisch-inhaltliche Zieldimensionen mathematischer Bildung im Kita- und Grundschulalter. Neben einer theoretischen Fundierung verschiedener Zielbereiche werden Instrumente für deren Messung aufgeführt. Des Weiteren erörtern die Autorinnen und Autoren Gelingensbedingungen für eine effektive und wirkungsvolle frühe mathematische Bildung in der Praxis. Sie geben zudem Empfehlungen für die Weiterentwicklung der Stiftungsangebote und die wissenschaftliche Begleitung der Stiftungsarbeit im Bereich Mathematik. Das Schlusskapitel des Bandes beschreibt die Umsetzung dieser fachlichen Empfehlungen in den inhaltlichen Angeboten der Stiftung "Haus der kleinen Forscher"

Media and Material - Proceedings of the Research Group on Primary Mathematics Education within the GDM 2011

Der Tagungsband dokumentiert Ergebnisse der Herbsttagung des Arbeitskreises Grundschule in der Gesellschaft für Didaktik der Mathematik (GDM) vom November 2011 zum Thema „Medien und Materialien“. Das Rahmenthema der Tagung wurde in fünf Hauptvorträgen im Plenum diskutiert. Zusätzlich setzten sich Arbeitsgruppen zu den Themenfeldern Arithmetik, Daten, Zufall und Wahrscheinlichkeit, Geometrie und Sachrechnen sowie Gruppen zu den Bereichen Kommunikation & Kooperation, PriMa Medien und Vorschulische Bildung, intensiv mit aktuellen Forschungsfragen auseinander.The Proceedings of the 2011 Conference of the Research Group on Primary Mathematics Education (Arbeitskreis Grundschule in der GDM) focus on media and didactical material (representations). Five invited talks addressed the main theme in plenum. Additionally, working groups on the research areas arithmetic, geometry, modelling, data & probability, as well as groups on communication & co-operation, IT, and last not least early mathematics education offered discussions on current research issues

The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation

<p>Abstract</p> <p>Background</p> <p>Pregnancy represents an exclusive situation in which the immune and the endocrine system cooperate to prevent rejection of the embryo by the maternal immune system. While immature dendritic cells (iDC) in the early pregnancy decidua presumably contribute to the establishment of peripheral tolerance, glycoprotein-hormones of the transforming growth factor beta (TGF-beta) family including activin A (ActA) and inhibin A (InA) are candidates that could direct the differentiation of DCs into a tolerance-inducing phenotype.</p> <p>Methods</p> <p>To test this hypothesis we generated iDCs from peripheral-blood-monocytes and exposed them to TGF-beta1, ActA, as well as InA and Dexamethasone (Dex) as controls.</p> <p>Results</p> <p>Both glycoprotein-hormones prevented up-regulation of HLA-DR during cytokine-induced DC maturation similar to Dex but did not influence the expression of CD 40, CD 83 and CD 86. Visualization of the F-actin cytoskeleton confirmed that the DCs retained a partially immature phenotype under these conditions. The T-cell stimulatory capacity of DCs was reduced after ActA and InA exposure while the secretion of cytokines and chemokines was unaffected.</p> <p>Conclusion</p> <p>These findings suggest that ActA and InA interfere with selected aspects of DC maturation and may thereby help preventing activation of allogenic T-cells by the embryo. Thus, we have identified two novel members of the TGF-beta superfamily that could promote the generation of tolerance-inducing DCs.</p

Clinico-genetic findings in 509 frontotemporal dementia patients

Abstract Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-driven differences in biomarker profiles, disease severity and clinical manifestation by recruiting 509 FTD patients from different centers of the German FTLD consortium where individuals were clinically assessed including biomarker analysis. Exome sequencing as well as C9orf72 repeat analysis were performed in all patients. These genetic analyses resulted in a diagnostic yield of 18.1%. Pathogenic variants in C9orf72 (n = 47), GRN (n = 26), MAPT (n = 11), TBK1 (n = 5), FUS (n = 1), TARDBP (n = 1), and CTSF (n = 1) were identified across all clinical subtypes of FTD. TBK1-associated FTD was frequent accounting for 5.4% of solved cases. Detection of a homozygous missense variant verified CTSF as an FTD gene. ABCA7 was identified as a candidate gene for monogenic FTD. The distribution of APOE alleles did not differ significantly between FTD patients and the average population. Male sex was weakly associated with clinical manifestation of the behavioral variant of FTD. Age of onset was lowest in MAPT patients. Further, high CSF neurofilament light chain levels were found to be related to GRN-associated FTD. Our study provides large-scale retrospective clinico-genetic data such as on disease manifestation and progression of FTD. These data will be relevant for counseling patients and their families

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements