403 research outputs found
Approximations for the delivery splitting model
Consumer Demand;Operational Research;Stocks
Meizothrombin formation during factor Xa-catalyzed prothrombin activation:Formation in a purified system and in plasma
Meizothrombin and thrombin formation were quantitated during factor Xa-catalyzed activation of human prothrombin in reaction systems containing purified proteins and in plasma. In the purified system considerable amounts of meizothrombin accumulated when prothrombin was activated by factor Xa (with or without accessory components) under initial steady state conditions. The ratio of the rates of meizothrombin and thrombin formation was not influenced by variation of the pH, temperature, or ionic strength of the reaction medium. When 2-mu-M prothrombin was activated by the complete prothrombinase complex (factor Xa, factor Va, Ca2+, and phospholipid) 80-90% of the initially formed reaction product was meizothrombin. Lowering the prothrombin concentration from 2 to 0.03-mu-M caused a gradual decrease in the ratio of meizothrombin/thrombin formation from 5 to 0.6. When the phosphatidylserine content of the phospholipid vesicles was varied between 20 and 1 mol% and prothrombin activation was analyzed at 2-mu-M prothrombin the relative amount of meizothrombin formed decreased from 85 to 55%. With platelets, cephalin, or thromboplastin as procoagulant lipid, thrombin was the major reaction product and only 30-40% of the activation product was meizothrombin. We also analyzed complete time courses of prothrombin activation both with purified proteins and in plasma. In reaction systems with purified proteins substantial amounts of meizothrombin accumulated under a wide variety of experimental conditions. However, little or no meizothrombin was detected in plasma in which coagulation was initiated via the extrinsic pathway with thromboplastin or via the intrinsic pathway with kaolin plus phospholipid (cephalin, platelets, or phosphatidylserine-containing vesicles). Thus, thrombin was the only active prothrombin activation product that accumulated during ex vivo coagulation experiments in plasma
The Effect of Nuclear Rotation on the Collective Transport Coefficients
We have examined the influence of rotation on the potential energy and the
transport coefficients of the collective motion (friction and mass
coefficients). For axially symmetric deformation of nucleus Th-224 we have
found that at excitations corresponding to temperatures T > 1 MeV the shell
correction to the liquid drop energy practically does not depend on the angular
rotation. The friction and mass coefficients obtained within the linear
response theory for the same nucleus at temperatures larger than T=2 MeV are
rather stable with respect to rotation provided that the contributions from
spurious states arising due to the violation of rotation symmetry are removed.
At smaller excitations both friction and mass parameters corresponding to the
elongation mode are growing functions of rotational frequency.Comment: 16 pages, 5 eps figures, Latex, submitted to Nucl.Phys.
Toezicht ten tijde van Corona:Vasthouden aan de maatschappelijke opdracht
Nu de Corona pandemie een jaar onderweg is, is het belangrijk om ook stil te staan bij hetgeen zich de afgelopen periode heeft afgespeeld en na te denken over de toekomst. Het continue lessen trekken uit de praktijk blijft essentieel om deze (en andere) pandemie(en) verder het hoofd te kunnen bieden. Met deze analyse wordt daarom voortgeborduurd op het eerder verschenen âSignalement 2020â en de publicatie âTussen Wal en Schipâ uit 2019. De wetenschappelijke adviesraad van de NVTZ geeft 'Toezicht ten tijde van Corona - Vasthouden aan de maatschappelijke opdracht' uit in een te downloaden online document
Complementarity of the Maldacena and Karch-Randall Pictures
We perform a one-loop test of the holographic interpretation of the
Karch-Randall model, whereby a massive graviton appears on an AdS_4 brane in an
AdS_5 bulk. Within the AdS/CFT framework, we examine the quantum corrections to
the graviton propagator on the brane, and demonstrate that they induce a
graviton mass in exact agreement with the Karch-Randall result. Interestingly
enough, at one loop order, the spin 0, spin 1/2 and spin 1 loops contribute to
the dynamically generated (mass)^2 in the same 1: 3: 12 ratio as enters the
Weyl anomaly and the 1/r^3 corrections to the Newtonian gravitational
potential.Comment: 20 pages, Revtex 3, Discussion on the absence of a scalar ghost
clarified; Additional details on the computation give
Coherent quantum transport in narrow constrictions in the presence of a finite-range longitudinally polarized time-dependent field
We have studied the quantum transport in a narrow constriction acted upon by
a finite-range longitudinally polarized time-dependent electric field. The
electric field induces coherent inelastic scatterings which involve both
intra-subband and inter-sideband transitions. Subsequently, the dc conductance
G is found to exhibit suppressed features. These features are recognized as the
quasi-bound-state (QBS) features which are associated with electrons making
transitions to the vicinity of a subband bottom, of which the density of states
is singular. Having valley-like instead of dip-like structures, these QBS
features are different from the G characteristics for constrictions acted upon
by a finite-range time-modulated potential. In addition, the subband bottoms in
the time-dependent electric field region are shifted upward by an energy
proportional to the square of the electric field and inversely proportional to
the square of the frequency. This effective potential barrier is originated
from the square of the vector potential and it leads to the interesting
field-sensitive QBS features. An experimental set-up is proposed for the
observation of these features.Comment: 8 pages, 4 figure
An inventory control policy for liquefied natural gas as a transportation fuel
In this paper, we study a novel stochastic inventory management problem that arises in storage and refueling facilities for Liquefied Natural Gas (LNG) as a transportation fuel. In this inventory problem, the physio-chemical properties of LNG play a key role in the design of inventory policies. These properties are: (1) LNG suffers from both quantity decay and quality deterioration and (2) the quality of on-hand LNG can be upgraded by mixing it with higher-quality LNG. Given that LNG quality can be upgraded, an inventory control policy for this problem needs to consider the removal of LNG as a decision variable. We model and solve the problem by means of a Markov Decision Process (MDP) and study the structural characteristics of the optimal policy. The insights obtained in the analysis of the optimal policy are translated into a simple, though effective, inventory control policy in which actions (i.e., replenishment and/or removal) are driven by both the quality and the quantity of the inventories. We assess the performance of our policy by means of a numerical study and show that it performs close to optimal in many numerical instances. The main conclusion of our study is that it is important to take quality into consideration when design inventory control policies for LNG, and that the most effective way to cope with quality issues in an LNG inventory system involves both the removal and the replenishment of inventories
Motor-Driven Bacterial Flagella and Buckling Instabilities
Many types of bacteria swim by rotating a bundle of helical filaments also
called flagella. Each filament is driven by a rotary motor and a very flexible
hook transmits the motor torque to the filament. We model it by discretizing
Kirchhoff's elastic-rod theory and develop a coarse-grained approach for
driving the helical filament by a motor torque. A rotating flagellum generates
a thrust force, which pushes the cell body forward and which increases with the
motor torque. We fix the rotating flagellum in space and show that it buckles
under the thrust force at a critical motor torque. Buckling becomes visible as
a supercritical Hopf bifurcation in the thrust force. A second buckling
transition occurs at an even higher motor torque. We attach the flagellum to a
spherical cell body and also observe the first buckling transition during
locomotion. By changing the size of the cell body, we vary the necessary thrust
force and thereby obtain a characteristic relation between the critical thrust
force and motor torque. We present a sophisticated analytical model for the
buckling transition based on a helical rod which quantitatively reproduces the
critical force-torque relation. Real values for motor torque, cell body size,
and the geometry of the helical filament suggest that buckling should occur in
single bacterial flagella. We also find that the orientation of pulling
flagella along the driving torque is not stable and comment on the biological
relevance for marine bacteria.Comment: 15 pages, 11 figure
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
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