238 research outputs found
Added value of frailty and social support in predicting risk of 30-day unplanned re-admission or death for patients with heart failure: an analysis from OPERA-HF
Background:
Models for predicting the outcome of patients hospitalized for heart failure (HF) rarely take a holistic view. We assessed the ability of measures of frailty and social support in addition to demographic, clinical, imaging and laboratory variables to predict short-term outcome for patients discharged after a hospitalization for HF.
Methods:
OPERA-HF is a prospective observational cohort, enrolling patients hospitalized for HF in a single center in Hull, UK. Variables were combined in a logistic regression model after multiple imputation of missing data to predict the composite outcome of death or readmission at 30âŻdays. Comparisons were made to a model using clinical variables alone. The discriminative performance of each model was internally validated with bootstrap re-sampling.
Results:
1094 patients were included (mean age 77 [interquartile range 68â83] years; 40% women; 56% with moderate to severe left ventricular systolic dysfunction) of whom 213 (19%) had an unplanned re-admission and 60 (5%) died within 30âŻdays. For the composite outcome, a model containing clinical variables alone had an area under the receiver-operating characteristic curve (AUC) of 0.68 [95% CI 0.64â0.72]. Adding marital status, support from family and measures of physical frailty increased the AUC (pâŻ<âŻ0.05) to 0.70 [95% CI 0.66â0.74].
Conclusions:
Measures of physical frailty and social support improve prediction of 30-day outcome after an admission for HF but predicting near-term events remains imperfect. Further external validation and improvement of the model is required
Systematic event generator tuning for the LHC
In this article we describe Professor, a new program for tuning model
parameters of Monte Carlo event generators to experimental data by
parameterising the per-bin generator response to parameter variations and
numerically optimising the parameterised behaviour. Simulated experimental
analysis data is obtained using the Rivet analysis toolkit. This paper presents
the Professor procedure and implementation, illustrated with the application of
the method to tunes of the Pythia 6 event generator to data from the LEP/SLD
and Tevatron experiments. These tunes are substantial improvements on existing
standard choices, and are recommended as base tunes for LHC experiments, to be
themselves systematically improved upon when early LHC data is available.Comment: 28 pages. Submitted to European Physical Journal C. Program sources
and extra information are available from
http://projects.hepforge.org/professor
Tidal friction in close-in satellites and exoplanets. The Darwin theory re-visited
This report is a review of Darwin's classical theory of bodily tides in which
we present the analytical expressions for the orbital and rotational evolution
of the bodies and for the energy dissipation rates due to their tidal
interaction. General formulas are given which do not depend on any assumption
linking the tidal lags to the frequencies of the corresponding tidal waves
(except that equal frequency harmonics are assumed to span equal lags).
Emphasis is given to the cases of companions having reached one of the two
possible final states: (1) the super-synchronous stationary rotation resulting
from the vanishing of the average tidal torque; (2) the capture into a 1:1
spin-orbit resonance (true synchronization). In these cases, the energy
dissipation is controlled by the tidal harmonic with period equal to the
orbital period (instead of the semi-diurnal tide) and the singularity due to
the vanishing of the geometric phase lag does not exist. It is also shown that
the true synchronization with non-zero eccentricity is only possible if an
extra torque exists opposite to the tidal torque. The theory is developed
assuming that this additional torque is produced by an equatorial permanent
asymmetry in the companion. The results are model-dependent and the theory is
developed only to the second degree in eccentricity and inclination
(obliquity). It can easily be extended to higher orders, but formal accuracy
will not be a real improvement as long as the physics of the processes leading
to tidal lags is not better known.Comment: 30 pages, 7 figures, corrected typo
Effective K-factors for gg -> H -> WW -> lnu lnu at the LHC
A simulation of the search for the Standard Model Higgs boson at the LHC, in
the channel gg -> H -> WW -> lnu lnu, is described. Higher-order QCD
corrections are taken into account by using a reweighting procedure, which
allows us to combine event rates obtained with the PYTHIA Monte Carlo program
with the most up-to-date theoretical predictions for the transverse-momentum
spectra of the Higgs signal and its corresponding WW background. With this
method the discovery potential for Higgs masses between 140 and 180 GeV is
recalculated and the potential statistical significance of this channel is
found to increase considerably. For a Higgs mass of 165 GeV a
signal-to-background ratio of almost 2:1 can be obtained. A statistical
significance of five standard deviations might already be achieved with an
integrated luminosity close to 0.4 fb^{-1}. Using this approach, an
experimental effective K-factor of about 2.04 is obtained for the considered
Higgs signature, which is only about 15 % smaller than the theoretical
inclusive K-factor.Comment: 16 pages, 8 eps figures, comparison of jet veto efficiencies between
PYTHIA and HERWIG added, to appear on JHE
Unweighted event generation in hadronic WZ production at order(alpha_S)
We present an algorithm for unweighted event generation in the partonic
process pp -> WZ (j) with leptonic decays at next-to-leading order in alpha_S.
Monte Carlo programs for processes such as this frequently generate events with
negative weights in certain regions of phase space. For simulations of
experimental data one would like to have unweighted events only. We demonstrate
how the phase space from the matrix elements can be combined to achieve
unweighted event generation using a second stage Monte Carlo integration over a
volume of real emissions (jets). Observable quantities are kept fixed in the
laboratory frame throughout the integration. The algorithm is applicable to a
broader class of processes and is CPU intensive.Comment: 9 pages, 4 figure
Knowledge-based energy functions for computational studies of proteins
This chapter discusses theoretical framework and methods for developing
knowledge-based potential functions essential for protein structure prediction,
protein-protein interaction, and protein sequence design. We discuss in some
details about the Miyazawa-Jernigan contact statistical potential,
distance-dependent statistical potentials, as well as geometric statistical
potentials. We also describe a geometric model for developing both linear and
non-linear potential functions by optimization. Applications of knowledge-based
potential functions in protein-decoy discrimination, in protein-protein
interactions, and in protein design are then described. Several issues of
knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe
Magnetic Field Amplification in Galaxy Clusters and its Simulation
We review the present theoretical and numerical understanding of magnetic
field amplification in cosmic large-scale structure, on length scales of galaxy
clusters and beyond. Structure formation drives compression and turbulence,
which amplify tiny magnetic seed fields to the microGauss values that are
observed in the intracluster medium. This process is intimately connected to
the properties of turbulence and the microphysics of the intra-cluster medium.
Additional roles are played by merger induced shocks that sweep through the
intra-cluster medium and motions induced by sloshing cool cores. The accurate
simulation of magnetic field amplification in clusters still poses a serious
challenge for simulations of cosmological structure formation. We review the
current literature on cosmological simulations that include magnetic fields and
outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure
EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.
We studied three patients with severe skeletal dysplasia, T cell immunodeficiency, and developmental delay. Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis. Patient-derived fibroblasts showed abnormal HS composition and altered fibroblast growth factor 2 signaling, which was rescued by overexpression of wild-type EXTL3 cDNA. Interleukin-2-mediated STAT5 phosphorylation in patients' lymphocytes was markedly reduced. Interbreeding of the extl3-mutant zebrafish (box) with Tg(rag2:green fluorescent protein) transgenic zebrafish revealed defective thymopoiesis, which was rescued by injection of wild-type human EXTL3 RNA. Targeted differentiation of patient-derived induced pluripotent stem cells showed a reduced expansion of lymphohematopoietic progenitor cells and defects of thymic epithelial progenitor cell differentiation. These data identify EXTL3 mutations as a novel cause of severe immune deficiency with skeletal dysplasia and developmental delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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