Isolation and characterization of bioactive compound from

No Abstract

Stability of nano-oil by pH control in stationary conditions

The purpose of this study is to investigate the stability of nano-oil by pH control in stationary conditions. The nano-oil was prepared by dispersing an optimal composition of 0.5 vol.% 70 nm hexagonal boron nitride (hBN) nanoparticles in SAE 15W-40 diesel engine oil by sonication technique. Hydrochloric (HCl) acid and Sodium Hydroxide (NaOH) were used as a dispersing agent to determine the stability of the dispersion. The dispersion stability was evaluated by using the sedimentation method with the help of Ultra Violet-Visible (UV-Vis) spectrophotometer. It was demonstrated that the suspension in the alkaline region with a pH value of 11 to 13 was stable over the period of 60 days

Transient Semi-Circular Lid-Driven Cavity Flow using Non- Uniform Structured Grid Method with Upwind Scheme

In this article, two-dimensional lid-driven cavity flow in a semi-circular cavity is simulated using a non-uniform finite different method with structured grid. NavierStokes and continuity equations are simplified using a non-dimensional streamfunction– vorticity approach. A Reynolds number of 1000 is used and the vorticity and streamfunction contour plot is monitored with convergence criteria of 1x10-7 set to both the vorticity and the streamfunction value. The result shows that the primary vortex moves from the upper left cavity corner to the upper right corner, while the magnitude of the streamfunction grows at the primary vortex center. The primary vortex size decreases steadily as the time increases. This phenomenon is greatly affected by the increasing size of the secondary vortex at the lower left. Slight changes of vortex size are observed as the flow achieves a steady state condition. Validation of the simulation results shows the current value deviation from the established result is less than 5%. In future, it is recommended to use a better numerical method so that the simulation is more stable and so that the calculation time can be reduced

Isolation of novel para-pentyl phenyl benzoate from Mondia whitei.(Hook.F.) skeels (periplocaceae), its structure, synthesis and neuropharmacological evaluation

Background: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous system effect but which has not been scientifically investigated, hence this study.Methodology: Fresh fruits of Mondia whitei were collected and identified by a taxonomist. They were chopped into small pieces and extracted with absolute ethanol. The crude extract was subjected to various chromatographic techniques to isolate a novel compound whose structure was elucidated from the analysis of the crystal data and by extensive use of spectroscopy. The structure was confirmed by synthesis. The compound was subjected to anxiolytic and sedative activity assay. Computational analysis of the receptor binding event of isolated compound at the gamma amino butyric acid A receptor was also evaluated.Results: The structure of the compound was elucidated as para pentyl phenyl benzoate. The neuropharmacological evaluation of the compound indicated significant (p<0.05) depression of the central nervous system. The binding characteristics of the compound to gamma amino butyric acid A receptors appears to be more favorable than those obtained for gamma amino butyric acid, chlorpromazine, benzamidine, and is comparable with the affinity obtained for pentobarbitone and diazepam.Conclusion: These present data provide evidence for the role of para pentyl phenyl benzoate in the habitual consumption of the fruit as well as its central nervous system activities.Keywords: Mondia whitei, Periplocaceae, isolation and synthesis, sedative and anxiolytic effect and Para pentylphenyl benzoat

Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

Peer reviewe

Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search

Peer reviewe

Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos, and b quarks

Peer reviewe

Challenges and controversies in resectable non-small cell lung cancer:a clinician's perspective

The treatment landscape of resectable early-stage non-small cell lung cancer (NSCLC) is transforming due to the approval of novel adjuvant and neoadjuvant systemic treatments. The European Medicines Agency (EMA) recently approved adjuvant osimertinib, adjuvant atezolizumab, adjuvant pembrolizumab, and neoadjuvant nivolumab combined with chemotherapy, and the approval of other agents or new indications may follow soon. Despite encouraging results, many unaddressed questions remain. Moreover, the transformed treatment paradigm in resectable NSCLC can pose major challenges to healthcare systems and magnify existing disparities in care as differences in reimbursement may vary across different European countries. This Viewpoint discusses the challenges and controversies in resectable early-stage NSCLC and how existing inequalities in access to these treatments could be addressed.</p

Challenges and controversies in resectable non-small cell lung cancer:a clinician's perspective

The treatment landscape of resectable early-stage non-small cell lung cancer (NSCLC) is transforming due to the approval of novel adjuvant and neoadjuvant systemic treatments. The European Medicines Agency (EMA) recently approved adjuvant osimertinib, adjuvant atezolizumab, adjuvant pembrolizumab, and neoadjuvant nivolumab combined with chemotherapy, and the approval of other agents or new indications may follow soon. Despite encouraging results, many unaddressed questions remain. Moreover, the transformed treatment paradigm in resectable NSCLC can pose major challenges to healthcare systems and magnify existing disparities in care as differences in reimbursement may vary across different European countries. This Viewpoint discusses the challenges and controversies in resectable early-stage NSCLC and how existing inequalities in access to these treatments could be addressed.</p

Diversity of Fisheries in Sarawak, Northwest Borneo: Present Status and Conservation Issues

Information on fisheries resources in East Malaysia is scarce and poorly known. The current review aims to compile a checklist of fisheries resources in the Northwest Borneo (Sarawak, Malaysia) from available published literature, address the resources' present status, and suggest future monitoring needs for selected critical species. The study also aims to determine several Sarawak land-use issues that are in flux and responsible for habitat degradation. Five hundred sixty-four species belonging to 123 families and 32 orders were recorded from Sarawak waters. Freshwater fish species comprised 48.0% of the total, followed by a marine (36.6%), marine-euryhaline (12.9%), and brackish water (2.5%) species. Of this, Cyprinidae was the most dominant group accounting for the greatest number of species (82 species), followed by Balitoridae (34 species), Bagridae (21 species) and Penaeidae (21 species). Therefore, available fisheries resources should be managed carefully as 48 species (9.0%) are currently vulnerable to extinction. Furthermore, the presence of 20 alien species in Sarawak water bodies also requires attention from the authorities due to the potential disruption of aquatic ecological balance. Changing land use issues in Sarawak such as forest degradation, agricultural expansion, peatland deforestation and conversion, logging, destruction of mangrove forests, and construction of hydroelectric power dams and flood mitigation channels pose significant challenges to fishery management in Sarawak. Our study documents the priority of fishery monitoring and conservation in Sarawak water bodies to ensure sustainable management of fisheries resources