64 research outputs found
Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994
- Author
- A Festa
- A Jager
- A Levey
- A Zernecke
- Ajay Yesupriya
- AS Krolewski
- AS Levey
- AS Levey
- AV Kshirsagar
- AY Chu
- BC Hu
- BI Freedman
- C Argano
- C Ruster
- CA Houlihan
- CA Jones
- CC Hsu
- CD Stehouwer
- CD Stehouwer
- D Binder
- D de Zeeuw
- DC Crawford
- Diane T Smelser
- DR Jacobs Jr
- DV Zaykin
- E Selvin
- E Zintzaras
- EL Knight
- EW Gunter
- F Gaspari
- G Dell'Omo
- G Dell'Omo
- G Lettre
- G Placha
- Giuseppina Imperatore
- H Tang
- HJ Mattix
- HM Kramer
- IS Hoffmann
- J Coresh
- J Coresh
- J Danziger
- JC Verhave
- JF Navarro
- JH Warram
- JI Barzilay
- JJ Snyder
- JM Leon
- JP Ioannidis
- JR Gonzalez
- K Ichikawa
- L Nordfors
- LA Hindorff
- M Ashburner
- M Bamshad
- M Bamshad
- M Chang
- M Sinha
- MA Kaunisto
- Man-huei Chang
- ME Keebler
- MJ Sarnak
- MR Weir
- MT Schram
- N Pannacciulli
- N Yang
- National Center for Health Statistics
- Nicole F Dowling
- PM Ridker
- R Woodruff
- Ramal Moonesinghe
- Renée M Ned
- RJ Hogg
- RT Gansevoort
- S Carbon
- SD Nath
- SJ Hwang
- SK Iyengar
- SM Herrmann
- T Konta
- T Trepels
- TK Hansen
- VL Parsons
- WG Miller
- Y Benjamini
- Y Benjamini
- Y Liu
- YK Yee
- Publication venue
- BioMed Central
- Publication date
- 01/11/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Albuminuria, a common marker of kidney damage, serves as an important predictive factor for the progression of kidney disease and for the development of cardiovascular disease. While the underlying etiology is unclear, chronic, low-grade inflammation is a suspected key factor. Genetic variants within genes involved in inflammatory processes may, therefore, contribute to the development of albuminuria.</p> <p>Methods</p> <p>We evaluated 60 polymorphisms within 27 inflammatory response genes in participants from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), a population-based and nationally representative survey of the United States. Albuminuria was evaluated as logarithm-transformed albumin-to-creatinine ratio (ACR), as ACR â„ 30 mg/g, and as ACR above sex-specific thresholds. Multivariable linear regression and haplotype trend analyses were conducted to test for genetic associations in 5321 participants aged 20 years or older. Differences in allele and genotype distributions among non-Hispanic whites, non-Hispanic blacks, and Mexican Americans were tested in additive and codominant genetic models.</p> <p>Results</p> <p>Variants in several genes were found to be marginally associated (uncorrected P value < 0.05) with log(ACR) in at least one race/ethnic group, but none remained significant in crude or fully-adjusted models when correcting for the false-discovery rate (FDR). In analyses of sex-specific albuminuria, <it>IL1B </it>(rs1143623) among Mexican Americans remained significantly associated with increased odds, while <it>IL1B </it>(rs1143623), <it>CRP </it>(rs1800947) and <it>NOS3 </it>(rs2070744) were significantly associated with ACR â„ 30 mg/g in this population (additive models, FDR-P < 0.05). In contrast, no variants were found to be associated with albuminuria among non-Hispanic blacks after adjustment for multiple testing. The only variant among non-Hispanic whites significantly associated with any outcome was <it>TNF </it>rs1800750, which failed the test for Hardy-Weinberg proportions in this population. Haplotypes within <it>MBL2</it>, <it>CRP</it>, <it>ADRB2, IL4R</it>, <it>NOS3</it>, and <it>VDR </it>were significantly associated (FDR-P < 0.05) with log(ACR) or albuminuria in at least one race/ethnic group.</p> <p>Conclusions</p> <p>Our findings suggest a small role for genetic variation within inflammation-related genes to the susceptibility to albuminuria. Additional studies are needed to further assess whether genetic variation in these, and untested, inflammation genes alter the susceptibility to kidney damage.</p
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
- Author
- Abante J
- Abecassis BS
- Aben N
- Aghamirzaie D
- Ahsen ME
- Aittokallio T
- Akhtari FS
- Al-lazikani B
- Alam T
- Allam A
- Allen C
- Altarawy D
- Alves V
- Amadoz A
- Anchang B
- Angel Pujana M
- Antolin AA
- Ash JR
- Ba-alawi W
- Bagheri M
- Bajic V
- Ball G
- Ballester PJ
- Baptista D
- Bare C
- Bateson M
- Bender A
- Bertrand D
- Boroevich KA
- Bosdriesz E
- Bougouffa S
- Bounova G
- Brouwer T
- Bryant B
- Bulusu KC
- Calaza M
- Calderone A
- Calza S
- Capuzzi S
- Carbonell-Caballero J
- Carlin D
- Carter H
- Castagnoli L
- Celebi R
- Cesareni G
- Chang H
- Chen G
- Chen H
- Chen H
- Cheng L
- Chernomoretz A
- Chicco D
- Cho K-H
- Cho S
- Choi D
- Choi J
- Choi K
- Choi M
- Coker E
- Combinatio A-SD
- Cortes-Ciriano I
- Cserzo M
- Cubuk C
- Curtis C
- Dang CC
- de Almeida MP
- De Cock M
- de Esch I
- de Graaf C
- De Maeyer D
- De Niz C
- de Ruiter JR
- De Troyer E
- Di Veroli GY
- Dijkstra T
- Dopazo J
- Draghici S
- Drosou A
- Dry JR
- Dumontier M
- Ehrhart F
- Eid F-E
- ElHefnawi M
- Elmarakeby H
- Engin HB
- Evelo C
- Falcao AO
- Farag S
- Fawell S
- Fernandez-Lozano C
- Fisch K
- Flobak A
- Fornari C
- Foroushani ABK
- Fotso DC
- Fourches D
- Friend S
- Frigessi A
- Gao F
- Gao X
- Garnett MJ
- Gerold JM
- Gestraud P
- Ghazoui Z
- Ghosh S
- Gillberg J
- Godoy-Lorite A
- Godynyuk L
- Godzik A
- Goldenberg A
- Gomez-Cabrero D
- Gonen M
- Gray H
- Grechkin M
- Guan Y
- Guimera R
- Guinney J
- Guney E
- Haibe-Kains B
- Han Y
- Hase T
- He D
- He L
- Heath LS
- Hellton KH
- Helmer-Citterich M
- Hidalgo MR
- Hidru D
- Hill SM
- Hochreiter S
- Hong S
- Hovig E
- Hsueh Y-C
- Hu Z
- Huang JK
- Huang RS
- Hunyady L
- Hwang J
- Hwang TH
- Hwang W
- Hwang Y
- Isayev O
- Jack J
- Jahandideh S
- Jang IS
- Jeon M
- Ji J
- Jo Y
- Kamola PJ
- Kanev GK
- Kang J
- Karacosta L
- Karimi M
- Kaski S
- Kazanov M
- Khamis AM
- Khan SA
- Kiani NA
- Kim A
- Kim J
- Kim J
- Kim K
- Kim K
- Kim S
- Kim Y
- Kim Y
- Kirk PDW
- Kitano H
- Klambauer G
- Knowles D
- Ko M
- Kohn-Luque A
- Kooistra AJ
- Kuenemann MA
- Kuiper M
- Kurz C
- Kwon M
- Laegreid A
- Lederer S
- Lee H
- Lee J
- Lee YW
- Leppaho E
- Lewis R
- Li J
- Li L
- Liley J
- Lim WK
- Lin C
- Liu Y
- Lopez Y
- Low J
- Lysenko A
- Machado D
- Madhukar N
- Malpartida AB
- Mamitsuka H
- Marabita F
- Marchal K
- Marttinen P
- Mason D
- Mason MJ
- Mazaheri A
- Mehmood A
- Mehreen A
- Menden MP
- Michaut M
- Miller RA
- Mitsopoulos C
- Modos D
- Moo K
- Motsinger-Reif A
- Movva R
- Muraru S
- Muratov E
- Mushthofa M
- Nagarajan N
- Nakken S
- Nath A
- Neto EC
- Neuvial P
- Newton R
- Nguyen T
- Ning Z
- Norman T
- Oliva B
- Olsen C
- Palmeri A
- Panesar B
- Papadopoulos S
- Park J
- Park S
- Park S
- Pawitan Y
- Peluso D
- Pendyala S
- Peng J
- Perfetto L
- Pirro S
- Plevritis S
- Politi R
- Poon H
- Porta E
- Prellner I
- Preuer K
- Ramnarine R
- Reid JE
- Reyal F
- Richardson S
- Ricketts C
- Rieswijk L
- Rocha M
- Rodriguez-Gonzalvez C
- Roell K
- Romeo Aznar V
- Rotroff D
- Rukawa P
- Sadacca B
- Saez-Rodriguez J
- Safikhani Z
- Safitri F
- Sales-Pardo M
- Sauer S
- Schlichting M
- Seoane JA
- Serra J
- Shang M-M
- Sharma A
- Sharma H
- Shen Y
- Shiga M
- Shin M
- Shkedy Z
- Shopsowitz K
- Sinai S
- Skola D
- Smirnov P
- Soerensen IF
- Soerensen P
- Song J-H
- Song SO
- Soufan O
- Spitzmueller A
- Steipe B
- Stolovitzky G
- Suphavilai C
- Szalai B
- Tamayo SP
- Tamborero D
- Tang EKY
- Tang J
- Tanoli Z-U-R
- Tarres-Deulofeu M
- Tegner J
- Thommesen L
- Tonekaboni SAM
- Tran H
- Truong A
- Tsunoda T
- Turu G
- Tzeng G-Y
- Van Daele D
- van Engelen B
- van Laarhoven T
- Van Moerbeke M
- van Westen GJP
- Verbeke L
- Videla S
- Vis D
- Vogel R
- Voronkov A
- Votis K
- Walk OBD
- Wang A
- Wang D
- Wang H-QH
- Wang P-W
- Wang S
- Wang W
- Wang X
- Wang X
- Wennerberg K
- Wernisch L
- Wessels L
- Westerman BA
- White SR
- Wijayawardena B
- Willighagen E
- Wolfinger R
- Wurdinger T
- Xie L
- Xie S
- Xu H
- Yadav B
- Yau C
- Yeerna H
- Yin JW
- Yu M
- Yu M
- Yu T
- Yun SJ
- Zakharov A
- Zamichos A
- Zanin M
- Zaslavskiy M
- Zeng L
- Zenil H
- Zhang F
- Zhang P
- Zhang W
- Zhao H
- Zhao L
- Zheng W
- Zoufir A
- Zucknick M
- Publication venue
- Publication date
- 01/01/2019
- Field of study
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZenecaâs large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
- Baye BA
- Bazmandegan G
- Becker JS
- Bedi N
- Beghi E
- Behzadifar M
- Bejot Y
- Bekuma TTT
- Bell ML
- Bello AK
- Ben L
- Bender RG
- Bennett DA
- Bennitt FB
- Bensenor IM
- Benziger CP
- Berhe K
- Berman AE
- Bernabe E
- Bernstein RS
- Bertolacci GJ
- Bhagavathula AS
- Bhageerathy R
- Bhala N
- Bhandari D
- Bhardwaj P
- Bhat AG
- Bhattacharyya K
- Bhattarai S
- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
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- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
- Borzouei S
- Bose D
- Bosetti C
- Boston S
- Boufous S
- Bourne R
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- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
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- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
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- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
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- Chalek J
- Chandan JS
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- Chirinos-Caceres JL
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- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
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- Comfort H
- Compton K
- Conti S
- Cooper OR
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- Cortesi PA
- Costa VM
- Cousin E
- Cowden RG
- Cowie BC
- Cromwell EA
- Croneberger AJ
- Cross DH
- Cross M
- Crowe CS
- Cruz JA
- Cummins S
- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
- Das Gupta R
- Das Neves J
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- Davey G
- Davila-Cervantes CA
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- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
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- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
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- Dereje ND
- Deribe K
- Dervenis N
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- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
- Dianatinasab M
- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
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- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
- Eskandari K
- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
- Fareed M
- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
- Ferrara P
- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
- Francis JM
- Frank TD
- Franklin RC
- Freitas M
- Fu W
- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
- Gholamian A
- Ghosh R
- Giampaoli S
- Gilani SA
- Gill PS
- Gill TK
- Gillum RF
- Ginawi IA
- Ginindza TG
- Gitimoghaddam M
- Giussani G
- Glagn M
- Glushkova EV
- Gnedovskaya EV
- Godinho MA
- Goharinezhad S
- Golechha M
- Goli S
- Gomez RS
- Gona PN
- Gopalani SV
- Goren E
- Gorini G
- Gorman TM
- Gottlich HC
- Goudarzi H
- Goudarzian AH
- Goulart AC
- Goulart BNG
- Grada A
- Greaves F
- Grivna M
- Grosso G
- Gubari MIM
- Gudi N
- Gugnani HC
- Guimaraes ALS
- Guimaraes RA
- Guled RA
- Gultie T
- Guo G
- Guo Y
- Gupta R
- Gupta R
- Gupta T
- Haagsma JA
- Hachinski V
- Haddock B
- Hafezi-Nejad N
- Hafiz A
- Hagins H
- Haile LM
- Haile TG
- Haj-Mirzaian A
- Haj-Mirzaian A
- Hall BJ
- Halvaei I
- Hamadeh RR
- Hameed S
- Hamidi S
- Hamilton EB
- Hammer MS
- Han C
- Han H
- Handiso DW
- Hanif A
- Hankey GJ
- Hanson SW
- Haririan H
- Haro JM
- Harvey JD
- Hasaballah AI
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- Umeokonkwo CD
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- Upadhyay E
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- Venketasubramanian N
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- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
- Wilson S
- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
- Aryal KK
- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
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- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Zimmermann CM
- Ziviani E
- Zoladek T
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- Zorzano A
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- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
- Al-Taher RN
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- Alakaloko F
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- Alberto C
- Albozidi A
- Alcantara E
- Aldirawi MAM
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- Algabri HNO
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- Choo CSC
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- Chung JH
- Cino EL
- Cletus C
- Coghill G
- Collins N
- Comert HSY
- Contreras CS
- Coon J
- Cordonnier A
- Cordova KH
- Cornelli F
- Cornwall H
- Corona MQ
- Correa A
- Correa C
- Cortez LFG
- Cosoreanu V
- Costa EC
- Costas-Chavarri A
- Cripovich A
- Cruzado GJS
- Cunningham A
- Cury EK
- Czauderna P
- da Cunha AG
- da Silva EAD
- da Silva JAN
- da Silva KI
- Dagilyte R
- Daher AP
- Dahman NBH
- Dalek NFRA
- Dallegre MB
- Dalloul H
- Damiani A
- Dania B
- Darras OM
- Darwish A
- Darwish AS
- Dass A
- Dassonville M
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- Davis JK
- de Almeida TL
- de Andrade SO
- de Fernandez y Alcazar FR
- de Fraga JCS
- de Guzman J
- de Holanda FC
- De La Cruz RR
- de Oliveira DF
- de Oliveira DP
- de Souza RF
- de Vos C
- Dedeke F
- Defago VH
- Defert C
- Delefortrie T
- Delforge X
- Dendusic N
- Derbew M
- Derks T
- Deya C
- Deyab A
- Deyl RT
- Di Siervi O
- Dias AIBDS
- Dieudonne L
- Dimatatac DM
- Djordjevic I
- do Nascimento SD
- Dogar S
- Doheim MF
- Dominguez D
- Dominguez MA
- dos Santos CS
- dos Santos MSF
- Dosselman LJ
- Douiri A
- Drah W
- Dube AM
- Duchesne C
- Duggan E
- Dure C
- Ebeido A
- Echegaray MD
- Egbuchulem IK
- Ejinkeonye EC
- Ekenze SO
- Ekwunife OH
- El Tallaa MA
- El-Ghazaly M
- Elassall GMH
- Elayeb A
- Elebute OA
- Elewaily M
- Elfiky M
- Elgammudi M
- Elghazaly SM
- Elhadi A
- Elhadi M
- Elhajjaji YA
- Elhattab A
- Elias RA
- Elisante J
- Elkaloush AA
- Elkhazmi EOA
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- Elsiraffy OO
- Elstad M
- Elzohiri M
- Elzowawi F
- Emam OS
- Emil S
- Ensar N
- Ercin S
- Erdem M
- Eren E
- Ergenekon E
- Eroglu E
- Erturk N
- Eshkabilov S
- Espineda B
- Espinosa SC
- Espinoza PP
- Essa TM
- Essamilghi KAM
- Ezidiegwu US
- Ezomike UO
- Faboya OM
- Fachin C
- Fadhle MJ
- Fajardo GYP
- Faks V
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- Feliz E
- Ferdinando DLT
- Ferdousi T
- Fernandez JY
- Ferreira JL
- Ferreira MDSS
- Ferrer MF
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- Garcia I
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- Gargurevich PPA
- Garnier H
- Garrett-Cox R
- Gasana G
- Gashugi IS
- Gatzinsky V
- Gavrila B
- Gavrilovska-Brzanov A
- Gee O
- Gerus S
- Geze S
- Ghabayen ATS
- Ghallab A
- Ghaly KAE
- Ghanem WH
- Ghayth S
- Ghazzawi I
- Ghorab IA
- Ghosh D
- Gilardi J
- Giovanoni LS
- Goddard L
- Goebel P
- Gohil H
- Gomes AL
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- Goncalves PCB
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- Gonzalez DE
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- Gosain A
- Grabowski A
- Graneli C
- Greenberg J
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- Grosos C
- Grottling E
- Grynberg L
- Guadagno E
- Guayelema M
- Guazzotti M
- Guerin F
- Guimaraes P
- Guinsburg R
- Guisse C
- Guo X
- Gurgel do Amaral AC
- Gurskas P
- Gutierrez EA
- Gutierrez NT
- Guzman NJT
- Habiba A
- Hagander L
- Hagander L
- Haidari SA
- Haider N
- Hajajreh MS
- Hakan N
- Halabi YA
- Hall N
- Hall T
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- Hamidi N
- Hamidovic A
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- Hamilton A
- Hammato AY
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- Hammouri AG
- Hamzah SNABH
- Han Y
- Hanifah NABM
- Haraux E
- Harilal S
- Harper L
- Hasan S
- Hasan S
- Hasanain DK
- Hashim HHB
- Hashim I
- Hashim S
- Hassan MA
- Hassan MYM
- Hassan ZBM
- Herdan MO
- Herrera C
- Herrera L
- Hery G
- Hinojosa AS
- Hinostroza D
- Hisham I
- Hodgman E
- Honhar M
- Horacio B
- Horozic D
- Hospital SI
- Hossini SL
- Hu D
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- Huespe E
- Hukic L
- Huq U
- Hussain SR
- Hussein OG
- Hussien M
- Hwang IJ
- Hyeon CS
- Hyman G
- Ibarra D
- Ibrahim EAA
- Ibrahim F
- Ibrahim MA
- Ibukunolu O
- Igoche M
- Ihediwa G
- Imamoglu M
- Ionescu S
- Iracelay S
- Iriondo M
- Ishak S
- Ismail EM
- Ismavel VA
- Isolan PMBS
- Itangishaka I
- Ivanov M
- Jabaiti MS
- Jabang JN
- Jaber D
- Jacobson J
- Jain S
- Jaiteh M
- Jallow CS
- Jalo I
- Jamal MU
- Jaramillo M
- Jauregui L
- Jauri C
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- Jeremie N
- Jester I
- Joda AE
- Joharifard S
- Johnson S
- Jones B
- Jones C
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- Jonuzi A
- Jooma U
- Joubeh S
- Jovcheski L
- Juhasz L
- Julio L
- Junes MDC
- Juricic M
- Jusabani M
- Jyun KWY
- Kader S
- Kalicinsk P
- Kamel TM
- Kamilovski M
- Kannessan H
- Kano Y
- Kapihya C
- Karabulut R
- Karakus SC
- Karamustafic A
- Karavdic K
- Karim S
- Karim S
- Kaya H
- Kayed YIO
- Kayibanda E
- Kchiche N
- Kcomt SG
- Kelay A
- Keles E
- Keshtgar A
- Khaled A
- Khalel WIA
- Khalid HM
- Khamag O
- Khatatba LZA
- Khattak MAK
- Khlevner J
- Khorana J
- Kihiko D
- Kim H-Y
- King S
- Kist IN
- Kluppel EN
- Knorr C
- Knurowska A
- Kohaut J
- Koipapi S
- Korlacki W
- Koshy RM
- Kostic A
- Koszutski T
- Kowalewsk G
- Krause H
- Krayem Y
- Krisanova D
- Krishnaswami S
- Kufeji D
- Kukkady A
- Kumar V
- Kumolalo FO
- Kunfah SMP
- Kurian M
- Kurt G
- Kwasau H
- Laberge J-M
- Labonia C
- Ladino AMF
- Ladipo-Ajayi O
- Lahlooh RA
- Lakhoo K
- Lander T
- Langer M
- Langley J
- Lapouble F
- Lara S
- Latiff ZA
- Lawal T
- Lawalbarau A
- Layas T
- Laymouna MA
- Le Gall C
- Leal PO
- Leather AJM
- Lechmiannandan A
- Lee JY
- Lee S
- Leech M
- Leite MTC
- Leles KDDP
- Leon CD
- Leon JLA
- Leon NRM
- Lerma S
- Letic E
- Levard G
- Levitt M
- Leyba MF
- Li H
- Li S
- Li Z
- Liang L
- Liljesthrom K
- Lim F
- Lin N
- Lindert J
- Liu Y
- Liubsys A
- Liukitithara S
- Liyenzero PO
- Ljuhar D
- Lobos P
- Lodhia J
- Lofberg K
- Losa GN
- Losty P
- Lotfollahzadeh S
- Lu J
- Lubbad W
- Lucio P
- Lui Y
- Lukac M
- Lule J
- Luo W
- Lv J
- Lv Z
- Lyttle BD
- Mac C
- Macdonald A
- Machado ABS
- Machemedze S
- Madieh J
- Madziba S
- Magro NMH
- Mahmoud AM
- Mahmud K
- Mahmud R
- Mairami AB
- Maistry N
- Makepeace LM
- Makhmud A
- Malaga FPD
- Malcius D
- Maldonado JEG
- Malik J
- Malik S
- Mancera J
- Mangray H
- Manirambona E
- Manjira E
- Manni F
- Mansfield S
- Mansour I
- Mansour MA
- Manteola ER
- Marcos D
- Marianella D
- Marin AM
- Marmol M
- Marques GMN
- Marta O
- Martin AD
- Martin B
- Martinez HG
- Martinez-Leo B
- Martins BMR
- Matias MA
- Matos JPV
- Matour BM
- Mazzuca RB
- Mbonicura JC
- Mbonisweni A
- Mccluney S
- Medard P
- Meftah A
- Mellado DH
- Meloche-Dumas L
- Mena A
- Mendizabal DB
- Menin FA
- Mercado P
- Mert MK
- Mesic A
- Meyer KF
- Michael V
- Middlesworth W
- Middleton T
- Mieres C
- Mikneviciute A
- Milisic E
- Millan C
- Miranda CT
- Miriam A
- Mironescu A
- Mirza MB
- Misk RA
- Mitul A
- Mitul AR
- Modekwe V
- Modi V
- Mohammad MA
- Mohammed A
- Mohammed AA
- Mohammed HM
- Mohammed KA
- Mohammed MM
- Mohammed OAA
- Moitt N
- Molina M
- Molinelli M
- Monawar AB
- Montoya D
- Moore AC
- Mora M
- Moraes M
- Morales A
- Morales LB
- Morales O
- Morejon VJ
- Moreno ME
- Mori FT
- Moriya E
- Morjan M
- Mose M
- Motee J
- Motter SB
- Motter SB
- Mounira BNEI
- Mouti MB
- Mouttalib S
- Mshelbwala PM
- Msuya D
- Mugambi S
- Mugo R
- Muhic A
- Mulu J
- Mumtaz U
- Munoz G
- Muntean L
- Murad AMI
- Muradi T
- Muragijimana JDD
- Muraveji Q
- Murillo IVE
- Murshidi RM
- Murtadi HM
- Murzaie MY
- Muslimovich AM
- Mussein HM
- Mustufa H
- Mutlu M
- Mvukiyehe JP
- Mwai T
- Nageh M
- Nah SA
- Naidoo R
- Naim NABM
- Naim SRR
- Naranjo K
- Nassar I
- Nataraja RM
- Naumeri F
- Naunova VC
- Ndata A
- Ndayishimiye I
- Ndungu J
- Negash S
- Negida A
- Negrete A
- Nemer AA
- Nemer R
- Neyra MSL
- Nezerwa YC
- Ngerncham M
- Ngwenya S
- Nisar MU
- Niyukuri A
- Nkuliza D
- Nkunzimana E
- Nofal AH
- Noor WR
- Nor MTM
- Nour I
- Nour IR
- Nour IR
- Novotny N
- Nuntasunti W
- Nwangwu EI
- Nwankwo EP
- Nwosu DC
- O'Connor J
- O'Connor Z
- Obeso AS
- Obianyo NE
- Ochieng K
- Ochieng R
- Odi AA-NB
- Ogundoyin O
- Ojeda AG
- Olabisi OO
- Olanrewaju M
- Olayade K
- Olori S
- Olulana DI
- Omari RY
- Omling E
- Ortiz RS
- Osagie O
- Osazuwa M
- Oshiba AM
- Osman M
- Osowicka M
- Osuigwe AN
- Osuoji RI
- Otuneye AT
- Outani O
- Oviedo JJM
- Owiwi Y
- Owusu S
- Owusu-Sekyere F
- Oyebanji L
- Oyinloye A
- Ozcelik Z
- Ozen MA
- Pachl M
- Padilla CP
- Pajouhandeh F
- Palacios N
- Palomino AG
- Pandit GS
- Papa A
- Pardo L
- Pardo LM
- Pardy C
- Paredes ER
- Paredes VS
- Parigi GB
- Parker S
- Parmentier B
- Pasaoglu M
- Pasierbek M
- Pasqua N
- Patel A
- Patkowski D
- Patzer L
- Pauzi SFM
- Peraza JL
- Perez JO
- Perez MO
- Perez RD
- Pernik MN
- Pesara LMH
- Petel MR
- Peycelon M
- Phannua R
- Philipo GS
- Piche N
- Picon CMDJT
- Pigeolet M
- Pilkington M
- Pinar B
- Piotrowska A
- Planka L
- Poenaru D
- Poocharoen W
- Popovic N
- Porras JD
- Portilla EF
- Pos L
- Prabhu PS
- Prat J
- Puentes MC
- Puglia P
- Puig MG
- Puligandla P
- Putruele D
- Qabaja MM
- Qadomi AB
- Qawwash A
- Qi TTH
- Qudah HA
- Quevedo LMB
- Quinteros EFD
- Quiroz NH
- Qunaibi MAF
- Qureshi T
- Qutishat H
- Qwaider YZ
- Raboe E
- Rackova T
- Radwan AS
- Raffaele A
- Raicevic M
- Raj A
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- Rani Z
- Raposo JW
- Rasaki A
- Rashid S
- Rashwan H
- Ravetta P
- Ravi K
- Raymond KJ
- Raza R
- Reda A
- Rehman WU
- Rengura C
- Reuter C
- Rex D
- Reyes GY
- Rhodes H
- Ribas B
- Riboni C
- Rieth A
- Rincon LC
- Rissmann A
- Risteski T
- Rite S
- Rivarola NI
- Rivera AC
- Rivera JRCC
- Roberts CA
- Roberts K
- Roberts R
- Rojas N
- Rolle U
- Romano PG
- Rosa BR
- Rosas FA
- Roszkiewicz A
- Ruan W
- Rudolfson N
- Ruzgar N
- Rygl M
- Saad AM
- Saad MM
- Sabbatini S
- Sabic A
- Sabti S
- Sadagurschi M
- Sadek K
- Sadek M
- Safa N
- Safus A
- Sahnoun L
- Sahuanay VRC
- Salah M
- Salawu MM
- Salazar K
- Saldana L
- Saleem A
- Saleem M
- Saleh A
- Saleh M
- Salem HK
- Salha AAS
- Salim JM
- Salinas V
- Salo M
- Samad L
- Samadi AZ
- Samarah YA
- Samarakkody U
- Sambo YT
- Samy D
- San Miguel DO
- Sanchez A
- Sanchez B
- Sanchez CIA
- Sanchez J
- Sanchez JS
- Sanchez N
- Saousen B
- Sara N
- Saracevic A
- Sarhan OAK
- Sarihan H
- Sarkaz TL
- Sayeed F
- Sbaih MF
- Scalabre A
- Scherl H
- Schmedding A
- Schopf LF
- Sehic A
- Sehwiel AS
- Sekyere O
- Selak N
- Sempertegui D
- Serban AM
- Seref K
- Serezo B
- Sevdalis N
- Seyi-Olajide J
- Sferco CA
- Shabana OS
- Shahbal S
- Shaheen AA
- Shaheen N
- Shajin T
- Shaklawoon A
- Shalaby A
- Shalaby H
- Shalluf HA
- Shan CH
- Sharabati F
- Sharabati M
- Sharif M
- Sharif RAM
- Shaw K
- Shehada M
- Shehu I
- Sheir H
- Sherer K
- Sherzad A
- Shikha A
- Shinondo P
- Shnishah AE
- Shokri HA
- Shonubi A
- Shoubaki A
- Shu Q
- Siddiqui SM
- Sidler D
- Sigalet D
- Sihem B
- Sikwete G
- Silva E
- Silva J
- Silva MDA
- Silva RV
- Silva XG
- Silva Y
- Sim M
- Simeon T
- Simon S
- Sindi O
- Singer G
- Singh M
- Sivaraj J
- Sivasubramaniam M
- Siyotula T
- Skvaril J
- Slavkovi A
- Slavkovic M
- Smith ER
- Sobrero H
- Soccorso G
- Sokolovic E
- Sola J
- Solanki M
- Soldan CP
- Soliman NA
- Son J
- Song ES
- Sonmez K
- Soomro A
- Sotelo LO
- Souhem T
- Soula E
- Sowe B
- Sriniworn A
- St-Louis E
- St-Vil D
- Stark D
- Stichhauer R
- Stojanovic M
- Stringer M
- Strumila A
- Sueiras I
- Suleiman F
- Sultana S
- Sundeep PT
- Suradi HH
- Sutcliffe J
- Suzen A
- Svensson E
- Svirsky A
- Swessi H
- Syed S
- Syovata F
- Szklarz MT
- Tababa O
- Tabari AK
- Tabiri S
- Tadesse A
- Tahyneh AAA
- Takrouney MH
- Talat N
- Tamada H
- Tamaddun HFB
- Tang W
- Tanimola AG
- Tanming P
- Tanny ST
- Tantush SA
- Tarabishi AS
- Tarek A
- Tarmohamed M
- Tarniba SA
- Tarrado X
- Tasker D
- Tauffer MG
- Teague W
- Telles L
- Temilade BB
- Teo R
- Teran A
- Terzic S
- Testoni D
- Thaiwatcharamas K
- Thiessen J
- Thomas AH
- Thomas G
- Thomas MC
- Thompson H
- Till H
- Tillig B
- Tobor S
- Toczewski K
- Tom A
- Toplicic D
- Toral E
- Torres-Canchala L
- Toselli L
- Touabti S
- Toufik IA
- Trainba S
- Trein CS
- Trojanova B
- Trypens A
- Tumi M
- Turkyilmaz C
- Turkyilmaz Z
- Tuyishime E
- Ubhi H
- Ugwu JO
- Ugwunne CA
- Ulasi I
- Ullrich S
- Unchon GL
- Urquizo MML
- Vacek J
- Vaitkiene A
- Valencia S
- Valeria P
- Valerio-Vazquez R
- Valladares PS
- Vanis N
- Vaquila J
- Varela MF
- Vargas OP
- Vatta F
- Vazquez MEM
- vd Merwe E
- Velana J
- Velasco JJCR
- Vellusamy VMM
- Venant N
- Venkatraman SS
- Verdeata R
- Verduga L
- Vergara C
- Verkauskas G
- Veronica S
- Vervoort D
- Vianney BJM
- Vida L
- Vidal CRZ
- Vierboom L
- Villalba AV
- Vinskaite A
- von Bismarck S
- von Delft D
- Vosoughi A
- Wafa T
- Walker G
- Wang D
- Wang J
- Wang J
- Wang P
- Waseem B
- Weeratunga N
- Weiszewsk A
- Wen G
- Wester T
- Wijekoon N
- Wilke A
- Williams I
- Williams O
- Williams R
- Wilson MDF
- Win WSP
- Wishah BDM
- Wishah N
- Wissanji H
- Wolak P
- Wolny A
- Wong J
- Wong M
- Wright NJ
- Wu G
- Wyrzykowski D
- Xie H
- Yacoub MA
- Yaghi B
- Yaghi DH
- Yalcinkaya A
- Yang H-B
- Yanis AH
- Yao Y
- Yapo B
- Yeniay AO
- Yola MM
- Yong F
- Youn JK
- Yousuf H
- Yu M
- Yu R
- Yuen QS
- Yuldashev RZ
- Yunus A
- Zaghlol LY
- Zain M
- Zaman ASK
- Zanellato JB
- Zea-Salazar LE
- Zeinelabdeen A
- Zelada JA
- Zhao X
- Zhu J
- Zhu L
- Zidan M
- Zivanovic D
- Zreeg DAS
- Zurikat RO
- Zvizdic N
- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36â39) and median bodyweight at presentation was 2·8 kg (2·3â3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; pâ€0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88â4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59â2·79], p<0·0001), sepsis at presentation (1·20 [1·04â1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4â5 vs ASA 1â2, 1·82 [1·40â2·35], p<0·0001; ASA 3 vs ASA 1â2, 1·58, [1·30â1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02â1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41â2·71], p=0·0001; parenteral nutrition 1·35, [1·05â1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47â0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50â0·86], p=0·0024) or percutaneous central line (0·69 [0·48â1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
- Author
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- Wang PC
- Wang TT
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- Wang X
- Wang X
- Wang X
- Wasan A
- Watelet JâB
- Watts WJ
- Wawrzyniak K
- Weakley J
- Weber R
- Weber R
- Wechsler ME
- Wei CC
- Wei JL
- Weinberg EA
- Weinhold B
- Weissman JD
- Weitzel EK
- Welch KC
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- Welch KC.
- Wellborn PS
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- Won HK
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- Wong IW
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- Wong SJ
- Wood AJ
- Wood AJ
- Woodard T
- Woodhouse BM
- Woods CM
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA
- Woodworth BA.
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Workman AD
- Wormald PJ
- Wormald PJ
- Wright ED
- Wu AW
- Wu AW
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- Wu D
- Wu J
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- Wuister AM
- WuokkoâLandĂ©n A
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- Yamada T
- Yamasaki A
- Yan C
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- Yan CH
- Yan CH
- Yan CH
- Yan CH
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- Yan M
- Yancey KL
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- Yang C
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- Yaniv D
- Yaniv D
- Yao Y
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- Yatsunenko T
- Yayik AM
- Yel L
- Yelverton JC
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- Yip J
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- Yoo F
- Yoo HS
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- Yoon HY
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- Zalmanovici Trestioreanu A
- Zariwala MA
- Zeiger J
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- Zeng M
- Zhai GT
- Zhang L
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- Zhang N
- Zhang N
- Zhang N
- Zhang Q
- Zhang S
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao CY
- Zhao K
- Zhao K
- Zhao L
- Zhao YC
- Zhao YC
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- ZielinskaâBlizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
Differential induction of adrenomedullin, interleukins and tumour necrosis factor-α by lipopolysaccharide in rat tissues in vivo
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2005
- Field of study
1. The aim of the present study was to determine the temporal changes in tissue adrenomedullin (AM) and cytokine contents and cytokine and preproAM mRNA levels in the kidney, liver, adrenal gland and spleen of lipopolysaccharide (LPS)-treated rats. 2. Rats were injected with LPS (10 mg/kg, i.p.). Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA levels, respectively; ELISA and reverse transcription-polymerase chain reaction were used to follow the changes in cytokines and their mRNA levels, respectively. 3. In the kidney, the preproAM mRNA levels were increased 1 and 3 h after LPS treatment, whereas AM levels were decreased at 3 h. Interleukin (IL)-6 and IL-1ÎČ levels were increased at 3 and 6 h, respectively. 4. The preproAM mRNA levels were elevated in the liver 3 h after LPS injection. Concentrations of tumour necrosis factor (TNF)-α and IL-1ÎČ were increased at l and 6 h, respectively. 5. There were no changes in the levels of either preproAM mRNA or AM in the adrenal gland and the spleen. In the spleen, TNF-α levels were elevated at 1 and 3 h after LPS injection and IL-1ÎČ was elevated at 1 and 6 h after LPS injection, whereas in the adrenal gland IL-1ÎČ was elevated at 6 h after injection. 6. The mRNA levels of the three cytokines were elevated at all three time intervals examined in the kidney, liver, adrenal gland and spleen, with the exception that TNF-α mRNA was not elevated in the adrenal gland at 6 h after LPS injection and IL-1ÎČ mRNA was not elevated in the spleen at 3 and 6 h. 7. The plasma concentrations of TNF-α were increased at 1 and 3 h after LPS injection, whereas plasma concentration of IL-1ÎČ and IL-6 were elevated at 3 and 6 h for both. 8. The present results suggest that the biosynthesis and secretion of AM may be differentially regulated in various tissues of rats injected with LPS and that AM may interact with cytokines during inflammation. © 2005 Blackwell Publishing Asia Pty Ltd.link_to_subscribed_fulltex
Increased adrenomedullin expression in lungs in endotoxaemia
- Publication venue
- 'Society for Endocrinology'
- Publication date
- Field of study
An ontogenic study of adrenomedullin gene expression in the rat lung, adrenal, kidney, and heart
- Author
- A Vadivel
- AM Elhawary
- B Semmekrot
- CD Walker
- E Marinoni
- F Satoh
- F Tang
- F Tang
- F. Tang
- G Carraro
- G Clementi
- G Falk
- G Mazzocchi
- H He
- H Kano
- H Yin
- H Zink
- HW Li
- I Szokodi
- IS Hwang
- IS Hwang
- IS Hwang
- J Sakata
- JR Cockcroft
- K Kitamura
- K Kitamura
- KJ Livak
- KM Caron
- LM Montuenga
- LY Wong
- M Dvorakova
- P. F. Wong
- R Muff
- RC Vari
- S Kaufman
- SA Hamid
- SD Brain
- SY Man
- T Shindo
- T Yamaguchi
- T Yamaguchi
- T Yoshimoto
- W. S. O
- WK Samson
- Y Asada
- Y Ichiki
- Y Isumi
- YY Li
- YY Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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