New Horizons in Brazilian Contemporary Music: Grupo Novo Horizonte de São Paulo, 1988-99

Brazil's foremost ensemble of the late twentieth century, Grupo Novo Horizonte de São Paulo, transformed Brazilian contemporary music by cultivating a new mixed-chamber repertory and giving sustained support to a generation of emerging composers. That this cosmopolitan group took, then outgrew, the Pierrot ensemble as its cornerstone signals the medium it forged: a localized, evolving spectacle with a richly internationalist heritage. This article offers a panoramic view of the musical, intercultural and historical contexts that underpin Grupo Novo Horizonte's practices and legacy. Analysing landmark works by Sílvio Ferraz, Harry Crowl and others allows us to draw further connections between the group, the Brazilianness of late twentieth-century compositional aesthetic, and the realities of contemporary classical music-making in Brazil

A systematic review of measures of self-reported adherence to unsupervised home-based rehabilitation exercise programmes, and their psychometric properties

BACKGROUND: Adherence is an important factor contributing to the effectiveness of exercise-based rehabilitation. However, there appears to be a lack of reliable, validated measures to assess self-reported adherence to prescribed but unsupervised home-based rehabilitation exercises. OBJECTIVES: A systematic review was conducted to establish what measures were available and to evaluate their psychometric properties. DATA SOURCES: MEDLINE, EMBASE, PsycINFO CINAHL (June 2013) and the Cochrane library were searched (September 2013). Reference lists from articles meeting the inclusion criteria were checked to ensure all relevant papers were included. STUDY SELECTION: To be included articles had to be available in English; use a self-report measure of adherence in relation to a prescribed but unsupervised home-based exercise or physical rehabilitation programme; involve participants over the age of 18. All health conditions and clinical populations were included. DATA EXTRACTION: Descriptive data reported were collated on a data extraction sheet. The measures were evaluated in terms of eight psychometric quality criteria. RESULTS: 58 studies were included, reporting 61 different measures including 29 questionnaires, 29 logs, two visual analogue scales and one tally counter. Only two measures scored positively for one psychometric property (content validity). The majority of measures had no reported validity or reliability testing. CONCLUSIONS: The results expose a gap in the literature for well-developed measures that capture self-reported adherence to prescribed but unsupervised home-based rehabilitation exercises

Theory and practice in visual interfaces for semi-structured document discovery and selection

With the increase in electronic publications, and indeed the availability of existing publications in digital form, as well as the encouragement of open access publication, comes a challenge. That challenge is to create assistive software to aid in the discovery and selection of relevant documents to one’s information need. Visual interfaces have begun to address the need of information seekers in finding publications and wading through the large result sets that are returned from search engines. There is currently, little evidence to suggest that these interfaces are based on systematic research on requirements. In this article, we examine areas which contribute to the theory and practice of visual interfaces directly relating to the discovery and selection of publications. We bring together work from different fields in a targeted approach to assist the future creation of these interfaces

Dynamic and influential interaction of cancer cells with normal epithelial cells in 3D culture

BACKGROUND: The cancer microenvironment has a strong impact on the growth and dynamics of cancer cells. Conventional 2D culture systems, however, do not reflect in vivo conditions, impeding detailed studies of cancer cell dynamics. This work aims to establish a method to reveal the interaction of cancer and normal epithelial cells using 3D time-lapse. METHODS: GFP-labelled breast cancer cells, MDA-MB-231, were co-cultured with mCherry-labelled non-cancerous epithelial cells, MDCK, in a gel matrix. In the 3D culture, the epithelial cells establish a spherical morphology (epithelial sphere) thus providing cancer cells with accessibility to the basal surface of epithelia, similar to the in vivo condition. Cell movement was monitored using time-lapse analyses. Ultrastructural, immunocytochemical and protein expression analyses were also performed following the time-lapse study. RESULTS: In contrast to the 2D culture system, whereby most MDA-MB-231 cells exhibit spindle-shaped morphology as single cells, in the 3D culture the MDA-MB-231 cells were found to be single cells or else formed aggregates, both of which were motile. The single MDA-MB-231 cells exhibited both round and spindle shapes, with dynamic changes from one shape to the other, visible within a matter of hours. When co-cultured with epithelial cells, the MDA-MB-231 cells displayed a strong attraction to the epithelial spheres, and proceeded to surround and engulf the epithelial cell mass. The surrounded epithelial cells were eventually destroyed, becoming debris, and were taken into the MDA-MB-231 cells. However, when there was a relatively large population of normal epithelial cells, the MDA-MB-231 cells did not engulf the epithelial spheres effectively, despite repeated contacts. MDA-MB-231 cells co-cultured with a large number of normal epithelial cells showed reduced expression of monocarboxylate transporter-1, suggesting a change in the cell metabolism. A decreased level of gelatin-digesting ability as well as reduced production of matrix metaroproteinase-2 was also observed. CONCLUSIONS: This culture method is a powerful technique to investigate cancer cell dynamics and cellular changes in response to the microenvironment. The method can be useful for various aspects such as; different combinations of cancer and non-cancer cell types, addressing the organ-specific affinity of cancer cells to host cells, and monitoring the cellular response to anti-cancer drugs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12935-014-0108-6) contains supplementary material, which is available to authorized users

Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR

Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPARα/γ agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concerted action of isoflavones

From highly relevant to not relevant: examining different regions of relevance

User relevance judgments are central to both the systems and user-oriented approaches to information retrieval (IR) systems research and development. User-oriented relevance research has also operated on two largely unconnected tracks. First, a relevance level track that examines users' criteria for relevance judgments. Second, a regions of relevance track that examines the measurement of users' relevance judgments. Users judgments and criteria for highly relevant items have been central issues for much of the relevance research. Findings are presented from four separate studies of relevance judgments by 55 users, conducting their initial online search on a particular information problem. In three studies, the number of items judged "partially" relevant (on a scale of relevant, partially relevant or not relevant) was positively correlated with different aspects of changes in users', including: (1) information problem definition, (2) search intermediaries' perceptions that a user's question and information problem has changed during the mediated search interaction, (3) personal knowledge due to the search interaction, and (4) criteria for making relevance judgments. Users with high knowledge and topic levels were more likely to judge items as highly relevant. Differences between users' criteria for highly, partially and non-relevant items are also identified. Findings suggest the need to expand the framework for relevance research and further identify the characteristics of the middle region of relevance or partial relevance as: (1) partially relevant items may play an important role in the early stages of a user's information seeking process over time for a particular information problem and (2) a relationship may exist between partially relevant items retrieved and changes in users' information problems during an information seeking process. Results also suggest that partially relevant items may be useful at the early stages of users' information seeking processes. We propose a useful concept of relevance as a relationship and an effect on the movement of a user through the iterative stages of their information seeking process. Users' relevance judgments can also be plotted on a three-dimensional spatial model of relevance level, region and time. Implications for the development of IR systems, searching practice and relevance research are also discussed

Median Measure: An Approach to IR Evaluation

In this paper we report results from three studies examining 1295 relevance judgments by 36 IR system end-users. We examined both the region of the relevance judgment, from non-relevant to highly relevant, and motivations or levels of their relevance judgments. Our study has three major findings. First, the frequency distributions of relevance judgments by IR system end-users tend to take on a bi-modal shape with peaks at the extremes (non relevant/relevant) with a flatter middle range. Second, the different type of scale (interval or ordinal) used in each study did not alter the shape of the relevance frequency distributions. And third, on an interval scale, the median point of relevance judgment distributions correlates with the point where relevant and partially relevant items begin to be retrieved. The median point of a relevance judgment distribution may provide a measure of user/IR system interaction to supplement precision/recall measures. The implications of our investigation for relevance theory and IR systems evaluation are discussed

Grey Tuesday, online cultural activism and the mash-up of music and politics (originally published in October 2004)

This paper is included in the First Monday Special Issue: Music and the Internet, published in July 2005. Special Issue editor David Beer asked authors to submit additional comments regarding their articles. I write this introduction on March 29, 2005 , the day that Internet file-sharing finally made it to the U.S. Supreme Court in MGM v. Grokster – for a full overview of the case see the EFF website, www.eff.org/IP/P2P/MGM_v_Grokster/ . It is a moment long-anticipated by the content industries and the resistive coalition of “copyfighters” – high noon in the nation’s highest legal institution. From this vantage point it would be premature to speculate on the case’s likely long-term impacts on the music industry – on and off-line – and technological innovation. What is certain is that more people are participants in the musical world than at any time in history, and a Supreme Court decision cannot arrest that tide. The mash-up aesthetic has spread since the Grey Album cast it into the public consciousness, from dedicated national radio shows to the 47th GRAMMY awards, which opened with an attempted live mash-up of six acts. Cease and desist letters remain a genuine threat to remix DJs and websites even as the scene’s emerging stars are courted by major labels. Meanwhile, Downhill Battle continues to develop creative and attention-grabbing activist projects centered on copyright and fair use issues. The lifespan of the mash-up genre cannot be predicted, but the combustible mixture of music and politics is perennial. In 2003, a little–known DJ by the name of Danger Mouse created a "mash–up" album that remixed the music of the Beatles’ White Album and hiphop star Jay–Z’s Black Album to produce a new record called The Grey Album. The swift and draconian legal reaction to the online dissemination of this technically illegal but culturally fascinating artifact gave rise to a "day of digital civil disobedience," organized by music activism group Downhill Battle. Grey Tuesday, as the day of action was known, marks a potentially new site for a blend of online political and cultural activism in the highly charged realm of intellectual property expansionism. This paper examines emergent examples of musical and Internet activism including a detailed look at Grey Tuesday itself; considers the cultural significance of the mash–up genre and the value of the musical "amateur;" and concludes with a brief consideration of "semiotic democracy" and the new mix — or, if you will, mash–up — of culture and politics that has emerged as a consequence of the rise of digital networks

Grey Tuesday, online cultural activism and the mash–up of music and politics

In 2003, a little–known DJ by the name of Danger Mouse created a "mash–up" album that remixed the music of the Beatles’ White Album and hiphop star Jay–Z’s Black Album to produce a new record called The Grey Album. The swift and draconian legal reaction to the online dissemination of this technically illegal but culturally fascinating artifact gave rise to a "day of digital civil disobedience," organized by music activism group Downhill Battle. Grey Tuesday, as the day of action was known, marks a potentially new site for a blend of online political and cultural activism in the highly charged realm of intellectual property expansionism. This paper examines emergent examples of musical and Internet activism including a detailed look at Grey Tuesday itself; considers the cultural significance of the mash–up genre and the value of the musical "amateur;" and concludes with a brief consideration of "semiotic democracy" and the new mix — or, if you will, mash–up — of culture and politics that has emerged as a consequence of the rise of digital networks