Urbanització del carrer Remei i pont sobre el riu Sec a Cerdanyola del Vallès.

El projecte consisteix en la realització d’un pont, amb pila intermèdia, que connectarà el barri del Banús amb el barri de la Farigola, a Cerdanyola del Vallés. Es tracta d’un pont in-situ de formigó armat i posttesat, amb alleugeridors (porexpan). També hi ha una sèrie de murs d’escullera i les obres d’urbanització per a connectar els dos carrers

La fauna mirmecològica (Hymenoptera, Formicidae) del Parc Natural de Sant Llorenç del Munt i l’Obac

Tot i linterès que desperten els estudis faunistics als parc naturals, vàrem detectar un desconeixement de la fauna mirmecològica del Parc Natural de Sant Llorenç del Munt i lObac, ja que només shavia fet un mostreig per Cerdà et al. (1989) en una zona concreta de la Collada de tres Creus de la Serra de lObac en la que es varen determinar 24 espècies de formigues. Per tal daconseguir una imatge més real de la riquesa mirmecològica daquest parc, es varen fer tres mostrejos diferents A, B i C. A: estudi de la fauna epiedàfica, fet al 2006; B: estudi post-incendi duna zona cremada al 2003, realitzat al 2007 i C: estudi bianual els anys 2006-2007 que es varen utilitzar per a la realització duna tesi doctoral (Herraiz, 2010). Als mostrejos A i B, es varen utilitzar trampes pitfall de 8 cm de diàmetre actives 14 dies. Per al mostreig C es varen utilitzar trampes pitfalls de 2 cm de diàmetre actives 7 dies i la caça a vista dels exemplars observats a cada una de les 68 zones durant una hora. Es varen determinar un total de 33625 formigues, pertanyents a 65 espècies (22 ja trobades per Cerdà) de 23 gèneres. Ja que a Catalunya shan citat 185 espècies de formigues, aquelles 65 més Tapinoma erraticum (Latreille, 1798) i Myrmica sabuleti Meinert, 1861 trobades per Cerdà i quatre espècies daportacions posteriors, representen un 38,4 % de la fauna mirmecològica catalana, sent un dels parcs amb major diversitat mirmecològica de Catalunya, després del Parc Natural dels Aiguamolls de lEmpordà (Herraiz & Espadaler, 2020).Despite the interest in wildlife studies in natural parks, we detected a lack of knowledge of the myrmecological fauna of the Natural Park of Sant Llorenç del Munt i lObac, as only a sampling had been done by Cerdà et al. (1989) in a specific area of the Collada de tres Creus in the Serra de lObac, in which 24 species of ants were determined. In order to get a more real picture of the myrmecological richness of this park, three different samples A, B and C were taken. A: an epiedaphic fauna study in 2006; B: post-fire study of a burned area in 2003 (also carried out in 2007) and C: a biannual one in 2006-2007 that were used to develop a doctoral thesis (Herraiz, 2010). In the A and B samples, 8 cm diameter pitfall traps active for 14 days were used. For the C study, 7 cm diameter pitfalls active for 7 days were utilized, active for 7 days, as well as the sight hunting of specimens observed in each of the 68 areas for one hour. A total of 33,625 ants were determined, belonging to 65 species (22 in Cerdàs study) of 23 genera. From the 185 species of ants that have been found in Catalonia, those 65 species, plus Tapinoma erraticum (Latreille, 1798) and Myrmica sabuleti Meinert, 1861 collected by Cerdà and four additional species collected in recent studies, represent more than a third (38.4 %) of the myrmecological fauna from Catalonia, being one of the parks with the greatest myrmecological diversity in Catalonia after the Aiguamolls de lEmpordà Natural Park (Herraiz & Espadaler, 2020)

Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with A

Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma

Medulloblastoma is the primary malignant tumor of the Central Nervous System (CNS) most common in pediatrics. We present here, the histological, molecular, and functional analysis of a cohort of 88 pediatric medulloblastoma tumor samples. The WNT-activated subgroup comprised 10% of our cohort, and all WNT-activated patients had exon 3 CTNNB1 mutations and were immunostained for nuclear β-catenin. One novel heterozygous CTNNB1 mutation was found, which resulted in the deletion of β-catenin Ser37 residue (ΔS37). The ΔS37 β-catenin variant ectopically expressed in U2OS human osteosarcoma cells displayed higher protein expression levels than wild-type β-catenin, and functional analysis disclosed gain-of-function properties in terms of elevated TCF/LEF transcriptional activity in cells. Our results suggest that the stabilization and nuclear accumulation of ΔS37 β-catenin contributed to early medulloblastoma tumorigenesis.This work was funded by Asociación Pablo Ugarte APU (BC/A/14/015), Pequerropa (BC/A/15/010), and the childhood cancer support Platform from EITB Media, SAU (BIO13/CI/016/BC). R.P. was funded by Ministerio de Economía y Competitividad (Spain and Fondo Europeo de Desarrollo Regional, grant number SAF2016-79847-R). C.E.N.-X. was funded by Instituto de Salud Carlos III (Spain and the European Social Fund+, grant number: CP20/00008). P.A.-P. was supported by a Basque Government fellowship (PRE_2020_2_0116)

Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation

Altres ajuts: Fundació Marato TV3 [20152030/31].Atrial fibrillation (AF) has been associated with intracellular calcium disturbances in human atrial myocytes, but little is known about the potential influence of sex and we here aimed to address this issue. Alterations in calcium regulatory mechanisms were assessed in human atrial myocytes from patients without AF or with long-standing persistent or permanent AF. Patch-clamp measurements revealed that L-type calcium current (I ) density was significantly smaller in males with than without AF (−1.15 ± 0.37 vs. −2.06 ± 0.29 pA/pF) but not in females with AF (−1.88 ± 0.40 vs. −2.21 ± 0.0.30 pA/pF). In contrast, transient inward currents (I ) were more frequent in females with than without AF (1.92 ± 0.36 vs. 1.10 ± 0.19 events/min) but not in males with AF. Moreover, confocal calcium imaging showed that females with AF had more calcium spark sites than those without AF (9.8 ± 1.8 vs. 2.2 ± 1.9 sites/µm 2) and sparks were wider (3.0 ± 0.3 vs. 2.2 ± 0.3 µm) and lasted longer (79 ± 6 vs. 55 ± 8 ms), favouring their fusion into calcium waves that triggers I s and afterdepolarizations. This was linked to higher ryanodine receptor phosphorylation at s2808 in women with AF, and inhibition of adenosine A or beta-adrenergic receptors that modulate s2808 phosphorylation was able to reduce the higher incidence of I in women with AF. Perturbations of the calcium homoeostasis in AF is sex-dependent, concurring with increased spontaneous SR calcium release-induced electrical activity in women but not in men, and with diminished I density in men only. This work was supported by grants from The Spanish Ministry of Science Innovation and Universities

One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m 2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (−3.39 and −2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (−0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (−2.93 and −2.78 kg, respectively), BMI (−1.05 and −0.99, respectively), waist circumference (−3.37 and −3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL, respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (−5.42 and −5.74 mg/dL, respectively). Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at as ISRCTN89898870

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery

To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after pancreatic surgery

Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologists has generated a wealth of knowledge related to the contribution of stem/progenitor cells to both organogenesis and self-renewal of endocrine organs. This review provides an up-to-date and comprehensive overview of the role of tissue stem cells in the development and self-renewal of endocrine organs. Pathways governing crucial steps in both development and stemness maintenance, and that are known to be frequently altered in a wide array of endocrine disorders, including cancer, are also described. Crucially, this plethora of information is being channeled into the development of potential new cell-based treatment modalities for endocrine-related illnesses, some of which have made it through clinical trials