Perbandingan Pengelolaan Ruang Terbuka Hijau Kota Semarang Dan Kota Surabaya Tahun 2010-2015

. Green Open Space is an importat element in creating qualified city in realizing ecological city in order of ecological city realization. The government policy related to the 30% proportion provision constitute the minimum size in an effort to ensure an urban development balance. Management of green open space is one of general policy and regional development programs in environment space sector by the municipality to fulfill extents of green open space. Manajement of green open space in the city of Semarang and Surabaya is done through of planning, organizing, directing, and monitoring. Research method uses descriptively qualitative approach with observation, interview, and literary review as the data collecting technique. The interviewees are Sub Field Head of Spatial Planning and Environment of Bappeda Semarang, Landscape Gardening Division Head of Hygiene and Landscaping Gardening Department of Semarang, Sub Section Head of Spatial Planning, Housing and Environment of Bappeko Surabaya, Staff of Green open Space Planning of Hygiene and Green Open Space of Surabaya In the manajement comparative of green open space in the city of semarang and Surabaya in 2010-2015, the are similarities and differences. Differences in management of Green Open Space in Semarang and Surabaya there is in quality of human resources, leadership style, budget and the involvement of private sector. The presence of this research can be used as an input in the management of Green Open Space in the city of Semarang and Surabaya Recommendation could be done to Semarang city is to improve the quality of human resources of relevan agencies and conducting CSR with private sector. Whereas the recommendation could be done to Surabaya city is to give strict punishment for the people who founded illegal building on land designated as Green Open Space

IMPLEMENTASI MODEL PEMBELAJARAN SELF DIRECTED LEARNING DALAM MELATIH KEMANDIRIAN BELAJAR PESERTA DIDIK (Studi di PKBM Homeschooling Taman Sekar Bandung)

Pendekatan dan model pembelajaran sebagai salah satu komponen pembelajaran memiliki peranan dalam upaya pencapaian tujuan pembelajaran. Model pembelajaran self directed learning merupakan salah satu model yang memberikan otonomi kepada peserta didik dalam mengatur proses belajar dalam bentuk inisiatif sendiri, pengaturan diri, eksplorasi diri, dan kebebasan belajar untuk mencapai hasil belajar yang optimal dan meningkatkan kemandirian belajar. Penelitian ini bertujuan untuk mengetahui implementasi model pembelajaran self directed learning, upaya tutor dalam melatih kemandirian belajar, dan tingkat kemandirian belajar peserta didik di Homeschooling Taman Sekar Bandung. Penelitian ini menggunakan metode deskriptif dan pendekatan kualitatif. Teknik pengumpulan data yang digunakan adalah wawancara, observasi dan studi dokumentasi. Subjek penelitian berjumlah enam orang yaitu terdiri dari dua orang peserta didik, dua orang tutor dan dua orang orang tua. Berdasarkan hasil temuan penelitian, dapat ditemukan bahwa 1) Implementasi model pembelajaran self directed learning terdiri dari empat tahap yaitu perencanaan, terdiri dari identifikasi kebutuhan dan kemampuan peserta didik serta pembuatan rencana belajar juga pemilihan metode dan sumber belajar. Pelaksanaan pembelanjaran, menggunakan metode yang variatif dan didasarkan pada kondisi peserta didik, pengawasan tutor kepada peserta didik secara langsung melalui WhatsApp, activity book ataupun secara langsung saat pembelajaran dan melakukan evaluasi baik dalam proses pembelajaran maupun hasil belajar peserta didik. 2) Upaya tutor dalam melatih kemandirian belajar dengan perannya sebagai pengajar, pembimbing, pendorong kreativitas dan motivator. 3) Tingkat kemandirian peserta didik memiliki otonomi diri, manajemen pembelajaran, meraih kebebasan belajar serta memiliki kendali terhadap pembelajarannya. Approaches and learning models as one of the components of learning have a role in achieving learning objectives. The self-directed learning model is a model that gives autonomy to students in managing the learning process in the form of self-initiative, self-regulation, self-exploration, and freedom of learning to achieve optimal learning outcomes and increase learning independence. This study aims to determine the implementation of the self-directed learning model, the tutor's efforts in training independent learning, and the level of learning independence of students at Homeschooling Taman Sekar Bandung. This study uses a descriptive method and a qualitative approach. Data collection techniques used are interviews, observation and documentation studies. The research subjects were six people consisting of two students, two tutors and two parents. Based on the research findings, it can be found that 1) The implementation of the self-directed learning learning model consists of four stages, namely planning, consisting of identifying the needs and abilities of students and making study plans as well as selecting learning methods and resources. The implementation of spending, using varied methods and based on the condition of students, supervision of tutors to students directly through WhatsApp, activity books or directly during learning and evaluating both in the learning process and student learning outcomes. 2) The tutor's efforts to train independent learning with its role as a teacher, mentor, encourager of creativity and motivator. 3) The level of independence of students has self-autonomy, learning management, achieves freedom of learning and has control over their learning

Canadians’ trust in government in a time of crisis: Does it matter?

The ability of governments and nations to handle crises and protect the lives of citizens is heavily dependent on the public’s trust in their governments and related social institutions. The aim of the present research was to understand public trust in government during a time of crisis, drawing on interview data (N = 56) collected during the COVID-19 pandemic (2021). In addition to the general public (n = 11), participants were sampled to obtain diversity as it relates to identifying as First Nations, Métis, and Inuit (n = 7), LGBT2SQ+ (n = 5), low-income (n = 8), Black Canadians (n = 7), young adult (n = 8), and newcomers to Canada (n = 10). Data were coded in consideration of social theories of trust, and specifically the nature of trust between individuals and institutions working with government in pandemic management. Canadians’ trust in government was shaped by perceptions of pandemic communication, as well as decision-making and implementation of countermeasures. Data suggest that although participants did not trust government, they were accepting of measures and messages as presented through government channels, pointing to the importance of (re)building trust in government. Perhaps more importantly however, data indicate that resources should be invested in monitoring and evaluating public perception of individuals and institutions generating the evidence-base used to guide government communication and decision-making to ensure trust is maintained. Theoretically, our work adds to our understanding of the nature of trust as it relates to the association between interpersonal and institutional trust, and also the nature of trust across institutions

Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI

Although enzyme replacement therapy (ERT) is available for several lysosomal storage disorders, the benefit of this treatment to the skeletal system is very limited. Our previous work has shown the importance of the Toll-like receptor 4/TNF-alpha inflammatory pathway in the skeletal pathology of the mucopolysaccharidoses (MPS), and we therefore undertook a study to examine the additive benefit of combining anti-TNF-alpha therapy with ERT in a rat model of MPS type VI.MPS VI rats were treated for 8 months with Naglazyme® (recombinant human N-acetyl-galactosamine-4-sulfatase), or by a combined protocol using Naglazyme® and the rat-specific anti-TNF-alpha drug, CNTO1081. Both protocols led to markedly reduced serum levels of TNF-alpha and RANKL, although only the combined treatment reduced TNF-alpha in the articular cartilage. Analysis of cultured articular chondrocytes showed that the combination therapy also restored collagen IIA1 expression, and reduced expression of the apoptotic marker, PARP. Motor activity and mobility were improved by ERT, and these were significantly enhanced by combination treatment. Tracheal deformities in the MPS VI animals were only improved by combination therapy, and there was a modest improvement in bone length. Ceramide levels in the trachea also were markedly reduced. MicroCT analysis did not demonstrate any significant positive effects on bone microarchitecture from either treatment, nor was there histological improvement in the bone growth plates.The results demonstrate that combining ERT with anti-TNF-alpha therapy improved the treatment outcome and led to significant clinical benefit. They also further validate the usefulness of TNF-alpha, RANKL and other inflammatory molecules as biomarkers for the MPS disorders. Further evaluation of this combination approach in other MPS animal models and patients is warranted

Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference

Nanoparticle conjugates have the potential for delivering siRNA, splice-shifting oligomers or nucleic acid vaccines, and can be applicable to anticancer therapeutics. This article compares tripartite conjugates with gold nanoparticles or synthetic methoxypoly(ethylene glycol)-block-polyamidoamine dendrimers

Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate´s phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection.J.T.S. holds a research contract from the Fundación para la Formación e Investigación de los Profesionales de la Salud de Extremadura (FundeSalud), Instituto de Salud Carlos III. M.F.R. holds a clinical research contract “Juan Rodés” (JR14/00036) from the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Ageing of the global population has become a public health concern with an important socio-economic dimension. Ageing is characterized by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed "inflammageing". The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions. We provide an overview of low grade inflammation (LGI) and determine the potential drivers and the effects of the "inflamed" phenotype observed in the elderly. We discuss the role of gut microbiota and immune system crosstalk and the gut-brain axis. Then, we focus on major health complications associated with LGI in the elderly, including mental health and wellbeing, metabolic abnormalities and infections. Finally, we discuss the possibility of manipulating LGI in the elderly by nutritional interventions. We provide an overview of the evidence that exists in the elderly for omega-3 fatty acid, probiotic, prebiotic, antioxidant and polyphenol interventions as a means to influence LGI. We conclude that slowing, controlling or reversing LGI is likely to be an important way to prevent, or reduce the severity of, age-related functional decline and the onset of conditions affecting health and well-being; that there is evidence to support specific dietary interventions as a strategy to control LGI; and that a continued research focus on this field is warranted

FAKTOR-FAKTOR HIGIENE SANITASI YANG BERHUBUNGAN DENGAN KUMAN PADA MAKANAN DI INSTALASI GIZI RSUD Dr.Soeselo KABUPATEN TEGAL

Rumah Sakit memiliki derajat kontaminasi yang tinggi. Sedangkan Isntalasi Gizi merupakan unit penunjang Rumah Sakit yang berfungsi dalam penyediaan makanan bagi pasien maupun tenagaKesehatan. Pasien di Rumah Sakit sangat rentan terhadap penyakit, sehingga makanan di Rumah Sakit harus diperhatikan. Tujuan dari penelitian ini adalah untuk mengetahui hubungan higiene sanitasi dengan angka kuman dan mrngidentifikasi Eschericia coli pada makanan di Instalasi Gizi RSUD dr.Soeselo Kabupaten Tegal. Jenis penelitian ini adalah Explanatory Research menggunakan metode observasi dengan pendekatan cross sectional. Penelitian ini dilaksanakan di Instalasi Gizi RSUD dr. Soeselo Kab. Tegal pada tangga 10 November sampai dengan 14 Desmber 2005. Populasi dalam penelitian ini adalah seluruh makanan yang disajikan untuk pasien yang dioleh oleh Instalasi Gizi RSUD dr.Soeselo Kabupaten Tegal. Sedangkan jumlah sampel makanan dalam penelitian ini sesuai dengan jumlah hari pelaksanaan indentifikasi. Yaitu 30 sampel dalam 30 kali identifikasi. Analisa data menggunakan analisa univariat dengan distribusi frekuensi dan bivariat dengan tabulasi silang dan menggunakan uji statistik Korelasi Rank Spearman. Berdasarkan hasil penelitian dapat diketahui bahwa rata-rata skor sanitasi dapur pada Instalasi Gizi adalah 16 yang berartibahwa rata-rata sanitasi dapur termasuk dalam kategori sedang. Sedangkan rata-rata skor sanitasi makanan adalah 14,97, yang berarti bahwa rata-rata sanitasi makanan termasuk dalam kategori sedang. Sedangkan pada rata-rata skor higiene penjamah adalah 4,78 yang berarti bahwa rata-rata higiene penjamah termasuk dalam kategori sedang. Sedangkan hasil uji statistik menunjukkan bahwa ada hubungan antara sanitasi dapur dengan angka kuman (P=0,20), ada hubungan antara sanitasi makanan dengan angka kuman (p=0,038), dan tidak ada hubungan antara higiene penjamah dengan angka kuman (p=0,404). Pada pemeriksaan Eschericia coli, semua sampel makanan tidak mengandung Eschericia coli. Kata Kunci: higiene sanitasi, angka kuman,Eschercia coli, Instalasi Gizi THE HYGIENE AND SANITATION FACTORS WHICH ARE CORRELATE WITH THE NUMBER OF BACTERIA AND Eschericia coli CONTENT IN FOOD AT NUTRITIONAL UNIT OD Dr. SOESELO GENERAL HOSPITAL, TEGAL DISTRICT Hospital has a high contamination degree. Nutritional unit is a hospital supporting unit which has function in supplying food for patient and medical staff. The hospital patient is very sensitive against the disease, so that the management of food in hospital is very crucial. The objective of this research was to find the relationship between hygiene and sanitation with the number of bacteria as well as to identify Eschericia coli on food at nutritional iunit of Dr. Soeselo General Hospital, Tegal Regency. This research was held from november, 10 xth to Desember, 14 xth 2005. The population of this research was the entire food for the patient prepared by nutritional unit of Dr. Soeselo General Hospital Tegal Regency as many as 30 samples taken by 30 times identification. Univariat analysis by frequency distribution and bivariat analysis by cross tabulation using statistical test of Rank Spearman correlation was used to test the hypothesis. The result showed that the kitchen sanitation average in the nutritional unit was 16. lt means that the kitchen sanitation item average was in medium level. Meanwhile the food sanitation average was 14,97. lt also means that the food sanitation item average of the food handler was in medium level. Whereas the personal hygiene average was 4,78. lt means that the personal hygiene item was loaded by the average of the food handler. lt shows that the personal hygiene of the nutritional unit was in medium level too. The result of the statistical test showed that kitchen sanitation correlates with the number of bacteria (p=0,020), food sanitation correlates with the number of bacteria (p=0,038), but personal hygiene doesn't correlate with the number of bacteria (p=0,404). There was not Esschericia coli found on food samples in test. Keyword : Hygiene and sanitation, number of bactria, Eschericia coli, Nutritional uni

Perubahan Sosial Dan Budaya Dalam Memilih Pasangan Hidup Perempauan Di Desa Binuang Kecematan Balusu Kabupaten Barru

Penelitian ini bertujuan untuk mengetahui: 1) untuk mengetahuai Gambaran perubahan sosial dan budaya dalam memilih pasangan hidup perempuan di Desa Binuang Kecamatan Balusu Kabupaten Barru. 2) untuk mengetahui faktor-faktor yang mempengaruhi perubahan sosial dan budaya dalam memilih pasangan hidup perempuan di Desa Binuang Kecematan Balusu Kabupaten Barru. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif, yaitu suatu proses pengumpulan data secara sistematis dan intensif untuk memperoleh pengetahuan dan informasi. Maka dalam penelitian ini peneliti mengamati dan berinteraksi dengan masyarakat yang berada di Desa Binuang Kecamatan Balusu Kabupaten Barru dengan wawancara dengan mengkaji dokumentasinya. Berdasarkan hasil penelitian, maka dapat diketahui bahwa: 1) gambaran perubahan sosial dan budaya dalam memilih pasangan hidup perempuan di Desa Binuang Kecamatan Balusu Kabupaten Barru ada empat yaitu: Harta, Keturunan, Kecantikan, dan Agamanya. 2) faktor-faktor yang mempengaruhi perubahan sosial dan budaya dalam memilih pasangan hidup di Desa Binuang Kecamatan Binuang Kabupaten Barru yaitu latar belakang keluarga dan karakteristik personal. Latar belakang keluarga terbagi menjadi empat bagian yaitu: sosial-ekonmi, pendidikan, agama, dan pernikahan antar ras dan suku. Karakterristik personal terbagi menjadi tiga bagian yaitu: Sikap dan tingkah laku individu, perbedaan Usia, dan Memiliki kesamaan sikap dan nilai