26 research outputs found
Recent work on human nature: Beyond traditional essences
Kronfeldner M, Roughley N, Toepfer G. Recent work on human nature: Beyond traditional essences. Philosophy Compass. 2014;9(9):642-652.Recent philosophical work on the concept of human nature disagrees on how to respond to the Darwinian challenge, according to which biological species do not have traditional essences. Three broad kinds of reactions can be distinguished: (1) conservative intrinsic essentialism, which defends essences in the traditional sense, (2) eliminativism, which suggests dropping the concept of human nature altogether, and (3) constructive approaches, which argue that revisions can generate sensible concepts of human nature beyond traditional essences. The different constructive approaches pick out one or two of the three epistemic roles that are fused in traditional essentialist conceptions of human nature: descriptive (descriptivism), explanatory (explanativism), definitional (taxonomic relationalism), or explanatory and definitional (property cluster essentialism). These turns towards diverging epistemic roles are best interpreted pluralistically: there is a plurality of concepts of human nature that have to be clearly distinguished, each with a legitimate role in respective scientific contexts
Broad targeting of resistance to apoptosis in cancer
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer
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Promote Democratic Citizenship among Rural Women: A Chinese NGOâs Two Models
A Beijing-based non-governmental organization (NGO) strives to empower rural Chinese women and migrant girls by increasing their awareness of constitutional rights and promoting their capacities to exercise their civil and political rights. This article reports the NGO leadersâ perceptions of the goals, strategies, and challenges in their citizenship endeavor, and analyzes their educational activities in theoretical and cultural contexts. By reporting a tension between the two founding leaders and unpacking the different approaches they take to engaging rural women, we demonstrate how the conceptualization of human rights education in the rural Chinese context is influenced by three approaches to human rightsâthe Confucian emphasis of rites, the Western tradition of emphasizing law, and the âhuman functional capacitiesâ approachâand how the implementation process is constrained by Chinaâs political framework, the social conditions of rural women, and the NGO leadersâ vantage points
Morality in the making : thought, action, and the social context /
Errata slip inserted.Includes bibliographies and indexes
Academic stress in Chinese schools and a proposed preventive intervention program
While American educators fret about the mediocre educational performance of American students in international contests (e.g. the Program for International Student Assessment) and wonder why the Chinese education system produces such high-achieving students, educators, journalists, and public officials in China want to know what causes and how to prevent the high levels of academic stress that Chinese students, their families, and their school systems experience. So far, much of the blame for these toxic levels of stress has been directed to the Gaokao, the Chinese national college entrance exam that takes place in June each year. But to date, top-down Chinese educational reforms have been ineffective in reducing the problem. In this article, we build a case for strengthening bottom-up efforts at the school level in China and propose an evidence-based approach for addressing the challenge of academic stress experienced by Chinese students