The Minimal Phantom Sector of the Standard Model: Higgs Phenomenology and Dirac Leptogenesis

We propose the minimal, lepton-number conserving, SU(3)xSU(2)xU(1) gauge-singlet, or phantom, extension of the Standard Model. The extension is natural in the sense that all couplings are of O(1) or forbidden due to a phantom sector global U(1)_D symmetry, and basically imitates the standard Majorana see-saw mechanism. Spontaneous breaking of the U(1)_D symmetry triggers consistent electroweak gauge symmetry breaking only if it occurs at a scale compatible with small Dirac neutrino masses and baryogenesis through Dirac leptogenesis. Dirac leptogenesis proceeds through the usual out-of-equilibrium decay scenario, leading to left and right-handed neutrino asymmetries that do not fully equilibrate after they are produced. The model contains two physical Higgs bosons and a massless Goldstone boson. The existence of the Goldstone boson suppresses the Higgs to bb branching ratio and instead the Higgs bosons will mainly decay to invisible Goldstone and/or to visible vector boson pairs. In a representative scenario, we estimate that with 30 fb^-1 integrated luminosity, the LHC could discover this invisibly decaying Higgs, with mass ~120 GeV. At the same time a significantly heavier, partner Higgs boson with mass ~210 GeV could be found through its vector boson decays. Electroweak constraints as well as astrophysical and cosmological implications are analysed and discussed.Comment: 21 pages, 4 figures. Corrected typos and added references. To appear in JHE

A simple approach to describe hadron production rates in e+e−e^+ e^- annihilation

We show that, based on the idea of string fragmentation, the production rates of light flavored mesons and baryons originating from fragmentation can be described by the spin, the binding energy of the particle, and a strangeness suppression factor. Apart from a normalization factor, $e^+ e^-$ data at different center-of-mass energies can be described simultaneously. Applying to the heavy flavor production, we find that our predictions are in good agreement with data.Comment: latex(stwol.sty), 4 pages, 2 figure

Singularities In Scalar-Tensor Cosmologies

In this article, we examine the possibility that there exist special scalar-tensor theories of gravity with completely nonsingular FRW solutions. Our investigation in fact shows that while most probes living in such a Universe never see the singularity, gravity waves always do. This is because they couple to both the metric and the scalar field, in a way which effectively forces them to move along null geodesics of the Einstein conformal frame. Since the metric of the Einstein conformal frame is always singular for configurations where matter satisfies the energy conditions, the gravity wave world lines are past inextendable beyond the Einstein frame singularity, and hence the geometry is still incomplete, and thus singular. We conclude that the singularity cannot be entirely removed, but only be made invisible to most, but not all, probes in the theory.Comment: 23 pages, latex, no figure

Unconventional Cosmology

I review two cosmological paradigms which are alternative to the current inflationary scenario. The first alternative is the "matter bounce", a non-singular bouncing cosmology with a matter-dominated phase of contraction. The second is an "emergent" scenario, which can be implemented in the context of "string gas cosmology". I will compare these scenarios with the inflationary one and demonstrate that all three lead to an approximately scale-invariant spectrum of cosmological perturbations.Comment: 45 pages, 10 figures; invited lectures at the 6th Aegean Summer School "Quantum Gravity and Quantum Cosmology", Chora, Naxos, Greece, Sept. 12 - 17 2012, to be publ. in the proceedings; these lecture notes form an updated version of arXiv:1003.1745 and arXiv:1103.227

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.

We studied three patients with severe skeletal dysplasia, T cell immunodeficiency, and developmental delay. Whole-exome sequencing revealed homozygous missense mutations affecting exostosin-like 3 (EXTL3), a glycosyltransferase involved in heparan sulfate (HS) biosynthesis. Patient-derived fibroblasts showed abnormal HS composition and altered fibroblast growth factor 2 signaling, which was rescued by overexpression of wild-type EXTL3 cDNA. Interleukin-2-mediated STAT5 phosphorylation in patients' lymphocytes was markedly reduced. Interbreeding of the extl3-mutant zebrafish (box) with Tg(rag2:green fluorescent protein) transgenic zebrafish revealed defective thymopoiesis, which was rescued by injection of wild-type human EXTL3 RNA. Targeted differentiation of patient-derived induced pluripotent stem cells showed a reduced expansion of lymphohematopoietic progenitor cells and defects of thymic epithelial progenitor cell differentiation. These data identify EXTL3 mutations as a novel cause of severe immune deficiency with skeletal dysplasia and developmental delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development

Transcription factor induction of vascular blood stem cell niches in vivo

The hematopoietic niche is a supportive microenvironment composed of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specify niche endothelial cells and orchestrate HSPC homeostasis remain largely unknown. Using multi-dimensional gene expression and chromatin accessibility analyses in zebrafish, we define a conserved gene expression signature and cis-regulatory landscape that are unique to sinusoidal endothelial cells in the HSPC niche. Using enhancer mutagenesis and transcription factor overexpression, we elucidate a transcriptional code that involves members of the Ets, Sox, and nuclear hormone receptor families and is sufficient to induce ectopic niche endothelial cells that associate with mesenchymal stromal cells and support the recruitment, maintenance, and division of HSPCs in vivo. These studies set forth an approach for generating synthetic HSPC niches, in vitro or in vivo, and for effective therapies to modulate the endogenous niche

Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

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