ANALYSIS OF METHODICAL DEFECTS IN PHD AND DOCTORAL THESIS ON ECONOMICS

The aim of the article is to consider the most typical defectswhich can be found in PhD and doctoral dissertations on economic sciences. The research is based on a work experience of the author as the member of dissertation council, the reviewer and the opponent of dissertation works.Methods. The methods of the analysis, comparison, and generalization are used while researching the problem.Results and scientific novelty. The miscalculations and errors in master’s and doctoral dissertations on economics which have methodical nature and not depend on a specific subject of work are disclosed and systematized. In particular, the following questions concerning the process of work are studied out on specific examples: work with information sources, Internet resources; options of correct and incorrect use o tools of information technologies; applied problems of results of scientific research, etc.Practical significance of the publication consists, firstly, in recommendations of the author concerning leveling and elimination of common defects of dissertation works and scientific articles; secondly, in the proposal of the general and methodical plan for introduction of training standards in a postgraduate study.Цель публикации – рассмотреть наиболее типичные недостатки, встречающиеся в кандидатских и докторских диссертациях по экономическим наукам. Статья основана на опыте работы автора в качестве члена диссертационного совета, рецензента и оппонента диссертационных работ. Методы. В работе использованы методы анализа, сравнения, обобщения. Результаты и научная новизна. Вскрыты и систематизированы имеющие методический характер и не зависящие от конкретной темы работы просчеты и ошибки, имеющиеся в кандидатских и докторских диссертациях экономической проблематики. В частности, на конкретных примерах разобраны вопросы, касающиеся работы с информационными источниками, интернет-ресурсами; варианты правильного и неверного использования инструментария информационных технологий; прикладные проблемы результатов научных исследований и др. Практическая значимость публикации заключается, во-первых, в рекомендациях автора по поводу нивелирования и устранения общих недостатков диссертационных работ и научных статей; во-вторых, в предложении общеметодического плана по внедрению стандартов обучения в аспирантуре

Outcomes of renal transplantation in patients with AL amyloidosis: an international collaboration through The International Kidney and Monoclonal Gammopathy Research Group

Effective systemic therapies suppress toxic light chain production leading to an increased proportion of patients with light chain (AL) amyloidosis who survive longer albeit with end-stage renal disease. There is a critical need to identify patients in this population who benefit from renal transplantation. This multicenter, observational study from five countries includes 237 patients with AL amyloidosis who underwent renal transplantation between 1987 and 2020. With a median follow-up of 8.5 years, the median overall survival from renal transplantation was 8.6 years and was significantly longer in patients with complete and very good partial hematologic responses (CR + VGPR) compared to less than VGPR (9 versus 6.8 years; HR: 1.5, P = 0.04 [95% CI: 1–2.1]) at renal transplantation. Median graft survival was 7.8 years and was better in the CR + VGPR group (8.3 vs 5.7 years, HR: 1.4, P = 0.05 [95% CI: 1–2]). The frequency and time to amyloid recurrence in the graft was also lower (16% vs 37%, p = 0.01) and longer (median time not achieved vs 10 years, p = 0.001) in the CR + VGPR group. Comparing CR vs. VGPR there was no difference in overall or graft survival. Although 69 patients (29%) experienced hematologic relapse, treatment effectively prevented graft loss in the majority (87%). Renal transplantation in selected AL amyloidosis patients is associated with extended overall and renal graft survival. Patients with hematologic CR or VGPR have the most favorable outcomes, and these patients should be considered for renal transplantation

African Linguistics in Central and Eastern Europe, and in the Nordic Countries

Non peer reviewe

Communication, Trust, and the Formation of Multi-Layered Urban Communities in the Medieval Mediterranean

o Réalisation : Jean-Christophe Besset o Centre Jean Berard, Naples, Italie 2019 o Film réalisé dans le cadre de l’Atelier de la Méditerranée « Ports et zones portuaires de la Méditerranée Antique »o Session 2 Paysage urbaino Modérateur : Ivan Fumado Ortega (Université de Valencia)Two concomitant processes shaped the Mediterranean during the high middle ages (11th-13th centuries), namely urbanization and the expansion of the frontiers of Latin Christendom. This yielded rapidly growing urban centers, that were inhabited by extremely diverse populations, and were often characterized by geo-political and social instability. The implications of this complex social configuration on such issues as ethnoreligious and cultural encounters, or long-distance trade networks, received considerable scholarly attention. Yet the challenges that such conditions presented to the formation of municipal mechanisms and promotion of urban development are still often overlooked.This paper will aim to address the reciprocal connection between the changing cityscapes of the medieval Mediterranean, and their social and institutional circumstances through the case study of Frankish Acre. Acre reveals a tension betweengradually intensifying municipal and legal mechanisms, aimed to increase the level of social cohesion among an extremely heterogeneous population, and constant instability, which has disintegrating and decentralizing effects. This was manifested in the changes that took place in Acre’s cityscape, as rising tensions between the different groups in Acre’s population led to the fragmentation of the cityscape. Yet if previously this process was considered to encompass almost exclusively to the dominions of the Italian communes, this paper will argue it was far more extensive, resulting in the division ofthe cityscape into the port area, and an outer ring, the two developing almost independently of one another, thus reflecting social and institutional stratification.Based on this case study, the paper will aim to address new methodological approaches and a new theoretical framework for the study of urban centers in the medieval Mediterranean

Communication, Trust, and the Formation of Multi-Layered Urban Communities in the Medieval Mediterranean

o Réalisation : Jean-Christophe Besset o Centre Jean Berard, Naples, Italie 2019 o Film réalisé dans le cadre de l’Atelier de la Méditerranée « Ports et zones portuaires de la Méditerranée Antique »o Session 2 Paysage urbaino Modérateur : Ivan Fumado Ortega (Université de Valencia)Two concomitant processes shaped the Mediterranean during the high middle ages (11th-13th centuries), namely urbanization and the expansion of the frontiers of Latin Christendom. This yielded rapidly growing urban centers, that were inhabited by extremely diverse populations, and were often characterized by geo-political and social instability. The implications of this complex social configuration on such issues as ethnoreligious and cultural encounters, or long-distance trade networks, received considerable scholarly attention. Yet the challenges that such conditions presented to the formation of municipal mechanisms and promotion of urban development are still often overlooked.This paper will aim to address the reciprocal connection between the changing cityscapes of the medieval Mediterranean, and their social and institutional circumstances through the case study of Frankish Acre. Acre reveals a tension betweengradually intensifying municipal and legal mechanisms, aimed to increase the level of social cohesion among an extremely heterogeneous population, and constant instability, which has disintegrating and decentralizing effects. This was manifested in the changes that took place in Acre’s cityscape, as rising tensions between the different groups in Acre’s population led to the fragmentation of the cityscape. Yet if previously this process was considered to encompass almost exclusively to the dominions of the Italian communes, this paper will argue it was far more extensive, resulting in the division ofthe cityscape into the port area, and an outer ring, the two developing almost independently of one another, thus reflecting social and institutional stratification.Based on this case study, the paper will aim to address new methodological approaches and a new theoretical framework for the study of urban centers in the medieval Mediterranean

ANALYSIS OF METHODICAL DEFECTS IN PHD AND DOCTORAL THESIS ON ECONOMICS

The aim of the article is to consider the most typical defectswhich can be found in PhD and doctoral dissertations on economic sciences. The research is based on a work experience of the author as the member of dissertation council, the reviewer and the opponent of dissertation works.Methods. The methods of the analysis, comparison, and generalization are used while researching the problem.Results and scientific novelty. The miscalculations and errors in master’s and doctoral dissertations on economics which have methodical nature and not depend on a specific subject of work are disclosed and systematized. In particular, the following questions concerning the process of work are studied out on specific examples: work with information sources, Internet resources; options of correct and incorrect use o tools of information technologies; applied problems of results of scientific research, etc.Practical significance of the publication consists, firstly, in recommendations of the author concerning leveling and elimination of common defects of dissertation works and scientific articles; secondly, in the proposal of the general and methodical plan for introduction of training standards in a postgraduate study

Kidney injury and disease in patients with haematological malignancies.

Acute kidney injury (AKI) is common in patients with cancer, especially in those with haematological malignancies. Kidney injury might be a direct consequence of the underlying haematological condition. For example, in the case of lymphoma infiltration or extramedullary haematopoiesis, it might be caused by a tumour product; in the case of cast nephropathy it might be due to the presence of monoclonal immunoglobulin; or it might result from tumour complications, such as hypercalcaemia. Kidney injury might also be caused by cancer treatment, as many chemotherapeutic agents are nephrotoxic. High-intensity treatments, such as high-dose chemotherapy followed by haematopoietic stem cell transplantation, not only increase the risk of infection but can also cause AKI through various mechanisms, including viral nephropathies, engraftment syndrome and sinusoidal obstruction syndrome. Some conditions, such as thrombotic microangiopathy, might also result directly from the haematological condition or the treatment. Novel immunotherapies, such as immune checkpoint inhibitors and chimeric antigen receptor T cell therapy, can also be nephrotoxic. As new therapies for haematological malignancies with increased anti-tumour efficacy and reduced toxicity are developed, the number of patients receiving these treatments will increase. Clinicians must gain a good understanding of the different mechanisms of kidney injury associated with cancer to better care for these patients