270 research outputs found
New sources of partial resistance to bacterial spot race T2 in processing tomatoes
- Author
- Alejandra Borges
- Astua-Monge G
- Berrueta C
- Berrueta C
- Berry SZ
- Gallardo GS
- Galván GA
- González M Giménez G
- Guillermo A Galván
- Gustavo Giménez
- Jones JB
- Jones JB
- Jones JB
- Koenraadt H
- Lugon-Lima M
- Marcuzzo LL.
- María C Berrueta
- McCULLAGH R
- Mello SCM
- Mendes de
- MONTELONGO MJ.
- Pohronezny K
- Quezado-Duval AM
- Scott JW
- Scott JW
- Scott JW
- Scott JW
- ScotT JW
- Scott JW
- Silva AM
- Silva-Lobo VL
- SPYRIDES-CUNHA MH
- Stall RE
- Yang W
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
- Author
- A Giraldo
- A Gomez
- A Mendoza Sanchez
- A Recalde
- A Stella
- A Umar
- A Wagner
- AD Clarizia
- Adriana Della Valle
- AL Moisio
- Alexandra Martins
- AM Wielandt
- André Escremim de Paula
- AR Cajal
- BA Thompson
- Benedito Mauro Rossi
- BM Rossi
- BM Rossi
- C Castro-Mujica Mdel
- C Castro-Mujica Mdel
- C Houdayer
- C Nique Carbajal
- C Ortiz
- C Sarroca
- CA Vaccaro
- CA Vaccaro
- CA Vaccaro
- Carlos Alberto Vaccaro
- Carlos Sarroca
- CG Rasuck
- Claudia Barletta-Carrillo
- CM Egoavil
- Constantino Dominguez-Barrera
- DD Buchanan
- DE Germini
- DV Viana
- E Borras
- Edenir Inêz Palmero
- Eivind Hovig
- Enrique Spirandelli
- Erika Maria Monteiro-Santos
- Evaluation of Genomic Applications in P Prevention Working G
- FC Silva da
- Florencia Neffa
- Florencia Spirandelli
- Francisco López-Kostner
- G Casey
- G Chong
- G Ponti
- G Yeo
- GH Garcia
- H Hampel
- H Kobayashi
- H Song
- Henrique de Campos Reis Galvão
- HF Vasen
- HF Vasen
- Hélène Tubeuf
- I Borelli
- I Thiffault
- IN Freitas de
- J Norum
- J Risco
- JP Plazzer
- JT Dunnen den
- Julio Sanchez de Monte
- K Alvarez
- Karin Alvarez
- L Perez-Cabornero
- L. Lena Morillas
- Luis Gustavo Capochin Romagnolo
- M Aarnio
- M Clendenning
- M Cruz-Correa
- M Dominguez-Valentin
- M Nystrom-Lahti
- M Pinheiro
- M Pinheiro
- M Rodriguez-Soler
- M Roque
- M Tanyi
- MA Ramirez-Ramirez
- MA RodriguezBigas
- Maria del Carmen Castro-Mujica
- MD Valentin
- MD Valentin
- Melva Gutiérrez Angulo
- Mev Dominguez-Valentin
- NJ Froggatt
- Norma Teresa Rossi
- O Soukarieh
- P Ashton-Prolla
- P Koehler-Santos
- P Lastella
- P Vahteristo
- Pablo German Kalfayan
- Patricia Ashton-Prolla
- Patrik Wernhoff
- Pål Møller
- Richard Quispe
- RP Kuiper
- Rui Manuel Reis
- S Gupta
- Sabrina Daniela da Silva
- Sergio Chialina
- SMO Leite
- Susana Revollo
- Tamara Alejandra Piñero
- V Alonso-Espinaco
- W Sjursen
- WE Jesus-Monge De
- Ximena Taborga
- Y Montenegro
- Yenni Rodriguez
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spectrum of patients with suspected LS in Latin America.
Methods: Eleven LS hereditary cancer registries and 34 published LS databases were used to identify unrelated families that fulfilled the Amsterdam II (AMSII) criteria and/or the Bethesda guidelines or suggestive of a dominant colorectal (CRC) inheritance syndrome.
Results: We performed a thorough investigation of 15 countries and identified 6 countries where germline genetic testing for LS is available and 3 countries where tumor testing is used in the LS diagnosis. The spectrum of pathogenic MMR variants included MLH1 up to 54%, MSH2 up to 43%, MSH6 up to 10%, PMS2 up to 3% and EPCAM up to 0.8%. The Latin America MMR spectrum is broad with a total of 220 different variants which 80% were private and 20% were recurrent. Frequent regions included exons 11 of MLH1 (15%), exon 3 and 7 of MSH2 (17 and 15%, respectively), exon 4 of MSH6 (65%), exons 11 and 13 of PMS2 (31% and 23%, respectively). Sixteen international founder variants in MLH1, MSH2 and MSH6 were identified and 41 (19%) variants have not previously been reported, thus representing novel genetic variants in the MMR genes. The AMSII criteria was the most used clinical criteria to identify pathogenic MMR carriers although microsatellite instability, immunohistochemistry and family history are still the primary methods in several countries where no genetic testing for LS is available yet.
Conclusion: The Latin America LS pathogenic MMR variants spectrum included new variants, frequently altered genetic regions and potential founder effects, emphasizing the relevance implementing Lynch syndrome genetic testing and counseling in all of Latin America countries.Radium Hospital Foundation (Oslo, Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, Helse Sør-Øst (Norway) in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript, the French Association Recherche contre le Cancer (ARC) in the analysis, and interpretation of data, the Groupement des Entreprises Françaises dans la Lutte contre le Cancer (Gefluc) in the analysis, and interpretation of data, the Association Nationale de la Recherche et de la Technologie (ANRT, CIFRE PhD fellowship to H.T.) in the analysis, and interpretation of data and by the OpenHealth Institute in the analysis, and interpretation of data. Barretos Cancer Hospital received financial support by FINEP-CT-INFRA (02/2010)info:eu-repo/semantics/publishedVersio
A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area
- Author
- Amaral Renara Nichio
- Amorim Andre Marcio Araujo
- Antar Guilherme de Medeiros
- Antunes Kelly
- Araújo Anderson Geyson Alves de
- Barbosa Daniel Elias Ferreira
- Baumgratz Jose Fernando A.
- Bueno Vinícius Resende
- Cardoso Pedro Henrique
- Carrijo Tatiana Tavares
- Chagas Aline Pitol
- Cosenza Braz Antonio Pereira
- Couto Dayvid Rodrigues
- Dalcin Eduardo Couto
- Delgado Camila Nardy
- Depiantti Gabriel da Cruz
- Dias Henrique Machado
- Dittrich Vinicius Antônio de Oliveira
- Dutra Valquíria F.
- Evangelista Paulo Henrique Labiak
- Feletti Thamara Arão
- Ferreira Daniele Monteiro
- Firmino Aline Delon
- Forzza Rafaela Campostrini
- Freitas Joelcio
- Freitas Leandro
- Furtado Samyra Gomes
- Garbin Mário Luis
- Giacomin Leandro Lacerda
- Goldenberg Renato
- Gomes Mario
- Gonzaga Diego Rafael
- Heiden Gustavo
- Lanna João
- Lirio Elton John de
- Lopes Claudia Rabelo
- Lopes Isabel Tamires de França Viana
- Luber Jaquelini
- Marques Danilo
- Matos Fernando Bittencourt de
- Meireles Leonardo D
- Menini Neto Luiz
- Meyer Fabrício Schmitz
- Monge Marcelo
- Moraes Pedro Luís Rodrigues de
- Moraes Quélita dos Santos
- Moreira Marina Muniz
- Morim Marli Pires
- Nakajima Jimi Naoki
- Oliveira Felipe Alves de
- Oliveira Juliana R. P. M.
- Oliveira Marcelo Trovó Lopes de
- Pederneiras Leandro Cardoso
- Peixoto Ariane Luna
- Pereira Jovani Bernardino de Souza
- Pereira Luciana C.
- Prado Jefferson
- Rapini Alessandro
- Reginato Marcelo
- Rollim Isis de Mello
- Salimena Fátima Regina Gonçalves
- Salino Alexandre
- Schwartsburd Pedro Bond
- Silva Andrews Vinicius
- Silva Christian da
- Silva Leonardo Nogueira da
- Silva Luís Alexandre Estevão da
- Soares Bethina Stein
- Soares Nayara D.
- Sobral Marcos
- Sousa Hian Carlos Ferreira de
- Souza Filipe Soares
- Sylvestre Lana da Silva
- Tuler Amélia Carlos
- Versiane Ana Flávia Alves
- Viana Pedro Lage
- Zorzanelli João Paulo Fernandes
- Zorzanelli Raquel Fernandes
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of “Parque Nacional do Caparaó” (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states
Drug-induced anaphylaxis, elicitors, risk factors, and management in Latin America
- Author
- Alcaraz Duarte Perla
- Arias Cruz Alfredo
- Bernstein Jonathan A.
- Calderón Juan Carlos
- Canamar David Eugenio Roman
- Castillo Antonio J.
- Cherrez Ojeda Iván
- Cuello Mabel Noemi
- De Barayazarra Susana
- D’Onofrio Silva Ana Carolina
- Ensina Luis Felipe
- Falco Alicia de
- Fernandoz Ramíre Zuluaga Luis
- Giavina Bianchi Pedro
- González Díaz Sandra Nora
- Guerzet Ayres Bastos Patricia
- Gómez Maximiliano
- Jaller Rodolfo
- Jares Edgardo
- Juan Pineda Ángeles
- Macías Weinmann Alejandra
- Mancilla Ávila Octavio
- Monge Patricia
- Monsell Silvana
- Monteiro Luciane
- Morelo Rocha Felix Mara
- Morfín Maciel Blanca
- Piraino Pedro
- Rangel Gonzalez Diana María
- Santoyo Grandados Illian
- Serrano Reyes Carlos
- Serrano Roberto Gustavo
- Solé Dirceu
- Sánchez Borges Mario
- Villa Ricardo Cardona
- Vinuesa Miguel
- Weisz Adriana
- Zanacchi Viviana Andrea
- Publication venue
- Publication date
- 15/11/2021
- Field of study
Nonsteroidal anti-inflammatory drugs were the most frequent triggers of drug-induced anaphylaxis in Latín America, whereas antibiotics elicited faster onset and more scvere reactions. An improvement was observed in epinephrinc use and adherence to guidelines in the emergency department treatment of anaphylaxis in Latín America compared with our last report.Facultad de Ciencias Médica
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bożena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Boren Samuel
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Burns Douglas
- Burns Dustin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Buttignol Michael
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calpas Betty
- Calvelli Valerio
- Calvert Brian
- Calvo Enrique
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Caputo Claudio
- Carlin Roberto
- Carnes Andrew
- Carpinteyro Severiano
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castiñeiras De Saa Juan Ramon
- Castle James
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Celik Ali
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadeeva Marina
- Chamizo Llatas Maria
- Chang Paoti
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Chen Geng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Ye
- Chen Yi
- Chen Zhenyu
- Chenarani Shirin
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiorboli Massimiliano
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Minkyoo
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chtchipounov Leonid
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Cieri Davide
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cipriani Marco
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clarke Christopher
- Clement Emyr
- Clerbaux Barbara
- Cockerill David JA
- Cocoros Alice
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Connor Patrick
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooperstein Stephane
- Cornelis Tom
- Corpe Louie
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costanza Francesco
- Coubez Xavier
- Couderc Fabrice
- Coughlan John A
- Courbon Benoit
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremonesi Matteo
- Cristella Leonardo
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Curras Esteban
- Curry David
- Cussans David
- Custódio Analu
- Cutts David
- Czellar Sandor
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- D'imperio Giulia
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damarseckin Serdal
- Damgov Jordan
- Danilov Mikhail
- Daponte Vincenzo
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- Davignon Olivier
- de Barbaro Pawel
- De Boer Wim
- De Bruyn Isabelle
- De Castro Manzano Pablo
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Nardo Guglielmo
- De Oliveira Martins Carley
- De Palma Mauro
- De Remigis Paolo
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wit Adinda
- De Wolf Eddi A
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delannoy Hugo
- Delcourt Martin
- Delgado Peris Antonio
- Delgado Andrea
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
- Demiroglu Zuhal Seyma
- Denegri Daniel
- Depasse Pierre
- Derdzinski Mark
- Dermenev Alexander
- Deroover Kevin
- Dev Nabarun
- Devetak Damir
- Dewanjee Ram Krishna
- Dey Sourav
- Di Francesco Agostino
- Di Guida Salvatore
- Di Marco Emanuele
- Di Maria Riccardo
- Di Matteo Leonardo
- Di Mattia Alessandro
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dini Paolo
- Dishaw Adam
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Dittmer Susan
- Doan Thi Hien
- Dobson Marc
- Dobur Didar
- Dodd Laura
- Dogra Sunil
- Dolen James
- Dolinska Ganna
- Dominguez Aaron
- Donato Silvio
- Donegà Mauro
- Dordevic Milos
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dosselli Umberto
- Dozen Candan
- Draeger Arne-Rasmus
- Dragicevic Marko
- Dragoiu Cosmin
- Dremin Igor
- Dreyer Torben
- Driga Olga
- Du Pree Tristan
- Duarte Javier
- Dube Sourabh
- Dubinin Mikhail
- Duchardt Deborah
- Dudenas Vytautas
- Dudero Phillip Russell
- Dudko Lev
- Dugad Shashikant
- Duggan Daniel
- Duh Yi-ting
- Dumanoglu Isa
- Dunne Patrick
- Dupont Niels
- Durgut Süleyman
- Duric Senka
- Durkin Lloyd Stanley
- Dutt Suneel
- Dutta Dipanwita
- Dutta Suchandra
- Dutta Valentina
- Dünser Marc
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Eerola Paula
- El Mamouni Houmani
- Elliott-Peisert Anna
- Ellison John Anthony
- Ellithi Kamel Ali
- Elmer Peter
- Elumakhov Dmitry
- Elvira Victor Daniel
- Elwood Adam
- Eminizer Nicholas
- Endres Matthias
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
- Erdmann Martin
- Erdmann Wolfram
- Erdweg Sören
- Eren Engin
- Ershov Alexander
- Erö Janos
- Escalante Del Valle Alberto
- Esch Thomas
- Eskandari Tadavani Esmaeel
- Esposito Marco
- Etesami Seyed Mohsen
- Eusebi Ricardo
- Evangelou Ioannis
- Evans Andrew
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- Yetkin Taylan
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- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
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- You Can
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- Yusli Mohd Nizam
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- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Sunan Kalijaga State Islamic University
- Publication date
- 01/01/2012
- Field of study
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
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- Bean Alice
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- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnamian Hadi
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- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Bellato Marco
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
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- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
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- Bose Tulika
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- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
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- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
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- Brom Jean-Marie
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- Brown Robert M
- Brun Hugues
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- Bylsma Ben
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- Castiñeiras De Saa Juan Ramon
- Castle James
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Celik Ali
- Cenna Francesca
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadeeva Marina
- Chamizo Llatas Maria
- Chang Paoti
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- Chao Yuan
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- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Chen Geng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
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- Chen Ye
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- Chen Zhenyu
- Chenarani Shirin
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
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- Chierici Roberto
- Chinellato Jose
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- Chlebana Frank
- Cho Sungwoong
- Choi Minkyoo
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chtchipounov Leonid
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
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- Ciulli Vitaliano
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- Claes Daniel R
- Clare Robert
- Clarida Warren
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- Clement Emyr
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- Cocoros Alice
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- Cooperstein Stephane
- Cornelis Tom
- Corpe Louie
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- Tonelli Manganote Edmilson José
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- Vorobyev Alexey
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- Wagner-Kuhr Jeannine
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- Wang Chunjie
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- Wang Hui
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- Wang Jing
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- Wang Quan
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- Wang Sean-Jiun
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- Wang Zhixing
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- Wayand Stefan
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- Weiler Thomas
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- Wetzel James
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- Wickramage Nadeesha
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- Williams Thomas
- Williamson Shawn
- Wimpenny Stephen
- Winer Brian L
- Winn Dave
- Wissing Christoph
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- Wright Jack
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- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Wöhrmann Clemens
- Würthwein Frank
- Xia Fan
- Xiao Meng
- Xie Si
- Xie Wei
- Xin Yongjie
- Xu Lingshan
- Xu Qiao
- Xu Zijun
- Yagil Avraham
- Yalvac Metin
- Yang Mingming
- Yang Unki
- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Search for anomalous couplings in boosted WW/WZ -> l nu q(q)over-bar production in proton-proton collisions at root s=8TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akbiyik Melike
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amin Nick
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arndt Till
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Ather Mohsan Waseem
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Aushev Tagir
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baur Sebastian
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bożena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bondu Olivier
- Boos Edouard
- Boren Samuel
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Bravo Cameron
- Breedon Richard
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brito Lucas
- Brivio Francesco
- Brochero Cifuentes Javier Andres
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- Publication venue
- Publication date
- 01/01/2017
- Field of study
Peer reviewe
Familial Breast Cancer in Costa Rica: An Initial Approach
- Publication venue
- Vicerractoría Investigación
- Publication date
- 01/09/2004
- Field of study
Cancer is a worldwide problem because of its high rates of incidence and associated mortality. By 2000, more than 6.2 million people died from this illness worldwide. Among all types of cancer, breast cancer is one of the most studied. Each year, one million new cases are diagnosed around the world. We can classify breast cancer into two main kinds: sporadic cases and those which are a product of inherited genetic alterations. Approximately 5-10% of breast cancer cases are the result of inherited mutations, or alterations in breast cancer susceptibility genes, BRCA1 and BRCA2. Like other countries, Costa Rica possesses high rates of incidence and mortality for breast cancer. According to the "Registro Nacional de Tumores" (National Office of Tumor Records), in 2000 breast cancer had the highest rate of incidence and in 2002 it had the highest rate of mortality in comparison to other types of cancer. For this reason and the generalized lack of knowledge in the field we conducted an epidemiological research on breast cancer patients from Hospital San Juan de Dios, San José, Costa Rica, to find families with a history of breast cancer, and to determine the occurrence of familial cases within the population studied. So far, we have found 23 families, within which we discovered very informative cases that have rendered the identification of a pattern of inheritance. These findings allow us to announce that in Costa Rica there are several cases of inherited breast cancer and that we need more research is needed to improve the prevention, control, and treatment of this disease. Rev. Biol. Trop. 52(3): 531-536. Epub 2004 Dic 15.El cáncer es un problema a nivel mundial porque posee altas tasas de incidencia y mortalidad. Para el año 2000 más de 6.2 millones de personas murieron a causa de esta enfermedad. El cáncer de mama es uno de los tipos de cáncer más estudiados en el mundo por las mismas razones. Cada año, se diagnostican más de un millón de casos nuevos de cáncer de mama alrededor del mundo. Podemos clasificar al cáncer de mama en dos tipos principales: los casos esporádicos y los que son producto de alteraciones genéticas heredables. De todos los casos que son diagnosticados en la población, aproximadamente de un 5 a un 10 % son resultado de mutaciones heredadas o alteraciones en los genes de susceptibilidad BRCA1 y BRCA2. Como en otros países, Costa Rica posee altas tasas de incidencia y mortalidad para el cáncer de mama. Según el Registro Nacional de Tumores para el año 2000 el cáncer de mama tuvo la tasa de incidencia más alta y para el 2002 alcanzó la tasa de mortalidad más alta en comparación con otros tipos de cáncer. Por esta razón y por la falta de conocimiento existente decidimos realizar un estudio epidemiológico de los pacientes con cáncer de mama del Hospital San Juan de Dios para encontrar familias con un historial de cáncer de mama y determinar la existencia de casos de cáncer de mama familiares en esta población. Hemos encontrado 23 familias dentro de las cuales hayamos casos informativos que nos han permitido identificar un patrón de herencia. Estos hallazgos nos permiten afirmar que en Costa Rica se dan casos de cáncer de mama heredados y que necesitamos más investigación para mejorar el tratamiento de los pacientes que sufren de cáncer de mama
Familial Breast Cancer in Costa Rica: An Initial Approach
- Publication venue
- 'Universidad de Costa Rica'
- Publication date
- 03/05/2016
- Field of study
Cancer is a worldwide problem because of its high rates of incidence and associated mortality. By 2000, more than 6.2 million people died from this illness worldwide. Among all types of cancer, breast cancer is one of the most studied. Each year, one million new cases are diagnosed around the world. We can classify breast cancer into two main kinds: sporadic cases and those which are a product of inherited genetic alterations. Approximately 5-10% of breast cancer cases are the result of inherited mutations, or alterations in breast cancer susceptibility genes, BRCA1 and BRCA2. Like other countries, Costa Rica possesses high rates of incidence and mortality for breast cancer. According to the “Registro Nacional de Tumores” (National Office of Tumor Records), in 2000 breast cancer had the highest rate of incidence and in 2002 it had the highest rate of mortality in comparison to other types of cancer. For this reason and the generalized lack of knowledge in the field we conducted an epidemiological research on breast cancer patients from Hospital San Juan de Dios, San José, Costa Rica, to find families with a history of breast cancer, and to determine the occurrence of familial cases within the population studied. So far, we have found 23 families, within which we discovered very informative cases that have rendered the identification of a pattern of inheritance. These findings allow us to announce that in Costa Rica there are several cases of inherited breast cancer and that we need more research is needed to improve the prevention, control, and treatment of this disease.El cáncer es un problema a nivel mundial porque posee altas tasas de incidencia y mortalidad. Para el año 2000 más de 6.2 millones de personas murieron a causa de esta enfermedad. El cáncer de mama es uno de los tipos de cáncer más estudiados en el mundo por las mismas razones. Cada año, se diagnostican más de un millón de casos nuevos de cáncer de mama alrededor del mundo. Podemos clasificar al cáncer de mama en dos tipos principales: los casos esporádicos y los que son producto de alteraciones genéticas heredables. De todos los casos que son diagnosticados en la población, aproximadamente de un 5 a un 10 % son resultado de mutaciones heredadas o alteraciones en los genes de susceptibilidad BRCA1 y BRCA2. Como en otros países, Costa Rica posee altas tasas de incidencia y mortalidad para el cáncer de mama. Según el Registro Nacional de Tumores para el año 2000 el cáncer de mama tuvo la tasa de incidencia más alta y para el 2002 alcanzó la tasa de mortalidad más alta en comparación con otros tipos de cáncer. Por esta razón y por la falta de conocimiento existente decidimos realizar un estudio epidemiológico de los pacientes con cáncer de mama del Hospital San Juan de Dios para encontrar familias con un historial de cáncer de mama y determinar la existencia de casos de cáncer de mama familiares en esta población. Hemos encontrado 23 familias dentro de las cuales hayamos casos informativos que nos han permitido identificar un patrón de herencia. Estos hallazgos nos permiten afirmar que en Costa Rica se dan casos de cáncer de mama heredados y que necesitamos más investigación para mejorar el tratamiento de los pacientes que sufren de cáncer de mama
Expression Profiling of Virulence and Pathogenicity Genes of Xanthomonas axonopodis pv. citri
- Author
- Publication venue
- American Society for Microbiology
- Publication date
- 01/02/2005
- Field of study
DNA macroarrays of 279 genes of Xanthomonas axonopodis pv. citri potentially associated with pathogenicity and virulence were used to compare the transcriptional alterations of this bacterium in response to two synthetic media. Data analysis indicated that 31 genes were up-regulated by synthetic medium XVM2, while only 7 genes were repressed. The results suggest that XVM2 could be used as an in vitro system to identify candidate genes involved in pathogenesis of X. axonopodis pv. citri
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