233 research outputs found
First Progress Report of the Highway Bridge Impact Investigation
Division of Highways, State of IllinoisBureau of Public Roads, U.S. Department of Commerc
Fundamental constants and tests of general relativity - Theoretical and cosmological considerations
The tests of the constancy of the fundamental constants are tests of the
local position invariance and thus of the equivalence principle. We summarize
the various constraints that have been obtained and then describe the
connection between varying constants and extensions of general relativity. To
finish, we discuss the link with cosmology, and more particularly with the
acceleration of the Universe. We take the opportunity to summarize various
possibilities to test general relativity (but also the Copernican principle) on
cosmological scales.Comment: Proceedings of the workshop ``The nature of gravity, confronting
theory and experiment in space'', ISSI, Bern, october 200
Search for the Proton Decay Mode proton to neutrino K+ in Soudan 2
We have searched for the proton decay mode proton to neutrino K+ using the
one-kiloton Soudan 2 high resolution calorimeter. Contained events obtained
from a 3.56 kiloton-year fiducial exposure through June 1997 are examined for
occurrence of a visible K+ track which decays at rest into mu+ nu or pi+ pi0.
We found one candidate event consistent with background, yielding a limit,
tau/B > 4.3 10^{31} years at 90% CL with no background subtraction.Comment: 13 pages, Latex, 3 tables and 3 figures, Accepted by Physics Letters
Facts, Values and Quanta
Quantum mechanics is a fundamentally probabilistic theory (at least so far as
the empirical predictions are concerned). It follows that, if one wants to
properly understand quantum mechanics, it is essential to clearly understand
the meaning of probability statements. The interpretation of probability has
excited nearly as much philosophical controversy as the interpretation of
quantum mechanics. 20th century physicists have mostly adopted a frequentist
conception. In this paper it is argued that we ought, instead, to adopt a
logical or Bayesian conception. The paper includes a comparison of the orthodox
and Bayesian theories of statistical inference. It concludes with a few remarks
concerning the implications for the concept of physical reality.Comment: 30 pages, AMS Late
Menus for Feeding Black Holes
Black holes are the ultimate prisons of the Universe, regions of spacetime
where the enormous gravity prohibits matter or even light to escape to
infinity. Yet, matter falling toward the black holes may shine spectacularly,
generating the strongest source of radiation. These sources provide us with
astrophysical laboratories of extreme physical conditions that cannot be
realized on Earth. This chapter offers a review of the basic menus for feeding
matter onto black holes and discusses their observational implications.Comment: 27 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk
Search for dark matter produced in association with a hadronically decaying vector boson in pp collisions at sqrt (s) = 13 TeV with the ATLAS detector
A search is presented for dark matter produced in association with a hadronically decaying W or Z boson using 3.2 fb−1 of pp collisions at View the MathML sources=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with a hadronic jet compatible with a W or Z boson and with large missing transverse momentum are analysed. The data are consistent with the Standard Model predictions and are interpreted in terms of both an effective field theory and a simplified model containing dark matter
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