Galactic Archaeology and Minimum Spanning Trees

Chemical tagging of stellar debris from disrupted open clusters and associations underpins the science cases for next-generation multi-object spectroscopic surveys. As part of the Galactic Archaeology project TraCD (Tracking Cluster Debris), a preliminary attempt at reconstructing the birth clouds of now phase-mixed thin disk debris is undertaken using a parametric minimum spanning tree (MST) approach. Empirically-motivated chemical abundance pattern uncertainties (for a 10-dimensional chemistry-space) are applied to NBODY6-realised stellar associations dissolved into a background sea of field stars, all evolving in a Milky Way potential. We demonstrate that significant population reconstruction degeneracies appear when the abundance uncertainties approach 0.1 dex and the parameterised MST approach is employed; more sophisticated methodologies will be required to ameliorate these degeneracies

Simple and accurate modelling of the gravitational potential produced by thick and thin exponential discs

We present accurate models of the gravitational potential produced by a radially exponential disc mass distribution. The models are produced by combining three separate Miyamoto–Nagai discs. Such models have been used previously to model the disc of the Milky Way, but here we extend this framework to allow its application to discs of any mass, scalelength, and a wide range of thickness from infinitely thin to near spherical (ellipticities from 0 to 0.9). The models have the advantage of simplicity of implementation, and we expect faster run speeds over a double exponential disc treatment. The potentials are fully analytical, and differentiable at all points. The mass distribution of our models deviates from the radial mass distribution of a pure exponential disc by <0.4 per cent out to 4 disc scalelengths, and <1.9 per cent out to 10 disc scalelengths. We tabulate fitting parameters which facilitate construction of exponential discs for any scalelength, and a wide range of disc thickness (a user-friendly, web-based interface is also available). Our recipe is well suited for numerical modelling of the tidal effects of a giant disc galaxy on star clusters or dwarf galaxies. We consider three worked examples; the Milky Way thin and thick disc, and a discy dwarf galaxy

An H I Survey of Six Local Group Analogs. II. H I Properties of Group Galaxies

We have conducted an H I 21cm emission-line survey of six loose groups of galaxies chosen to be analogs to the Local Group. The survey was conducted using the Parkes multibeam instrument and the Australia Telescope Compact Array (ATCA) over a 1Mpc2 area and covering the full depth of each group, with an MH I sensitivity of 7 × 105 M. Our survey detected 110sources, 61 of which are associated with the six groups. All of these sources were confirmed with ATCA observations or were previously cataloged by HIPASS. The sources all have optical counterparts and properties consistent with dwarf irregular or late-type spiral galaxies. We present here the H I properties of the groups and their galaxies. We derive an H I mass function (HIMF) for the groups that is consistent with being flatter than the equivalent field HIMF. We also derive a circular velocity distribution function, tracing the luminous dark matter halos in the groups, that is consistent with those of the Local Group and HIPASS galaxies, both of which are shallower than that of clusters or predictions from cold dark matter models of galaxy formation

A search for new members of the βPictoris, Tucana-Horologium and ɛCha moving groups in the RAVE data base

We report on the discovery of new members of nearby young moving groups, exploiting the full power of combining the Radial Velocity Experiment (RAVE) survey with several stellar age diagnostic methods and follow-up high-resolution optical spectroscopy. The results include the identification of one new and five likely members of the βPictoris moving group, ranging from spectral types F9 to M4 with the majority being M dwarfs, one K7 likely member of the εCha group and two stars in the Tucana-Horologium association. Based on the positive identifications, we foreshadow a great potential of the RAVE data base in progressing towards a full census of young moving groups in the solar neighbourhood

Single-lined Spectroscopic Binary Star Candidates from a Combination of the RAVE and Gaia DR2 Surveys

The combination of the final version of the Radial Velocity Experiment (RAVE) spectroscopic survey data release 6 with radial velocities (RVs) and astrometry from Gaia DR2 allows us to identify and create a catalog of single-lined binary star candidates (SB1), their inferred orbital parameters, and to inspect possible double-lined binary stars (SB2). A probability function for the detection of RV variations is used for identifying SB1 candidates. The estimation of orbital parameters for main-sequence dwarfs is performed by matching the measured RVs with theoretical velocity curves sampling the orbital parameter space. The method is verified by studying a mock sample from the SB 9 catalog. Studying the boxiness and asymmetry of the spectral lines allows us to identify possible SB2 candidates, while matching their spectra to a synthetic library indicates probable properties of their components. From the RAVE catalog we select 37,664 stars with multiple RV measurements and identify 3838 stars as SB1 candidates. Joining Rave and Gaia DR2 yields 450,646 stars with RVs measured by both surveys and 27,716 of them turn out to be SB1 candidates, which is an increase by an order of magnitude over previous studies. For main-sequence dwarf candidates we calculate their most probable orbital parameters: orbital periods are not longer than a few years and primary components have masses similar to the solar mass. All our results are available in the electronic version

Single-lined Spectroscopic Binary Star Candidates from a Combination of the RAVE and Gaia DR2 Surveys

The combination of the final version of the Radial Velocity Experiment (RAVE) spectroscopic survey data release 6 with radial velocities (RVs) and astrometry from Gaia DR2 allows us to identify and create a catalog of single-lined binary star candidates (SB1), their inferred orbital parameters, and to inspect possible double-lined binary stars (SB2). A probability function for the detection of RV variations is used for identifying SB1 candidates. The estimation of orbital parameters for main-sequence dwarfs is performed by matching the measured RVs with theoretical velocity curves sampling the orbital parameter space. The method is verified by studying a mock sample from the SB 9 catalog. Studying the boxiness and asymmetry of the spectral lines allows us to identify possible SB2 candidates, while matching their spectra to a synthetic library indicates probable properties of their components. From the RAVE catalog we select 37,664 stars with multiple RV measurements and identify 3838 stars as SB1 candidates. Joining Rave and Gaia DR2 yields 450,646 stars with RVs measured by both surveys and 27,716 of them turn out to be SB1 candidates, which is an increase by an order of magnitude over previous studies. For main-sequence dwarf candidates we calculate their most probable orbital parameters: orbital periods are not longer than a few years and primary components have masses similar to the solar mass. All our results are available in the electronic version.Funding for RAVE has been provided by: the Leibniz-Institut für Astrophysik Potsdam (AIP); the Australian Astronomical Observatory; the Australian National University; the Australian Research Council; the French National Research Agency; the German Research Foundation (SPP 1177 and SFB 881); the European Research Council (ERC-StG 240271 Galactica); the Istituto Nazionale di Astrofisica at Padova; The Johns Hopkins University; the National Science Foundation of the USA (AST-0908326); the W. M. Keck foundation; the Macquarie University; the Netherlands Research School for Astronomy; the Natural Sciences and Engineering Research Council of Canada; the Slovenian Research Agency (core funding No. P1-0188); the Swiss National Science Foundation; the Science & Technology Facilities Council of the UK; Opticon; Strasbourg Observatory; and the Universities of Basel, Groningen, Heidelberg and Sydney. T.Z. thanks the Research School of Astronomy & Astrophysics in Canberra for support through a Distinguished Visitor Fellowship

Monkey Steering Responses Reveal Rapid Visual-Motor Feedback

The neural mechanisms underlying primate locomotion are largely unknown. While behavioral and theoretical work has provided a number of ideas of how navigation is controlled, progress will require direct physiolgical tests of the underlying mechanisms. In turn, this will require development of appropriate animal models. We trained three monkeys to track a moving visual target in a simple virtual environment, using a joystick to control their direction. The monkeys learned to quickly and accurately turn to the target, and their steering behavior was quite stereotyped and reliable. Monkeys typically responded to abrupt steps of target direction with a biphasic steering movement, exhibiting modest but transient overshoot. Response latencies averaged approximately 300 ms, and monkeys were typically back on target after about 1 s. We also exploited the variability of responses about the mean to explore the time-course of correlation between target direction and steering response. This analysis revealed a broad peak of correlation spanning approximately 400 ms in the recent past, during which steering errors provoke a compensatory response. This suggests a continuous, visual-motor loop controls steering behavior, even during the epoch surrounding transient inputs. Many results from the human literature also suggest that steering is controlled by such a closed loop. The similarity of our results to those in humans suggests the monkey is a very good animal model for human visually guided steering

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements