1,077 research outputs found
Dendritic cell density and activation status in human breast cancer â CD1a, CMRF-44, CMRF-56 and CD-83 expression
- Author
- A Troy
- AD McLellan
- AD McLellan
- AJ Troy
- AJ Troy
- AM Neville
- B J Coventry
- BD Hock
- BD Hock
- BJ Coventry
- BJ Coventry
- BJ Coventry
- BJ Coventry
- BJ Coventry
- C Esche
- CN Baxevanis
- D Bell
- D Gabrilovich
- D Gibbs
- D N J Hart
- DI Gabrilovich
- DI Gabrilovich
- DN Hart
- DN Hart
- EE Hillenbrand
- EE Hillenbrand
- F Garrido
- G Pirtskhalaishvili
- I Algarra
- K Ambe
- K Steinbrink
- K Steinbrink
- LJ Zhou
- NA Zeid
- P Hersey
- P-L Lee
- PI Haigh
- R Soiffer
- R Thomas
- S Schroder
- S Tsujitani
- S Tsujitani
- S Tsujitani
- S Tsujitani
- S Vendetti
- S Vuckovic
- SM Kiertscher
- T De Smedt
- U Grohmann
- XD Zhang
- Y Becker
- Publication venue
- Nature Publishing Group
- Publication date
- 01/01/2002
- Field of study
Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent âpoor immunogenicityâ previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient. We have therefore examined CD1a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers. The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade
Molecular diversity of anthracnose pathogen populations associated with UK strawberry production suggests multiple introductions of three different Colletotrichum species.
- Author
- AG Buddie
- Antonio Zapparata
- AR Ureña-Padilla
- B Denoyes-Rothan
- B Denoyes-Rothan
- BC Sutton
- BJ Smith
- BS Weir
- C Garrido
- Charles R. Lane
- CM Howard
- CM Howard
- D Jones
- DW Simpson
- EJ Calleja
- Eric Holub
- F Ronquist
- Giovanni Vannacci
- JC Guerber
- JL Maas
- K Tamura
- M Kearse
- MA Whitelaw-Weckert
- Mark Gijzen
- MG Beech
- Michael R. Thon
- MZ Du
- NA Peres
- P Talhinhas
- PV MartĂnez-Culebras
- R Baroncelli
- R Baroncelli
- R Baroncelli
- R Baroncelli
- R Sepp
- Riccardo Baroncelli
- RJ Mason-Gamer
- RJ O'Connell
- S Freeman
- S Freeman
- S Sreenivasaprasad
- S Sreenivasaprasad
- Sabrina Sarrocco
- Serenella A. Sukno
- Surapareddy Sreenivasaprasad
- U Damm
- W Van Hemelrijck
- ZJ Jelev
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Fragaria Ă ananassa (common name: strawberry) is a globally cultivated hybrid species belonging to Rosaceae family. Colletotrichum acutatum sensu lato (s.l.) is considered to be the second most economically important pathogen worldwide affecting strawberries. A collection of 148 Colletotrichum spp. isolates including 67 C. acutatum s.l. isolates associated with the phytosanitary history of UK strawberry production were used to characterize multi-locus genetic variation of this pathogen in the UK, relative to additional reference isolates that represent a worldwide sampling of the diversity of the fungus. The evidence indicates that three different species C. nymphaeae, C. godetiae and C. fioriniae are associated with strawberry production in the UK, which correspond to previously designated genetic groups A2, A4 and A3, respectively. Among these species, 12 distinct haplotypes were identified suggesting multiple introductions into the country. A subset of isolates was also used to compare aggressiveness in causing disease on strawberry plants and fruits. Isolates belonging to C. nymphaeae, C. godetiae and C. fioriniae representative of the UK anthracnose pathogen populations showed variation in their aggressiveness. Among the three species, C. nymphaeae and C. fioriniae appeared to be more aggressive compared to C. godetiae. This study highlights the genetic and pathogenic heterogeneity of the C. acutatum s.l. populations introduced into the UK linked to strawberry production
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer
- Author
- A H Allam
- A Neesse
- A Neesse
- A V Biankin
- A Xue
- AB Seymour
- AD Rhim
- AK Witkiewicz
- AM LeBeau
- AR Shekouh
- AV Biankin
- B Hinz
- BC Ozdemir
- BJ Cochran
- BJ Cochran
- C Gaggioli
- C Vennin
- D Croucher
- D Goldstein
- D Herrmann
- D Herrmann
- D Mahadevan
- D N Saunders
- D Telgenhoff
- DD Von Hoff
- DR Croucher
- DR Croucher
- E Cerami
- F Al-Ejeh
- G Finak
- H Shiomi
- HW Smith
- I Garrido-Laguna
- J Condeelis
- J Gao
- J Gore
- J Lee
- J Li
- J P Morton
- J R W Conway
- JA Lee
- JJ Lee
- JP Morton
- K Kessenbrock
- K L Vine
- L Harris
- M C Lucas
- M J Cowley
- M Nobis
- M Pajic
- M Pinese
- M Ranson
- MJ Duffy
- ML Nyström
- N L E Harris
- N Waddell
- P Bailey
- P Carmeliet
- P Timpson
- P Timpson
- R Cicchi
- R F Shearer
- R Kalluri
- R Smith
- RF Shearer
- RG Rowe
- RL Siegel
- S Nurmenniemi
- S Ulisse
- SC Barry
- SR Hingorani
- SR Hingorani
- TK Stutchbury
- WA Schroder
- Y Takeuchi
- ZS Boyd
- Ă Babur
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/03/2017
- Field of study
Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity. SerpinB2 expression, particularly in the stromal compartment, is associated with reduced metastasis and prolonged survival in pancreatic ductal adenocarcinoma (PDAC) and our genomic analysis revealed that SERPINB2 is frequently deleted in PDAC. We show that SerpinB2 is required by stromal cells for normal collagen remodelling in vitro, regulating fibroblast interaction and engagement with collagen in the contracting matrix. In a pancreatic cancer allograft model, co-injection of PDAC cancer cells and SerpinB2(-/-) mouse embryonic fibroblasts (MEFs) resulted in increased tumour growth, aberrant remodelling of the extracellular matrix (ECM) and increased local invasion from the primary tumour. These tumours also displayed elevated proteolytic activity of the primary biochemical target of SerpinB2-urokinase plasminogen activator (uPA). In a large cohort of patients with resected PDAC, we show that increasing uPA mRNA expression was significantly associated with poorer survival following pancreatectomy. This study establishes a novel role for SerpinB2 in the stromal compartment in PDAC invasion through regulation of stromal remodelling and highlights the SerpinB2/uPA axis for further investigation as a potential therapeutic target in pancreatic cancer
TRY plant trait database - enhanced coverage and open access
- Author
- Aakala T
- Abedi M
- Acosta ATR
- Adamidis GC
- Adamson K
- Aiba M
- Albert CH
- Alcantara JM
- Alcazar CC
- Aleixo I
- Ali H
- Amiaud B
- Ammer C
- Amoroso MM
- Anand M
- Anderson C
- Anh TDL
- Anten N
- Antos J
- Apgaua DMG
- Ashman TL
- Asmara DH
- Asner GP
- Aspinwall M
- Atkin O
- Aubin I
- Baastrup-Spohr L
- Bahalkeh K
- Bahn M
- Baker T
- Baker WJ
- Bakker JP
- Baldocchi D
- Baltzer J
- Banerjee A
- Baranger A
- Barlow J
- Barneche DR
- Baruch Z
- Bastianelli D
- Battles J
- Bauerle W
- Bauters M
- Bazzato E
- Beckmann M
- Beeckman H
- Beierkuhnlein C
- Bekker R
- Belfry G
- Belluau M
- Beloiu M
- Benavides R
- Benomar L
- Berdugo-Lattke ML
- Berenguer E
- Bergamin R
- Bergmann J
- Berner L
- Bernhardt-Romermann M
- Bigler C
- Bjorkman AD
- Blackman C
- Blanco C
- Blonder B
- Blumenthal D
- Bocanegra-Gonzalez KT
- Boeckx P
- Bohlman S
- Bohning-Gaese K
- Boisvert-Marsh L
- Bond W
- Bond-Lamberty B
- Bonisch G
- Boom A
- Boonman CCF
- Bordin K
- Boughton EH
- Boukili V
- Bowman DMJS
- Bravo S
- Brendel MR
- Broadley MR
- Brown KA
- Bruelheide H
- Brumnich F
- Bruun HH
- Bruy D
- Buchanan SW
- Bucher SF
- Buchmann N
- Buitenwerf R
- Bunker DE
- Burger J
- Burrascano S
- Burslem DFRP
- Butterfield BJ
- Byun C
- Caccianiga M
- Cadotte M
- Cailleret M
- Camac J
- Camarero JJ
- Campany C
- Campetella G
- Campos JA
- Cano-Arboleda L
- Canullo R
- Carbognani M
- Carlucci MB
- Carvalho F
- Casanoves F
- Castagneyrol B
- Catford JA
- Cavender-Bares J
- Cerabolini BEL
- Cervellini M
- Chacon-Madrigal E
- Chapin FS
- Chapin K
- Chelli S
- Chen AP
- Chen SC
- Cherubini P
- Chianucci F
- Choat B
- Chung KS
- Chytry M
- Ciccarelli D
- Coll L
- Collins CG
- Conti L
- Coomes D
- Cornelissen JHC
- Cornwell WK
- Corona P
- Coyea M
- Craine J
- Craven D
- Cromsigt JPGM
- Csecserits A
- Cufar K
- Cuntz M
- da Silva AC
- Dahlin KM
- Dainese M
- Dalke I
- Dalle Fratte M
- Danihelka J
- Dannoura M
- Dawson S
- de Beer AJ
- de Dios VR
- De Frutos A
- de Gasper AL
- De Long JR
- Dechant B
- Delagrange S
- Delpierre N
- Derroire G
- Dias AS
- Diaz S
- Diaz-Toribio MH
- Dimitrakopoulos PG
- Dobrowolski M
- Doktor D
- Domingues TF
- Dong N
- Dransfield J
- Dressler S
- Drevojan P
- Duarte L
- Ducouret E
- Dullinger S
- Durka W
- Duursma R
- Dymova O
- E-Vojtko A
- Eckstein RL
- Ejtehadi H
- Elser J
- Emilio T
- Engemann K
- Erfanian MB
- Erfmeier A
- Esquivel-Muelbert A
- Esser G
- Estiarte M
- Fagan WF
- Fagundez J
- Falster DS
- Fan Y
- Fang JY
- Farris E
- Fazlioglu F
- Feng YH
- Fernandez-Mendez F
- Ferrara C
- Ferreira J
- Fidelis A
- Finegan B
- Firn J
- Flowers TJ
- Flynn DFB
- Fontana V
- Forey E
- Forgiarini C
- Francois L
- Frangipani M
- Frank D
- Frenette-Dussault C
- Freschet GT
- Fry EL
- Fyllas NM
- Gachet S
- Gallagher R
- Ganade G
- Ganga F
- Garcia-Palacios P
- Gargaglione V
- Garnier E
- Garrido JL
- Garvizu GS
- Gea-Izquierdo G
- Gibson D
- Gillison AN
- Giroldo A
- Glasenhardt MC
- Gleason S
- Gliesch M
- Goldberg E
- Goldel B
- Gonzalez-Akre E
- Gonzalez-Andujar JL
- Gonzalez-Melo A
- Gonzalez-Robles A
- Graae BJ
- Granda E
- Graves S
- Green WA
- Gregor T
- Gross N
- Guerin GR
- Gunther A
- Gutierrez AG
- Haddock L
- Haines A
- Hall J
- Hambuckers A
- Han WX
- Harrison SP
- Hattingh W
- Hawes JE
- He PC
- He TH
- Heberling JM
- Helm A
- Hempel S
- Hentschel J
- Herault B
- Heres AM
- Herz K
- Heuertz M
- Hickler T
- Hietz P
- Higuchi P
- Hipp AL
- Hirons A
- Hock M
- Hogan JA
- Holl K
- Honnay O
- Hornstein D
- Hou EQ
- Hough-Snee N
- Hovstad KA
- Ichie T
- Igic B
- Illa E
- Isaac M
- Ishihara M
- Ivanov L
- Ivanova L
- Iversen CM
- Izquierdo J
- Jackson B
- Jackson RB
- Jactel H
- Jagodzinski AM
- Jandt U
- Jansen S
- Jenkins T
- Jentsch A
- Jespersen JRP
- Jiang GF
- Johansen JL
- Johnson D
- Jokela EJ
- Joly CA
- Jordan GJ
- Joseph GS
- Junaedi D
- Junker RR
- Justes E
- Kabzems R
- Kane J
- Kaplan Z
- Kattenborn T
- Kattge J
- Kavelenova L
- Kearsley E
- Kempel A
- Kenzo T
- Kerkhoff A
- Khalil MI
- Kinlock NL
- Kissling WD
- Kitajima K
- Kitzberger T
- Kjoller R
- Klein T
- Kleyer M
- Klimesova J
- Klipel J
- Kloeppel B
- Klotz S
- Knops JMH
- Kohyama T
- Koike F
- Kollmann J
- Komac B
- Komatsu K
- Konig C
- Kraft NJB
- Kramer K
- Kreft H
- Kuhn I
- Kumarathunge D
- Kuppler J
- Kurokawa H
- Kurosawa Y
- Kuyah S
- Laclau JP
- Lafleur B
- Lallai E
- Lamb E
- Lamprecht A
- Larkin DJ
- Laughlin D
- Lavorel S
- Le Bagousse-Pinguet Y
- le Maire G
- le Roux E
- le Roux PC
- Leadley P
- Lee T
- Lens F
- Lewis SL
- Lhotsky B
- Li XE
- Li YZ
- Lichstein JW
- Liebergesell M
- Lim JY
- Lin YS
- Linares JC
- Liu CJ
- Liu DJ
- Liu U
- Livingstone S
- Llusia J
- Lohbeck M
- Lopez-Garcia A
- Lopez-Gonzalez G
- Lososova Z
- Louault F
- Lukacs BA
- Lukes P
- Luo YJ
- Lussu M
- Ma SY
- Mack M
- Maire V
- Makela A
- Makinen H
- Malhado ACM
- Mallik A
- Manning P
- Manzoni S
- Marchetti Z
- Marchino L
- Marcilio-Silva V
- Marcon E
- Marignani M
- Markesteijn L
- Marques M
- Martin A
- Martinez-Garza C
- Martinez-Vilalta J
- Maskova T
- Mason K
- Mason N
- Massad TJ
- Masse J
- Mayrose I
- Mazzochini GG
- McCarthy J
- McCormack ML
- McCulloh K
- McFadden IR
- McGill BJ
- McPartland MY
- Medeiros JS
- Medlyn B
- Meerts P
- Mehrabi Z
- Meir P
- Melo FPL
- Mencuccini M
- Meredieu C
- Messier J
- Meszaros I
- Metsaranta J
- Michaletz ST
- Michelaki C
- Migalina S
- Milla R
- Miller JED
- Minden V
- Ming R
- Mokany K
- Moles AT
- Molnar VA
- Molofsky J
- Molz M
- Montgomery RA
- Monty A
- Moravcova L
- Moreno-Martinez A
- Moretti M
- Mori AS
- Mori S
- Morris D
- Morrison J
- Mucina L
- Mueller S
- Muir CD
- Muller SC
- Munoz F
- Myers-Smith IH
- Myster RW
- Nagano M
- Naidu S
- Narayanan A
- Natesan B
- Negoita L
- Nelson AS
- Neuschulz EL
- Ni J
- Niedrist G
- Nieto J
- Niinemets U
- Nolan R
- Nottebrock H
- Nouvellon Y
- Novakovskiy A
- Nystuen KO
- O'Grady A
- O'Hara K
- O'Reilly-Nugent A
- Oakley S
- Oberhuber W
- Ohtsuka T
- Oliveira R
- Ollerer K
- Olson ME
- Onipchenko V
- Onoda Y
- Onstein RE
- Ordonez JC
- Osada N
- Ostonen I
- Ottaviani G
- Otto S
- Overbeck GE
- Ozinga WA
- Pahl AT
- Paine CET
- Pakeman RJ
- Papageorgiou AC
- Parfionova E
- Partel M
- Patacca M
- Paula S
- Paule J
- Pauli H
- Pausas JG
- Peco B
- Penuelas J
- Perea A
- Pereira CMR
- Peri PL
- Petisco-Souza AC
- Petraglia A
- Petritan AM
- Phillips OL
- Pierce S
- Pillar VD
- Pinho BX
- Pisek J
- Pomogaybin A
- Poorter H
- Portsmuth A
- Poschlod P
- Potvin C
- Pounds D
- Powell AS
- Power SA
- Prentice IC
- Prinzing A
- Puglielli G
- Pysek P
- Raevel V
- Rammig A
- Ransijn J
- Ray CA
- Reich PB
- Reichstein M
- Reid DEB
- Rejou-Mechain M
- Ribeiro S
- Richardson S
- Riibak K
- Rillig MC
- Riviera F
- Robert EMR
- Roberts S
- Robroek B
- Roddy A
- Rodrigues AV
- Rogers A
- Rollinson E
- Rolo V
- Romermann C
- Ronzhina D
- Roscher C
- Rosell JA
- Rosenfield MF
- Rossi C
- Roy DB
- Royer-Tardif S
- Ruger N
- Ruiz-Peinado R
- Rumpf SB
- Rusch GM
- Ryo M
- Sack L
- Saldana A
- Salgado-Negret B
- Salguero-Gomez R
- Santa-Regina I
- Santacruz-Garcia AC
- Santos J
- Sardans J
- Scalon MC
- Schamp B
- Scherer-Lorenzen M
- Schleuning M
- Schmid B
- Schmidt M
- Schmitt S
- Schneider JV
- Schowanek SD
- Schrader J
- Schrodt F
- Schuldt B
- Schurr F
- Semchenko M
- Seymour C
- Sfair JC
- Sharpe JM
- Sheppard CS
- Sheremetiev S
- Shiodera S
- Shipley B
- Shovon TA
- Siebenkas A
- Sierra C
- Silva M
- Silva V
- Sitzia T
- Sjoman H
- Slot M
- Smith NG
- Sodhi D
- Soltis D
- Soltis P
- Somers B
- Sonnier G
- Sorensen MV
- Sosinski EE
- Soudzilovskaia NA
- Souza AF
- Spasojevic M
- Sperandii MG
- Stan AB
- Stegen J
- Steinbauer K
- Stephan JG
- Sterck F
- Stojanovic DB
- Strydom T
- Suarez ML
- Svenning JC
- Svitkova I
- Svitok M
- Svoboda M
- Swaine E
- Swenson N
- Tabarelli M
- Takagi K
- Tappeiner U
- Tarifa R
- Tarin T
- Tautenhahn S
- Tauugourdeau S
- Tavsanoglu C
- te Beest M
- Tedersoo L
- Thiffault N
- Thom D
- Thomas E
- Thompson K
- Thornton PE
- Thuiller W
- Tichy L
- Tissue D
- Tjoelker MG
- Tng DYP
- Tobias J
- Torok P
- Torres-Ruiz JM
- Tothmeresz B
- Treurnicht M
- Trivellone V
- Trolliet F
- Trotsiuk V
- Tsakalos JL
- Tsiripidis I
- Tysklind N
- Umehara T
- Usoltsev V. A.
- Vadeboncoeur M
- Vaezi J
- Valderrama MY
- Valladares F
- Vamosi J
- van Bodegom PM
- van Breugel M
- Van Cleemput E
- van de Weg M
- van der Merwe S
- van der Plas F
- van der Sande MT
- van Kleunen M
- Van Meerbeek K
- Vanderwel M
- Vanselow KA
- Varhammar A
- Varone L
- Vassilev K
- Vellend M
- Veneklaas EJ
- Verbeeck H
- Verheyen K
- Vibrans A
- Vieira I
- Villacis J
- Violle C
- Vivek P
- Wagner K
- Waldram M
- Waldron A
- Walker AP
- Waller M
- Walther G
- Wang F
- Wang H
- Wang WQ
- Watkins H
- Watkins J
- Weber U
- Weedon JT
- Wei LP
- Weigelt P
- Weiher E
- Wells AW
- Wellstein C
- Wenk E
- Werner GDA
- Westoby M
- Westwood A
- White PJ
- Whitten M
- Williams M
- Winkler DE
- Winter K
- Wirth C
- Womack C
- Wright IJ
- Wright J
- Wright SJ
- Ximenes F
- Yamada T
- Yamaji K
- Yanai R
- Yankov N
- Yguel B
- Zanini KJ
- Zanne AE
- Zeleny D
- Zhao YP
- Zheng J
- Zheng JM
- Zieminska K
- Zirbel CR
- Zizka G
- Zo-Bi IC
- Zotz G
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/01/2020
- Field of study
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
Time to positivity in blood cultures of adults with Streptococcus pneumoniae bacteremia
- Author
- AA Marfin
- BJ George
- C Farinas-Alvarez
- CF Norris
- DM Musher
- EF Vigano
- EF Vigano
- EM Castillo
- ER Alpern
- F Blot
- F Blot
- FR Cockerill 3rd
- Galo Peralta
- GS Marshall
- H Laurichesse
- I Raad
- J Maugein
- JF Plouffe
- JH Jorgensen
- Jose Carlos Garrido
- LJ La Scolea Jr
- LM Bell
- Luis Ansorena
- M Santosham
- MA Kelley
- MarĂa JosĂ© RodrĂguez-Lera
- MarĂa PĂa Roiz
- MI Neuman
- PR Murray
- R Khatib
- RC Bone
- TD Sullivan
- TD Sullivan
- VB Malgrange
- Y Haimi-Cohen
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
BACKGROUND: previous studies have established that bacterial blood concentration is related with clinical outcome. Time to positivity of blood cultures (TTP) has relationship with bacterial blood concentration and could be related with prognosis. As there is scarce information about the usefulness of TTP, we study the relationship of TTP with clinical parameters in patients with Streptococcus pneumoniae bacteremia. METHODS: TTP of all cases of Streptococcus pneumoniae bacteremia, detected between January 1995 and December 2004 using the BacT/Alert automated blood culture system in a teaching community hospital was analyzed. When multiple cultures were positive only the shortest TTP was selected for the analysis. RESULTS: in the study period 105 patients with Streptococcus pneumoniae bacteremia were detected. Median TTP was 14.1 hours (range 1.2 h to 127 h). Immunosuppressed patients (n = 5), patients with confusion (n = 19), severe sepsis or shock at the time of blood culture extraction (n = 12), those with a diagnosis of meningitis (n = 7) and those admitted to the ICU (n = 14) had lower TTP. Patients with TTP in the first quartile were more frequently hospitalized, admitted to the ICU, had meningitis, a non-pneumonic origin of the bacteremia, and a higher number of positive blood cultures than patients with TTP in the fourth quartile. None of the patients with TTP in the 90(th )decile had any of these factors associated with shorter TTP, and eight out of ten patients with TTP in the 10(th )decile had at least one of these factors. The number of positive blood cultures had an inverse correlation with TTP, suggesting a relationship of TTP with bacterial blood concentration. CONCLUSION: Our data support the relationship of TTP with several clinical parameters in patients with Streptococcus pneumoniae bacteremia, and its potential usefulness as a surrogate marker of outcome
Effect of electronic patient record use on mortality in End Stage Renal Disease, a model chronic disease: retrospective analysis of 9 years of prospectively collected data
- Author
- AX Garg
- B Padilla
- BA Walters
- BJ Chaudhry
- CA Stidley
- CM Boyd
- D Lawrence
- G Garcia-Garcia
- JA Lorch
- JA Lorch
- JF Fries
- Jonathan A Lorch
- K Kalantar-Zadeh
- M Chasin
- M Teng
- RA Rettig
- S Heffler
- SM Asch
- T Garrido
- The University of Michigan Kidney Epidemiology and Cost Center
- U.S. Renal Data System USRDS 2006
- VE Pollak
- VE Pollak
- VE Pollak
- VE Pollak
- VE Pollak
- VE Pollak
- VE Pollak
- Victor E Pollak
- WF Owen
- WW Stead
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>In chronic disease, health information technology promises but has yet to demonstrate improved outcomes and decreased costs. The main aim of the study was to determine the effects on mortality and cost of an electronic patient record used in daily patient care in a model chronic disease, End Stage Renal Disease, treated by chronic maintenance hemodialysis. Dialysis treatment is highly regulated, and near uniform in treatment modalities and drugs used.</p> <p>Methods</p> <p>The particular electronic patient record, patient-centered and extensively coded, was used first in patient care in 3 dialysis units in New York, NY in 1998, 1999, and 2000. All data were stored "live"; none were archived. By December 31, 2006, the patients had been treated by maintenance hemodialysis for a total of 3924 years. A retrospective analysis was made using query tools embedded in the software. The United States Renal Data System dialysis population served as controls. In all there were 1790 patients, with many underlying primary diseases and multiple comorbid conditions affecting many organ systems. Year by year mortality, hospital admissions, and staffing were analyzed, and the data were compared with national data compiled by the United States Renal Data System.</p> <p>Results</p> <p>Analyzed by calendar year after electronic patient record implementation, mortality decreased strikingly. In years 3â9 mortality was lower than in years 1â2 by 23%, 48%, and 34% in the 3 units, and was 37%, 37%, and 35% less than that reported by the United States Renal Data System. Clinical staffing was 25% fewer per 100 patients than the national average, thereby lowering costs.</p> <p>Conclusion</p> <p>To our knowledge, this is the first demonstration that an electronic patient record, albeit of particular design, can have a favorable effect on outcomes and cost in chronic disease. That the population studied has many underlying diseases affecting all organ systems suggests that the electronic patient record design may enable application to many fields of medical practice.</p
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâ„20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60â€pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â€{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
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- Addy TN
- Adelman J
- Adomeit S
- Adye T
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- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
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- Alconada Verzini MJ
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- Aleksandrov IN
- Alexa C
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- Alexandre G
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- Alimonti G
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- Alison J
- Allbrooke BMM
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- Allport PP
- Allwood-Spiers SE
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- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gadatsch S
- Gadatsch S
- Gadomski S
- Gadomski S
- Gagliardi G
- Gagliardi G
- Gagnon P
- Gagnon P
- Galea C
- Galea C
- Galhardo B
- Galhardo B
- Gallas EJ
- Gallas EJ
- Gallo V
- Gallo V
- Gallop BJ
- Gallop BJ
- Gallus P
- Gallus P
- Galster G
- Galster G
- Gan KK
- Gan KK
- Gandrajula RP
- Gandrajula RP
- Gao J
- Gao YS
- Gao YS
- Gaob J
- Garberson F
- Garberson F
- Garcia Navarro JE
- Garcia Navarro JE
- Garcia BRM
- Garcia C
- Garcia C
- Garcia JAB
- Garcia-Sciveres M
- Garcia-Sciveres M
- Gardner RW
- Gardner RW
- Garelli N
- Garelli N
- Garonne V
- Garonne V
- Garrido MDMC
- Gatti C
- Gatti C
- Gaudio G
- Gaudio G
- Gaur B
- Gaur B
- Gauthier L
- Gauthier L
- Gauzzi P
- Gauzzi P
- Gavrilenko IL
- Gavrilenko IL
- Gay C
- Gay C
- Gaycken G
- Gaycken G
- Gazis EN
- Gazis EN
- Ge P
- Ge P
- Gecse Z
- Gecse Z
- Gee CNP
- Gee CNP
- Geerts DAA
- Geerts DAA
- Geich-Gimbel C
- Geich-Gimbel C
- Gellerstedt K
- Gellerstedt K
- Gemme C
- Gemme C
- Gemmell A
- Gemmell A
- Genest MH
- Genest MH
- Gentile S
- Gentile S
- George M
- George M
- George S
- George S
- Gerbaudo D
- Gerbaudo D
- Gershon A
- Gershon A
- Ghazlane H
- Ghazlane H
- Ghodbane N
- Ghodbane N
- Giacobbe B
- Giacobbe B
- Giagu S
- Giagu S
- Giangiobbe V
- Giangiobbe V
- Giannetti P
- Giannetti P
- Gianotti F
- Gianotti F
- Gibbard B
- Gibbard B
- Gibson SM
- Gibson SM
- Gilchriese M
- Gilchriese M
- Gillam TPS
- Gillam TPS
- Gillberg D
- Gillberg D
- Gillman AR
- Gillman AR
- Gingrich DM
- Gingrich M
- Giokaris N
- Giokaris N
- Giordani MP
- Giordani MP
- Giordano R
- Giordano R
- Giorgi FM
- Giorgi FM
- Giraud PF
- Giraud PF
- Giugni D
- Giugni D
- Giuliani C
- Giuliani C
- Giunta M
- Giunta M
- Gjelsten BK
- Gjelsten BK
- Gkialas I
- Gkialas I
- Gladilin LK
- Gladilin LK
- Glasman C
- Glasman C
- Glatzer J
- Glatzer J
- Glazov A
- Glazov A
- Glonti GL
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- Goblirsch-Kolb M
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- Goddard JR
- Goddard JR
- Godfrey J
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- Godlewski J
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- Goeringer C
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- Goessling C
- Goessling C
- Goldfarb S
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- Golling T
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- Golubkov D
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- Gomes A
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- Gonalo R
- Goncalo R
- Gonella L
- Gonella L
- Gonzalez de la Hoz S
- Gonzalez de la Hoz S
- Gonzalez Parra G
- Gonzalez Parra G
- Gonzalez BA
- Gonzalez-Sevilla S
- Gonzalez-Sevilla S
- Goossens L
- Goossens L
- Gorbounov PA
- Gorbounov PA
- Gordon HA
- Gordon HA
- Gorelov I
- Gorelov I
- Gorini B
- Gorini B
- Gorini E
- Gorini E
- Gorisek A
- Gorisek A
- Gornicki E
- Gornicki E
- Goshaw AT
- Goshaw AT
- Gostkin MI
- Gostkin MI
- Gouighri M
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- Goujdami D
- Goujdami D
- Goulette MP
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- Goussiou AG
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- Goy C
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- Gozpinar S
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- Grabas HMX
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- Graber L
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- Grabowska-Bold I
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- Grafstroem P
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- Gramstad E
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- Grancagnolo F
- Grancagnolo S
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- Grancagnoloa F
- Grassi V
- Grassi V
- Gratchev V
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- Gray HM
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- Graziani E
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- Grebenyuk OG
- Grebenyuk OG
- Greenwood ZD
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- Gregersen K
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- Gregor IM
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- Grenier P
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- Griffiths J
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- Grillo AA
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- Grimm K
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- Grinstein S
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- Griso SP
- Grivaz J-F
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- Grohs JP
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- Grohsjean A
- Gross AGE
- Gross E
- Grosse-Knetter J
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- Grossi GC
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- Groth-Jensen J
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- Grout ZJ
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- Guan L
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- Guescini F
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- Guest D
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- Gueta O
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- Guicheney C
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- Guido E
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- Guillemin T
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- Guindon S
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- Gul U
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- Gumpert C
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- Gunther J
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- Guo J
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- Gutierrez P
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- Gutschow C
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- Guttman N
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- Guyot C
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- Haefner P
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- Hansen JD
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- Harenberg T
- Harkusha S
- Harper D
- Harrington RD
- Harris OM
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- Hartjes F
- Harvey A
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- Hasegawa Y
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- Hawkings RJ
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
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- Zimmermann S
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- Zinonos Z
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- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreâofâmassframeisusedtosuppressthelargemultiâjetbackground.ThecrossâsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
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- Trincaz-Duvoid S
- Tripiana MF
- Triplett N
- Trischuk W
- Trocmé B
- Troncon C
- Trottier-McDonald M
- Trovatelli M
- True P
- Trzebinski M
- Trzupek A
- Tsarouchas C
- Tseng JC
- Tsiakiris M
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsiskaridze S
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsung JW
- Tsuno S
- Tsybychev D
- Tua A
- Tudorache A
- Tudorache V
- Tuggle JM
- Turala M
- Turecek D
- Turk Cakir I
- Turra R
- Tuts PM
- Tykhonov A
- Tylmad M
- Tyndel M
- Tzanakos G
- Uchida K
- Ueda I
- Ueno R
- Ughetto M
- Ugland M
- Uhlenbrock M
- Ukegawa F
- Unal G
- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Urbaniec D
- Urquijo P
- Usai G
- Vacavant L
- Vacek V
- Vachon B
- Vahsen S
- Valencic N
- Valentinetti S
- Valero A
- Valery L
- Valkar S
- Valladolid Gallego E
- Vallecorsa S
- Valls Ferrer JA
- Van Berg R
- Van Der Deijl PC
- van der Geer R
- van der Graaf H
- Van Der Leeuw R
- van der Poel E
- van der Ster D
- van Eldik N
- van Gemmeren P
- Van Nieuwkoop J
- van Vulpen I
- Vanadia M
- Vandelli W
- Vaniachine A
- Vankov P
- Vannucci F
- Vari R
- Varnes EW
- Varol T
- Varouchas D
- Vartapetian A
- Varvell KE
- Vassilakopoulos VI
- Vazeille F
- Vazquez Schroeder T
- Veloso F
- Veneziano S
- Ventura A
- Ventura D
- Venturi M
- Venturi N
- Vercesi V
- Verducci M
- Verkerke W
- Vermeulen JC
- Vest A
- Vetterli MC
- Vichou I
- Vickey Boeriu OE
- Vickey T
- Viehhauser GH
- Viel S
- Villa M
- Villaplana Perez M
- Vilucchi E
- Vincter MG
- Vinek E
- Vinogradov VB
- Virzi J
- Vitells O
- Viti M
- Vivarelli I
- Vives Vaque F
- Vlachos S
- Vladoiu D
- Vlasak M
- Vogel A
- Vokac P
- Volpi G
- Volpi M
- Volpini G
- von der Schmitt H
- von Radziewski H
- von Toerne E
- Vorobel V
- Vorwerk V
- Vos M
- Voss R
- Vossebeld JH
- Vranjes Milosavljevic M
- Vranjes N
- Vrba V
- Vreeswijk M
- Vu Anh T
- Vuillermet R
- Vukotic I
- Vykydal Z
- Wagner P
- Wagner W
- Wahlen H
- Wahrmund S
- Wakabayashi J
- Walch S
- Walder J
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- Walkowiak W
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- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
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- Weingarten J
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- Werth M
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- Wetter J
- Weydert C
- Whalen K
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- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LA
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
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- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wittig T
- Wittkowski J
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
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- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
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- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yen AL
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- ZeniĆĄ T
- Zerwas D
- Zevi Della Porta G
- Zhang D
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- ZivkoviÄ L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
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