207 research outputs found
Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma
- Author
- A Hildesheim
- AT Chan
- B Gaston
- B Gruhne
- B Lima
- B Metz
- C Bosetti
- C Yi
- CA Staab
- CA Staab
- CA Staab
- Chad M Thompson
- CM Schonhoff
- CM Schonhoff
- CM Thompson
- CM Thompson
- CM Thompson
- D Nguyen-Van
- D Yao
- D Yasokawa
- DE Jensen
- DF Hou
- DT Hess
- EJ Whalen
- EM Henderson
- F Cerimele
- GM Marsh
- GM Marsh
- H Wu
- H Zheng
- HE Marshall
- HE Marshall
- HM Lander
- IARC
- J Levitskaya
- JB Mannick
- JB Mannick
- JB Mannick
- JE Whalan
- JO Hoog
- JS Kimbell
- KK Chung
- KW Lo
- L Barnes
- L Uotila
- LG Que
- LG Que
- M Colasanti
- M Hauptmann
- M Holmstrom
- M Koivusalo
- M Sulc
- MG Masucci
- N Raab-Traub
- NP Dantuma
- P Wang
- PE Moore
- R Dolcetti
- R Pannu
- RA Woutersen
- RC Grafstrom
- RC Grafstrom
- RC Grafstrom
- RG Liteplo
- Roland C Grafström
- SC Tsai
- SH Pan
- SJ Flint
- T Kokkola
- TF Schulz
- TL Vaughan
- TM Monticello
- W Godoy
- W Henle
- WD Kerns
- WW Jung
- X Gao
- YR Chen
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
Occupational exposure to formaldehyde has been linked to nasopharyngeal carcinoma. To date, mechanistic explanations for this association have primarily focused on formaldehyde-induced cytotoxicity, regenerative hyperplasia and DNA damage. However, recent studies broaden the potential mechanisms as it is now well established that formaldehyde dehydrogenase, identical to S-nitrosoglutathione reductase, is an important mediator of cGMP-independent nitric oxide signaling pathways. We have previously described mechanisms by which formaldehyde can influence nitrosothiol homeostasis thereby leading to changes in pulmonary physiology. Considering evidences that nitrosothiols govern the Epstein-Barr virus infection cycle, and that the virus is strongly implicated in the etiology of nasopharyngeal carcinoma, studies are needed to examine the potential for formaldehyde to reactivate the Epstein-Barr virus as well as additively or synergistically interact with the virus to potentiate epithelial cell transformation
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aesky S
- Agar-Savedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
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- Alviggi MG
- Amako K
- Amelung C
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- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ï lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ï, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan ÎČ in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
CD44 Expression in Oro-Pharyngeal Carcinoma Tissues and Cell Lines
- Author
- A Colombatti
- Abirami Rajarajan
- AC Woodman
- Angela Stokes
- Balvinder K. Bloor
- BF Haynes
- BK Bloor
- BK Bloor
- C Herold-Mende
- C Stoll
- D Naor
- D Naor
- D Tarin
- DL Hudson
- DT Oliveira
- DT Oliveira
- E Ioachim
- Edward W. Odell
- EJ Franzmann
- EP Reategui
- F Carinci
- G Repassy
- GR Screaton
- GR Screaton
- H Gorham
- Hemini Desai
- I Fonseca
- I Okamoto
- I Stamenkovic
- J Ostwald
- J Piffko
- J Piffko
- J Sugar
- J Vandekerckhove
- J Zhou
- JG Haggerty
- JP Rodrigo
- KC Zoon
- LY Bourguignon
- M Cardinali
- M Kan
- M Kanke
- M Kunishi
- M Lukk
- M Masuda
- M Zoller
- ME Prince
- MF Spafford
- MP Martegani
- MY Kuo
- Neil A. Hotchin
- NL van Hal
- P Boukamp
- P Dall
- P Hirvikoski
- PN Goodfellow
- R Bahar
- R Hernandez Gaspar
- RC Grafstrom
- Rebecca Ceder
- RK O'Donnell
- Roland C. Grafström
- S Jalkanen
- S Kawashiri
- S Kilpinen
- S Mori
- S Sato
- SB Fox
- SJ Wang
- T Soukka
- T Ue
- TA Brown
- YH Lin
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Expression of CD44, a transmembrane hyaluronan-binding glycoprotein, is variably considered to have prognostic significance for different cancers, including oral squamous cell carcinoma. Although unclear at present, tissue-specific expression of particular isoforms of CD44 might underlie the different outcomes in currently available studies. We mined public transcriptomics databases for gene expression data on CD44, and analyzed normal, immortalized and tumour-derived human cell lines for splice variants of CD44 at both the transcript and protein levels. Bioinformatics readouts, from a total of more than 15,000 analyses, implied an increased CD44 expression in head and neck cancer, including increased expression levels relative to many normal and tumor tissue types. Also, meta-analysis of over 260 cell lines and over 4,000 tissue specimens of diverse origins indicated lower CD44 expression levels in cell lines compared to tissue. With minor exceptions, reverse transcribed polymerase chain reaction identified expression of the four main isoforms of CD44 in normal oral keratinocytes, transformed lines termed DT and HaCaT, and a series of paired primary and metastasis-derived cell lines from oral or pharyngeal carcinomas termed HN4/HN12, HN22/HN8 and HN30/HN31. Immunocytochemistry, Western blotting and flow cytometric assessments all confirmed the isoform expression pattern at the protein level. Overall, bioinformatic processing of large numbers of global gene expression analyses demonstrated elevated CD44 expression in head and neck cancer relative to other cancer types, and that the application of standard cell culture protocols might decrease CD44 expression. Additionally, the results show that the many variant CD44 exons are not fundamentally deregulated in a diverse range of cultured normal and transformed keratinocyte lines
Measurement of the W±Z boson pair-production cross section in pp collisions at âs=13TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
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- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
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- Adelman J
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- Agricola J
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- Ahlen SP
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- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
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- AlconadaVerzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
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- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
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- Araque JP
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- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
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- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
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- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- zur Nedden M
- Zwalinski L
- Publication venue
- Netherlands
- Publication date
- 01/01/2016
- Field of study
published_or_final_versio
Search for anomalous couplings in the W tb vertex from the measurement of double differential angular decay rates of single top quarks produced in the t-channel with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Alkire SP
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amako K
- Amaral Coutinho Y
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/10/2015
- Field of study
The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper uses 4.6 fbâ1 of proton-proton collision data at âs =7 TeV collected with the ATLAS detector at the LHC. Two parameters are measured simultaneously in this analysis. The fraction f 1 of decays containing transversely polarised W bosons is measured to be 0.37 ± 0.07 (stat.âsyst.). The phase ÎŽ â between amplitudes for transversely and longitudinally polarised W bosons recoiling against left-handed b-quarks is measured to be â0.014Ï Â± 0.036Ï (stat.âsyst.). The correlation in the measurement of these parameters is 0.15. These values result in two-dimensional limits at the 95% confidence level on the ratio of the complex coupling parameters g R and V L, yielding Re[g R /V L] â [â0.36, 0.10] and Im[g R /V L] â [â0.17, 0.23] with a correlation of 0.11. The results are in good agreement with the predictions of the Standard Model
Measurement of W+Wâ production in association with one jet in protonâproton collisions at sqrt(s) = 8TeV with the ATLAS detector
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- Zhemchugov A
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
The production of W boson pairs in association with one jet in pp collisions at View the MathML sources=8 TeV is studied using data corresponding to an integrated luminosity of 20.3 fbâ1 collected by the ATLAS detector during 2012 at the CERN Large Hadron Collider. The cross section is measured in a fiducial phase-space region defined by the presence of exactly one electron and one muon, missing transverse momentum and exactly one jet with a transverse momentum above 25 GeV and a pseudorapidity of |η|<4.5|η|<4.5. The leptons are required to have opposite electric charge and to pass transverse momentum and pseudorapidity requirements. The fiducial cross section is found to be View the MathML sourceÏWWfid,1-jet=136±6(stat)±14(syst)±3(lumi) fb. In combination with a previous measurement restricted to leptonic final states with no associated jets, the fiducial cross section of WW production with zero or one jet is measured to be View the MathML sourceÏWWfid,â€1-jet=511±9(stat)±26(syst)±10(lumi) fb. The ratio of fiducial cross sections in final states with one and zero jets is determined to be 0.36±0.050.36±0.05. Finally, a total cross section extrapolated from the fiducial measurement of WW production with zero or one associated jet is reported. The measurements are compared to theoretical predictions and found in good agreement
Charged-particle distributions at low transverse momentum in âs=13 13 TeV pp interactions measured with the ATLAS detector at the LHC
- Author
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- Aad G
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- Abdallah J
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- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yuen SPY
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang R
- Zhang X
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Measurements of distributions of charged particles produced in protonâproton collisions with a centre-of-mass energy of 13 TeV are presented. The data were recorded by the ATLAS detector at the LHC and correspond to an integrated luminosity of 151 ÎŒb â1 ÎŒbâ1 . The particles are required to have a transverse momentum greater than 100 MeV and an absolute pseudorapidity less than 2.5. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the dependence of the mean transverse momentum on multiplicity are measured in events containing at least two charged particles satisfying the above kinematic criteria. The results are corrected for detector effects and compared to the predictions from several Monte Carlo event generators
Search for pair production of Higgs bosons in the bbÂŻbbÂŻ final state using proton-proton collisions at âs=13ââTeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
- Zu Theenhausen HM
- Zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
A search for Higgs-boson pair production in the bb ÂŻ bb ÂŻ final state is carried out with 3.2ââfb â1 of proton-proton collision data collected at s â =13ââTeV with the ATLAS detector. The data are consistent with the estimated background and are used to set upper limits on the production cross section of Higgs-boson pairs times branching ratio to bb ÂŻ bb ÂŻ for both nonresonant and resonant production. In the case of resonant production of Kaluza-Klein gravitons within the Randall-Sundrum model, upper limits in the 24 to 91 fb range are obtained for masses between 600 and 3000 GeV, at the 95% confidence level. The production cross section times branching ratio for nonresonant Higgs-boson pairs is also constrained to be less than 1.22 pb, at the 95% confidence level
Measurement of the inelastic proton-proton cross section at âs=13 TeV with the ATLAS detector at the LHC
- Author
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- Aad G
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- Abdallah J
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- Chatterjee A
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- Zobernig G
- Zoccoli A
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
This Letter presents a measurement of the inelastic proton-proton cross section using 60ââÎŒb â1 of pp collisions at a center-of-mass energy âs of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.0710 â6 , where M X is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event. In this Ο range the scintillators are highly efficient. For diffractive events this corresponds to cases where at least one proton dissociates to a system with M X >13ââGeV . The measured cross section is compared with a range of theoretical predictions. When extrapolated to the full phase space, a cross section of 78.1±2.9ââmb is measured, consistent with the inelastic cross section increasing with center-of-mass energy
Measurement of the photon identification efficiencies with the ATLAS detector using LHC Run-1 data
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
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- Adelman J
- Adomeit S
- Adye T
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- Agricola J
- Aguilar-Saavedra JA
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- Akesson TPA
- Akimov AV
- Alberghi GL
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- Albrand S
- Alconada Verzini MJ
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- Alexa C
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- Yildiz HD
- Yorita K
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- Young CJS
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
© 2016, CERN for the benefit of the ATLAS collaboration.The algorithms used by the ATLAS Collaboration to reconstruct and identify prompt photons are described. Measurements of the photon identification efficiencies are reported, using 4.9 fb- 1 of pp collision data collected at the LHC at s=7 TeV and 20.3 fb- 1 at s=8 TeV. The efficiencies are measured separately for converted and unconverted photons, in four different pseudorapidity regions, for transverse momenta between 10 GeV and 1.5 TeV. The results from the combination of three data-driven techniques are compared to the predictions from a simulation of the detector response, after correcting the electromagnetic shower momenta in the simulation for the average differences observed with respect to data. Data-to-simulation efficiency ratios used as correction factors in physics measurements are determined to account for the small residual efficiency differences. These factors are measured with uncertainties between 0.5% and 10% in 7 TeV data and between 0.5% and 5.6% in 8 TeV data, depending on the photon transverse momentum and pseudorapidity
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