Labour markets, engineering workers, and redundancy in west Newcastle

This is a study of the mechanisms and processes involved in people’s distribution to jobs. To this end labour market behaviour of two samples of redundant male engineering workers from the North East of England is contrasted and compared. The research is set in a framework that recognises the existence of a market structured to induce a complex interplay of both hierarchical and lateral organisation and movement, with certain people tending, at particular times, to lock into a horizontal multi-employer pattern of job change, and others staying immobile within the confines of a single institution. Within this broad framework there may be tendencies for both hierarchical and lateral segmentation to occur inhibiting mobility for different groups of workers. The inhibitions may not, however, be of life-time significance with the consequence that any differentiation may not be a permanent distinction. At particular times in their lives, or in certain circumstances, individuals may switch from a lateral to a hierarchical pattern of movement, or cross over from one segment to another. A major aim is to specify the nature of any segmentation or sectoral divisions and to look at the role they play in the distribution of labour, particularly by seeing- how they affect people's attempts to exercise choice and discretion in pursuit of work objectives. To this end, people's work objectives and orientations are traced through time and different contexts, including redundancy, and changing perceptions and motivations are related to labour market strategies and final destinations in the job structure. Certain factors - such as 'job interest', 'good pay', 'security', etc - liable to rank amongst an individual’s scale of employment priorities, and/or feature as characteristic of work-places in Newcastle, are focussed upon and examined, and evaluated for their significance as general labour market 'structuring agents', serving to sub-divide the work-force into different segments. The extent to which the influence of these 'structuring agents' can vary with time and circumstances, as workplace conditions, opportunities in the market, and people's orientations, change, and the consequences this has for hierarchical and lateral divisions and movement, is studied. Research findings are discussed and evaluated in the light of existing labour market theories

Towards An Analytical Framework

In this article, we explore the relationship between industrial clusters and social upgrading in developing countries. Our article focuses on the hitherto little-considered influence of the economic and regulatory environment on the social upgrading of a cluster and on its governance system. In doing so, we develop an analytical framework that seeks to explain how the enabling environment and different actors in cluster governance can either facilitate and/or hinder the process of social upgrading in cluster settings in developing countries. Finally, the conclusion outlines our main findings, the research and policy implications of our analysis

JAK-STAT signaling in inflammatory breast cancer enables chemotherapy-resistant cell states

Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+CD24- cells possess stem cell-like features and contribute to disease progression, and we previously described a CD44+CD24-pSTAT3+ breast cancer cell subpopulation that is dependent on JAK2/STAT3 signaling. Here we report that CD44+CD24- cells are the most frequent cell-type in IBC and are commonly pSTAT3+. Combination of JAK2/STAT3 inhibition with paclitaxel decreased IBC xenograft growth more than either agent alone. IBC cell lines resistant to paclitaxel and doxorubicin were developed and characterized to mimic therapeutic resistance in patients. Multi-omic profiling of parental and resistant cells revealed enrichment of genes associated with lineage identity and inflammation in chemotherapy resistant derivatives. Integrated pSTAT3 ChIP-seq and RNA-seq analyses showed pSTAT3 regulates genes related to inflammation and epithelial to mesenchymal transition (EMT) in resistant cells, as well as PDE4A, a cAMP-specific phosphodiesterase. Metabolomic characterization identified elevated cAMP signaling and CREB as a candidate therapeutic target in IBC. Investigation of cellular dynamics and heterogeneity at the single cell level during chemotherapy and acquired resistance by CyTOF and single cell RNA-seq identified mechanisms of resistance including a shift from luminal to basal/mesenchymal cell states through selection for rare pre-existing subpopulations or an acquired change. Lastly, combination treatment with paclitaxel and JAK2/STAT3 inhibition prevented the emergence of the mesenchymal chemo-resistant subpopulation. These results provide mechanistic rational for combination of chemotherapy with inhibition of JAK2/STAT3 signaling as a more effective therapeutic strategy in IBC

Practical Considerations for High Spatial and Temporal Resolution Dynamic Transmission Electron Microscopy

Although recent years have seen significant advances in the spatial resolution possible in the transmission electron microscope (TEM), the temporal resolution of most microscopes is limited to video rate at best. This lack of temporal resolution means that our understanding of dynamic processes in materials is extremely limited. High temporal resolution in the TEM can be achieved, however, by replacing the normal thermionic or field emission source with a photoemission source. In this case the temporal resolution is limited only by the ability to create a short pulse of photoexcited electrons in the source, and this can be as short as a few femtoseconds. The operation of the photo-emission source and the control of the subsequent pulse of electrons (containing as many as 5 x 10{sup 7} electrons) create significant challenges for a standard microscope column that is designed to operate with a single electron in the column at any one time. In this paper, the generation and control of electron pulses in the TEM to obtain a temporal resolution <10{sup -6} s will be described and the effect of the pulse duration and current density on the spatial resolution of the instrument will be examined. The potential of these levels of temporal and spatial resolution for the study of dynamic materials processes will also be discussed

Dissecting the physiology and pathophysiology of glucagon-like peptide-1

Copyright © 2018 Paternoster and Falasca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. An aging world population exposed to a sedentary life style is currently plagued by chronic metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an unprecedented rate. One of the most promising pharmacological approaches for the management of type 2 diabetes takes advantage of the peptide hormone glucagon-like peptide-1 (GLP-1) under the form of protease resistant mimetics, and DPP-IV inhibitors. Despite the improved quality of life, long-term treatments with these new classes of drugs are riddled with serious and life-threatening side-effects, with no overall cure of the disease. New evidence is shedding more light over the complex physiology of GLP-1 in health and metabolic diseases. Herein, we discuss the most recent advancements in the biology of gut receptors known to induce the secretion of GLP-1, to bridge the multiple gaps into our understanding of its physiology and pathology

Rhetorical representations of masculinities in South Africa: Moving towards a material-discursive understanding of men

A material-discursive perspective holds advantage in understanding male realities. It seeks to inte- grate dominant approaches that appear anaemic in their failure to capture the interplay between the material and discursive realms of human existence. Three dominant metaphorical themes in the rhetorical representation of South African masculinities are described in an attempt to illustrate the complexity of embodied masculine experience. In this sense the discussion seeks to reveal the dynamic nature of masculine debate and lived experience across differing contexts. It serves to underline the importance of adopting a material-discursive perspective in understanding men, which recognizes that they do not exist as a homogeneous social group, and as such experience their mas- culinities in a variable and changing fashion. The theoretical amalgamation of social representations and rhetoric is argued to provide a useful analytical tool in an endeavour of this nature. It is suggested that the rhetorical approach problematizes an overly consensual view of social reality that social representations theory typically promotes