52 research outputs found
An agonistâantagonist cerebellar nuclear system controlling eyelid kinematics during motor learning
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/01/2012
- Field of study
The presence of two antagonistic groups of deep cerebellar nuclei neurons has been reported as necessary for a proper dynamic control of learned motor responses. Most models of cerebellar function seem to ignore the biomechanical need for a double activationâdeactivation system controlling eyelid kinematics, since most of them accept that, for closing the eyelid, only the activation of the orbicularis oculi (OO) muscle (via the red nucleus to the facial motor nucleus) is necessary, without a simultaneous deactivation of levator palpebrae motoneurons (via unknown pathways projecting to the perioculomotor area). We have analyzed the kinetic neural commands of two antagonistic types of cerebellar posterior interpositus neuron (IPn) (types A and B), the electromyographic (EMG) activity of the OO muscle, and eyelid kinematic variables in alert behaving cats during classical eyeblink conditioning, using a delay paradigm. We addressed the hypothesis that the interpositus nucleus can be considered an agonistâantagonist system controlling eyelid kinematics during motor learning. To carry out a comparative study of the kineticâkinematic relationships, we applied timing and dispersion pattern analyses. We concluded that, in accordance with a dominant role of cerebellar circuits for the facilitation of flexor responses, type A neurons fire during active eyelid downward displacementsâi.e., during the active contraction of the OO muscle. In contrast, type B neurons present a high tonic rate when the eyelids are wide open, and stop firing during any active downward displacement of the upper eyelid. From a functional point of view, it could be suggested that type B neurons play a facilitative role for the antagonistic action of the levator palpebrae muscle. From an anatomical point of view, the possibility that cerebellar nuclear type B neurons project to the perioculomotor areaâi.e., more or less directly onto levator palpebrae motoneuronsâis highly appealing
A relevant IgE-reactive 28 kDa protein identified from Salsola kali pollen extract by proteomics is a natural degradation product of an integral 47 kDa polygalaturonase
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2017
- Field of study
[EN] A highly prevalent IgE-binding protein band of 28 kDa is observed when Salsola kali pollen extract is incubated with individual sera from Amaranthaceae pollen sensitized patients. By an immunoproteomic analysis of S. kali pollen extract, we identified this protein band as an allergenic polygalacturonase enzyme. The allergen, named Sal k 6, exhibits a pI of 7.14 and a molecular mass of 39,554.2 Da. It presents similarities to Platanaceae, Poaceae, and Cupressaceae allergenic polygalacturonases. cDNA-encoding sequence was subcloned into the pET41b vector and produced in bacteria as a His-tag fusion recombinant protein. The far-UV CD spectrum determined that rSal k 6 was folded. Immunostaining of the S. kali pollen protein extract with a rSal k 6-specific pAb and LC-MS/MS proteomic analyses confirmed the co-existence of the 28 kDa band together with an allergenic band of about 47 kDa in the pollen extract. Therefore, the 28 kDa was assigned as a natural degradation product of the 47 kDa integral polygalacturonase. The IgE-binding inhibition to S. kali pollen extract using rSal k 6 as inhibitor showed that signals directed to both protein bands of 28 and 47 kDa were completely abrogated. The average prevalence of rSal k 6 among the three populations analyzed was 30%, with values correlating well with the levels of grains/m(3) of Amaranthaceae pollen. Sal k 6 shares IgE epitopes with Oleaceae members (Fraxinus excelsior, Olea europaea and Syringa vulgaris), with IgE-inhibition values ranging from 20% to 60%, respectively. No IgE-inhibition was observed with plant-derived food extracts.This work was supported by grants SAF2011-26716 and SAF2014-53209-R from the Ministerio de Economia y Competitividad and RIRAAF Network RD12/0013/0015 from the ISCIII. R.B. was a fellow of the Ramon y Cajal program of the Ministerio de Economia y Competitividad (Spain). C.O-S. is supported by a contract of the Programa Operativo de Empleo Juvenil y la Iniciativa de Empleo Juvenil (YEI) with the participation of the Consejeria de Education, Juventud y Deporte de la Comunidad de Madrid y del Fondo Social Europeo.Mas-GarcĂa, S.; Oeo-Santos, C.; Cuesta-Herranz, J.; DĂaz-Perales, A.; ColĂĄs, C.; FernĂĄndez, J.; Barber, D.... (2017). A relevant IgE-reactive 28 kDa protein identified from Salsola kali pollen extract by proteomics is a natural degradation product of an integral 47 kDa polygalaturonase. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865(8):1067-1076. https://doi.org/10.1016/j.bbapap.2017.05.007S106710761865
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity
- Author
- AdriĂĄn Povo-Retana
- Antonio Castrillo
- Antonio Castrillo
- Carles Foguet
- Carlota Alvarez-Lucena
- Francesc Mas
- Juan Vladimir de la Rosa Medina
- Juan Vladimir de la Rosa Medina
- Lisardo BoscĂĄ
- Lisardo BoscĂĄ
- Lisardo BoscĂĄ
- Marco Fariñas
- Marina Mojena
- Marta Cascante
- Marta Cascante
- Miguel A. FernĂĄndez-Moreno
- Miguel A. FernĂĄndez-Moreno
- Rodrigo Landauro-Vera
- Sergio SĂĄnchez-GarcĂa
- Silvia Marin
- Silvia Marin
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/08/2023
- Field of study
In recent years, the central role of cell bioenergetics in regulating immune cell function and fate has been recognized, giving rise to the interest in immunometabolism, an area of research focused on the interaction between metabolic regulation and immune function. Thus, early metabolic changes associated with the polarization of macrophages into pro-inflammatory or pro-resolving cells under different stimuli have been characterized. Tumor-associated macrophages are among the most abundant cells in the tumor microenvironment; however, it exists an unmet need to study the effect of chemotherapeutics on macrophage immunometabolism. Here, we use a systems biology approach that integrates transcriptomics and metabolomics to unveil the immunometabolic effects of trabectedin (TRB) and lurbinectedin (LUR), two DNA-binding agents with proven antitumor activity. Our results show that TRB and LUR activate human macrophages toward a pro-inflammatory phenotype by inducing a specific metabolic rewiring program that includes ROS production, changes in the mitochondrial inner membrane potential, increased pentose phosphate pathway, lactate release, tricarboxylic acids (TCA) cycle, serine and methylglyoxal pathways in human macrophages. Glutamine, aspartate, histidine, and proline intracellular levels are also decreased, whereas oxygen consumption is reduced. The observed immunometabolic changes explain additional antitumor activities of these compounds and open new avenues to design therapeutic interventions that specifically target the immunometabolic landscape in the treatment of cancer
FamĂlies botĂ niques de plantes medicinals
- Author
- Alcoverro Godoy Carmen
- Alles Pascual Roser
- Alvarez Lorenzo Paula
- AnglĂ Herrero Oriol
- Bagan Perez Nuria
- Balaguer Pi Nuria
- Balcells Mestre Maria
- Ballesté Mårquez Jéssica
- Bartolomé Schneider Carla
- Batlle de Balle Mercadé Laura
- Belmonte Llorens Judit
- Bujedo Moreno Sergi
- Caballero Roman Aitor
- Calafat Gestoso Mario
- Camps Vilar Nuria
- CardĂșs Agra Aida
- Casas Serrano Rut
- Castanheira Margarida
- Castilla i AmorĂłs Laia
- Castro de la Cortina Laia
- Chavero Pieres Marta
- Ciocia Nicola
- Collado Lorenzo Jessica
- Corominas Auguets MĂČnica
- Costa Santamaria Berta
- Dalmases Gener Marc de
- Dios Regadera Montserrat de
- Domingo Gesteiro AdriĂĄn
- Dorado Cordero Desirée
- Escrigas AlbĂł Helena Evangelista
- Farré Carrera Laia
- Farré Segura Jordi
- FernĂĄndez CatalĂĄn Miren
- FernĂĄndez MartĂnez Gerard
- Ferreras Barrero Oriol
- Forcen Arenas Meritxell
- Formiga Ribas Estel
- FragĂŒet Español Beatriz
- Fuertes Flores Lara
- FĂ bregas VĂ zquez JĂșlia
- Garcia i Salvador Nestor
- GarcĂa Marquina Cristian
- Garrell Soler Gemma
- Garrido Lopez Ainoa
- GimĂ©nez GarcĂa del Moral MarĂa
- Gispert Latorre Laia
- Gomez de la Peña Celia
- Gomez-Guiu Hormigos Ma. Lourdes
- Grau Calzada Victoria
- Grau Ortiz Miquel
- Grima Arcos NĂșria
- Gómez Fusté Clà udia Maria
- HerrĂĄez Nieto Silvia
- Hurtado Espino Silvia
- Iglesias Rodrigo Mireia
- Izquierdo PĂ©rez Noelia
- Kaichouh Agrirch Mimoun
- Labraña Sånchez Carme
- Lara Arteaga Maria Dolores
- Lasurt Barés Claudia
- Llarden Mediavilla Arnau
- Llibre Perez Monica
- Llibre Perez Sandra
- Llorca Lorenzo Sonia
- Llorente Lopez Xavier
- Luque Castro AdriĂ
- Luque Salvat Marc
- LĂłpez Alonso Javier
- LĂłpez Ruiz Sergio
- Madurell i Blanes Laura
- Manouchehri Aminian S.
- March RodrĂguez Elena
- Martell Alonso ClĂ udia
- Martinez Alguacil Helena
- Martinez Bosch Laia
- MartĂnez Riveros HĂ©ctor
- MartĂnez Samitier Ălex
- Mas RincĂłn Irene
- Matas Ayala AnaĂŻs
- Miranda Jimenez Cristina
- Molas Casellas JĂșlia
- Molina TrullĂ s JĂșlia
- Moner Gomez Sofia
- Moral Anter David
- Morera Nadal JĂșlia
- Moya Martinez Mari Carmen
- Munte Jesus Guillem
- Nadal Serrano Maria de Lluc
- Narvaez Serrano Daniel Lluis
- Navarro Pinin Laura
- Nevado Maza Sara
- Oliver Sintes CristĂłbal
- Oros Olondriz Alberto
- Ortega Herrero Natalia
- Ortega Moreno Angel
- PachĂłn DĂaz Carles
- Pagans Llivina Silvia
- Pau Parra Alba
- Perez Prats Marc
- Pino Alamos Maria Pilar
- Pons Hospital Santiago
- Pucuji Tierra Lizeth EstefanĂ
- Puig Puig JĂșlia
- RaventĂłs Aymar Cristina
- Redondo Vahle Ana
- Reyner Parra AndrĂ©s JoaquĂm
- Riba Baqués Marta
- Rio Martinez Helena
- Rodriguez Isidro Pol
- Roig Rossello Mariona
- Roig Turner Gemma
- Rojas Ligeron John Henry
- Ros Peña Alba
- Rosendo MasiĂ Cristina
- Rubio Petit NĂșria
- Ruiz Avila Genesis
- RuĂz Mateo HĂ©ctor
- Sanchez Perez Cristina
- SantomĂ CardĂșs Alex
- Sanz Peñalver Sara
- Soler Mallart Guillem
- TanyĂ Rovira Anna
- Thorson Bofarull Leif
- Torres Solera Olga
- Torres Vila Maria
- Turu Pedrola Marta
- Vega RodrĂguez Laura
- Veiret Duart Gabriel
- Vela PĂ©rez Miriam
- Ventura Molina Pere
- Vidal Bernaltes Marta
- Vintu Stefan Silviu
- Ye Wenxi
- Publication venue
- Publication date
- 01/09/2014
- Field of study
Facultat de Farmà cia, Universitat de Barcelona. Ensenyament: Grau de Farmà cia, Assignatura: Botà nica FarmacÚutica, Curs: 2013-2014, Coordinadors: Joan Simon, CÚsar Blanché i
Maria Bosch.Els materials que aquĂ es presenten sĂłn els recull de 175 treballs dâuna famĂlia botĂ nica dâinterĂšs medicinal realitzats de manera individual. Els treballs han estat realitzat
per la totalitat dels estudiants dels grups M-2 i M-3 de lâassignatura BotĂ nica FarmacĂšutica
durant els mesos dâabril i maig del curs 2013-14. Tots els treballs sâhan dut a terme a travĂ©s de la plataforma de GoogleDocs i han estat tutoritzats pel professor de lâassignatura i revisats i finalment co-avaluats entre els propis estudiants. Lâobjectiu principal de lâactivitat ha estat fomentar lâaprenentatge autĂČnom i col·laboratiu en BotĂ nica farmacĂšutica
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
- Abbadie F
- Achkar A
- Ackroyd A
- Adamczyk A
- Adarraga Cansino Md
- Addala A
- Adnet F
- Agarwal G
- Ageno W
- Agnelli G
- Agnelli G
- Al Ahmad W
- Al-Refaie F
- Alexandra Jf
- Alikhan R
- Allameddine A
- Altarriba Es
- Amado FernĂĄndez C
- Amitrano M
- Amore M
- Angelini E
- Antignani Pl
- Aquilanti S
- Aranda Blazquez R
- Arden C
- Arellano Rodrigo E
- Armengou Arxe A
- Arone A
- Asaro G
- Attanzio Mt
- Attinasi V
- Austin A
- Axthelm C
- Axthelm P
- Bakhai A
- Balbarini A
- Ballaz Quincoces A
- Banfi E
- Banyai M
- Barcellona D
- Barillari G
- Bartolini C
- Barton T
- Bartone M
- Bauersachs R
- Bauersachs R
- Beato PĂ©rez Jl
- Bedate DĂaz P
- Belhassane A
- Bellanuova I
- Bellisi M
- Bellizzi A
- Benaroya B
- Bergmann K
- Berremili T
- Beschorner U
- Bianchi M
- Bianchini G
- Binias Kh
- Birr V
- Blanco-Molina Ma
- Boari B
- Body R
- Bonnin C
- Boral M
- Bortoluzzi C
- Bosler F
- Bramlage P
- Bratsch H
- Brauer G
- Bresin Durand Mg
- Brisot D
- Brodmann M
- Brousse C
- Brucoli C
- Burghard S
- Calandra G
- Calvo Mijares N
- Camporese G
- Canafoglia L
- Cancellieri E
- Cannavacciuolo F
- Caprioli C
- Carlizza A
- Carnovali M
- Carrasco ExpĂłsito M
- Carrasco Mas A
- Carugati A
- Casarsa C
- Castellote Mc
- Castrodeza Sanz R
- Catalini R
- Cavazza S
- Cayman C
- Cazaubon M
- Cañas Alcåntara I
- Cenci C
- Ceresa F
- Cereto Castro F
- Chacko J
- Champion O
- Chandra D
- Chanut M
- Charters F
- Chevalet P
- Church A
- Ciampa A
- Ciarambino T
- Cillari E
- Cisneros de la Fuente E
- Clemente M
- Clements J
- Clifford P
- Cohen At
- Connault J
- Constans J
- Conti F
- Cordeanu M
- Cosmi B
- Couturaud F
- Cox D
- Crouch M
- Crowther M
- D'Alessandro A
- D'Angelo A
- D'Antoni S
- Davies E
- Davies M
- de Ancos Aracil C
- De Bartolomeo G
- De Campora P
- de Daborenea GonzĂĄlez Md
- De Dedker L
- De Franciscis S
- De Gaudenzi E
- de la Fuente Aguado J
- De La Fuente T
- de las Revillas Fa
- De Santis F
- De Tommaso I
- Decoulx E
- del Carmen FernĂĄndez-CapitĂĄn M
- del Toro Cervera J
- Delgado Bregel Jl
- Delpin S
- Demann C
- Demmig A
- Derrien B
- Di Francesco L
- Di Maggio R
- Di Micco P
- Di Michele D
- Di Minno G
- Di Nisio M
- Di Salvo M
- Diamand Jm
- Diard A
- Dimitri S
- Donadio F
- Douadi Y
- Drebes A
- Dres P
- Dupas S
- Durant C
- DĂez FernĂĄndez F
- DâAvino M
- Eberhad Rieker E
- Eberlein U
- Edhery S
- Eischer L
- Elias HernĂĄndez T
- Emter E
- Enea I
- Enger F
- Eschenburg J
- Eschenburg Ju
- Ewad H
- Fabbian F
- Falanga A
- Falvo N
- Farcas Taralunga C
- Felis S
- FernĂĄndez Iglesias A
- Ferrari E
- Ferri Bataler R
- Fiore V
- Fontanella A
- Forkmann L
- Franco E
- Frank J
- Frank U
- Franklin S
- Frausini G
- Freischmidt H
- Fritsche I
- Fronk Em
- Fuorlo M
- Gaillard C
- Gallerani M
- Gamberini S
- Garcia Ma
- GarcĂa GarcĂa Jm
- GarcĂa Loizaga A
- GarcĂa-Bragado Dalmau F
- Garrigues D
- Gassauer M
- George J
- Gerofke H
- Ghirarduzzi A
- Ghizzi G
- Gianniello F
- Gibbs C
- Gillet Jl
- Giordana P
- Girke F
- Gitt Ak
- Giudice G
- Goebels Mc
- Goh T
- GonzĂĄlez Porras Jr
- GonzĂĄlez Lg
- Grange C
- Grare F
- Grenot Mc
- GrĂŒn-Himmelmann K
- Guarnera G
- Guercini F
- Guggenbichler S
- Guil GarcĂa M
- Gupta S
- Gutierrez Ja
- Hadj Henni A
- Hartmann K
- Heilberger P
- Heinsius A
- Held M
- Herman G
- Hernando LĂłpez E
- Herold J
- Hertrich F
- Heuser S
- Hidden-Henic V
- Hirschl M
- Holmes J
- Holtea D
- Hommel H
- Hottin D
- HĂ€rtel D
- HĂŒtte G
- Imbert B
- Imberti D
- Iosub Di
- Iozzi E
- Irvine N
- Jackson-Voyzey E
- Jacquinandi V
- Jakob D
- Jara Palomares L
- Jaras Mj
- Jeanneret C
- Jiménez Castro D
- JimĂ©nez-RodrĂguez Madridejos R
- Jones N
- Joya Seijo D
- Jungandreas K
- Jurus C
- Jörg Gr
- Kalka C
- Kallat A
- Karcher J
- Karl-Wollweber S
- Keilhau Da
- Kerr P
- Kesteven P
- Kittel K
- Knittel M
- Knolinski T
- Kopplin U
- Kroschel U
- Kröger K
- KubicekâHofmann C
- Köhler C
- Körner I
- La Forgia S
- La Regina M
- Lacoste A
- Lacut K
- Laeis P
- Landolfi R
- Laroche Jp
- Lecumberri R
- Lench T
- Leschke M
- Lester W
- Lewis M
- LluĂs Padierna M
- Lodigiani C
- Lorenzo HernĂĄndez A
- Lowe G
- Lutz A
- LĂłpez Castellanos Gt
- López Jiménez L
- LĂłpez Gt
- LĂłpez-SĂĄez Jb
- LĂŒbbert G
- Madridano Cobo O
- Mainez Saiz C
- Mancuso G
- Manfredini R
- Manzano Espinosa L
- Marchena Yglesias Pj
- Marconi L
- Marcucci R
- Marencke Gh
- Margheriti R
- Marongiu S
- Marra A
- Marrocco F
- Martin M
- Martinelli I
- MartĂn del Pozo M
- MartĂnez N
- Masotti L
- Mazollier C
- McCormack T
- McCoye A
- McGrane F
- Mearelli F
- Mearns B
- Melibovsky L
- Mersel T
- Milesi V
- Millón Caño Ja
- Miserey G
- Mismetti P
- Modeliar Remond Ss
- Mommi V
- Monreal Bosch M
- Monreal M
- Montagna Es
- Monte Secades R
- Mora LujĂĄn Jm
- Moral Moral P
- Moreno Flores A
- Moriarty A
- Morretti T
- Morris W
- Mortensen K
- Mos L
- Moysidis T
- Mugno F
- Muñoz RodrĂguez Fj
- Narayanan M
- Nedey C
- Nelles H
- Nestler K
- Neumeister A
- Nieto RodrĂguez Ja
- Nitti C
- Nou M
- NĂșñez FernĂĄndez Mj
- Oettler W
- Olivieri O
- Oncala Sibajas E
- Onesta M
- Oo N
- Orlandini F
- Ortiz de Saracho J
- Ott I
- Otto A
- Ouvry P
- Pagliara V
- Paiella L
- Pala P
- Palasciano G
- Palla A
- Paoletti O
- Paolucci G
- Parisi R
- Parra Caballero P
- Pasca S
- Pasin M
- Pasligh M
- PatanĂš F
- Pedrajas Navas Jm
- Pennacchioni M
- Pepe C
- Pernod G
- Pertermann A
- Perticone F
- Peter Marschang P
- Peuch B
- Pfister R
- Piccinni Gc
- Pichot O
- Pierri F
- Piloquet Fx
- Pindur P
- Pinto A
- Piovella F
- Pivetti G
- Pizzini Am
- Placentino M
- Poli D
- Pons MartĂn del Campo I
- Porreca E
- Portillo SĂĄnchez J
- Poulain V
- Pourhassan S
- Predel D
- Prisco D
- Pudollek T
- PĂ©rez Rus G
- Quere I
- Quezada Loaiza A
- Quintavalla R
- Ramthor M
- Rancan E
- Ray P
- Reed M
- Reimer D
- Rennebaum C
- Reppel M
- Reynaldo P
- Ria L
- Richter R
- Rief P
- Riera Mestre A
- Rifai A
- Rivera Gallego A
- RodrĂguez BeltrĂĄn Em
- RoldĂĄn Schilling V
- Romero Pizarro Y
- Roncero LĂĄzaro A
- Rose P
- Rossetto V
- RothenbĂŒcher G
- Rothhagen B
- Rovinelli M
- Roy Pm
- Rubino P
- Rudolff S
- Ruiz J
- Rupoli S
- Russo V
- Saby Jc
- Saccullo G
- Sada S
- Saja K
- Sala G
- Salmi R
- Salvi A
- Samaden A
- San RomĂĄn TerĂĄn Cm
- Sangiuolo R
- Santalla Valle Ea
- Santini C
- Schafnitzl W
- Schellong S
- Schenone A
- Schiller M
- Schlosser A
- Schmeink P
- Schmeink T
- Schmidt J
- Schnabl S
- Schneider H
- Schnupp S
- Schulze M
- SchÀfer A
- Schön N
- Sciacqua A
- Sechtem U
- Sedl S
- Serra R
- Severino S
- Sevestre Ma
- Signorelli Ss
- Silvestri E
- Silvestris F
- Simon F
- Simonot-Lalandec E
- Siniscalchi V
- Siragusa S
- Sivakumaran M
- Sohal M
- Sollazzo V
- Solomons G
- Sonnenschein K
- Sorvillo S
- Stachowitz J
- Staub D
- Stephan D
- Stoshikj S
- Strafino C
- StĂŒcker M
- Sultanzadeh Sj
- Suriñach Caralt Jm
- SĂĄnchez Fuentes D
- Sånchez Muñoz-Torrero Jf
- SĂĄnchez Ălvarez J
- Talerico A
- Testa S
- Thachil J
- Thieme M
- Tiefenbacher C
- Tirado Miranda R
- Tissot A
- TodolĂ Parra Ja
- Tonello C
- Tosi F
- Tropeano P
- Tsantilas D
- Tufano A
- Usandizaga de Antonio E
- Vallarelli S
- Vaquero de Sedas M
- Venton T
- Verdecchia P
- Vetrano V
- Vieth P
- ViganĂČ S
- Villalta Blanch J
- Villalta S
- Villanueva Montes Ma
- Villaverde Ălvarez I
- Vincentelli Gm
- Violo C
- Vital-Durand D
- Vodoungnon H
- Voigts B
- vom Dahl J
- von Bilderling P
- von Maltik T
- Wakeling J
- Walby C
- Waldron M
- Watt S
- Weber H
- Weinmann S
- Weinrich K
- Werner N
- Werno Hs
- Werth S
- Weyer M
- Willcock W
- Willich Sn
- Wirtz P
- Wittig I
- Wittig K
- Wucherpfennig P
- Zafar A.
- Zanatta N
- Zierock P
- Zingaretti O
- Zorzi F
- zur Nieden T
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 01/01/2017
- Field of study
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. HallarÄker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
- A. Jaremczuk-Kaczmarczyk
- A. Jarzebowski
- A. Jefferies
- A. Jekthammer
- A. Jerzewski
- A. John Camm
- A. John Camm
- A. John Camm
- A. Jones
- A. Kaczmarzyk-Radka
- A. Karczmarczyk
- A. Katta
- A. Kemmel
- A. Khan
- A. Khokhlov
- A. Koch
- A. Kolesnikova
- A. Kolodzinska
- A. Komlo
- A. Konopka
- A. Kopf
- A. Krueger
- A. Krzesiak-Lodyga
- A. Lavoie
- A. Lawande
- A. Lee
- A. Lettenström
- A. Leyva RendĂłn
- A. Lindberg
- A. Lindh
- A. Lindourkova
- A. Lischka-Lindner
- A. Lo Buglio
- A. Lopes
- A. Lopez
- A. Lucassen
- A. Ludkova
- A. Lysek-Jozefowicz
- A. Mannermyr
- A. Manzanal Rey
- A. Mariani
- A. Markiewicz
- A. Marquand
- A. Martin Vila
- A. Martinelli
- A. Maselli
- A. Matoltsy
- A. Mauric
- A. Meirino
- A. Menezes Lorga Filho
- A. Merliss
- A. Metzgier-Gumiela
- A. Mielot
- A. Mirtl
- A. Miyashita
- A. Mizuno
- A. Mowafy
- A. Murray
- A. Naguib
- A. Nagy
- A. Nakagomi
- A. Nakata
- A. Navarro
- A. Negrete Palma
- A. Negri
- A. Niemirycz-Makurat
- A. Nowak
- A. Nygaard
- A. Ohanissian
- A. Ohlsson
- A. Olofsson
- A. Ortiz
- A. Osberg
- A. Ota
- A. Oto
- A. Ovsannikova
- A. Page
- A. Papp
- A. Parkhomenko
- A. Pawelska-Buczen
- A. Pedersen
- A. Phrommintikul
- A. Pinter
- A. Pizzini
- A. Plauskat
- A. Podczeck-Schweighofer
- A. Postolache
- A. Pronk
- A. Pustelnik
- A. Quick
- A. Quietzsch
- A. Quisi
- A. Raczynska
- A. Raisaro
- A. Ramdass
- A. Reda
- A. Rodrigues
- A. Ross
- A. Sabir
- A. Sage
- A. Said
- A. Salinas
- A. Sapatyi
- A. Sasaki
- A. Scaccianoce
- A. Seoane Blanco
- A. Sidor
- A. Singal
- A. Skein
- A. Soliman
- A. Soma
- A. Sossich
- A. Spyropoulos
- A. Srinivas
- A. Sriwichian
- A. Stallinga-de Vos
- A. Steffens
- A. Suissa
- A. Sulc
- A. Svilaas
- A. Sword
- A. Szczepanska
- A. Szilagyi
- A. Szulowska
- A. Taguchi
- A. Talkenberger
- A. Tangsirira
- A. Tetlak
- A. Thatcher
- A. Therkelsen
- A. Thomson
- A. Tomasello
- A. Ushakov
- A. Vandorpe
- A. Vertes
- A. Vishnevsky
- A. Vonbank
- A. Wakeman
- A. Waldman
- A. Warke
- A. Wassef
- A. Wierzbicka
- A. Williams
- A. Wilson
- A. Wirdby
- A. Wutthimanop
- A. Yagensky
- A. Yoshimura
- A. Zateyshchikova
- A. Ăstrem
- A.-B. Ekstrand
- A.-K. Ascoop
- A.-M. Barbuto
- A.-M. Ohlin
- A.A. Damonte
- A.A. Fernandez
- A.B. Lensebraaten
- A.C. Billiaux
- A.C. Ingaramo
- A.C. Rothwell
- A.C. Tovar Castaneda
- A.C.P. Barretto
- A.D. Hrabar
- A.G. Ravi Shankar
- A.J. Kleiban
- A.J. McLeod
- A.L. Baek
- A.L. Cappi
- A.L. Tufare
- A.M. Jackson
- A.P. Drummond Wainstein
- A.P. Macagnan
- A.R. Kelsall
- A.R. Park
- A.S. Pandey
- Ajay K. Kakkar
- Ajay K. Kakkar
- Alex Parkhomenko
- Alex Spyropoulos
- Alexander G.G. Turpie
- Ali Oto
- Antonio Carlos Pereira Barretto
- B. Allasia
- B. Alzand
- B. Ayres
- B. Chatlaong
- B. Clarke
- B. Conway
- B. Coutu
- B. Crousillat
- B. Curyllo
- B. Deshpande
- B. Dolecka
- B. Doucet
- B. Dubois
- B. Dudzik-Richter
- B. Eriksson
- B. Fox
- B. Gaszner
- B. Ghezai
- B. Gosciniecka
- B. Hawkins
- B. Herrero Maeso
- B. Hoffmann
- B. Ikitimur
- B. Jacobson
- B. Jacobson
- B. Jansson
- B. Jimeno Besa
- B. Kurylo
- B. Kurylo
- B. Li
- B. Liu
- B. Lokesh
- B. Martinsson
- B. Mautner
- B. Merkely
- B. Mooso
- B. Naratreekoon
- B. Okopien
- B. Opielowska-Nowak
- B. Ostrowska-Pomian
- B. Racz
- B. Raghuraman
- B. Ramjattan
- B. Rzyczkowska
- B. Sarai
- B. Schaefer
- B. SchneeweiĂ
- B. Schweitzer
- B. Sievers
- B. Silaruks
- B. Singh
- B. Sinha
- B. Stephanie
- B. Strohmer
- B. Subbaraman
- B. Unterkircher
- B. Uppelschoten
- B. Vandrus
- B. Vanhauwaert
- B. Vishwanathan
- B. Vogel
- B. Voigts
- B. Ward
- B. Wollaert
- B. Wozakowska-Kaplon
- B. Zhou
- B.-T. Kellner
- B.A.J. Stockins Fernandez
- B.C. Jung
- B.E. Groenemeijer
- B.R. Park
- B.Y. Sayin
- Barry Jacobson
- Bernard J. Gersh
- C. A'Court
- C. Arabetti
- C. Astudillo
- C. Axthelm
- C. Batta
- C. Beltra
- C. Bergeron
- C. Bergeron
- C. Bester
- C. Boshoff
- C. Bothin
- C. Bouvy
- C. Bradshaw
- C. Brike
- C. Brotons Cuixart
- C. Bugueño Gutiérrez
- C. Buiks
- C. Bulla
- C. Buzzetti
- C. Cannon
- C. CantĂș Brito
- C. Chami
- C. Chigbo
- C. Ciabatta
- C. Conejeros
- C. Correa
- C. Corros Vicente
- C. Costantini Ortiz
- C. D'Arienzo
- C. Dias
- C. Dooldeniya
- C. DĂaz de la Vega
- C. Ellervik
- C. Femiano
- C. Fonseca
- C. Fritz
- C. Funosas
- C. Giles
- C. Gines Garcia
- C. Gomez
- C. GrÀssjö
- C. Guldener
- C. GĂłmez Pajuelo
- C. Hagn
- C. Hawkins
- C. HernĂĄndez Herrera
- C. Herrick
- C. Hines
- C. Houzvic
- C. Hutton
- C. Jacobs
- C. Jean
- C. Juergens
- C. Kongsin
- C. Lara
- C. Latella
- C. Lewis
- C. Liley
- C. Lodigiani
- C. Martinelli
- C. Mazzone
- C. McCarthy
- C. McIntosh
- C. Moncada
- C. Moro Serrano
- C. Mulholland
- C. Munhoz da Fontoura Tavares
- C. Mussap
- C. Nanzer Vital
- C. Nilsson
- C. Ogurusu
- C. Ormundo
- C. Orosco
- C. Ortiz Cortes
- C. Paul
- C. Pisani
- C. Queirantes
- C. Ramesh
- C. Ravenhorst
- C. Reichelt
- C. Reimer
- C. Rey
- C. Richard
- C. Ricotti
- C. Rivera Ramos
- C. Robertson
- C. Roca Saumell
- C. Rodrigo
- C. Santolaya
- C. Scarone
- C. Scheurwegs
- C. Schubert
- C. Schwencke
- C. Seamark
- C. Simon Valero
- C. Singh
- C. Singleton
- C. Smessaert
- C. Stoll
- C. Stöcklöcker
- C. Sugimoto
- C. Takanaka
- C. Thorsen
- C. Tondo
- C. Torres
- C. Treasure
- C. Vantomme
- C. Verdi
- C. Vicente
- C. Villan
- C. Wöhrer
- C. Yeo
- C. Zecca
- C.-J. Kim
- C.-J. Lindholm
- C.A. Almeida FernĂĄndez
- C.A. Neden
- C.C. Broilo França
- C.G. Foo
- C.H. Del Carlo
- C.H. Gimenez
- C.J. SĂĄnchez DĂaz
- C.K. Ching
- C.L. Bai
- C.L. Gonzalez Garcia
- C.M. Diaz Lopez
- C.P. Jones
- C.R. Costantini Frack
- C.R. Frack Costantini
- C.S. Lee
- Carlos Jerjes SĂĄnchez DĂaz
- Carmela Alonso
- Concepcion Alonso
- D. Adak
- D. Alpay
- D. Alvarez
- D. Amstutz
- D. Andrzejewski
- D. Aras
- D. Armaganijan
- D. Atar
- D. Belenky
- D. Bertolim Precoma
- D. Blaszczyk
- D. Buckert
- D. Cassidy
- D. Castro Fernandez
- D. Chemello
- D. Cholsaringkarl
- D. Colquhoun
- D. Conde
- D. Coulshed
- D. Cresp
- D. Crimmins
- D. Davies
- D. De Cleen
- D. Denie
- D. Diercks
- D. Eccleston
- D. Edwards
- D. Faes
- D. Farquhar
- D. Fielder
- D. Fitzmaurice
- D. Fitzpatrick
- D. Flores MartĂnez
- D. Fournier
- D. Galley
- D. Geatch
- D. Genc
- D. Glatzel
- D. Goodwin
- D. Gray
- D. Greyling
- D. Guanaes
- D. Guedj-Meynier
- D. Gulyas
- D. Ikeda
- D. Jackson
- D. Jain
- D. Kernick
- D. Kettles
- D. Kociolek
- D. Komar
- D. Konyushenko
- D. Kroll
- D. Kruczyk
- D. Kusiak
- D. Kustrzycka-Kratochwil
- D. Lesniewska-Krynska
- D. Leung
- D. Lopes
- D. LĂłpez Villezca
- D. Martinez Vasquez
- D. Merritt
- D. Michalik
- D. Montes
- D. Moreira
- D. Naik
- D. Nicolaus
- D. Nishijima
- D. O'Donnell
- D. Obadia
- D. Otero Tomera
- D. Platonov
- D. Plevak
- D. Poli
- D. Redpath
- D. Reimer
- D. Roy
- D. Rozewska-Furmanek
- D. Russell
- D. Sanchez
- D. Santos
- D. Seamark
- D. Shah
- D. Shah
- D. Shepherd
- D. Theodoro
- D. Tragen
- D. Uzun Alkan
- D. Van Lier
- D. Vandenbroeck
- D. Wright
- D. Zanolin
- D. Zateyshchikov
- D.-G. Shin
- D.-K. Kim
- D.B. Kim
- D.C. Esteves
- D.C. Sobral Filho
- D.D. Chen
- D.F. Cumberlidge
- D.H. Kim
- D.J. Choi
- D.R. Ryu
- D.W. Wang
- D.Y. Hu
- Dan Atar
- David A. Fitzmaurice
- David Fitzmaurice
- Dayi Hu
- E. Ahbeck
- E. Alborough
- E. Aleksandrova
- E. Banfi
- E. Barraquer Feu
- E. Bearez
- E. Bekieszczuk
- E. Belisario Falchetto
- E. Berge
- E. Blumberg
- E. Broton
- E. Buckley
- E. Burke
- E. Calvo Martinez
- E. Cardona Muñoz
- E. Chuquiure Valenzuela
- E. Corrihons
- E. Daros
- E. Davies
- E. Deweerd
- E. Domanska
- E. Ducasse
- E. EiĂfeller
- E. Ellie
- E. Eriksen
- E. EscrivĂĄ Montserrat
- E. Fernandes
- E. Fernandez Escobar
- E. Fernandez Mas
- E. Feys
- E. Fisher
- E. Fulop
- E. Gasior
- E. Gjertsen
- E. Gorbunova
- E. Hartranft
- E. Hettwer Magedanz
- E. Hevia Rodriguez
- E. Jaskulska-Niedziela
- E. Kamenska
- E. Kiralyhazine Gyorke
- E. Kis
- E. Kochanska
- E. Korczowska
- E. Kowal
- E. Krcova
- E. Kremis
- E. Kropacheva
- E. Lanna Figueiredo
- E. Lewicka
- E. Lichota
- E. Lileeva
- E. Loyd
- E. Lustosa
- E. LĂłpez Rosas
- E. Malone
- E. Mazur
- E. Mesolella
- E. Miedlar
- E. Molina
- E. Mollica Poeta
- E. MĂĄrquez Contreras
- E. Nagata
- E. Noori
- E. Novikova
- E. Okuyan
- E. Otaki
- E. Ozcelik
- E. Palmegiani
- E. Panchenko
- E. Pawlik-Rak
- E. Pena Garcia
- E. Polkanova
- E. Prochazkova
- E. Raymenants
- E. Rodriguez
- E. Saga
- E. Salomone
- E. Schaflinger
- E. Serralvo
- E. Shutemova
- E. Staniszewska
- E. Strieder
- E. Stuart
- E. Szuchnik
- E. Tiraferri
- E. Vanhalst
- E. Villeda Espinosa
- E. Watson
- E. Wilford
- E. Yakupov
- E. Yeter
- E. Yildirim
- E. Zaatout
- E. Zhuravleva
- E. Zidkova
- E. Zinka
- E.A. Choi
- E.B. Karaayvaz
- E.D. Alaguibe
- E.G. Lino
- E.H. Choi
- E.H. Lee
- E.J. Gonzalez Felix
- E.J. Yoon
- E.M. Esheiba
- E.M. Jang
- E.M. Koomen
- E.M. Pogliani
- E.P. Gurfinkel
- E.R. Fernandes Manenti
- E.S. Heo
- Elizaveta Panchenko
- F. Ahmed
- F. Al-Khalili
- F. Alban
- F. Aras
- F. Ayala-Paredes
- F. Banaeian
- F. Berli
- F. Bernsten
- F. Bitakova
- F. Bosman
- F. Busch
- F. Calcagnoli
- F. Casassus
- F. Chemin
- F. Chieza
- F. Choudhary
- F. Colombo Berra
- F. Cools
- F. Cosmi
- F. da Silva Paulitsch
- F. Diez
- F. Dormal
- F. Epelde Gonzalo
- F. Fernandez Voena
- F. Ferroni
- F. Flores Silva
- F. ForcignanĂČ
- F. Freihoff
- F. Freire
- F. Geerlings
- F. Germini
- F. Gits
- F. Guerra
- F. Hakimi
- F. Hoshino
- F. Igansi
- F. Iseki
- F. Jannuzzi
- F. Juhasz
- F. Kahl
- F. Lanas
- F. Lillo
- F. Macellari
- F. Melone
- F. Mendez Zurita
- F. Minetti
- F. Okuda
- F. Paganelli
- F. Perez
- F. Petrie
- F. Ridocci Soriano
- F. Robin
- F. Rolandi
- F. Roquette
- F. Scouller
- F. Sellem
- F. Shaik
- F. Sztanyik
- F. Toyota
- F. Tradati
- F. Van Durme
- F. van Zyl
- F. Villaça Guimarães Filho
- F. Yilmaz
- F.A. Alves da Costa
- F.E. Camazzola
- F.J. Bermudez Jimenez
- F.J. Zurbrigk
- F.R. Jaufeerally
- F.Z. Wang
- Frank Cools
- Frank Misselwitz
- Freek W.A. Verheugt
- G. Agnelli
- G. Ambrosio
- G. Angel
- G. Arriagada
- G. Avanzino
- G. Baglioni
- G. Bantwal
- G. BarĂłn Esquivias
- G. Berko
- G. Biazus
- G. Boggian
- G. Bonkowski
- G. Brauer
- G. Burns
- G. Campagna
- G. Cancho Corchado
- G. Charme Vilches
- G. Ciliberti
- G. Cimmino
- G. Conway
- G. Di Minno
- G. Dresser
- G. Du Plessis
- G. Duranti
- G. Eggers
- G. Elise
- G. Engelthaler
- G. Giacomi
- G. Glanowska
- G. Guazzaloca
- G. Hergdt
- G. Hollanders
- G. Jaguszewska
- G. Jethoo
- G. Juhasz
- G. Junior
- G. Kamalov
- G. Kania
- G. Kulkarni
- G. Königer
- G. Lehmann
- G. Lim
- G. Llamas EsperĂłn
- G. Lochorn
- G. Maehara
- G. Mairesse
- G. Marcos Gomez
- G. Martini
- G. Melo
- G. Menken
- G. MillĂĄn
- G. Monako
- G. Monniot
- G. Nagibovich
- G. Oldfield
- G. Opolski
- G. Palareti
- G. Paparella
- G. Pearl
- G. Perez Prados
- G. Pickavance
- G. Piseddu
- G. Poirier
- G. Pozas
- G. Raczak
- G. Rangel
- G. Rehling
- G. Reis
- G. Rodier
- G. Rogers
- G. Romero Cardona
- G. Santana
- G. Sas
- G. Serviddio
- G. Skjelvan
- G. Sottilota
- G. Starmer
- G. Stuchlik
- G. SvÀrd
- G. Szalai
- G. Szantai
- G. Szumczyk-Muszytowska
- G. Tanabe
- G. Tarr
- G. Taylor
- G. Tian
- G. Tincani
- G. Tobajas
- G. Trzcinski
- G. van Leeuwen
- G. Van Zon
- G. Vervoort
- G. Vijayaraghavan
- G. Yousef
- G. Zapata
- G. Zubeeva
- G.-B. Eriksson
- G.-B. Nam
- G.-S. Hwang
- G.-U. Heinz
- G.A. Sambadaro
- G.B. Aranha Rosito
- G.H. Lee
- G.R. AraĂșjo
- G.R. de AraĂșjo
- G.S. Fu
- G.S. Zhang
- G.Z. Tao
- Giancarlo Agnelli
- Giuseppe Ambrosio
- Gloria Kayani
- Govindan Vijayaraghavan
- H. Aaröe
- H. Abdelrahman
- H. Adriaansen
- H. Ahlmark
- H. Ando
- H. Antonsen
- H. Arai
- H. Asano
- H. Bae
- H. Begum
- H. Bellotti Lopes
- H. Burianova
- H. Capiau
- H. Chibana
- H. Choi
- H. Claussen
- H. Darius
- H. Date
- H. Dimitri
- H. Doi
- H. DomĂnguez
- H. Drexel
- H. Floegel
- H. Gibbs
- H. Handel
- H. Hey
- H. Hirayama
- H. Hohensee
- H. Hosokawa
- H. Ibsen
- H. Ikeda
- H. Inaba
- H. Jones
- H. Kakuda
- H. Kanai
- H. Kanda
- H. Kano
- H. Kato
- H. Kiat
- H. Kihara
- H. Kitazawa
- H. Kitazumi
- H. Klomps
- H. Komatsu
- H. Kubo
- H. Lauer
- H. Leuchtgens
- H. Li
- H. Li
- H. Lindvall
- H. Little
- H. Lubanda
- H. Maekawa
- H. Menke
- H. Michel
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- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
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- Abbiendi G
- Abbrescia M
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- Yzquierdo AP-C
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
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- Zecchinelli AG
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- Zghiche A
- Zhang F
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- Zhizhin I
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- Ziemons T
- Zientek M
- Zlebcik R
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- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
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- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ÂŻ
Recommended from our members
Search for low-mass dilepton resonances in Higgs boson decays to four-lepton final states in protonâproton collisions at âs=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- AdĂĄn DP
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- AimĂš C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alonso AG
- Alvarez JDR
- Alverson G
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- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Data Availability: This manuscript has no associated data or the data will not be deposited. [Authorsâ comment: For CMS Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2).]Copyright © CERN for the benefit of the CMS collaboration 2022. A search for low-mass dilepton resonances in Higgs boson decays is conducted in the four-lepton final state. The decay is assumed to proceed via a pair of beyond the standard model particles, or one such particle and a Z boson. The search uses protonâproton collision data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 137fbâ1, at a center-of-mass energy sâ=13TeV. No significant deviation from the standard model expectation is observed. Upper limits at 95% confidence level are set on model-independent Higgs boson decay branching fractions. Additionally, limits on dark photon and axion-like particle production, based on two specific models, are reported.SCOAP3
Recommended from our members
Precision measurement of the W boson decay branching fractions in proton-proton collisions at âs=13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abercrombie D
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- Afanasiev S
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- Alvarez JDR
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- Zalewski P
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- Zorbilmez C
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- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 26/04/2022
- Field of study
The leptonic and inclusive hadronic decay branching fractions of the W boson are measured using
proton-proton collision data collected at ffiffi s p Œ 13 TeV by the CMS experiment at the CERN LHC,
corresponding to an integrated luminosity of 35.9 fbâ1. Events characterized by the production of one or
two W bosons are selected and categorized based on the multiplicity and flavor of reconstructed leptons, the
number of jets, and the number of jets identified as originating from the hadronization of b quarks. A
binned maximum likelihood estimate of the W boson branching fractions is performed simultaneously in
each event category. The measured branching fractions of the W boson decaying into electron, muon, and
tau lepton final states are Ă°10.83 0.10Ă%, Ă°10.94 0.08Ă%, and Ă°10.77 0.21Ă%, respectively,
consistent with lepton flavor universality for the weak interaction. The average leptonic and inclusive
hadronic decay branching fractions are estimated to be Ă°10.89 0.08Ă% and Ă°67.32 0.23Ă%, respec tively. Based on the hadronic branching fraction, three standard model quantities are subsequently derived: the sum of squared elements in the first two rows of the CabibboâKobayashiâMaskawa (CKM) matrix
P ij jVijj 2 Œ 1.984 0.021, the CKM element jVcsj Œ 0.967 0.011, and the strong coupling constant at
the W boson mass scale, αSĂ°m2 WĂ ÂŒ 0.095 0.033
- âŠ