Análisis de políticas públicas de suelo y agua en la región del Maule en el marco de la evaluación ambiental estratégica

110 p.Para determinar el estado de conservación de los recursos productivos silvoagropecuarios de suelo y agua utilizados en la Región del Maule, se realiza una Evaluación Ambiental Estratégica de las políticas públicas aplicadas, usando la metodología OCDE. El análisis indica un importante deterioro de estos recursos porque los programas gubernamentales de gestión de ellos no son suficientes para preservarlos y/o recuperarlos. Si no se toman medidas correctivas, se espera que la degradación genere un importante efecto negativo sobre la economía de la Región del Maule. Estos impactos irían por el lado de reducción de productividad por erosión de suelo o por reducción de agua para riego. Se propone la consideración de instrumentos de gestión ambiental complementarios a los programas públicos actualmente aplicados./SUMMARY:To determine the state of conservation of soil and water resources used in the Maule Region, we conducted a Strategic Environmental Assessment of public policies applied, using the OECD methodology. The analysis indicates a significant deterioration of the resources because government programs management are not sufficient to preserve and/or back. If corrective measures are not taken, it is expected that the degradation generates a significant negative effect on the economy of the region of Maule. These impacts would go by the side of productivity by reducing soil erosion or by reducing irrigation water. It is proposed that consideration of environmental management tools to complement public programs currently used

Perspectivas economicas del cultivo de las leguminosas en la comuna de Curepto.

116 p.El presente trabajo de investigación se orienta a establecer las perspectivas económicas del cultivo de las Leguminosas en la comuna de Curepto en un entorno de mercados globalizados. Para abordar el estudio, se analizan. utilizando técnicas estadísticas. factures relevantes 4tre caracterizan, en el país. tanto la Demanda (evolución del consumo per capita) coma la Oferta (Estructura productiva campesina y puntos de equilibrio). Considerando un contexto de mercados globalizados, se examinan las tendencias de consumo mundial de leguminosas a objeto de establecer proyectar las perspectivas comerciales de estos productos Finalmente, se concluye respecto de las posibilidades competitivas. en mercados globalizados, del cultivo de leguminosas en la comuna de Curepto

A Blueprint for a Blockchain-Based Architecture to Power a Distributed Network of Tamper-Evident Learning Trace Repositories

The need to ensure privacy and data protection in educational contexts is driving a shift towards new ways of securing and managing learning records. Although there are platforms available to store educational activity traces outside of a central repository, no solution currently guarantees that these traces are authentic when they are retrieved for review. This paper presents a blueprint for an architecture that employs blockchain technology to sign and validate learning traces, allowing them to be stored in a distributed network of repositories without diminishing their authenticity. Our proposal puts participants in online learning activities at the center of the design process, granting them the option to store learning traces in a location of their choice. Using smart contracts, stakeholders can retrieve the data, securely share it with third parties and ensure it has not been tampered with, providing a more transparent and reliable source for learning analytics. Nonetheless, a preliminary evaluation found that only 56% of teachers surveyed considered tamper-evident storage a useful feature of a learning trace repository. These results motivate further examination with other end users, such as learning analytics researchers, who may have stricter expectations of authenticity for data used in their practice

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells.

Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated. Here, by interrogating chromatin reorganization during human pluripotent stem cell (hPSC) differentiation, we discover a role for the primate-specific endogenous retrotransposon human endogenous retrovirus subfamily H (HERV-H) in creating topologically associating domains (TADs) in hPSCs. Deleting these HERV-H elements eliminates their corresponding TAD boundaries and reduces the transcription of upstream genes, while de novo insertion of HERV-H elements can introduce new TAD boundaries. The ability of HERV-H to create TAD boundaries depends on high transcription, as transcriptional repression of HERV-H elements prevents the formation of boundaries. This ability is not limited to hPSCs, as these actively transcribed HERV-H elements and their corresponding TAD boundaries also appear in pluripotent stem cells from other hominids but not in more distantly related species lacking HERV-H elements. Overall, our results provide direct evidence for retrotransposons in actively shaping cell type- and species-specific chromatin architecture

Promoting and Implementing Digital STEM Education at Secondary Schools in Africa

This paper discusses an ongoing initiative aimed at promoting and implementing digital STEM education at secondary schools in Africa. This initiative, coined Go-Lab Goes Africa (GO-GA), is an innovation action supported by the European Commission through its H2020 Framework Programme for Research and Technological Development in Information and Communication Technologies (ICT). The general vision and the implementation strategy are outlined in detail, as well as the challenges faced and results achieved during its first year

Can scenario-planning support community-based natural resource management? Experiences from three countries in latin america

Community Based Natural Resource Management (CBNRM) is a concept critical to managing socio-ecological systems, but whose implementation needs strengthening. Scenario-planning is one approach that may offer benefits relevant to CBNRM, but whose potential is not yet well understood. We therefore designed, trialled and evaluated a scenario-planning method intended to support CBNRM at three cases, located in Colombia, Mexico and Argentina. Implementing scenario-planning was judged as worthwhile in all three cases, although aspects of it could be challenging to facilitate. The benefits generated were relevant to strengthening CBNRM: encouraging the participation of local people and using their knowledge; enhanced consideration and adaption of future change; and supporting the development of systems thinking. Tracing exactly when and how these benefits arise is challenging, but two elements of the method seemed particularly useful. Firstly, using a systematic approach to discuss how drivers of change may affect local socio-ecological systems helped to foster systems thinking and identify connections between issues. Secondly, explicitly focusing on how to use and respond to scenarios helped identify specific practical activities ('response options') that would support CBNRM despite the pressures of future change. Discussions about response options also highlighted the need for support by other actors (e.g. policy groups): this raises the question of when and how other actors and other sources of knowledge should be involved in scenario-planning, so as to encourage their buy-in to actions identified by the process. We suggest other CBNRM initiatives may benefit from adapting and applying scenario-planning. However, these initiatives should be carefully monitored since further research is required to understand how and when scenario-planning methods may produce benefits, and their strengths and weaknesses versus other methods

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Characterizing Emerging Canine H3 Influenza Viruses.

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned