102 research outputs found
Measurement of (anti)deuteron and (anti)proton production in DIS at HERA
The first observation of (anti)deuterons in deep inelastic scattering at HERA
has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV
using an integrated luminosity of 120 pb-1. The measurement was performed in
the central rapidity region for transverse momentum per unit of mass in the
range 0.3<p_T/M<0.7. The particle rates have been extracted and interpreted in
terms of the coalescence model. The (anti)deuteron production yield is smaller
than the (anti)proton yield by approximately three orders of magnitude,
consistent with the world measurements.Comment: 26 pages, 9 figures, 5 tables, submitted to Nucl. Phys.
Measurement of dijet photoproduction for events with a leading neutron at HERA
Differential cross sections for dijet photoproduction and this process in
association with a leading neutron, e+ + p -> e+ + jet + jet + X (+ n), have
been measured with the ZEUS detector at HERA using an integrated luminosity of
40 pb-1. The fraction of dijet events with a leading neutron was studied as a
function of different jet and event variables. Single- and double-differential
cross sections are presented as a function of the longitudinal fraction of the
proton momentum carried by the leading neutron, xL, and of its transverse
momentum squared, pT^2. The dijet data are compared to inclusive DIS and
photoproduction results; they are all consistent with a simple pion-exchange
model. The neutron yield as a function of xL was found to depend only on the
fraction of the proton beam energy going into the forward region, independent
of the hard process. No firm conclusion can be drawn on the presence of
rescattering effects.Comment: 40 pages, 18 figure
Deep inelastic inclusive and diffractive scattering at values from 25 to 320 GeV with the ZEUS forward plug calorimeter
Deep inelastic scattering and its diffractive component, , have been studied at HERA with the ZEUS
detector using an integrated luminosity of 52.4 pb. The method has
been used to extract the diffractive contribution. A wide range in the
centre-of-mass energy (37 -- 245 GeV), photon virtuality (20 -- 450
GeV) and mass (0.28 -- 35 GeV) is covered. The diffractive cross
section for GeV rises strongly with , the rise becoming
steeper as increases. The data are also presented in terms of the
diffractive structure function, , of the proton. For fixed
and fixed , \xpom F^{\rm D(3)}_2 shows a strong rise as \xpom \to
0, where \xpom is the fraction of the proton momentum carried by the
Pomeron. For Bjorken-, \xpom F^{\rm D(3)}_2 shows
positive scaling violations, while for
negative scaling violations are observed. The diffractive structure function is
compatible with being leading twist. The data show that Regge factorisation is
broken.Comment: 89 pages, 27 figure
State of the world’s plants and fungi 2020
Kew’s State of the World’s Plants and Fungi project provides assessments of our current knowledge of the diversity of plants and fungi on Earth, the global threats that they face, and the policies to safeguard them. Produced in conjunction with an international scientific symposium, Kew’s State of the World’s Plants and Fungi sets an important international standard from which we can annually track trends in the global status of plant and fungal diversity
The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set
Background
Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables.
Methods
Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set.
Results
Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001).
Conclusions
The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep learning models able to predict CAGE signal at STRs with high accuracy. These models unveil the importance of STR surrounding sequences not only to distinguish STR classes, but also to predict the level of transcription initiation. Importantly, genetic variants linked to human diseases are preferentially found at STRs with high transcription initiation level, supporting the biological and clinical relevance of transcription initiation at STRs. Together, our results extend the repertoire of non-coding transcription associated with DNA tandem repeats and complexify STR polymorphism
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