Wahlen in Argentinien: Niederlage, Rezession und Politikverdrossenheit; kann Präsident De La Rua weiter regieren?

"Die Wahlen vom 14. Oktober 2001 brachten der in Argentinien regierenden Koalition eine herbe Niederlage ein. Für den Präsidenten war das Wahlergebnis paradoxerweise nicht völlig unerfreulich, denn sowohl seine eigene Partei (UCR) als auch der Koalitionspartner (FREPASO) unterstützen ihn kaum oder nur zögerlich. Kann De La Rua seine politische Isolation überleben? Die Regierung will jedenfalls die relativ hohe Zahl der Nichtwähler als ein Zeichen dafür interpretieren, dass "alle Politiker" potenzielle Verlierer sind, und nicht nur der Präsident. Inzwischen verschärft sich die Wirtschaftskrise, und der Vertrauensverlust Argentiniens wird ohne eine starke politische Führung nicht zu überwinden sein." (Brennpkt. Lat.am/DÜI

La dificultad contramayoritaria de las burocracias públicas: democracia, ética y legitimidad institucional en América Latina

El concepto de dificultad contramayoritaria, aplicado al control de constitucionalidad, describe el problema de justificar que un tribunal declare inválida (inconstitucional) una ley, votada por los representantes de una mayoría de los ciudadanos. ¿Es esto legítimo? En el presente trabajo, analizamos un problema similar respecto a las burocracias públicas, relativamente menos discutido hasta ahora: ¿puede la burocracia pública tomar decisiones que considera justificadas, o tiene que limitarse a implementar las directivas del poder político en todos los casos? El debate se ha planteado con intensidad en México, durante los últimos años, pero afecta a la configuración institucional de otros países en América Latina.The concept of countermajoritarian difficulty, applied to constitutional review, describes the problem of justifying that a tribunal declares invalid (unconstitutional) a law that was voted by representatives of a majority of citizens. ¿Is this legitimate? The present work analyzes a similar problem for public bureaucracies, which has been comparatively less discussed until now: ¿can public bureaucracies take decisions that they consider justified, or must they be restricted to implement directions of the political power in all cases? This issue was intensely debated in Mexico for the past few years, but it affects the institutional configuration of other Latin American countries

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

La dificultad contramayoritaria de las burocracias públicas: Democracia, ética y legitimidad institucional en América Latina

españolEl concepto de dificultad contramayoritaria, aplicado al control de constitucionalidad, describe el problema de justificar que un tribunal declare inválida (inconstitucional) una ley, votada por los representantes de una mayoría de los ciudadanos. ¿Es esto legítimo? En el presente trabajo, analizamos un problema similar respecto a las burocracias públicas, relativamente menos discutido hasta ahora: ¿puede la burocracia pública tomar decisiones que considera justificadas, o tiene que limitarse a implementar las directivas del poder político en todos los casos? El debate se ha planteado con intensidad en México, durante los últimos años, pero afecta a la configuración institucional de otros países en América Latina

Poor Household Participation in Payments for Environmental Services: Lessons from the Silvopastoral Project in Quindío, Colombia

Payments for environmental services (PES), Poverty, Silvopastoral, Colombia,

Screening policies, preventive measures and in-hospital infection of COVID-19 in global surgical practices

Background: In a surgical setting, COVID-19 patients may trigger in-hospital outbreaks and have worse postoperative outcomes. Despite these risks, there have been no consistent statements on surgical guidelines regarding the perioperative screening or management of COVID-19 patients, and we do not have objective global data that describe the current conditions surrounding this issue. This study aimed to clarify the current global surgical practice including COVID-19 screening, preventive measures and in-hospital infection under the COVID-19 pandemic, and to clarify the international gaps on infection control policies among countries worldwide. Methods: During April 2-8, 2020, a cross-sectional online survey on surgical practice was distributed to surgeons worldwide through international surgical societies, social media and personal contacts. Main outcome and measures included preventive measures and screening policies of COVID-19 in surgical practice and centers' experiences of in-hospital COVID-19 infection. Data were analyzed by country's cumulative deaths number by April 8, 2020 (high risk, >5000; intermediate risk, 100-5000; low risk, <100). Results: A total of 936 centers in 71 countries responded to the survey (high risk, 330 centers; intermediate risk, 242 centers; low risk, 364 centers). In the majority (71.9%) of the centers, local guidelines recommended preoperative testing based on symptoms or suspicious radiologic findings. Universal testing for every surgical patient was recommended in only 18.4% of the centers. In-hospital COVID-19 infection was reported from 31.5% of the centers, with higher rates in higher risk countries (high risk, 53.6%; intermediate risk, 26.4%; low risk, 14.8%; P < 0.001). Of the 295 centers that experienced in-hospital COVID-19 infection, 122 (41.4%) failed to trace it and 58 (19.7%) reported the infection originating from asymptomatic patients/staff members. Higher risk countries adopted more preventive measures including universal testing, routine testing of hospital staff and use of dedicated personal protective equipment in operation theatres, but there were remarkable discrepancies across the countries. Conclusions: This large international survey captured the global surgical practice under the COVID-19 pandemic and highlighted the insufficient preoperative screening of COVID-19 in the current surgical practice. More intensive screening programs will be necessary particularly in severely affected countries/institutions