Eye tracking analysis of browser security indicators

Understanding the natural human behavior when people interact with Web browsers is essential for building more user-centric interface design that is customized based on user\u27s perception and experience. This paper presents the first empirical study of users\u27 interaction with security indicators in Web browsers in a controlled real life security risk. The work focuses on the natural and spontaneous behavior of the victim\u27s eyes on several predetermined area of interest, and empirically presents users\u27 evaluation of several online logon pages. The experiment and its results provide a quantitative evidence of the usability of visual security indicators in Internet Explorer (IE8). We first categorized a set of Websites and created phishing Web Pages using most known phishing techniques, and then a group of users from different backgrounds and age groups took the controlled experiment on an eye tracking machine. We found that the simplicity approach in Web design causes more damage rather than helping in online security, and that the current sleek design of Web pages helps users find the logon area and overlook the security indicators instead. We also found that the security certificate cue was not used by the participants to determine the legitimacy of the presented Websites. © 2012 IEEE

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Readability and Comprehensibility of Patient Information Leaflets for Antidiabetic Medications in Qatar

Background:The readability and comprehensibility of the patient information leaflets (PILs) provided with antidiabetic medications are of questionable standards; this issue negatively affects adherence to drug therapy, especially in patients with limited literacy skills. Objective: To evaluate the readability and comprehensibility of PILs supplied with medications used for the treatment of type 2 diabetes mellitus in Qatar. Methods: All PILs of the antidiabetic medications in Qatar were evaluated using the Flesch Reading Ease (FRE) score for readability. The Flesch-Kincaid Grade Level, Gunning-Fog Index, and SMOG Grading were used to estimate the comprehensibility of PILs in terms of school grade levels. Results: A total of 45 PILs were evaluated: 32 (71.1%) PILs of brand-name products and 13 (28.9%) for generics. Nine (20%) of the PILs were in English only; 8 (17.8%) were in English, Arabic, and French; and 28 (62.2%) were in English and Arabic. The mean FRE score was 37.71 (±15.85), and the most readable PIL had FRE score of 62. The mean scores for the comprehensibility evaluations were 10.96 (±2.67), 15.02 (±2.52), and 11.41 (±1.6) for the Flesch-Kincaid Grade Level, Gunning-Fog Index, and SMOG Grading, respectively. The most commonly used antidiabetic medication was metformin with 1372.9 (±552.9) as PILs’ mean number of words. Conclusion: Only 2.2% of PILs had acceptable readability scores. All PILs could be comprehended by at least an 11th grade student, which exceeds the recommended grade level for health-related materials. Approximately 20% of these PILs were in English only and were not readable by most patients.Scopu

The effect of bed rest after intrauterine insemination on pregnancy outcome

Objective: To compare the effect of bed rest after intrauterine insemination for 5, 10 and 20 mins on the pregnancy rate. Design: Randomized controlled trial. Setting: Integrated Fertility Center and Agial Fertility Center. Sample: Three hundred and 96 couples with mild male factor, cervical factor, or unexplained infertility between the periods from 1/2012 to 12/2012. Methods: Intrauterine insemination with controlled ovarian hyper-stimulation. Main outcome measures: The chemical and clinical pregnancy rates. Results: The couples were randomly subdivided equally into three groups: A, B, & C and they allocated for bed rest for 5, 10 and 20 min, respectively after insemination, the chemical and clinical pregnancy rates in group A (6.1% and 4.5%, respectively) were significantly lower than in group B (18.2% and 15.9%, respectively), and also they were significantly lower than in group C (23.5% and 19.7%, respectively), but there was no statistically significant difference in the pregnancy rates between groups B and C. Conclusions: Bed rest for 10 and 20 min after intrauterine insemination has a positive effect on the pregnancy rate, but there is no statistically significance difference between them. We recommend bed rest for at least 10 min after intrauterine insemination

Gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome

Objective: To compare between gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome. Design: Randomized controlled trial. Setting: Integrated Fertility Center and Agial Fertility Center. Sample: Fifty PCO female patients. Methods: The patients were subdivided in 2 groups according to computer generated randomized program: Group I: Twenty five PCO female patients treated by cidolut nor 5 mg tablets (two tablets every day for 5 days). Group II: Twenty five PCO female patients treated by cilest tablets (one tablet every day for 21 days). All patients were observed until withdrawal bleeding followed by ovulation induction by clomiphene citrate from the second day of menses (100 mg per day for 5 days). The patients were then followed up by: - transvaginal ultrasound follicular scanning in days 10, 12, and 14 of withdrawal bleeding until ovulation was detected with additional evaluation of the endometrial thickness and pattern - serum progesterone was measured 7 days after the expected day of ovulation - pregnancy test 15 days after ovulation to detect pregnancy and 2 weeks later by U/S to detect fetal pulsation. Main outcome measures: Endometrial thickness, number of mature follicles and serum progesterone level on day o f ovulation, and clinical pregnancy rate. Results: There was no significant difference between the two groups regarding pregnancy rate. Conclusions: A few studies show an apparent use of oral contraceptive pills in the improvement of ovulation induction by clomiphene citrate. Despite this, from the available data a causal relationship is not confirmed, so large prospective studies using larger sample size, and longer duration of treatment are needed. Meanwhile, close clinical surveillance of patients being treated with oral contraceptive pills is required

Effect of Whey Protein Edible Coating Incorporated with Mango Peel Extract on Postharvest Quality, Bioactive Compounds and Shelf Life of Broccoli

The present study evaluated the impact of edible coatings based on whey protein concentrate (WPC) and mango peel extract (MPE) on the shelf life, physicochemical, and microbial properties of minimally processed broccoli preserved at 5 ± 1 °C for 28 days. The variations in the physicochemical and microbial properties of the broccoli fresh-cuts were evaluated by determining the following parameter changes: weight loss, color, respiration rate, ascorbic acid content (AsA), sulforaphane content (SF), total phenolic content (TPC), antioxidant activity (AOA), total bacteria, fungi counts, and sensory evaluation. Broccoli fresh-cuts were treated with WPC alone or in combination with MPE (WPC/MPE) at 1% or 3%, and uncoated broccoli fresh-cuts were a control. The obtained results revealed that all the coated broccoli fresh-cuts showed lower weight loss than the uncoated broccoli fresh-cuts. The coating with WPC/MPE at 3% recorded the lowest weight loss among all treatments; however, it wasn’t significantly lower compared to WPC/MPE at 1%. The addition of MPE to WPC in coating solution at 1% and 3% resulted in a higher value of the (-a*), indicating better green color retention and decreased floret yellowing. All applied coatings significantly conserved the bioactive compounds (AsA, SF, and TPC) and AOA of broccoli fresh-cuts compared to uncoated ones. At the end of the storage period, the maximum values of the aforementioned bioactive compounds were recorded in the broccoli fresh-cuts coated with WPC/MPE at 3% followed by WPC/MPE at 1%, and WPC alone compared to uncoated broccoli fresh-cuts. The broccoli fresh-cuts coated with WPC/MPE at 3% recorded a higher score on sensory evaluation than those coated with WPC/MPE at 1%, followed by broccoli fresh-cuts coated with WPC alone. The WPC-based edible coating combined with MPE (WPC/MPE) at 3% showed the highest reduction in the total fungi and bacterial counts compared to all the other treatments

Effect of Whey Protein Edible Coating Incorporated with Mango Peel Extract on Postharvest Quality, Bioactive Compounds and Shelf Life of Broccoli

The present study evaluated the impact of edible coatings based on whey protein concentrate (WPC) and mango peel extract (MPE) on the shelf life, physicochemical, and microbial properties of minimally processed broccoli preserved at 5 &plusmn; 1 &deg;C for 28 days. The variations in the physicochemical and microbial properties of the broccoli fresh-cuts were evaluated by determining the following parameter changes: weight loss, color, respiration rate, ascorbic acid content (AsA), sulforaphane content (SF), total phenolic content (TPC), antioxidant activity (AOA), total bacteria, fungi counts, and sensory evaluation. Broccoli fresh-cuts were treated with WPC alone or in combination with MPE (WPC/MPE) at 1% or 3%, and uncoated broccoli fresh-cuts were a control. The obtained results revealed that all the coated broccoli fresh-cuts showed lower weight loss than the uncoated broccoli fresh-cuts. The coating with WPC/MPE at 3% recorded the lowest weight loss among all treatments; however, it wasn&rsquo;t significantly lower compared to WPC/MPE at 1%. The addition of MPE to WPC in coating solution at 1% and 3% resulted in a higher value of the (-a*), indicating better green color retention and decreased floret yellowing. All applied coatings significantly conserved the bioactive compounds (AsA, SF, and TPC) and AOA of broccoli fresh-cuts compared to uncoated ones. At the end of the storage period, the maximum values of the aforementioned bioactive compounds were recorded in the broccoli fresh-cuts coated with WPC/MPE at 3% followed by WPC/MPE at 1%, and WPC alone compared to uncoated broccoli fresh-cuts. The broccoli fresh-cuts coated with WPC/MPE at 3% recorded a higher score on sensory evaluation than those coated with WPC/MPE at 1%, followed by broccoli fresh-cuts coated with WPC alone. The WPC-based edible coating combined with MPE (WPC/MPE) at 3% showed the highest reduction in the total fungi and bacterial counts compared to all the other treatments